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and current treatments&#46; No patients were receiving treatment with nonsteroidal anti-inflammatory drugs&#44; anticoagulants&#44; or antiplatelet agents&#46; All patients signed an informed consent form&#44; which explained the procedure and possible side effects&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The laser used was a cooled dual system&#44; which made it possible to apply KTP laser light &#40;532<span class="elsevierStyleHsp" style=""></span>nm&#41; or Nd&#58;YAG laser light &#40;1064<span class="elsevierStyleHsp" style=""></span>nm&#41;&#46; The system comprises a sapphire crystal that serves to support the handpiece and remains at &#60;15<span class="elsevierStyleHsp" style=""></span>&#176;C thanks to a coolant &#40;distilled water&#41; circulating along the laserscope &#40;GEMINI&#44; IRIDEX Corporation&#44; California&#41;&#46; We used only Nd&#58;YAG laser light &#40;1064<span class="elsevierStyleHsp" style=""></span>nm&#41; on our patients&#46; The laser parameters applied were as follows&#58; fluence&#44; 100-200<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#59; pulse duration&#44; 30 to 65<span class="elsevierStyleHsp" style=""></span>ms&#59; and spot diameter&#44; 3-5<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The procedure was performed in the operating room&#46; All patients received 2&#37; mepivacaine before treatment&#46; Slight darkening of the area was observed during the procedure&#44; with peripheral clearing and contraction of the target tissue due to laser-induced necrosis&#46; Patients were followed up at 24<span class="elsevierStyleHsp" style=""></span>hours&#44; 1 week&#44; 1 month&#44; and 6 months&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">The vascular lesions were situated on the oral or genital mucosa&#44; as follows&#58; 6 cases of venous ectasia on the lip&#44; 3 venous malformations on the tongue&#44; and 2 venous malformations on the glans penis&#46; None of the lesions had been previously treated using other techniques&#46; Our patients were aged 14 to 89 years &#40;mean&#44; 54 years&#59; median&#44; 62 years&#41;&#46; The results of treatment of the vascular malformations are shown in <a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1-5</a> &#40;patients 7 to 11 in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The size of these lesions is specified in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The vascular dilations on the lip were all less than 10<span class="elsevierStyleHsp" style=""></span>mm&#59; the venous malformations on the tongue and glans penis were larger&#44; ranging from 18<span class="elsevierStyleHsp" style=""></span>mm &#40;smallest&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; to 30<span class="elsevierStyleHsp" style=""></span>mm &#40;largest&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Patients with several vascular malformations or larger malformations&#44; such as patients 7&#44; 8&#44; and 11&#44; underwent complementary tests&#46; Patient 7 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; underwent Doppler ultrasound&#44; which revealed a low-flow vascular lesion with no further abnormalities&#46; Two of the patients with multiple lesions&#8212;patient 8 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; and patient 11 &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#8212;underwent imaging studies&#46; Patient 8 had vascular malformations on the tongue&#44; thigh&#44; and genitals&#46; Doppler ultrasound revealed these malformations to be low-flow vascular malformations&#44; which responded very favorably to Nd&#58;YAG laser treatment&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Of particular interest&#44; patient 11&#44; who presented blue rubber bleb nevus syndrome&#44; is in follow-up in the dermatology&#44; pediatric&#44; digestive&#44; and maxillofacial surgery departments&#46; The patient has undergone several studies&#8212;imaging&#44; Doppler ultrasound&#44; magnetic resonance&#44; and endoscopy&#8212;which have shown vascular malformations involving the skin and digestive system&#44; as well as lymphangioma on the neck and right thigh&#46; The dual KTP and Nd&#58;YAG laser enabled us to treat venous malformations on both the glans penis and skin lesions at other sites&#44; with excellent results&#46; The remaining lesions were treated with surgery&#44; in the case of lymphangioma &#40;with compatible histopathology findings&#41;&#44; or with endoscopic sclerotherapy&#44; in the case of vascular malformations of the digestive system&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The remaining patients had a single venous malformation that was diagnosed based on symptoms&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Only 1 session was necessary in all cases&#46; The results were classified in terms of the degree of clearance of the lesion&#44; which was assessed using symptoms and photographs and according to a consensus of 2 dermatologists&#46; Clearance was classed as none &#40;0&#37;&#41;&#44; minimal &#40;25&#37;&#41;&#44; medium &#40;50&#37;&#41;&#44; partial &#40;75&#37;&#41;&#44; or complete &#40;100&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; This classification was similar to that used elsewhere to subjectively measure outcome&#46; Clearance was greater than 75&#37; in all cases&#46; Clearance was complete &#40;100&#37;&#41; in 9 patients &#40;81&#46;8&#37;&#41; and partial &#40;&#62;75&#37;&#41; in 2 &#40;patient 7 &#91;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#93; and patient 4 &#91;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#93;&#41;&#59; however&#44; these patients did not wish to undergo further interventions&#44; as they were satisfied with the outcome&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">As for adverse effects&#44; patient number 7 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; who was treated for a bulky lesion on the middle third of the tongue&#44; had edema and inflammation in the area and secondary discomfort on swallowing&#46; Both resolved satisfactorily after 1 week&#39;s therapy with amoxicillin-clavulanic acid and anti-inflammatory agents&#46; No