Original article
Treatment of Mucosal Vascular Malformations With Variable-Pulse Neodymium:Yttrium-Aluminum-Garnet Laser
Tratamiento de malformaciones vasculares de mucosas con láser Nd:YAG de pulso variable
A. Nuño-González
, E. Naz-Villalba, F.J. Vicente-Martín, A. Sánchez-Gilo, M. Gutiérrez-Pascual, E. Gómez de la Fuente, J.L. López-Estebaranz
Autor para correspondencia
Unidad de Dermatología, Hospital Universitario Fundación de Alcorcón, Madrid, Spain
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Nuño-González, E. Naz-Villalba, F.J. Vicente-Martín, A. Sánchez-Gilo, M. Gutiérrez-Pascual, E. Gómez de la Fuente, J.L. López-Estebaranz" "autores" => array:7 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Nuño-González" "email" => array:1 [ 0 => "anuno@fhalcorcon.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Naz-Villalba" ] 2 => array:2 [ "nombre" => "F.J." "apellidos" => "Vicente-Martín" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Sánchez-Gilo" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Gutiérrez-Pascual" ] 5 => array:2 [ "nombre" => "E." "apellidos" => "Gómez de la Fuente" ] 6 => array:2 [ "nombre" => "J.L." "apellidos" => "López-Estebaranz" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Dermatología, Hospital Universitario Fundación de Alcorcón, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento de malformaciones vasculares de mucosas con láser Nd:YAG de pulso variable" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 488 "Ancho" => 990 "Tamanyo" => 73174 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Venous malformation on the glans penis (patient 11) before and after a session of Nd:YAG laser treatment (fluence, 200<span class="elsevierStyleHsp" style=""></span>J/cm2; pulse duration, 30<span class="elsevierStyleHsp" style=""></span>ms; spot diameter, 3<span class="elsevierStyleHsp" style=""></span>mm).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Treatment of mucosal vascular lesions is a challenge for dermatologists, yet no consensus on the technique of choice has been reached. If the lesions are large, cause functional discomfort, or bleed frequently, treatment is essential. Several options are available,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> including surgery, sclerotherapy, transfixion, intralesional injection of corticosteroids, and laser therapy, although no clear best option has been established, and few studies compare the various techniques available.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1-3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Hemoglobin has absorption peaks at different wavelengths depending on oxidation state and how deep it lies in the tissue.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> Unlike other lasers, such as potassium titanyl phosphate (KTP) laser or pulsed dye laser, which use absorption peaks with shorter wavelengths (418, 542, and 577<span class="elsevierStyleHsp" style=""></span>nm),<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> the variable-pulse neodymium:yttrium-aluminum-garnet (Nd:YAG) vascular laser has a wavelength of 1064<span class="elsevierStyleHsp" style=""></span>nm and uses deoxyhemoglobin absorption peaks ranging from 800<span class="elsevierStyleHsp" style=""></span>nm to 1000<span class="elsevierStyleHsp" style=""></span>nm.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1-4</span></a> These characteristics make it an ideal choice for venous lesions, given its affinity for deoxyhemoglobin, its ability to penetrate tissue, and its minimal invasiveness; therefore, this device may prove to be the technique of choice for the treatment of mucosal vascular lesions, especially venous dilations and malformations.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2,4,5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We present our experience using a variable-pulse Nd:YAG laser to treat 11 patients with different types of venous dilation and malformations on the oral and genital mucosa at our center over 1 year.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Patients and Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">We present a cross-sectional observational study of a series of 11 patients, all of whom had mucosal venous dilations and malformations. Treatment was administered from June 2008 until September 2009.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Before treatment, we took a full clinical history, which included allergy, concomitant conditions, and current treatments. No patients were receiving treatment with nonsteroidal anti-inflammatory drugs, anticoagulants, or antiplatelet agents. All patients signed an informed consent form, which explained the procedure and possible side effects.