Compartir
array:24 [
"pii" => "S1578219011000990"
"issn" => "15782190"
"doi" => "10.1016/j.adengl.2011.11.012"
"estado" => "S300"
"fechaPublicacion" => "2011-11-01"
"aid" => "401"
"copyright" => "Elsevier España, S.L. and AEDV"
"copyrightAnyo" => "2010"
"documento" => "article"
"crossmark" => 0
"subdocumento" => "sco"
"cita" => "Actas Dermosifiliogr. 2011;102:722-5"
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:2 [
"total" => 3124
"formatos" => array:3 [
"EPUB" => 45
"HTML" => 2295
"PDF" => 784
]
]
"Traduccion" => array:1 [
"en" => array:19 [
"pii" => "S0001731011002183"
"issn" => "00017310"
"doi" => "10.1016/j.ad.2011.04.004"
"estado" => "S300"
"fechaPublicacion" => "2011-11-01"
"aid" => "401"
"copyright" => "Elsevier España, S.L. and AEDV"
"documento" => "article"
"crossmark" => 0
"subdocumento" => "sco"
"cita" => "Actas Dermosifiliogr. 2011;102:722-5"
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:2 [
"total" => 5635
"formatos" => array:3 [
"EPUB" => 53
"HTML" => 4833
"PDF" => 749
]
]
"en" => array:13 [
"idiomaDefecto" => true
"cabecera" => "<span class="elsevierStyleTextfn">Caso clínico</span>"
"titulo" => "A novel <span class="elsevierStyleItalic">EDA</span> gene mutation in a Spanish family with X-linked hypohidrotic ectodermal dysplasia"
"tienePdf" => "en"
"tieneTextoCompleto" => "en"
"tieneResumen" => array:2 [
0 => "en"
1 => "es"
]
"paginas" => array:1 [
0 => array:2 [
"paginaInicial" => "722"
"paginaFinal" => "725"
]
]
"titulosAlternativos" => array:1 [
"es" => array:1 [
"titulo" => "Una nueva mutación en el gen EDA en una familia española con displasia ectodérmica hipohidrótica ligada al cromosoma X"
]
]
"contieneResumen" => array:2 [
"en" => true
"es" => true
]
"contieneTextoCompleto" => array:1 [
"en" => true
]
"contienePdf" => array:1 [
"en" => true
]
"resumenGrafico" => array:2 [
"original" => 0
"multimedia" => array:7 [
"identificador" => "fig0005"
"etiqueta" => "Figure 1"
"tipo" => "MULTIMEDIAFIGURA"
"mostrarFloat" => true
"mostrarDisplay" => false
"figura" => array:1 [
0 => array:4 [
"imagen" => "gr1.jpeg"
"Alto" => 1113
"Ancho" => 1499
"Tamanyo" => 379975
]
]
"descripcion" => array:1 [
"en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A and B. Clinical features of the proband. C and D. Clinical features of the proband's mother. The proband has pointed teeth, absence of the tails of the eyebrows, a congenital scaring lesion on her nose (A), and sparse thin hair (B). Her mother exhibits similar clinical signs (C and D). She never developed her adult dentition.</p>"
]
]
]
"autores" => array:1 [
0 => array:2 [
"autoresLista" => "J. Cañueto, M.I. Zafra-Cobo, S. Ciria, P. Unamuno, R. González-Sarmiento"
"autores" => array:5 [
0 => array:2 [
"nombre" => "J."
"apellidos" => "Cañueto"
]
1 => array:2 [
"nombre" => "M.I."
"apellidos" => "Zafra-Cobo"
]
2 => array:2 [
"nombre" => "S."
"apellidos" => "Ciria"
]
3 => array:2 [
"nombre" => "P."
"apellidos" => "Unamuno"
]
4 => array:2 [
"nombre" => "R."
