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Vol. 106. Núm. 7.
Páginas 581-582 (septiembre 2015)
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Vol. 106. Núm. 7.
Páginas 581-582 (septiembre 2015)
Case for Diagnosis
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Cutaneous Nodules in Multiple Myeloma
Nódulos cutáneos asociados a mieloma múltiple
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S. Gómez-Armayonesa,
Autor para correspondencia
sara.gomez.armayones@gmail.com

Corresponding author.
, F. Climentb, O. Servitjea
a Servicio de Dermatología, Hospital Universitari de Bellvitge, Barcelona, Spain
b Servicio de Anatomía Patológica, Hospital Universitari de Bellvitge, Barcelona, Spain
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Medical History

The patient was a 76-year-old woman with a history of systemic hypertension and IgA κ multiple myeloma (stage IIIB) diagnosed 1 year previously after an episode of acute renal failure. The patient also had Bence-Jones proteinuria, normocytic normochromic anemia, and lytic lesions in the axial skeleton, sternum, and pelvis. She had received several cycles of bortezomib and melphalan, although her disease continued to progress.

Physical Examination

The clinical manifestations comprised multiple erythematous nodules measuring between 0.5cm and 3cm in diameter that had first appeared on the left heel 2 months previously (Fig. 1). The patient reported associated pain. She also had severe macroglossia, although no significant lesions were visible on the rest of the skin or mucosas.

Figure 1.

Clinical image.

(0.07MB).
Histopathology

Histopathology of the largest nodular lesion revealed a diffuse infiltrate of atypical cells throughout the dermis that were plasmablastic in appearance (Fig. 2). These cells were positive for Ki-67, CD56, CD79a, CD138, cyclin DI, and IgG κ (Fig. 3A) and negative for IgG λ (Fig. 3B).

Figure 2.

Hematoxylin-eosin, original magnification, ×20.

(0.17MB).
Figure 3.

Immunohistochemistry of IgG κ (A) and λ (B), original magnification, ×20.

(0.24MB).
Additional Tests

Although a radiograph of the affected limb was requested, the patient did not return to the clinic.

What is your diagnosis?

Diagnosis

Cutaneous plasmacytoma associated with multiple myeloma.

Clinical Course and Treatment

Given the poor response to initial chemotherapy and the progression of the disease, no further therapy was prescribed. The biopsy did not rule out bone involvement contiguous to the skin lesions.

Discussion

Skin involvement in multiple myeloma is very rare and generally occurs during the later stages of the disease.1 It was first described in 1910 by Bruno Bloch; to date, some 150 cases have been reported in the literature.2

The 4 known neoplasms of plasma cells are classic multiple myeloma, extramedullary plasmacytoma without multiple myeloma, solitary plasmacytoma of bone, and plasma cell leukemia.2 All 4 types can affect the skin, although the most common mechanism is by direct extension to the skin from an underlying bone lesion; metastatic lesions without contiguous bone involvement are less likely.3,4

Cutaneous plasmacytoma in the context of multiple myeloma is mainly associated with IgG and IgA.

Histopathology usually reveals a monomorphous dermal infiltrate of plasma cells with a diffuse interstitial or nodular pattern. Immunohistochemistry is usually positive for CD38, CD43, CD56, CD79a, CD138, epithelial membrane antigen, and κ and λ light chains.

The differential diagnosis includes diseases such as squamous cell carcinoma, skin metastases from internal neoplasms, cutaneous marginal zone lymphoma, cutaneous leishmaniasis, sarcoidosis, and amelanotic melanoma. However, the clinical setting of the patient should point us in the direction of plasmocytoma associated with multiple myeloma.

Treatment should be aimed at monoclonal gammopathy using autologous bone marrow transplant in persons aged less than 65 years and chemotherapy with bortezomib and melphalan, combined with local radiation therapy and surgical removal of the skin lesion where necessary.5

References
[1]
L. Requena, H. Kutzner, G. Palmedo, E. Calonje, C. Requena, G. Pérez, et al.
Cutaneous involvement in multiple myeloma: A clinicopathologic, immunohistochemical, and cytogenetic study of 8 cases.
Arch Dermatol, 139 (2003), pp. 475-486
[2]
N. Kato, K. Kimura, K. Yasukawa, K. Aikawa.
Metastatic cutaneous plasmacytoma: A case report associated with IgA lambda multiple myeloma and a review of the literature of metastatic cutaneous plasmacytomas associated with multiple myeloma and primary cutaneous plasmacytomas.
J Dermatol., 26 (1999), pp. 587-594
[3]
L. Requena.
Afectación cutánea específica en pacientes con mieloma múltiple. Estudio clínico-patológico, inmunohistoquímico y citogenético de 40 casos.
Actas Dermosifiliogr., 96 (2005), pp. 424-440
[4]
M.A. Ballester-Martínez, C. González-García, B. Fleta-Asín, A. Burdaspal-Moratilla, A. Santón-Roldán, N. Jiménez-Gómez, et al.
Cutaneous nodules as a diagnostic clue in multiple myeloma.
Am J Dermatopathol., 35 (2013), pp. 377-380
[5]
G. Santos, L. Sousa, T. Fernandes, A. João.
Case for diagnosis. Cutaneous involvement associated to multiple myeloma.
An Bras Dermatol, 89 (2014), pp. 173-174

Please cite this article as: Gómez-Armayones S, Climent F, Servitje O. Nódulos cutáneos asociados a mieloma múltiple. Actas Dermosifiliogr. 2015;106:581–582.

Copyright © 2014. Elsevier España, S.L.U. and AEDV
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