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The laser used was a cooled dual system, which made it possible to apply KTP laser light (532<span class="elsevierStyleHsp" style=""></span>nm) or Nd:YAG laser light (1064<span class="elsevierStyleHsp" style=""></span>nm). The system comprises a sapphire crystal that serves to support the handpiece and remains at <15<span class="elsevierStyleHsp" style=""></span>°C thanks to a coolant (distilled water) circulating along the laserscope (GEMINI, IRIDEX Corporation, California). We used only Nd:YAG laser light (1064<span class="elsevierStyleHsp" style=""></span>nm) on our patients. The laser parameters applied were as follows: fluence, 100-200<span class="elsevierStyleHsp" style=""></span>J/cm<span class="elsevierStyleSup">2</span>; pulse duration, 30 to 65<span class="elsevierStyleHsp" style=""></span>ms; and spot diameter, 3-5<span class="elsevierStyleHsp" style=""></span>mm (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The procedure was performed in the operating room. All patients received 2% mepivacaine before treatment. Slight darkening of the area was observed during the procedure, with peripheral clearing and contraction of the target tissue due to laser-induced necrosis. Patients were followed up at 24<span class="elsevierStyleHsp" style=""></span>hours, 1 week, 1 month, and 6 months.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">The vascular lesions were situated on the oral or genital mucosa, as follows: 6 cases of venous ectasia on the lip, 3 venous malformations on the tongue, and 2 venous malformations on the glans penis. None of the lesions had been previously treated using other techniques. Our patients were aged 14 to 89 years (mean, 54 years; median, 62 years). The results of treatment of the vascular malformations are shown in <a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1-5</a> (patients 7 to 11 in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The size of these lesions is specified in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. The vascular dilations on the lip were all less than 10<span class="elsevierStyleHsp" style=""></span>mm; the venous malformations on the tongue and glans penis were larger, ranging from 18<span class="elsevierStyleHsp" style=""></span>mm (smallest) (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>) to 30<span class="elsevierStyleHsp" style=""></span>mm (largest) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Patients with several vascular malformations or larger malformations, such as patients 7, 8, and 11, underwent complementary tests. Patient 7 (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) underwent Doppler ultrasound, which revealed a low-flow vascular lesion with no further abnormalities. Two of the patients with multiple lesions—patient 8 (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) and patient 11 (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>)—underwent imaging studies. Patient 8 had vascular malformations on the tongue, thigh, and genitals. Doppler ultrasound revealed these malformations to be low-flow vascular malformations, which responded very favorably to Nd:YAG laser treatment.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Of particular interest, patient 11, who presented blue rubber bleb nevus syndrome, is in follow-up in the dermatology, pediatric, digestive, and maxillofacial surgery departments. The patient has undergone several studies—imaging, Doppler ultrasound, magnetic resonance, and endoscopy—which have shown vascular malformations involving the skin and digestive system, as well as lymphangioma on the neck and right thigh. The dual KTP and Nd:YAG laser enabled us to treat venous malformations on both the glans penis and skin lesions at other sites, with excellent results. The remaining lesions were treated with surgery, in the case of lymphangioma (with compatible histopathology findings), or with endoscopic sclerotherapy, in the case of vascular malformations of the digestive system.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The remaining patients had a single venous malformation that was diagnosed based on symptoms.