"apellidos" => "González-Sarmiento"
]
]
]
]
]
"idiomaDefecto" => "en"
"Traduccion" => array:1 [
"en" => array:9 [
"pii" => "S1578219011000990"
"doi" => "10.1016/j.adengl.2011.11.012"
"estado" => "S300"
"subdocumento" => ""
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:1 [
"total" => 0
]
"idiomaDefecto" => "en"
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000990?idApp=UINPBA000044"
]
]
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011002183?idApp=UINPBA000044"
"url" => "/00017310/0000010200000009/v1_201304241340/S0001731011002183/v1_201304241340/en/main.assets"
]
]
"itemSiguiente" => array:19 [
"pii" => "S1578219011000898"
"issn" => "15782190"
"doi" => "10.1016/j.adengl.2011.11.002"
"estado" => "S300"
"fechaPublicacion" => "2011-11-01"
"aid" => "344"
"copyright" => "Elsevier España, S.L. and AEDV"
"documento" => "article"
"crossmark" => 0
"subdocumento" => "sco"
"cita" => "Actas Dermosifiliogr. 2011;102:726-9"
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:2 [
"total" => 4834
"formatos" => array:3 [
"EPUB" => 45
"HTML" => 3644
"PDF" => 1145
]
]
"en" => array:13 [
"idiomaDefecto" => true
"cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
"titulo" => "Influence of Neonatal and Maternal Factors on the Prevalence of Vernix Caseosa"
"tienePdf" => "en"
"tieneTextoCompleto" => "en"
"tieneResumen" => array:2 [
0 => "en"
1 => "es"
]
"paginas" => array:1 [
0 => array:2 [
"paginaInicial" => "726"
"paginaFinal" => "729"
]
]
"titulosAlternativos" => array:1 [
"es" => array:1 [
"titulo" => "Influencia de los factores neonatales y maternos en la prevalencia de vérnix caseosa"
]
]
"contieneResumen" => array:2 [
"en" => true
"es" => true
]
"contieneTextoCompleto" => array:1 [
"en" => true
]
"contienePdf" => array:1 [
"en" => true
]
"resumenGrafico" => array:2 [
"original" => 0
"multimedia" => array:7 [
"identificador" => "fig0010"
"etiqueta" => "Figure 2"
"tipo" => "MULTIMEDIAFIGURA"
"mostrarFloat" => true
"mostrarDisplay" => false
"figura" => array:1 [
0 => array:4 [
"imagen" => "gr2.jpeg"
"Alto" => 1410
"Ancho" => 1569
"Tamanyo" => 112715
]
]
"descripcion" => array:1 [
"en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Prevalence of epithelial desquamation and erythema toxicum neonatorum according to presence or absence of vernix caseosa.</p>"
]
]
]
"autores" => array:1 [
0 => array:2 [
"autoresLista" => "B. Monteagudo, J. Labandeira, E. León-Muiños, R. Romarís, A. Ramírez-Santos, D. González-Vilas, R. Fernández-Prieto, J. Toribio"
"autores" => array:8 [
0 => array:2 [
"nombre" => "B."
"apellidos" => "Monteagudo"
]
1 => array:2 [
"nombre" => "J."
"apellidos" => "Labandeira"
]
2 => array:2 [
"nombre" => "E."
"apellidos" => "León-Muiños"
]
3 => array:2 [
"nombre" => "R."
"apellidos" => "Romarís"
]
4 => array:2 [
"nombre" => "A."
"apellidos" => "Ramírez-Santos"
]
5 => array:2 [
"nombre" => "D."
"apellidos" => "González-Vilas"
]
6 => array:2 [
"nombre" => "R."
"apellidos" => "Fernández-Prieto"
]
7 => array:2 [
"nombre" => "J."
