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Journal Information
Vol. 103. Issue 8.
Pages 742-743 (October 2012)
Vol. 103. Issue 8.
Pages 742-743 (October 2012)
Cases and Research Letters
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Sustained Remission of Extramammary Paget Disease Following Treatment with Imiquimod 5% Cream
Remisión mantenida de la enfermedad de Paget extramamaria tras tratamiento con imiquimod al 5% en crema
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P. Herranz, E. Sendagorta
Corresponding author
elenasendagorta@hotmail.com

Corresponding author.
, M. Feito, C. Gómez-Fernandez
Servicio de Dermatología, Hospital Universitario La Paz, Madrid, Spain
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To the Editor:

The recent report by Hiraldo-Gamero et al.1 on the use of 5% imiquimod cream to treat extramammary Paget disease (EMPD) confirms the growing interest in this new nonsurgical treatment option for this disease. In 2009 we reported the results obtained in the treatment of 3 cases of EMPD of the vulva with clinical and pathologic features similar to those described by Hiraldo-Gamero.2

The 3 patients, aged 66, 58, and 82 years, had vulvar lesions up to 5cm in diameter (Fig. 1). In all 3 cases, the results of multiple biopsies (Fig. 2) revealed exclusively intraepidermal involvement, and exhaustive screening ruled out the possibility of underlying malignancy. Bearing in mind the comorbid conditions present in each case, treatment with imiquimod was chosen to avoid the risks associated with surgical excision, the approach traditionally used to treat such tumors. The regimen used was once daily application of 5% imiquimod cream for 3 weeks followed by application on alternate days for a further 13 weeks. All 3 patients completed treatment despite episodes of inflammation and moderate pain. Control biopsies were performed at 6 and 12 months. The 3 patients were followed up clinically every 3 months for 1 year after treatment and every 6 months thereafter. At the time of writing, they have completed a follow-up period of 53 months and remain in complete remission (Fig. 3). Green et al.,3 who recently reviewed reports in the literature on the use of imiquimod in EMPD, found complete remission of the disease in 21 of the 27 reported cases (78%). The factors that influence the success or failure of imiquimod therapy in this setting have not yet been clearly established. Factors that might explain the variability of response to treatment include the size of the lesion, its variable thickness in different areas, and the presence of extensive adnexal involvement.

Figure 1.

Erythematous plaque with whitish patches and erosions on the right labium majus of the vulva.

(0.18MB).
Figure 2.

Cells with abundant clear cytoplasm and pleomorphic nuclei (Paget cells) distributed throughout the full thickness of the epidermis. Immunohistochemical stains were positive for carcinoembryonic antigen, epithelial membrane antigen, and cytokeratin 7.

(0.26MB).
Figure 3.

Complete resolution of the lesions 3 months after completion of treatment.

(0.24MB).

We agree with Hiraldo-Gamero that the small number of published cases makes it difficult to draw conclusions concerning the efficacy and safety of 5% imiquimod cream in selected cases of EMPD. Our report provides additional evidence on the medium-term safety of this treatment and represents the longest follow-up period free of disease reported in the dermatologic literature.

References
[1]
A. Hiraldo-Gamero, E. Gómez-Moyano, J.M. Segura-Palacios, F. Sánchez-Fajardo, A. Sanz Trelles.
Extramammary Paget disease treated with 5% Imiquimod cream.
Actas Dermosifilogr, 102 (2011), pp. 554-556
[2]
E. Sendagorta, P. Herranz, M. Feito, P. Ramírez, U. Floristán, R. Feltes, et al.
Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod-proposal of a therapeutic schedule.
J Eur Acad Dermatol Venereol, 24 (2010), pp. 490-492
[3]
J.S. Green, N.M. Burkemper, S.W. Fosko.
Failure of extensive extramammary paget disease of the inguinal area to clear with imiquimod cream 5%, possible progression to invasive disease during therapy.
Arch Dermatol, 147 (2011), pp. 704-708

Please cite this article as: Herranz P, Sendagorta E, Feito M, Gómez-Fernandez C. Remisión mantenida de la enfermedad de Paget extramamaria tras tratamiento con imiquimod al 5% en crema. Actas Dermosifiliogr.2012;103:742-743.

Copyright © 2011. Elsevier España, S.L. and AEDV
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