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Only 1 session was necessary in all cases. The results were classified in terms of the degree of clearance of the lesion, which was assessed using symptoms and photographs and according to a consensus of 2 dermatologists. Clearance was classed as none (0%), minimal (25%), medium (50%), partial (75%), or complete (100%) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). This classification was similar to that used elsewhere to subjectively measure outcome. Clearance was greater than 75% in all cases. Clearance was complete (100%) in 9 patients (81.8%) and partial (>75%) in 2 (patient 7 [<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>] and patient 4 [<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>]); however, these patients did not wish to undergo further interventions, as they were satisfied with the outcome.</p><p id="par0065" class="elsevierStylePara elsevierViewall">As for adverse effects, patient number 7 (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), who was treated for a bulky lesion on the middle third of the tongue, had edema and inflammation in the area and secondary discomfort on swallowing. Both resolved satisfactorily after 1 week's therapy with amoxicillin-clavulanic acid and anti-inflammatory agents. No adverse effects were observed in the remaining cases, except for minimal edema that did not require treatment.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0070" class="elsevierStylePara elsevierViewall">Venous malformations are usually present from birth, although they can become clinically more evident and lead to aesthetic and functional discomfort with time. Vascular conditions can be treated with several types of laser and intense pulsed light (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Given that it does not involve surgery, causes minimal discomfort, and has few side effects, laser treatment has become the approach of choice for previously untreatable vascular lesions, such as the capillary malformation port wine stain. Initially, this lesion was treated with argon or ablative lasers (eg, CO<span class="elsevierStyleInf">2</span> or erbium-doped yttrium aluminum garnet). These lasers were not very specific for the wavelengths of hemoglobin and left a permanent scar, as they had to damage the surrounding dermis in order to damage the blood vessel.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Vascular lesions soon began to be treated using more specific approaches, such as pulsed dye laser, KTP laser, or Nd:YAG laser.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Variable pulse Nd:YAG lasers have numerous applications in clinical practice, for example, treatment of telangiectasia and reticular veins and venules of the leg, photorejuvenation, treatment of poikiloderma of Civatte, and treatment of vascular lesions, especially low-flow and deep lesions, such as venous malformations.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">This type of laser was first used in the 1990<span class="elsevierStyleHsp" style=""></span>s by maxillofacial surgeons,<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,8</span></a> otorhinolaryngologists, plastic surgeons, and dermatologists<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,7,9</span></a> to treat angioma, capillary malformations, and venous malformations at different sites, with favorable results. In 75% of cases, most lesions clear totally with 1 to 3 sessions.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,7-13</span></a> This procedure is gaining ground over the other, more invasive techniques used to date (surgery, transfixion,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> or sclerotherapy), which have more severe adverse effects.</p><p id="par0090" class="elsevierStylePara elsevierViewall">All published case series report that the adverse effects with Nd:YAG lasers are minimal. In order to reduce the side effects associated with increased temperature and tissue necrosis, as well as the subsequent edema induced by this laser, the system includes a contact cooling circuit in the handpiece that maintains the temperature below 15<span class="elsevierStyleHsp" style=""></span>°C throughout the procedure. Nevertheless, after treatment with Nd:YAG lasers, patients can experience edema, inflammation, or discomfort on swallowing, all of which can be managed with oral antibiotics or anti-inflammatory agents, as was the case with 1 of our patients. The larger the lesion, the greater the tissue necrosis caused by treatment and the more intense the subsequent edema; therefore, more than 1 session is sometimes necessary for the lesions to clear. It is important to bear this in mind, since the airway could be compromised in patients with venous malformations of the oral cavity.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Combinations of Nd:YAG and pulsed dye laser have also proven successful for venous malformations and dilations in the oral mucosa.