"apellidos" => "Toribio"
]
]
]
]
]
"idiomaDefecto" => "en"
"Traduccion" => array:1 [
"es" => array:9 [
"pii" => "S000173101100069X"
"doi" => "10.1016/j.ad.2011.01.006"
"estado" => "S300"
"subdocumento" => ""
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:1 [
"total" => 0
]
"idiomaDefecto" => "es"
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101100069X?idApp=UINPBA000044"
]
]
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000898?idApp=UINPBA000044"
"url" => "/15782190/0000010200000009/v1_201304241238/S1578219011000898/v1_201304241238/en/main.assets"
]
"itemAnterior" => array:19 [
"pii" => "S1578219011000941"
"issn" => "15782190"
"doi" => "10.1016/j.adengl.2011.11.007"
"estado" => "S300"
"fechaPublicacion" => "2011-11-01"
"aid" => "392"
"copyright" => "Elsevier España, S.L. and AEDV"
"documento" => "article"
"crossmark" => 0
"subdocumento" => "fla"
"cita" => "Actas Dermosifiliogr. 2011;102:717-21"
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:2 [
"total" => 15944
"formatos" => array:3 [
"EPUB" => 46
"HTML" => 14560
"PDF" => 1338
]
]
"en" => array:13 [
"idiomaDefecto" => true
"cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
"titulo" => "Treatment of Mucosal Vascular Malformations With Variable-Pulse Neodymium:Yttrium-Aluminum-Garnet Laser"
"tienePdf" => "en"
"tieneTextoCompleto" => "en"
"tieneResumen" => array:2 [
0 => "en"
1 => "es"
]
"paginas" => array:1 [
0 => array:2 [
"paginaInicial" => "717"
"paginaFinal" => "721"
]
]
"titulosAlternativos" => array:1 [
"es" => array:1 [
"titulo" => "Tratamiento de malformaciones vasculares de mucosas con láser Nd:YAG de pulso variable"
]
]
"contieneResumen" => array:2 [
"en" => true
"es" => true
]
"contieneTextoCompleto" => array:1 [
"en" => true
]
"contienePdf" => array:1 [
"en" => true
]
"resumenGrafico" => array:2 [
"original" => 0
"multimedia" => array:7 [
"identificador" => "fig0025"
"etiqueta" => "Figure 5"
"tipo" => "MULTIMEDIAFIGURA"
"mostrarFloat" => true
"mostrarDisplay" => false
"figura" => array:1 [
0 => array:4 [
"imagen" => "gr5.jpeg"
"Alto" => 488
"Ancho" => 990
"Tamanyo" => 73174
]
]
"descripcion" => array:1 [
"en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Venous malformation on the glans penis (patient 11) before and after a session of Nd:YAG laser treatment (fluence, 200<span class="elsevierStyleHsp" style=""></span>J/cm2; pulse duration, 30<span class="elsevierStyleHsp" style=""></span>ms; spot diameter, 3<span class="elsevierStyleHsp" style=""></span>mm).</p>"
]
]
]
"autores" => array:1 [
0 => array:2 [
"autoresLista" => "A. Nuño-González, E. Naz-Villalba, F.J. Vicente-Martín, A. Sánchez-Gilo, M. Gutiérrez-Pascual, E. Gómez de la Fuente, J.L. López-Estebaranz"
"autores" => array:7 [
0 => array:2 [
"nombre" => "A."
"apellidos" => "Nuño-González"
]
1 => array:2 [
"nombre" => "E."
"apellidos" => "Naz-Villalba"
]
2 => array:2 [
"nombre" => "F.J."
"apellidos" => "Vicente-Martín"
]
3 => array:2 [
"nombre" => "A."
"apellidos" => "Sánchez-Gilo"
]
4 => array:2 [
"nombre" => "M."
"apellidos" => "Gutiérrez-Pascual"
]
5 => array:2 [
"nombre" => "E."
"apellidos" => "Gómez de la Fuente"
]
6 => array:2 [
"nombre" => "J.L."
"apellidos" => "López-Estebaranz"
]
]
]
]
]
"idiomaDefecto" => "en"
"Traduccion" => array:1 [
"es" => array:9 [
"pii" => "S0001731011001761"
"doi" => "10.1016/j.ad.2011.01.011"
"estado" => "S300"
"subdocumento" => ""
"abierto" => array:3 [
"ES" => true
"ES2" => true
"LATM" => true
]
"gratuito" => true
"lecturas" => array:1 [
"total" => 0
]
"idiomaDefecto" => "es"
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731011001761?idApp=UINPBA000044"
]
]
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000941?idApp=UINPBA000044"
"url" => "/15782190/0000010200000009/v1_201304241238/S1578219011000941/v1_201304241238/en/main.assets"
]
"en" => array:16 [
"idiomaDefecto" => true
"cabecera" => "<span class="elsevierStyleTextfn">Caso Clínico</span>"
"titulo" => "A novel <span class="elsevierStyleItalic">EDA</span> gene mutation in a Spanish family with X-linked hypohidrotic ectodermal dysplasia"
"tieneTextoCompleto" => true
"paginas" => array:1 [
0 => array:2 [
"paginaInicial" => "722"
"paginaFinal" => "725"
]
]
"autores" => array:1 [
0 => array:4 [
"autoresLista" => "J. Cañueto, M.I. Zafra-Cobo, S. Ciria, P. Unamuno, R. González-Sarmiento"
"autores" => array:5 [
0 => array:4 [
"nombre" => "J."