adverse effects were observed in the remaining cases&#44; except for minimal edema that did not require treatment&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0070" class="elsevierStylePara elsevierViewall">Venous malformations are usually present from birth&#44; although they can become clinically more evident and lead to aesthetic and functional discomfort with time&#46; Vascular conditions can be treated with several types of laser and intense pulsed light &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Given that it does not involve surgery&#44; causes minimal discomfort&#44; and has few side effects&#44; laser treatment has become the approach of choice for previously untreatable vascular lesions&#44; such as the capillary malformation port wine stain&#46; Initially&#44; this lesion was treated with argon or ablative lasers &#40;eg&#44; CO<span class="elsevierStyleInf">2</span> or erbium-doped yttrium aluminum garnet&#41;&#46; These lasers were not very specific for the wavelengths of hemoglobin and left a permanent scar&#44; as they had to damage the surrounding dermis in order to damage the blood vessel&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Vascular lesions soon began to be treated using more specific approaches&#44; such as pulsed dye laser&#44; KTP laser&#44; or Nd&#58;YAG laser&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Variable pulse Nd&#58;YAG lasers have numerous applications in clinical practice&#44; for example&#44; treatment of telangiectasia and reticular veins and venules of the leg&#44; photorejuvenation&#44; treatment of poikiloderma of Civatte&#44; and treatment of vascular lesions&#44; especially low-flow and deep lesions&#44; such as venous malformations&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">This type of laser was first used in the 1990<span class="elsevierStyleHsp" style=""></span>s by maxillofacial surgeons&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;8</span></a> otorhinolaryngologists&#44; plastic surgeons&#44; and dermatologists<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;7&#44;9</span></a> to treat angioma&#44; capillary malformations&#44; and venous malformations at different sites&#44; with favorable results&#46; In 75&#37; of cases&#44; most lesions clear totally with 1 to 3 sessions&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;7-13</span></a> This procedure is gaining ground over the other&#44; more invasive techniques used to date &#40;surgery&#44; transfixion&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> or sclerotherapy&#41;&#44; which have more severe adverse effects&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">All published case series report that the adverse effects with Nd&#58;YAG lasers are minimal&#46; In order to reduce the side effects associated with increased temperature and tissue necrosis&#44; as well as the subsequent edema induced by this laser&#44; the system includes a contact cooling circuit in the handpiece that maintains the temperature below 15<span class="elsevierStyleHsp" style=""></span>&#176;C throughout the procedure&#46; Nevertheless&#44; after treatment with Nd&#58;YAG lasers&#44; patients can experience edema&#44; inflammation&#44; or discomfort on swallowing&#44; all of which can be managed with oral antibiotics or anti-inflammatory agents&#44; as was the case with 1 of our patients&#46; The larger the lesion&#44; the greater the tissue necrosis caused by treatment and the more intense the subsequent edema&#59; therefore&#44; more than 1 session is sometimes necessary for the lesions to clear&#46; It is important to bear this in mind&#44; since the airway could be compromised in patients with venous malformations of the oral cavity&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Combinations of Nd&#58;YAG and pulsed dye laser have also proven successful for venous malformations and dilations in the oral mucosa&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12&#44;15&#44;16</span></a> This type of laser causes a shift in the absorption spectrum of oxyhemoglobin&#44; as the pulsed dye component enables it to form methemoglobin&#44; thus exponentially increasing absorption from the Nd&#58;YAG laser light and producing a deep thermal effect at much lower doses&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;16</span></a> Published cases reveal the need for several sessions&#59; however&#44; this could be because the lesions treated were larger than those in our study&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">No comparisons between the different types of laser in the treatment of mucosal vascular lesions are available to give an indication of whether one is superior to the others&#46; Nor have any studies compared Nd&#58;YAG laser techniques with other techniques&#44; such as surgery or sclerotherapy&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">We present a series of 11 patients with mucosal venous malformations treated with a single session of Nd&#58;YAG laser light&#46; The results were excellent in all cases&#44; and no significant adverse effects were observed&#46; Our study is subject to the limitations of observational studies and does not have a control group&#44; thus restricting the validity of its findings&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In summary&#44; Nd&#58;YAG lasers are increasingly used to treat different types of low-flow &#40;venous&#41; vascular lesions&#44; such as venous malformations or vascular dilations in the form of venous lakes&#46; The treatment is fast&#44; safe&#44; and relatively easy to learn and does not cause bleeding&#46; Postoperative problems and discomfort are minimal&#44; as is potential residual scarring&#46; Therefore&#44; Nd&#58;YAG lasers are the approach of choice in the treatment of mucosal vascular lesions&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of Interest</span><p id="par0115" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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            4 => "Conclusions"
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            0 => "Resumen"
            1 => "Introducci&#243;n y objetivos"
            2 => "Pacientes y m&#233;todos"