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12,15,16</span></a> This type of laser causes a shift in the absorption spectrum of oxyhemoglobin, as the pulsed dye component enables it to form methemoglobin, thus exponentially increasing absorption from the Nd:YAG laser light and producing a deep thermal effect at much lower doses.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12,16</span></a> Published cases reveal the need for several sessions; however, this could be because the lesions treated were larger than those in our study.</p><p id="par0100" class="elsevierStylePara elsevierViewall">No comparisons between the different types of laser in the treatment of mucosal vascular lesions are available to give an indication of whether one is superior to the others. Nor have any studies compared Nd:YAG laser techniques with other techniques, such as surgery or sclerotherapy.</p><p id="par0105" class="elsevierStylePara elsevierViewall">We present a series of 11 patients with mucosal venous malformations treated with a single session of Nd:YAG laser light. The results were excellent in all cases, and no significant adverse effects were observed. Our study is subject to the limitations of observational studies and does not have a control group, thus restricting the validity of its findings.</p><p id="par0110" class="elsevierStylePara elsevierViewall">In summary, Nd:YAG lasers are increasingly used to treat different types of low-flow (venous) vascular lesions, such as venous malformations or vascular dilations in the form of venous lakes. The treatment is fast, safe, and relatively easy to learn and does not cause bleeding. Postoperative problems and discomfort are minimal, as is potential residual scarring. Therefore, Nd:YAG lasers are the approach of choice in the treatment of mucosal vascular lesions.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of Interest</span><p id="par0115" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:2 [ "identificador" => "xres95424" "titulo" => array:5 [ 0 => "Abstract" 1 => "Background and objectives" 2 => "Patients and methods" 3 => "Results" 4 => "Conclusions" ] ] 1 => array:2 [ "identificador" => "xpalclavsec82583" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres95423" "titulo" => array:5 [ 0 => "Resumen" 1 => "Introducción y objetivos" 2 => "Pacientes y métodos" 3 => "Resultados" 4 => "Conclusiones" ] ] 3 => array:2 [ "identificador" => "xpalclavsec82584" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Patients and Methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflict of Interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-11-14" "fechaAceptado" => "2011-01-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec82583" "palabras" => array:4 [ 0 => "Laser therapy" 1 => "Neodymium:yttrium-aluminum-garnet laser" 2 => "Mucosa" 3 => "Vascular lesions" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82584" "palabras" => array:4 [ 0 => "Terapia láser" 1 => "Láser Nd:YAG" 2 => "Mucosa" 3 => "Lesiones vasculares" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Treatment of mucosal vascular lesions is a challenge for dermatologists, although various approaches have proven efficacy, including surgery, sclerotherapy, intralesional injection of corticosteroids, transfixion, and laser therapy. The aim of this study was to describe the results of treatment with neodymium:yttrium-aluminum-garnet (Nd:YAG) laser in 11 patients with venous malformations and varicosities.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We describe the use of variable-pulse Nd:YAG to treat venous malformations or varicosities in the oral or genital mucosa of 8 women and 3 men seen in our hospital over a 1-year period.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The following laser parameters were used: wavelength, 1064<span class="elsevierStyleHsp" style=""></span>nm; fluence, 100 to 200<span class="elsevierStyleHsp" style=""></span>J/cm<span class="elsevierStyleSup">2</span>; spot diameter, 3 to 5<span class="elsevierStyleHsp" style=""></span>mm; and pulse duration, 30 to 65<span class="elsevierStyleHsp" style=""></span>ms. The size of the lesions ranged from 5 to 30<span class="elsevierStyleHsp" style=""></span>mm. In all cases, a clearance of 75% to 100% was achieved in a single session with excellent healing and no significant side effects.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Given its efficacy and ease of use, Nd:YAG may become a treatment of choice for mucosal vascular lesions. Comparative studies are now required to assess its potential superiority over other treatment options.