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dome-shaped lesion&#44; ulcerated on one side&#44; and hard to palpation&#46; The patient attended because the mass had increased in size and at some point there had been a small amount of bleeding&#46; Magnetic resonance imaging &#40;MRI&#41; was performed to investigate the clinical suspicion of a tumor of vascular origin&#46; The different projections &#40;sagittal plane on T2&#59; transverse plane on T1&#44; T2&#44; FFE T2&#44; and STIR&#41; showed a mass located in the subcutaneous cellular tissue&#44; which was presumed to be of vascular origin given that it was described as being dependent on and draining into the basilic vein &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; The lesion was mottled and multilobulated&#46; There was no intramuscular component and the surrounding tissues were unchanged&#46; On the basis of these findings&#44; we proceeded to surgical excision and histopathological study&#46; The tumor&#44; situated in the mid-dermis and deep dermis&#44; was composed of several well-demarcated lobules separated by fine bands of fibrous tissue with abundant dilated and congested vascular structures &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The lobules were arranged in aggregates of cells&#44; some with a basaloid appearance and others with a larger&#44; clearer cytoplasm&#44; arranged in cords&#44; trabeculae&#44; and solid nests with duct-like structures&#46; On immunohistochemical study&#44; most of the cells expressed pan cytokeratins&#44; and the luminal cells expressed carcinoembryonic antigen &#40;CEA&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Spiradenomas are rare benign tumors derived from the inferior portion of eccrine sweat ducts&#44; and they usually develop on the head&#44; neck&#44; trunk&#44; and&#44; less often&#44; the limbs&#46; Their main clinical characteristic is that they are generally painful&#46; Typically&#44; spiradenomas present in patients aged between 15 and 35 years of age and they are usually solitary&#44; although different clinical presentations have been described&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In 1986&#44; Cotton et al<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> described two cases of eccrine spiradenoma that they classified as giant vascular type due to their large size and high vascularity&#46; Since then&#44; to the best of our knowledge&#44; 12 further cases have been described &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The first description referred to a classic spiradenoma&#44; measuring over the established 2<span class="elsevierStyleHsp" style=""></span>cm diameter&#44; with the most salient feature being its high vascularity&#46; Many authors have described this high vascularity as the result of a stromal involution process due to ageing of the lesion&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;9</span></a> This concept is defended by some authors&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> but in our case the information supplied by MRI supported the existence of a tributary vessel&#46; This vessel made it easy to mistake the mass for a vascular tumor&#44; and it would also have promoted tumor growth&#46; The most notable feature in this case was the finding of an afferent vessel to the tumor with drainage into the basilic vein&#44; leading the radiologist to suspect a slow flow vascular malformation&#46; Similarly&#44; the marked vascularization of these tumors means that most eccrine spiradenomas are clinically diagnosed as benign or malignant neoplasms of vascular origin&#46; The most important differential diagnoses are angiosarcoma&#44; which expresses endothelial markers such as CD31 and CD34&#44; and chronic expansive hematoma&#44; which presents as an encapsulated tumor filled with blood and neovasculature&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">What was interesting about this case&#44; apart from the rarity of the condition&#44; was the ease with which a giant vascular eccrine spiradenoma could be mistaken for a lesion of vascular origin&#46;</p></span>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Organoid pattern of cell nests&#44; some of basaloid appearance with hyperchromatic nuclei and others with large clear cytoplasms&#44; separated by fibrous tracts containing abundant dilated and congestive vascular structures &#40;hematoxylin-eosin<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10&#41;&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Reference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age&#47;Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Size&#44; cm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Anatomic Location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Clinical Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cotton et al<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#47;male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Abdomen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Angiosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">84&#47;female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Occipital scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sebaceous cyst&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hey et al<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&#47;female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;5<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Thigh&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Venous thrombosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Senol et al<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#47;male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3-4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chest&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Angioma or thrombosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ko et al<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#47;female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Back&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Angiolipoma or neuroma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yamakoshi et al<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76&#47;male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>3&#46;4<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Shoulder&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Not stated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Kim et al<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&#47;female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;5<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Arm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Vascular malformation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tremezaygues et al<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">81&#47;male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;5<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2&#46;6<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Forearm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Not