            3 => "Resultados"
            4 => "Conclusiones"
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    "fechaRecibido" => "2010-11-14"
    "fechaAceptado" => "2011-01-25"
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            0 => "Laser therapy"
            1 => "Neodymium&#58;yttrium-aluminum-garnet laser"
            2 => "Mucosa"
            3 => "Vascular lesions"
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            0 => "Terapia l&#225;ser"
            1 => "L&#225;ser Nd&#58;YAG"
            2 => "Mucosa"
            3 => "Lesiones vasculares"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Treatment of mucosal vascular lesions is a challenge for dermatologists&#44; although various approaches have proven efficacy&#44; including surgery&#44; sclerotherapy&#44; intralesional injection of corticosteroids&#44; transfixion&#44; and laser therapy&#46; The aim of this study was to describe the results of treatment with neodymium&#58;yttrium-aluminum-garnet &#40;Nd&#58;YAG&#41; laser in 11 patients with venous malformations and varicosities&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We describe the use of variable-pulse Nd&#58;YAG to treat venous malformations or varicosities in the oral or genital mucosa of 8 women and 3 men seen in our hospital over a 1-year period&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The following laser parameters were used&#58; wavelength&#44; 1064<span class="elsevierStyleHsp" style=""></span>nm&#59; fluence&#44; 100 to 200<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#59; spot diameter&#44; 3 to 5<span class="elsevierStyleHsp" style=""></span>mm&#59; and pulse duration&#44; 30 to 65<span class="elsevierStyleHsp" style=""></span>ms&#46; The size of the lesions ranged from 5 to 30<span class="elsevierStyleHsp" style=""></span>mm&#46; In all cases&#44; a clearance of 75&#37; to 100&#37; was achieved in a single session with excellent healing and no significant side effects&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Given its efficacy and ease of use&#44; Nd&#58;YAG may become a treatment of choice for mucosal vascular lesions&#46; Comparative studies are now required to assess its potential superiority over other treatment options&#46;</p>"
      ]
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        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El tratamiento de las lesiones vasculares en las mucosas supone un reto para el dermat&#243;logo&#59; diversos tratamientos han probado su eficacia&#58; cirug&#237;a&#44; escleroterapia&#44; inyecci&#243;n intralesional de corticoides&#44; transfixi&#243;n y l&#225;ser&#46; El objetivo de este trabajo es describir los resultados del tratamiento de 11 malformaciones y ectasias venosas de mucosas con l&#225;ser Nd&#58;YAG&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Presentamos 11 pacientes&#44; 8 mujeres y tres varones con diferentes dilataciones y malformaciones venosas en la mucosa oral y genital tratados con l&#225;ser Nd&#58;YAG de pulso variable durante un a&#241;o en nuestro centro&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los par&#225;metros utilizados fueron una longitud de onda de 1&#46;064<span class="elsevierStyleHsp" style=""></span>nm&#44; una fluencia entre 100 y 200<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#44; un tama&#241;o de campo entre 3 y 5<span class="elsevierStyleHsp" style=""></span>mm y un tiempo de pulso entre 30 y 65<span class="elsevierStyleHsp" style=""></span>ms&#46; El tama&#241;o de las lesiones era de 5<span class="elsevierStyleHsp" style=""></span>mm la menor de ellas y de 30<span class="elsevierStyleHsp" style=""></span>mm la mayor&#46; En todos ellos se produjo un aclaramiento del 75-100&#37; de las lesiones con una sola sesi&#243;n&#44; con excelente cicatrizaci&#243;n y sin efectos adversos significativos&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Para el tratamiento de lesiones vasculares en las mucosas el l&#225;ser Nd&#58;YAG se posiciona como un tratamiento de elecci&#243;n por su eficacia y facilidad de uso&#44; aunque son necesarios futuros estudios comparativos que demuestren su superioridad frente a otras t&#233;cnicas&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Nu&#241;o-Gonz&#225;lez A&#44; et al&#46; Tratamiento de malformaciones vasculares de mucosas con l&#225;ser Nd&#58;YAG de pulso variable&#46; Actas Dermosifiliogr&#46;2011&#59;102&#58;717-721&#46;</p>"
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          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Venous malformation on the glans penis &#40;patient 10&#41; before and after a session of Nd&#58;YAG laser treatment &#40;fluence&#44; 130<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#59; pulse duration&#44; 30<span class="elsevierStyleHsp" style=""></span>ms&#59; spot diameter&#44; 5<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46;</p>"
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Venous malformation on the glans penis &#40;patient 11&#41; before and after a session of Nd&#58;YAG laser treatment &#40;fluence&#44; 200<span class="elsevierStyleHsp" style=""></span>J&#47;cm2&#59; pulse duration&#44; 30<span class="elsevierStyleHsp" style=""></span>ms&#59; spot diameter&#44; 3<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46;</p>"
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Abbreviation&#58; Nd&#58;YAG&#44; neodymium&#58;yttrium-aluminum-garnet&#46;</p>"