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El tratamiento de las lesiones vasculares en las mucosas supone un reto para el dermatólogo; diversos tratamientos han probado su eficacia: cirugía, escleroterapia, inyección intralesional de corticoides, transfixión y láser. El objetivo de este trabajo es describir los resultados del tratamiento de 11 malformaciones y ectasias venosas de mucosas con láser Nd:YAG.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Presentamos 11 pacientes, 8 mujeres y tres varones con diferentes dilataciones y malformaciones venosas en la mucosa oral y genital tratados con láser Nd:YAG de pulso variable durante un año en nuestro centro.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los parámetros utilizados fueron una longitud de onda de 1.064<span class="elsevierStyleHsp" style=""></span>nm, una fluencia entre 100 y 200<span class="elsevierStyleHsp" style=""></span>J/cm<span class="elsevierStyleSup">2</span>, un tamaño de campo entre 3 y 5<span class="elsevierStyleHsp" style=""></span>mm y un tiempo de pulso entre 30 y 65<span class="elsevierStyleHsp" style=""></span>ms. El tamaño de las lesiones era de 5<span class="elsevierStyleHsp" style=""></span>mm la menor de ellas y de 30<span class="elsevierStyleHsp" style=""></span>mm la mayor. En todos ellos se produjo un aclaramiento del 75-100% de las lesiones con una sola sesión, con excelente cicatrización y sin efectos adversos significativos.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Para el tratamiento de lesiones vasculares en las mucosas el láser Nd:YAG se posiciona como un tratamiento de elección por su eficacia y facilidad de uso, aunque son necesarios futuros estudios comparativos que demuestren su superioridad frente a otras técnicas.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Nuño-González A, et al. Tratamiento de malformaciones vasculares de mucosas con láser Nd:YAG de pulso variable. Actas Dermosifiliogr.2011;102:717-721.</p>" ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 444 "Ancho" => 990 "Tamanyo" => 77931 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Venous malformation on the tongue (patient 7) before and after a session of Nd:YAG laser treatment (fluence, 200<span class="elsevierStyleHsp" style=""></span>J/cm<span class="elsevierStyleSup">2</span>; pulse duration, 30<span class="elsevierStyleHsp" style=""></span>ms; spot diameter, 3<span class="elsevierStyleHsp" style=""></span>mm).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 491 "Ancho" => 990 "Tamanyo" => 99255 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Venous malformation on the tongue (patient 8) before and after a session of Nd:YAG laser treatment (fluence, 200<span class="elsevierStyleHsp" style=""></span>J/cm<span class="elsevierStyleSup">2</span>; pulse duration, 35<span class="elsevierStyleHsp" style=""></span>ms; spot diameter, 3<span class="elsevierStyleHsp" style=""></span>mm).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 388 "Ancho" => 990 "Tamanyo" => 72919 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Venous malformation on the tongue (patient 9) before and after a session of Nd:YAG laser treatment (fluence, 200<span class="elsevierStyleHsp" style=""></span>J/cm<span class="elsevierStyleSup">2</span>; pulse duration, 35<span class="elsevierStyleHsp" style=""></span>ms; spot diameter, 3<span class="elsevierStyleHsp" style=""></span>mm).</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 503 "Ancho" => 990 "Tamanyo" => 91364 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Venous malformation on the glans penis (patient 10) before and after a session of Nd:YAG laser treatment (fluence, 130<span class="elsevierStyleHsp" style=""></span>J/cm<span class="elsevierStyleSup">2</span>; pulse duration, 30<span class="elsevierStyleHsp" style=""></span>ms; spot diameter, 5<span class="elsevierStyleHsp" style=""></span>mm).</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 488 "Ancho" => 990 "Tamanyo" => 73174 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Venous malformation on the glans penis (patient 11) before and after a session of Nd:YAG laser treatment (fluence, 200<span class="elsevierStyleHsp" style=""></span>J/cm2; pulse duration, 30<span class="elsevierStyleHsp" style=""></span>ms; spot diameter, 3<span class="elsevierStyleHsp" style=""></span>mm).</p>" ] ] 5 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Abbreviation: Nd:YAG, neodymium:yttrium-aluminum-garnet.