"apellidos" => "Cañueto"
"email" => array:1 [
0 => "jcanueto@yahoo.es"
]
"referencia" => array:2 [
0 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">a</span>"
"identificador" => "aff0005"
]
1 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">¿</span>"
"identificador" => "cor0005"
]
]
]
1 => array:3 [
"nombre" => "M.I."
"apellidos" => "Zafra-Cobo"
"referencia" => array:1 [
0 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">a</span>"
"identificador" => "aff0005"
]
]
]
2 => array:3 [
"nombre" => "S."
"apellidos" => "Ciria"
"referencia" => array:1 [
0 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">b</span>"
"identificador" => "aff0010"
]
]
]
3 => array:3 [
"nombre" => "P."
"apellidos" => "Unamuno"
"referencia" => array:1 [
0 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">a</span>"
"identificador" => "aff0005"
]
]
]
4 => array:3 [
"nombre" => "R."
"apellidos" => "González-Sarmiento"
"referencia" => array:2 [
0 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">b</span>"
"identificador" => "aff0010"
]
1 => array:2 [
"etiqueta" => "<span class="elsevierStyleSup">c</span>"
"identificador" => "aff0015"
]
]
]
]
"afiliaciones" => array:3 [
0 => array:3 [
"entidad" => "Servicio de Dermatología, Hospital Universitario de Salamanca, Salamanca, Spain"
"etiqueta" => "<span class="elsevierStyleSup">a</span>"
"identificador" => "aff0005"
]
1 => array:3 [
"entidad" => "Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain"
"etiqueta" => "<span class="elsevierStyleSup">b</span>"
"identificador" => "aff0010"
]
2 => array:3 [
"entidad" => "IBMCC, Universidad de Salamanca-CSIC, Campus Miguel de Unamuno, Salamanca, Spain"
"etiqueta" => "<span class="elsevierStyleSup">c</span>"
"identificador" => "aff0015"
]
]
"correspondencia" => array:1 [
0 => array:3 [
"identificador" => "cor0005"
"etiqueta" => "⁎"
"correspondencia" => "Corresponding author."
]
]
]
]
"titulosAlternativos" => array:1 [
"es" => array:1 [
"titulo" => "Una nueva mutación en el gen EDA en una familia espa¿nola con displasia ectodérmica hipohidrótica ligada al cromosoma X"
]
]
"textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–7</span></a></p></span>"
"pdfFichero" => "main.pdf"
"tienePdf" => true
"fechaRecibido" => "2010-07-01"
"fechaAceptado" => "2011-04-03"
"PalabrasClave" => array:2 [
"en" => array:1 [
0 => array:4 [
"clase" => "keyword"
"titulo" => "Keywords"
"identificador" => "xpalclavsec82606"
"palabras" => array:3 [
0 => "X-linked hypohidrotic ectodermal dysplasia"
1 => "<span class="elsevierStyleItalic">EDA</span>"
2 => "Novel mutations"
]
]
]
"es" => array:1 [
0 => array:4 [
"clase" => "keyword"
"titulo" => "Palabras clave"
"identificador" => "xpalclavsec82605"
"palabras" => array:3 [
0 => "Displasia ectodérmica hipohidrótica ligada al cromosoma X"
1 => "<span class="elsevierStyleItalic">EDA</span>"
2 => "Mutación nueva"
]
]
]
]
"tieneResumen" => true
"resumen" => array:2 [
"en" => array:2 [
"titulo" => "Abstract"
"resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">X-linked hypohidrotic ectodermal dysplasia (XLHED) is characterized by abnormal development of the hair, teeth, and sweat glands. It is caused by mutations in the <span class="elsevierStyleItalic">EDA</span> gene, which maps to the X chromosome and encodes a protein called ectodysplasin-A, a member of the tumor necrosis factor-related ligand family. Affected males typically exhibit all the typical features of HED, but heterozygous carriers may show mild to moderate clinical manifestations. We describe the case of a Spanish family in which a novel heterozygous c.733 734insGA mutation at the <span class="elsevierStyleItalic">EDA</span> gene was identified. It was located in exon 5 and consisted of a frame-shift mutation at codon 245, which gave rise to an abnormal protein with a premature stop codon after 35 residues. Genetic analyses in families with XLHED are useful for checking carrier status, but they also provide information for genetic counseling and prenatal diagnosis.</p>"