stated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hatano et al<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52&#47;female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;5<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Arm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pilomatricoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Krishnan et al<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#47;male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chest&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Not stated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nokamura et al<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79&#47;male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>7<span class="elsevierStyleHsp" style=""></span>x<span class="elsevierStyleHsp" style=""></span>6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chest&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic expansive hematoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Moragon Gordon et al&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#47;female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Breast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Not stated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Our case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54&#47;female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;3<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>x<span class="elsevierStyleHsp" style=""></span>2&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Arm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hemangioma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Clinical Characteristics of Giant Vascular Eccrine Spiradenomas&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Giant vascular eccrine spiradenomas&#58; A report of two cases with histology&#44; immunohistology and electron microscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;W&#46;K&#46; Cotton"
                            1 => "D&#46;N&#46; Slater"
                            2 => "N&#46; Rooney"
                            3 => "J&#46;R&#46; Goepel"
                            4 => "P&#46;M&#46; Mills"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Histopathology"
                        "fecha" => "1986"
                        "volumen" => "10"
                        "paginaInicial" => "1093"
                        "paginaFinal" => "1099"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3023231"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vascular eccrine giant spiradenoma-A case report with histology and immunohistology of a rare variant of benign sweat gland tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Hey"
                            1 => "V&#46; Grouls"
                            2 => "G&#46; R&#246;ckelein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Z Hautkr"
                        "fecha" => "1988"
                        "volumen" => "3"
                        "paginaInicial" => "444"
                        "paginaFinal" => "447"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Giant vascular eccrine spiradenoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Senol"
                            1 => "A&#46; Ozcan"
                            2 => "S&#46; Sasmaz"
                            3 => "S&#46; Ozen"
                            4 => "H&#46; Ciralik"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1998"
                        "volumen" => "37"
                        "paginaInicial" => "221"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9556114"
                            "web" => "Medline"
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                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Giant eccrine spiradenoma&#58; Report of a case with immunohistochemical study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;Y&#46; Ko"
                            1 => "C&#46;W&#46; Lee"
                            2 => "S&#46;H&#46; Moon"
                            3 => "K&#46;W&#46; Song"
                            4 => "C&#46;K&#46; Park"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3346/jkms.2006.21.1.172"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Korean Med Sci"
                        "fecha" => "2006"
                        "volumen" => "21"
                        "paginaInicial" => "172"
                        "paginaFinal" => "176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16479087"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of giant vascular eccrine spiradenoma with unusual clinical features"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46; Yamakoshi"
                            1 => "T&#46; Makino"
                            2 => "H&#46; Watanabe"
                            3 => "M&#46; Furuichi"
                            4 => "K&#46; Matsui"
                            5 => "T&#46; Shimizu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2230.2008.03122.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2009"
                        "volumen" => "34"
                        "paginaInicial" => "e250"
                        "paginaFinal" => "e251"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19323658"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Giant vascular eccrine spiradenoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;H&#46; Kim"
                            1 => "E&#46; Cho"
                            2 => "J&#46;D&#46; Lee"
                            3 => "S&#46;H&#46; Cho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Dermatol"
                        "fecha" => "2011"
                        "volumen" => "19"
                        "paginaInicial" => "197"
                        "paginaFinal" => "200"
                      ]
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                  ]
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              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential considerations of skin tumors with florid vascularisation&#58; Report of a solitary giant vascular eccrine spiradenoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;L&#46; Tremezaygues"
                            1 => "C&#46; Pfohler"
                            2 => "T&#46; Vogt"
                            3 => "C&#46;S&#46; Muller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bcr.05.2011.4187"
                      "Revista" => array:2 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2011"
                      ]
                    ]
                  ]
                ]
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Journal Information
Vol. 106. Issue 10.
Pages 850-852 (December 2015)
Vol. 106. Issue 10.
Pages 850-852 (December 2015)
Case and Research Letters
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Giant Vascular Eccrine Spiradenoma
Espiradenoma ecrino vascular gigante
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E. Jorquera Barqueroa,
Corresponding author
jorroc@aedv.es