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Patient \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Sex \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Spot Size, mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Site \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Wavelength,mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Fluence, J/cm<span class="elsevierStyleSup">2</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Pulse Duration, ms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Spot Diameter, mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Outcome, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Side Effects \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lip \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lip \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">120 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lip \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lip \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lip \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">120 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lip \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">200 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tongue \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">200 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Discomfort while swallowing \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tongue \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">200 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tongue \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">200 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Glans penis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">130 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Glans penis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">200 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">None \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab181902.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Patients With Mucosal Venous Malformations Treated With Nd:YAG.</p>" ] ] 6 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Adapted from Astner et al.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Abbreviations. KTP, potassium titanyl phosphate; Nd:YAG, neodymium:yttrium-aluminum-garnet.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Type of Laser \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Wavelength, mm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Application in Types of Vascular Lesions \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pulsed dye \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">595 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Telangiectasia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pulsed dye \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">585-600 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hemangioma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Capillary malformations \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Venous lakes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Venous malformations \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Alexandrite \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">755 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Capillary malformations \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Venous lakes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diode \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">800 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Venous lakes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Venous malformations \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Nd:YAG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1064 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Venous lakes \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Venous malformations \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CO<span class="elsevierStyleInf">2</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 600 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pyogenic granuloma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lymphatic malformations \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intense pulsed light \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">500-670/870-1400 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Capillary malformations \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Telangiectasia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hemangioma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">KTP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">532 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Capillary malformations \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Telangiectasia \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab181901.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Types of Laser for the Treatment of Different Vascular Lesions.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treating vascular lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 12 | 10 | 22 |