]
"es" => array:2 [
"titulo" => "Resumen"
"resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La displasia ectodérmica hipohidrótica ligada al cromosoma X (XLHED) se caracteriza por un desarrollo anormal del pelo, los dientes y las glándulas sudoríparas. Está producida por mutaciones en el gen <span class="elsevierStyleItalic">EDA</span>, que se localiza en el cromosoma X y codifica para la proteína Ecdodisplasina A, miembro de la familia de ligandos relacionados con el factor de necrosis tumoral. Los varones afectados normalmente exhiben todas las características de la enfermedad, pero los portadores heterocigotos pueden mostrar manifestaciones de leves a moderadas. Aquí se describe una familia espa¿nola en la que hemos identificado una mutación c.733 734insGA, previamente no descrita, en el gen <span class="elsevierStyleItalic">EDA</span>. Se localizaba en el exón 5 y producía un cambio en la fase de lectura en el codón 245 de la proteína, lo que daba lugar a un codón de parada prematuro tras 35 residuos. El análisis genético en familias con XLHED es fundamental para la identificación de las portadoras, para el diagnóstico prenatal y en general para proporcionar un asesoramiento genético correcto.</p>"
]
]
"bibliografia" => array:2 [
"titulo" => "References"
"seccion" => array:1 [
0 => array:2 [
"identificador" => "bibs0005"
"bibliografiaReferencia" => array:7 [
0 => array:3 [
"identificador" => "bib0005"
"etiqueta" => "1"
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Towards a new classification of ectodermal dysplasias"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:1 [
0 => "J. Lamartine"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Clin Exp Dermatol"
"fecha" => "2003"
"volumen" => "28"
"paginaInicial" => "351"
"paginaFinal" => "355"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/12823289"
"web" => "Medline"
]
]
]
]
]
]
]
]
1 => array:3 [
"identificador" => "bib0010"
"etiqueta" => "2"
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Mutational spectrum of the ED1 gene in X-linked hypohidrotic ectodermal dysplasia"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:5 [
0 => "M.C. Vincent"
1 => "V. Biancalana"
2 => "D. Ginisty"
3 => "J.L. Mandel"
4 => "P. Calvas"
]
]
]
]
]
"host" => array:1 [
0 => array:2 [
"doi" => "10.1038/sj.ejhg.5200635"
"Revista" => array:6 [
"tituloSerie" => "Eur J Hum Genet"
"fecha" => "2001"
"volumen" => "9"
"paginaInicial" => "355"
"paginaFinal" => "363"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/11378824"
"web" => "Medline"
]
]
]
]
]
]
]
]
2 => array:3 [
"identificador" => "bib0015"
"etiqueta" => "3"
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "A novel de novo frame-shift mutation of the EDA gene in a Chinese Han family with hypohidrotic ectodermal dysplasia"
"autores" => array:1 [
0 => array:2 [
"etal" => true
"autores" => array:6 [
0 => "C. Huang"
1 => "Q. Yang"
2 => "T. Ke"
3 => "H. Wang"
4 => "X. Wang"
5 => "J. Shen"
]
]
]
]
]