Corresponding author.
, C. Lara Bohórquezb, I. de Alba Riojaa
a Servicio Dermatología M-Q y Venereología, Complejo hospitalario de Huelva, Huelva, Spain
b Servicio de Anatomía Patológica, Complejo hospitalario de Huelva , Huelva, Spain
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Table 1. Clinical Characteristics of Giant Vascular Eccrine Spiradenomas.
Full Text
To the Editor,

Giant vascular eccrine spiradenoma is a rare variant of eccrine spiradenoma characterized by its size (> 2cm diameter) and high vascularity, a feature that often leads to it being confused with tumors of vascular origin. We present a case of this rare tumor.

A 54-year-old woman presented with a tumor that had been present for years, measuring 2.3×2×2.6cm, located on the medial aspect of the left arm (Fig. 1A). The tumor was a reddish, dome-shaped lesion, ulcerated on one side, and hard to palpation. The patient attended because the mass had increased in size and at some point there had been a small amount of bleeding. Magnetic resonance imaging (MRI) was performed to investigate the clinical suspicion of a tumor of vascular origin. The different projections (sagittal plane on T2; transverse plane on T1, T2, FFE T2, and STIR) showed a mass located in the subcutaneous cellular tissue, which was presumed to be of vascular origin given that it was described as being dependent on and draining into the basilic vein (Fig. 1B). The lesion was mottled and multilobulated. There was no intramuscular component and the surrounding tissues were unchanged. On the basis of these findings, we proceeded to surgical excision and histopathological study. The tumor, situated in the mid-dermis and deep dermis, was composed of several well-demarcated lobules separated by fine bands of fibrous tissue with abundant dilated and congested vascular structures (Fig. 2). The lobules were arranged in aggregates of cells, some with a basaloid appearance and others with a larger, clearer cytoplasm, arranged in cords, trabeculae, and solid nests with duct-like structures. On immunohistochemical study, most of the cells expressed pan cytokeratins, and the luminal cells expressed carcinoembryonic antigen (CEA).

Figure 1.

A, Cutaneous component with a dome-like pedunculated vascular appearance and ulceration at the superior pole. B, MRI showing an exophytic multilobulated mass with a blood supply from and drainage to the basilic vein (arrow).

(0.08MB).
Figure 2.

Organoid pattern of cell nests, some of basaloid appearance with hyperchromatic nuclei and others with large clear cytoplasms, separated by fibrous tracts containing abundant dilated and congestive vascular structures (hematoxylin-eosin×10).

(0.42MB).

Spiradenomas are rare benign tumors derived from the inferior portion of eccrine sweat ducts, and they usually develop on the head, neck, trunk, and, less often, the limbs. Their main clinical characteristic is that they are generally painful. Typically, spiradenomas present in patients aged between 15 and 35 years of age and they are usually solitary, although different clinical presentations have been described.

In 1986, Cotton et al1 described two cases of eccrine spiradenoma that they classified as giant vascular type due to their large size and high vascularity. Since then, to the best of our knowledge, 12 further cases have been described (Table 1). The first description referred to a classic spiradenoma, measuring over the established 2cm diameter, with the most salient feature being its high vascularity. Many authors have described this high vascularity as the result of a stromal involution process due to ageing of the lesion.7,9 This concept is defended by some authors,9 but in our case the information supplied by MRI supported the existence of a tributary vessel. This vessel made it easy to mistake the mass for a vascular tumor, and it would also have promoted tumor growth. The most notable feature in this case was the finding of an afferent vessel to the tumor with drainage into the basilic vein, leading the radiologist to suspect a slow flow vascular malformation. Similarly, the marked vascularization of these tumors means that most eccrine spiradenomas are clinically diagnosed as benign or malignant neoplasms of vascular origin. The most important differential diagnoses are angiosarcoma, which expresses endothelial markers such as CD31 and CD34, and chronic expansive hematoma, which presents as an encapsulated tumor filled with blood and neovasculature.