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Patient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Spot Size&#44; mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Site&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Wavelength&#44;mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Fluence&#44; J&#47;cm<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Pulse Duration&#44; ms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Spot Diameter&#44; mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Outcome&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Side Effects&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lip&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lip&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">120&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lip&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lip&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lip&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">120&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lip&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tongue&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Discomfort while swallowing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tongue&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tongue&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glans penis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glans penis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab181902.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Patients With Mucosal Venous Malformations Treated With Nd&#58;YAG&#46;</p>"
        ]
      ]
      6 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Adapted from Astner et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#46; KTP&#44; potassium titanyl phosphate&#59; Nd&#58;YAG&#44; neodymium&#58;yttrium-aluminum-garnet&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Type of Laser&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Wavelength&#44; mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Application in Types of Vascular Lesions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulsed dye&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">595&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Telangiectasia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulsed dye&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">585-600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hemangioma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Capillary malformations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Venous lakes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Venous malformations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alexandrite&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">755&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Capillary malformations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Venous lakes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diode&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">800&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Venous lakes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Venous malformations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nd&#58;YAG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1064&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Venous lakes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Venous malformations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CO<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#160;600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pyogenic granuloma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lymphatic malformations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intense pulsed light&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">500-670&#47;870-1400&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Capillary malformations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Telangiectasia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hemangioma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">KTP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">532&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Capillary malformations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Telangiectasia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab181901.png"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Types of Laser for the Treatment of Different Vascular Lesions&#46;</p>"
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      ]
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
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                      "autores" => array:1 [
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                  "host" => array:1 [
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                  "contribucion" => array:1 [
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                      "autores" => array:1 [
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                            0 => "A&#46; Vesnaver"
                            1 => "D&#46;A&#46; Dovsak"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Railan"
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                            3 => "T&#46;E&#46; Rohrer"
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                            0 => "E&#46; T&#233;var"
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                            2 => "M&#46; Moratinos"
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                        0 => array:2 [
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                    0 => array:2 [
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                            3 => "J&#46; Luo"
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                      "titulo" => "Nd&#58; YAG lasers &#40;1&#44;064<span class="elsevierStyleHsp" style=""></span>nm&#41; in the treatment of venous malformations of the face and neck&#58; challenges and benefits"
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                      "doi" => "10.1007/s10103-007-0443-0"
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                      "titulo" => "Successful treatment of large venous malformation with dual wavelength 595 and 1064<span class="elsevierStyleHsp" style=""></span>nm system"
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Información de la revista
Vol. 102. Núm. 9.
Páginas 717-721 (noviembre 2011)
Visitas
22617
Vol. 102. Núm. 9.
Páginas 717-721 (noviembre 2011)
Original article
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Treatment of Mucosal Vascular Malformations With Variable-Pulse Neodymium:Yttrium-Aluminum-Garnet Laser
Tratamiento de malformaciones vasculares de mucosas con láser Nd:YAG de pulso variable
Visitas
22617
A. Nuño-González
Autor para correspondencia
anuno@fhalcorcon.es