| 2024 Octubre | 70 | 45 | 115 |
| 2024 Septiembre | 79 | 35 | 114 |
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| 2024 Junio | 123 | 44 | 167 |
| 2024 Mayo | 94 | 51 | 145 |
| 2024 Abril | 81 | 26 | 107 |
| 2024 Marzo | 121 | 39 | 160 |
| 2024 Febrero | 73 | 29 | 102 |
| 2024 Enero | 87 | 42 | 129 |
| 2023 Diciembre | 74 | 30 | 104 |
| 2023 Noviembre | 92 | 32 | 124 |
| 2023 Octubre | 95 | 17 | 112 |
| 2023 Septiembre | 104 | 37 | 141 |
| 2023 Agosto | 58 | 23 | 81 |
| 2023 Julio | 106 | 35 | 141 |
| 2023 Junio | 61 | 24 | 85 |
| 2023 Mayo | 93 | 31 | 124 |
| 2023 Abril | 77 | 32 | 109 |
| 2023 Marzo | 87 | 46 | 133 |
| 2023 Febrero | 118 | 19 | 137 |
| 2023 Enero | 109 | 40 | 149 |
| 2022 Diciembre | 112 | 57 | 169 |
| 2022 Noviembre | 93 | 24 | 117 |
| 2022 Octubre | 103 | 24 | 127 |
| 2022 Septiembre | 64 | 34 | 98 |
| 2022 Agosto | 108 | 31 | 139 |
| 2022 Julio | 74 | 45 | 119 |
| 2022 Junio | 86 | 36 | 122 |
| 2022 Mayo | 139 | 51 | 190 |
| 2022 Abril | 117 | 34 | 151 |
| 2022 Marzo | 95 | 67 | 162 |
| 2022 Febrero | 93 | 44 | 137 |
| 2022 Enero | 121 | 56 | 177 |
| 2021 Diciembre | 72 | 47 | 119 |
| 2021 Noviembre | 94 | 39 | 133 |
| 2021 Octubre | 107 | 53 | 160 |
| 2021 Septiembre | 81 | 46 | 127 |
| 2021 Agosto | 94 | 46 | 140 |
| 2021 Julio | 79 | 42 | 121 |
| 2021 Junio | 132 | 54 | 186 |
| 2021 Mayo | 77 | 56 | 133 |
| 2021 Abril | 82 | 54 | 136 |
| 2021 Marzo | 68 | 43 | 111 |
| 2021 Febrero | 67 | 32 | 99 |
| 2021 Enero | 25 | 29 | 54 |
| 2020 Diciembre | 34 | 24 | 58 |
| 2020 Noviembre | 29 | 34 | 63 |
| 2020 Octubre | 24 | 27 | 51 |
| 2020 Septiembre | 32 | 29 | 61 |
| 2020 Agosto | 29 | 33 | 62 |
| 2020 Julio | 26 | 32 | 58 |
| 2020 Junio | 45 | 39 | 84 |
| 2020 Mayo | 27 | 24 | 51 |
| 2020 Abril | 34 | 36 | 70 |
| 2020 Marzo | 58 | 51 | 109 |
| 2020 Febrero | 4 | 1 | 5 |
| 2020 Enero | 0 | 7 | 7 |
| 2019 Diciembre | 4 | 1 | 5 |
| 2019 Noviembre | 0 | 4 | 4 |
| 2019 Octubre | 0 | 4 | 4 |
| 2019 Septiembre | 6 | 17 | 23 |
| 2019 Agosto | 0 | 5 | 5 |
| 2019 Julio | 0 | 6 | 6 |
| 2019 Mayo | 2 | 12 | 14 |
| 2019 Abril | 0 | 6 | 6 |
| 2019 Marzo | 0 | 10 | 10 |
| 2019 Febrero | 2 | 0 | 2 |
| 2018 Diciembre | 1 | 0 | 1 |
| 2018 Noviembre | 3 | 0 | 3 |
| 2018 Octubre | 1 | 0 | 1 |
| 2018 Septiembre | 1 | 3 | 4 |
| 2018 Agosto | 0 | 3 | 3 |
| 2018 Julio | 0 | 2 | 2 |
| 2018 Mayo | 0 | 6 | 6 |
| 2018 Abril | 0 | 4 | 4 |
| 2018 Marzo | 9 | 1 | 10 |
| 2018 Febrero | 171 | 12 | 183 |
| 2018 Enero | 215 | 16 | 231 |
| 2017 Diciembre | 275 | 15 | 290 |
| 2017 Noviembre | 263 | 10 | 273 |
| 2017 Octubre | 211 | 12 | 223 |
| 2017 Septiembre | 284 | 12 | 296 |
| 2017 Agosto | 252 | 14 | 266 |
| 2017 Julio | 173 | 7 | 180 |
| 2017 Junio | 163 | 39 | 202 |
| 2017 Mayo | 102 | 14 | 116 |
| 2017 Abril | 159 | 11 | 170 |
| 2017 Marzo | 98 | 30 | 128 |
| 2017 Febrero | 90 | 11 | 101 |
| 2017 Enero | 174 | 19 | 193 |
| 2016 Diciembre | 219 | 15 | 234 |
| 2016 Noviembre | 280 | 21 | 301 |
| 2016 Octubre | 320 | 24 | 344 |
| 2016 Septiembre | 349 | 17 | 366 |
| 2016 Agosto | 421 | 21 | 442 |
| 2016 Julio | 251 | 11 | 262 |
| 2016 Junio | 25 | 20 | 45 |
| 2016 Mayo | 13 | 41 | 54 |
| 2016 Abril | 12 | 2 | 14 |
| 2016 Marzo | 11 | 10 | 21 |
| 2016 Febrero | 10 | 20 | 30 |
| 2016 Enero | 5 | 10 | 15 |
| 2015 Diciembre | 11 | 9 | 20 |
| 2015 Noviembre | 145 | 22 | 167 |
| 2015 Octubre | 306 | 27 | 333 |
| 2015 Septiembre | 211 | 13 | 224 |
| 2015 Agosto | 22 | 4 | 26 |
| 2015 Julio | 437 | 26 | 463 |
| 2015 Junio | 346 | 15 | 361 |
| 2015 Mayo | 470 | 26 | 496 |
| 2015 Abril | 426 | 38 | 464 |
| 2015 Marzo | 465 | 29 | 494 |
| 2015 Febrero | 425 | 19 | 444 |
| 2015 Enero | 428 | 21 | 449 |
| 2014 Diciembre | 426 | 21 | 447 |
| 2014 Noviembre | 431 | 18 | 449 |
| 2014 Octubre | 463 | 31 | 494 |
| 2014 Septiembre | 342 | 23 | 365 |
| 2014 Agosto | 359 | 32 | 391 |
| 2014 Julio | 402 | 34 | 436 |
| 2014 Junio | 444 | 30 | 474 |
| 2014 Mayo | 519 | 31 | 550 |
| 2014 Abril | 458 | 30 | 488 |
| 2014 Marzo | 454 | 40 | 494 |
| 2014 Febrero | 389 | 14 | 403 |
| 2014 Enero | 361 | 28 | 389 |
| 2013 Diciembre | 299 | 18 | 317 |
| 2013 Noviembre | 279 | 23 | 302 |
| 2013 Octubre | 49 | 10 | 59 |
| 2013 Septiembre | 32 | 12 | 44 |
| 2013 Agosto | 38 | 22 | 60 |
| 2013 Julio | 7 | 19 | 26 |
| 2013 Junio | 5 | 24 | 29 |
| 2013 Mayo | 17 | 31 | 48 |
| 2013 Abril | 8 | 30 | 38 |
| 2013 Marzo | 18 | 19 | 37 |
| 2013 Febrero | 57 | 6 | 63 |
| 2013 Enero | 320 | 7 | 327 |
| 2012 Diciembre | 114 | 7 | 121 |
| 2012 Noviembre | 2 | 2 | 4 |
| 2012 Octubre | 0 | 1 | 1 |
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