Table 1.

Clinical Characteristics of Giant Vascular Eccrine Spiradenomas.

Reference  Age/Sex  Size, cm  Anatomic Location  Clinical Diagnosis 
Cotton et al1  74/male  Abdomen  Angiosarcoma 
  84/female  Occipital scalp  Sebaceous cyst 
Hey et al2  63/female  3.5×1.5  Thigh  Venous thrombosis 
Senol et al3  60/male  3-4  Chest  Angioma or thrombosis 
Ko et al4  56/female  Back  Angiolipoma or neuroma 
Yamakoshi et al5  76/male  5×3.4×2.6  Shoulder  Not stated 
Kim et al6  49/female  2.5×2.5  Arm  Vascular malformation 
Tremezaygues et al7  81/male  1.5×2.6×2.9  Forearm  Not stated 
Hatano et al8  52/female  3.5×2.2  Arm  Pilomatricoma 
Krishnan et al10  31/male  2.5  Chest  Not stated 
Nokamura et al9  79/male  7×7xChest  Chronic expansive hematoma 
Moragon Gordon et al  60/female  5×Breast  Not stated 
Our case  54/female  2.3×2x2.6  Arm  Hemangioma 

What was interesting about this case, apart from the rarity of the condition, was the ease with which a giant vascular eccrine spiradenoma could be mistaken for a lesion of vascular origin.

References
[1]
D.W.K. Cotton, D.N. Slater, N. Rooney, J.R. Goepel, P.M. Mills.
Giant vascular eccrine spiradenomas: A report of two cases with histology, immunohistology and electron microscopy.
Histopathology, 10 (1986), pp. 1093-1099
[2]
A. Hey, V. Grouls, G. Röckelein.
Vascular eccrine giant spiradenoma-A case report with histology and immunohistology of a rare variant of benign sweat gland tumors.
Z Hautkr, 3 (1988), pp. 444-447
[3]
M. Senol, A. Ozcan, S. Sasmaz, S. Ozen, H. Ciralik.
Giant vascular eccrine spiradenoma.
Int J Dermatol, 37 (1998), pp. 221-223
[4]
J.Y. Ko, C.W. Lee, S.H. Moon, K.W. Song, C.K. Park.
Giant eccrine spiradenoma: Report of a case with immunohistochemical study.
J Korean Med Sci, 21 (2006), pp. 172-176
[5]
T. Yamakoshi, T. Makino, H. Watanabe, M. Furuichi, K. Matsui, T. Shimizu.
A case of giant vascular eccrine spiradenoma with unusual clinical features.
Clin Exp Dermatol, 34 (2009), pp. e250-e251
[6]
M.H. Kim, E. Cho, J.D. Lee, S.H. Cho.
Giant vascular eccrine spiradenoma.
Ann Dermatol, 19 (2011), pp. 197-200
[7]
L.L. Tremezaygues, C. Pfohler, T. Vogt, C.S. Muller.
Differential considerations of skin tumors with florid vascularisation: Report of a solitary giant vascular eccrine spiradenoma.
[8]
A. Hatano, T. Kobayashi, S. Fukuzumi, Y. Shirakashi, C. Nishimura, H. Gomi, et al.
Giant vascular eccrine spiradenoma mimicking calcifying epithelioma.
J Dermatol, 40 (2013), pp. 853-854
[9]
Y. Nakamura, Y. Teramot, K. Yamada, A. Yamamoto.
Giant vascular eccrine spiradenoma mimicking chronic expanding hematoma.
J Dtsch Dermatol Ges, 10 (2014), pp. 908-910
[10]
K. Krishnan, A. Thomas.
Giant vascular eccrine spiradenoma with unusual clinical presentation: A case report.
Open J Pathol, 4 (2014), pp. 21-24

Please cite this article as: Jorquera Barquero E, Lara Bohórquez C, de Alba Rioja I. Espiradenoma ecrino vascular gigante. Actas Dermosifiliogr. 2015;106:850–852.

Copyright © 2015. Elsevier España, S.L.U. and AEDV
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