Corresponding author.
, E. Naz-Villalba, F.J. Vicente-Martín, A. Sánchez-Gilo, M. Gutiérrez-Pascual, E. Gómez de la Fuente, J.L. López-Estebaranz
Unidad de Dermatología, Hospital Universitario Fundación de Alcorcón, Madrid, Spain
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Table 1. Patients With Mucosal Venous Malformations Treated With Nd:YAG.
Table 2. Types of Laser for the Treatment of Different Vascular Lesions.
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Abstract
Background and objectives

Treatment of mucosal vascular lesions is a challenge for dermatologists, although various approaches have proven efficacy, including surgery, sclerotherapy, intralesional injection of corticosteroids, transfixion, and laser therapy. The aim of this study was to describe the results of treatment with neodymium:yttrium-aluminum-garnet (Nd:YAG) laser in 11 patients with venous malformations and varicosities.

Patients and methods

We describe the use of variable-pulse Nd:YAG to treat venous malformations or varicosities in the oral or genital mucosa of 8 women and 3 men seen in our hospital over a 1-year period.

Results

The following laser parameters were used: wavelength, 1064nm; fluence, 100 to 200J/cm2; spot diameter, 3 to 5mm; and pulse duration, 30 to 65ms. The size of the lesions ranged from 5 to 30mm. In all cases, a clearance of 75% to 100% was achieved in a single session with excellent healing and no significant side effects.

Conclusions

Given its efficacy and ease of use, Nd:YAG may become a treatment of choice for mucosal vascular lesions. Comparative studies are now required to assess its potential superiority over other treatment options.

Keywords:
Laser therapy
Neodymium:yttrium-aluminum-garnet laser
Mucosa
Vascular lesions
Resumen
Introducción y objetivos

El tratamiento de las lesiones vasculares en las mucosas supone un reto para el dermatólogo; diversos tratamientos han probado su eficacia: cirugía, escleroterapia, inyección intralesional de corticoides, transfixión y láser. El objetivo de este trabajo es describir los resultados del tratamiento de 11 malformaciones y ectasias venosas de mucosas con láser Nd:YAG.

Pacientes y métodos

Presentamos 11 pacientes, 8 mujeres y tres varones con diferentes dilataciones y malformaciones venosas en la mucosa oral y genital tratados con láser Nd:YAG de pulso variable durante un año en nuestro centro.

Resultados

Los parámetros utilizados fueron una longitud de onda de 1.064nm, una fluencia entre 100 y 200J/cm2, un tamaño de campo entre 3 y 5mm y un tiempo de pulso entre 30 y 65ms. El tamaño de las lesiones era de 5mm la menor de ellas y de 30mm la mayor. En todos ellos se produjo un aclaramiento del 75-100% de las lesiones con una sola sesión, con excelente cicatrización y sin efectos adversos significativos.

Conclusiones

Para el tratamiento de lesiones vasculares en las mucosas el láser Nd:YAG se posiciona como un tratamiento de elección por su eficacia y facilidad de uso, aunque son necesarios futuros estudios comparativos que demuestren su superioridad frente a otras técnicas.