"host" => array:1 [
0 => array:2 [
"doi" => "10.1007/s10038-006-0071-8"
"Revista" => array:6 [
"tituloSerie" => "J Hum Genet"
"fecha" => "2006"
"volumen" => "51"
"paginaInicial" => "1133"
"paginaFinal" => "1137"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/17066260"
"web" => "Medline"
]
]
]
]
]
]
]
]
3 => array:3 [
"identificador" => "bib0020"
"etiqueta" => "4"
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Mutations leading to Xlinked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A"
"autores" => array:1 [
0 => array:2 [
"etal" => true
"autores" => array:6 [
0 => "P. Schneider"
1 => "S.L. Street"
2 => "O. Gaide"
3 => "S. Hertig"
4 => "A. Tardivel"
5 => "J. Tschopp"
]
]
]
]
]
"host" => array:1 [
0 => array:2 [
"doi" => "10.1074/jbc.M007008200"
"Revista" => array:6 [
"tituloSerie" => "J Biol Chem"
"fecha" => "2001"
"volumen" => "276"
"paginaInicial" => "1881"
"paginaFinal" => "1927"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/11038359"
"web" => "Medline"
]
]
]
]
]
]
]
]
4 => array:3 [
"identificador" => "bib0025"
"etiqueta" => "5"
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "High-resolution mapping of the X-linked hypohidrotic ectodermal dysplasia (EDA) locus"
"autores" => array:1 [
0 => array:2 [
"etal" => true
"autores" => array:6 [
0 => "J. Zonana"
1 => "M. Jones"
2 => "D. Browne"
3 => "M. Litt"
4 => "P. Kramer"
5 => "N. Brockdorff"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:6 [
"tituloSerie" => "Am J Hum Genet"
"fecha" => "1992"
"volumen" => "51"
"paginaInicial" => "1036"
"paginaFinal" => "1046"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/1357963"
"web" => "Medline"
]
]
]
]
]
]
]
]
5 => array:3 [
"identificador" => "bib0030"
"etiqueta" => "6"
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Molecular aspects of hypohidrotic ectodermal dysplasia"
"autores" => array:1 [
0 => array:2 [
"etal" => false
"autores" => array:1 [
0 => "M.L. Mikkola"
]
]
]
]
]
"host" => array:1 [
0 => array:1 [
"Revista" => array:5 [
"tituloSerie" => "Am J Med Genet A"
"fecha" => "2009"
"volumen" => "149"
"paginaInicial" => "2031"
"paginaFinal" => "2036"
]
]
]
]
]
]
6 => array:3 [
"identificador" => "bib0035"
"etiqueta" => "7"
"referencia" => array:1 [
0 => array:2 [
"contribucion" => array:1 [
0 => array:2 [
"titulo" => "Mutation analysis of the ED1 gene in two Chinese Han families with X-linked hypohidrotic ectodermal dysplasia"
"autores" => array:1 [
0 => array:2 [
"etal" => true
"autores" => array:6 [
0 => "X.J. Zhang"
1 => "J.J. Chen"
2 => "Y.X. Song"
3 => "S. Yang"
4 => "X.Y. Xiong"
5 => "A.P. Zhang"
]
]
]
]
]
"host" => array:1 [
0 => array:2 [
"doi" => "10.1007/s00403-003-0394-7"
"Revista" => array:6 [
"tituloSerie" => "Arch Dermatol Res"
"fecha" => "2003"
"volumen" => "295"
"paginaInicial" => "38"
"paginaFinal" => "42"
"link" => array:1 [
0 => array:2 [
"url" => "https://www.ncbi.nlm.nih.gov/pubmed/12682853"
"web" => "Medline"
]
]
]
]
]
]
]
]
]
]
]
]
]
"idiomaDefecto" => "en"
"url" => "/15782190/0000010200000009/v1_201304241238/S1578219011000990/v1_201304241238/en/main.assets"
"Apartado" => array:4 [
"identificador" => "6183"
"tipo" => "SECCION"
"en" => array:2 [
"titulo" => "Case Reports"
"idiomaDefecto" => true
]
"idiomaDefecto" => "en"
]
"PDF" => "https://static.elsevier.es/multimedia/15782190/0000010200000009/v1_201304241238/S1578219011000990/v1_201304241238/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
"EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011000990?idApp=UINPBA000044"
]