Palabras clave:
Terapia láser
Láser Nd:YAG
Mucosa
Lesiones vasculares
Texto completo
Introduction

Treatment of mucosal vascular lesions is a challenge for dermatologists, yet no consensus on the technique of choice has been reached. If the lesions are large, cause functional discomfort, or bleed frequently, treatment is essential. Several options are available,1 including surgery, sclerotherapy, transfixion, intralesional injection of corticosteroids, and laser therapy, although no clear best option has been established, and few studies compare the various techniques available.1-3

Hemoglobin has absorption peaks at different wavelengths depending on oxidation state and how deep it lies in the tissue.1,2 Unlike other lasers, such as potassium titanyl phosphate (KTP) laser or pulsed dye laser, which use absorption peaks with shorter wavelengths (418, 542, and 577nm),1 the variable-pulse neodymium:yttrium-aluminum-garnet (Nd:YAG) vascular laser has a wavelength of 1064nm and uses deoxyhemoglobin absorption peaks ranging from 800nm to 1000nm.1-4 These characteristics make it an ideal choice for venous lesions, given its affinity for deoxyhemoglobin, its ability to penetrate tissue, and its minimal invasiveness; therefore, this device may prove to be the technique of choice for the treatment of mucosal vascular lesions, especially venous dilations and malformations.1,2,4,5

We present our experience using a variable-pulse Nd:YAG laser to treat 11 patients with different types of venous dilation and malformations on the oral and genital mucosa at our center over 1 year.

Patients and Methods

We present a cross-sectional observational study of a series of 11 patients, all of whom had mucosal venous dilations and malformations. Treatment was administered from June 2008 until September 2009.

Before treatment, we took a full clinical history, which included allergy, concomitant conditions, and current treatments. No patients were receiving treatment with nonsteroidal anti-inflammatory drugs, anticoagulants, or antiplatelet agents. All patients signed an informed consent form, which explained the procedure and possible side effects.

The laser used was a cooled dual system, which made it possible to apply KTP laser light (532nm) or Nd:YAG laser light (1064nm). The system comprises a sapphire crystal that serves to support the handpiece and remains at <15°C thanks to a coolant (distilled water) circulating along the laserscope (GEMINI, IRIDEX Corporation, California). We used only Nd:YAG laser light (1064nm) on our patients. The laser parameters applied were as follows: fluence, 100-200J/cm2; pulse duration, 30 to 65ms; and spot diameter, 3-5mm (Table 1).

Table 1.

Patients With Mucosal Venous Malformations Treated With Nd:YAG.

Patient  Sex  Spot Size, mm  Site  Wavelength,mm  Fluence, J/cm2  Pulse Duration, ms  Spot Diameter, mm  Outcome, %  Side Effects 
Female  Lip  1064  100  50  100  None 
Male  Lip  1064  120  50  100  None 
Female  Lip  1064  100  50  100  None 
Female  Lip  1064  100  50  100  None 
Female  Lip  1064  120  50  100  None 
Female  Lip  1064  200  30  100  None 
Female  30  Tongue  1064  200  30  75  Discomfort while swallowing 
Female  20  Tongue  1064  200  35  100  None 
Female  18  Tongue  1064  200  35  100  None 
10  Male  27  Glans penis  1064  130  65  75  None 
11  Male  24  Glans penis  1064  200  30  100  None 

Abbreviation: Nd:YAG, neodymium:yttrium-aluminum-garnet.

The procedure was performed in the operating room. All patients received 2% mepivacaine before treatment. Slight darkening of the area was observed during the procedure, with peripheral clearing and contraction of the target tissue due to laser-induced necrosis. Patients were followed up at 24hours, 1 week, 1 month, and 6 months.

Results

The vascular lesions were situated on the oral or genital mucosa, as follows: 6 cases of venous ectasia on the lip, 3 venous malformations on the tongue, and 2 venous malformations on the glans penis. None of the lesions had been previously treated using other techniques. Our patients were aged 14 to 89 years (mean, 54 years; median, 62 years). The results of treatment of the vascular malformations are shown in Figs. 1-5 (patients 7 to 11 in Table 1). The size of these lesions is specified in Table 1. The vascular dilations on the lip were all less than 10mm; the venous malformations on the tongue and glans penis were larger, ranging from 18mm (smallest) (Fig. 3) to 30mm (largest) (Fig. 1).

Figure 1.

Venous malformation on the tongue (patient 7) before and after a session of Nd:YAG laser treatment (fluence, 200J/cm2; pulse duration, 30ms; spot diameter, 3mm).

(0.07MB).
Figure 2.

Venous malformation on the tongue (patient 8) before and after a session of Nd:YAG laser treatment (fluence, 200J/cm2; pulse duration, 35ms; spot diameter, 3mm).

(0.09MB).
Figure 3.

Venous malformation on the tongue (patient 9) before and after a session of Nd:YAG laser treatment (fluence, 200J/cm2; pulse duration, 35ms; spot diameter, 3mm).

(0.07MB).
Figure 4.

Venous malformation on the glans penis (patient 10) before and after a session of Nd:YAG laser treatment (fluence, 130J/cm2; pulse duration, 30ms; spot diameter, 5mm).

(0.09MB).
Figure 5.

Venous malformation on the glans penis (patient 11) before and after a session of Nd:YAG laser treatment (fluence, 200J/cm2; pulse duration, 30ms; spot diameter, 3mm).

(0.07MB).

Patients with several vascular malformations or larger malformations, such as patients 7, 8, and 11, underwent complementary tests. Patient 7 (Fig. 1) underwent Doppler ultrasound, which revealed a low-flow vascular lesion with no further abnormalities. Two of the patients with multiple lesions—patient 8 (Fig. 2) and patient 11 (Fig. 5)—underwent imaging studies. Patient 8 had vascular malformations on the tongue, thigh, and genitals. Doppler ultrasound revealed these malformations to be low-flow vascular malformations, which responded very favorably to Nd:YAG laser treatment.

Of particular interest, patient 11, who presented blue rubber bleb nevus syndrome, is in follow-up in the dermatology, pediatric, digestive, and maxillofacial surgery departments. The patient has undergone several studies—imaging, Doppler ultrasound, magnetic resonance, and endoscopy—which have shown vascular malformations involving the skin and digestive system, as well as lymphangioma on the neck and right thigh. The dual KTP and Nd:YAG laser enabled us to treat venous malformations on both the glans penis and skin lesions at other sites, with excellent results. The remaining lesions were treated with surgery, in the case of lymphangioma (with compatible histopathology findings), or with endoscopic sclerotherapy, in the case of vascular malformations of the digestive system.

The remaining patients had a single venous malformation that was diagnosed based on symptoms.

Only 1 session was necessary in all cases. The results were classified in terms of the degree of clearance of the lesion, which was assessed using symptoms and photographs and according to a consensus of 2 dermatologists. Clearance was classed as none (0%), minimal (25%), medium (50%), partial (75%), or complete (100%) (Table 1). This classification was similar to that used elsewhere to subjectively measure outcome. Clearance was greater than 75% in all cases. Clearance was complete (100%) in 9 patients (81.8%) and partial (>75%) in 2 (patient 7 [Fig. 1] and patient 4 [Fig. 4]); however, these patients did not wish to undergo further interventions, as they were satisfied with the outcome.

As for adverse effects, patient number 7 (Fig. 1), who was treated for a bulky lesion on the middle third of the tongue, had edema and inflammation in the area and secondary discomfort on swallowing. Both resolved satisfactorily after 1 week's therapy with amoxicillin-clavulanic acid and anti-inflammatory agents. No adverse effects were observed in the remaining cases, except for minimal edema that did not require treatment.

Discussion

Venous malformations are usually present from birth, although they can become clinically more evident and lead to aesthetic and functional discomfort with time. Vascular conditions can be treated with several types of laser and intense pulsed light (Table 2).1

Table 2.

Types of Laser for the Treatment of Different Vascular Lesions.

Type of Laser  Wavelength, mm  Application in Types of Vascular Lesions 
Pulsed dye  595  Telangiectasia 
Pulsed dye  585-600  Hemangioma 
    Capillary malformations 
    Venous lakes 
    Venous malformations 
Alexandrite  755  Capillary malformations 
    Venous lakes 
Diode  800  Venous lakes 
    Venous malformations 
Nd:YAG  1064  Venous lakes 
    Venous malformations 
CO2  10 600  Pyogenic granuloma 
    Lymphatic malformations 
Intense pulsed light  500-670/870-1400  Capillary malformations 
    Telangiectasia 
    Hemangioma 
KTP  532  Capillary malformations 
    Telangiectasia 

Adapted from Astner et al.1

Abbreviations. KTP, potassium titanyl phosphate; Nd:YAG, neodymium:yttrium-aluminum-garnet.

Given that it does not involve surgery, causes minimal discomfort, and has few side effects, laser treatment has become the approach of choice for previously untreatable vascular lesions, such as the capillary malformation port wine stain. Initially, this lesion was treated with argon or ablative lasers (eg, CO2 or erbium-doped yttrium aluminum garnet). These lasers were not very specific for the wavelengths of hemoglobin and left a permanent scar, as they had to damage the surrounding dermis in order to damage the blood vessel.5 Vascular lesions soon began to be treated using more specific approaches, such as pulsed dye laser, KTP laser, or Nd:YAG laser.6

Variable pulse Nd:YAG lasers have numerous applications in clinical practice, for example, treatment of telangiectasia and reticular veins and venules of the leg, photorejuvenation, treatment of poikiloderma of Civatte, and treatment of vascular lesions, especially low-flow and deep lesions, such as venous malformations.7

This type of laser was first used in the 1990s by maxillofacial surgeons,4,8 otorhinolaryngologists, plastic surgeons, and dermatologists2,7,9 to treat angioma, capillary malformations, and venous malformations at different sites, with favorable results. In 75% of cases, most lesions clear totally with 1 to 3 sessions.4,7-13 This procedure is gaining ground over the other, more invasive techniques used to date (surgery, transfixion,14 or sclerotherapy), which have more severe adverse effects.

All published case series report that the adverse effects with Nd:YAG lasers are minimal. In order to reduce the side effects associated with increased temperature and tissue necrosis, as well as the subsequent edema induced by this laser, the system includes a contact cooling circuit in the handpiece that maintains the temperature below 15°C throughout the procedure. Nevertheless, after treatment with Nd:YAG lasers, patients can experience edema, inflammation, or discomfort on swallowing, all of which can be managed with oral antibiotics or anti-inflammatory agents, as was the case with 1 of our patients. The larger the lesion, the greater the tissue necrosis caused by treatment and the more intense the subsequent edema; therefore, more than 1 session is sometimes necessary for the lesions to clear. It is important to bear this in mind, since the airway could be compromised in patients with venous malformations of the oral cavity.

Combinations of Nd:YAG and pulsed dye laser have also proven successful for venous malformations and dilations in the oral mucosa.11,12,15,16 This type of laser causes a shift in the absorption spectrum of oxyhemoglobin, as the pulsed dye component enables it to form methemoglobin, thus exponentially increasing absorption from the Nd:YAG laser light and producing a deep thermal effect at much lower doses.12,16 Published cases reveal the need for several sessions; however, this could be because the lesions treated were larger than those in our study.

No comparisons between the different types of laser in the treatment of mucosal vascular lesions are available to give an indication of whether one is superior to the others. Nor have any studies compared Nd:YAG laser techniques with other techniques, such as surgery or sclerotherapy.

We present a series of 11 patients with mucosal venous malformations treated with a single session of Nd:YAG laser light. The results were excellent in all cases, and no significant adverse effects were observed. Our study is subject to the limitations of observational studies and does not have a control group, thus restricting the validity of its findings.

In summary, Nd:YAG lasers are increasingly used to treat different types of low-flow (venous) vascular lesions, such as venous malformations or vascular dilations in the form of venous lakes. The treatment is fast, safe, and relatively easy to learn and does not cause bleeding. Postoperative problems and discomfort are minimal, as is potential residual scarring. Therefore, Nd:YAG lasers are the approach of choice in the treatment of mucosal vascular lesions.

Conflict of Interest

The authors declare that they have no conflicts of interest.

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Please cite this article as: Nuño-González A, et al. Tratamiento de malformaciones vasculares de mucosas con láser Nd:YAG de pulso variable. Actas Dermosifiliogr.2011;102:717-721.

Copyright © 2010. Elsevier España, S.L. and AEDV
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