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it was decided to evaluate sensitivity to change and its correlation with the generic 12-Item Short-Form Health Survey &#40;SF-12&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Population</span><p id="par0020" class="elsevierStylePara elsevierViewall">The study sample included 983 women from 101 dermatology clinics in the different Spanish autonomous communities&#46; The women consulted for female androgenetic alopecia and participated voluntarily after receiving appropriate information&#46; They started treatment with dietary supplements containing 5-&#945;-reductase enzyme inhibitor and had not received treatment with supplements in the previous 3 months&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Instruments</span><p id="par0025" class="elsevierStylePara elsevierViewall">Quality of life was evaluated using HSS-29 &#40;Appendix B1&#46; Additional Material&#41; and SF-12 &#40;Appendix B2&#46; Additional Material&#41;&#46; The HSS-29 questionnaire is a self-administered tool that makes it possible to evaluate HRQOL in patients with alopecia&#46; It was based on the Skindex-29 scale and is composed of 29 items distributed over 3<span class="elsevierStyleHsp" style=""></span>dimensions or domains&#58; symptoms &#40;7<span class="elsevierStyleHsp" style=""></span>items&#41;&#44; function &#40;12<span class="elsevierStyleHsp" style=""></span>items&#41;&#44; and emotions &#40;10<span class="elsevierStyleHsp" style=""></span>items&#41;&#46; The questionnaire takes a mean of 5<span class="elsevierStyleHsp" style=""></span>minutes to complete&#44; and each item is answered based on a Likert-type scale ranging from 0 &#40;never&#41; to 5 &#40;all the time&#41;&#46; The dimensions are scored by transforming the sum of all the responses to a linear scale ranging from 0 &#40;no impact&#41; to 100 &#40;maximum impact&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The SF-12 questionnaire contains 12<span class="elsevierStyleHsp" style=""></span>items covering 8 HRQOL domains&#58; physical dimension&#44; mental dimension&#44; physical functioning&#44; role-physical&#44; bodily pain&#44; general health&#44; role-emotional&#44; social functioning&#44; and mental health&#46; Reference guidelines are available for the Spanish version of SF-12 &#40;version 2&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Furthermore&#44; the patient and the clinician were asked their opinion on the volume&#44; density&#44; and texture of the hair&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Design</span><p id="par0040" class="elsevierStylePara elsevierViewall">Patients attended 2 visits&#44; one at baseline and the other after 6<span class="elsevierStyleHsp" style=""></span>months of treatment&#46; At the baseline visit&#44; patients initiated treatment with 5-&#945;-reductase enzyme inhibitor dietary supplements&#44; which they continued to take for 6<span class="elsevierStyleHsp" style=""></span>months&#46; They completed both questionnaires at each visit&#44; and the investigators evaluated the severity of alopecia using the Sinclair scale&#46; Both the patient and the clinician evaluated the volume&#44; density&#44; and texture of the hair as better&#44; worse&#44; or no change&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The project for cross-cultural adaptation to Spanish began in 2016&#44; according to the protocol approved by the Ethics Committee of Hospital 12 de Octubre on December 20 &#40;No&#46; 16&#47;392&#41;&#46; The second phase was carried out between January and October 2018&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Data Analysis</span><p id="par0050" class="elsevierStylePara elsevierViewall">First&#44; a descriptive analysis of the data was performed using a frequency table for nominal variables and measures of central tendency and dispersion for continuous variables&#46; Data for continuous variables were presented with their 95&#37;<span class="elsevierStyleHsp" style=""></span>CI&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Comparisons between groups and quantitative variables were made using the <span class="elsevierStyleItalic">t</span> test &#40;2<span class="elsevierStyleHsp" style=""></span>groups&#41; or 1-way analysis of variance &#40;&#8805;<span class="elsevierStyleHsp" style=""></span>3 groups&#41;&#46; If either of these tests could not be applied&#44; the Mann-Whitney test &#40;2<span class="elsevierStyleHsp" style=""></span>groups&#41; or the Kruskal-Wallis test &#40;&#8805;<span class="elsevierStyleHsp" style=""></span>3 groups&#41; was used&#46; Where necessary&#44; tests for paired data were applied&#46; Continuous variables were compared using the Fisher correlation coefficient in the case of absolutely continuous variables or the Spearman test in the case of those that were not&#46; All calculations were made using SAS Version 9&#46;4&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Baseline Visit</span><p id="par0060" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the characteristics of the patients included in the study&#46; The study population comprised 983 women with a mean age of 50 &#40;16&#46;3&#41; years and mainly &#40;83&#46;6&#37;&#41; grade 1&#8211;3 alopecia according to the Sinclair scale&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the total score and the score by dimensions on the HSS-29 scale&#46; The grade of alopecia is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; Emotion was the most affected domain&#44; with a mean score of 37&#46;7 &#40;95&#37;<span class="elsevierStyleHsp" style=""></span>CI&#44; 36&#46;3&#8211;39&#46;2&#41;&#59; the score was lower in the symptom and function domains&#44; with a mean of 27&#46;2 &#40;95&#37; CI&#44; 26&#46;0&#8211;28&#46;4&#41; and 19&#46;3 &#40;95&#37;<span class="elsevierStyleHsp" style=""></span>CI&#44; 17&#46;9&#8211;20&#46;6&#41;&#44; respectively&#46; We found that involvement was more pronounced as alopecia became more severe&#44; both in the overall score and in the various dimensions&#46; No significant differences were detected for age group with respect to the score on the scale as a whole or in its individual dimensions&#46; The baseline SF-12 score is also shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; The domain with the greatest impact on quality of life was role-emotional&#44; with a mean score of 20&#46;3 &#40;95&#37;<span class="elsevierStyleHsp" style=""></span>CI&#44; 20&#46;0&#8211;20&#46;6&#41;&#46; As in the HSS-29&#44; involvement was more pronounced as alopecia became worse in all the scores recorded for the SF-12&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">The correlation between both scales at baseline is presented in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46; All of the correlations studied using Pearson coefficients were negative and statistically significant &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span> &#46;001&#41;&#46; A higher score in the HSS-29 and all its subdimensions &#40;function&#44; emotion&#44; and symptoms&#41; was associated with a lower score&#44; i&#46;e&#46;&#44; reduced HRQOL&#44; in all of the dimensions of the SF-12 scale&#46; Similarly&#44; the mean scores on the SF-12 decreased as severity in the HSS-29 increased in its classified form&#46; When the study population was stratified by age group and severity of alopecia&#44; we observed the same negative correlation in all the groups&#44; except in patients with grade&#8239;5 alopecia&#46; No analysis was performed for this subgroup&#44; since it only included 3<span class="elsevierStyleHsp" style=""></span>women&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Follow-up Visit</span><p id="par0070" class="elsevierStylePara elsevierViewall">Of the 983 patients included in the initial project&#44; 967 &#40;98&#46;3&#37;&#41; were evaluated at 6<span class="elsevierStyleHsp" style=""></span>months&#46; Compared with the baseline score&#44; the global score on the HSS-29 scale at 6<span class="elsevierStyleHsp" style=""></span>months decreased overall and in the scores for the individual dimensions&#44; in which the differences were statistically significant &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; The mean score on the overall scale fell from 27&#46;5<span class="elsevierStyleHsp" style=""></span>&#40;18&#46;7&#41; at baseline to 19&#46;3<span class="elsevierStyleHsp" style=""></span>&#40;15&#46;7&#41; at the follow-up visit&#46; Significant changes were also observed for the function&#44; emotion&#44; and symptom dimensions&#44; from 19&#46;3<span class="elsevierStyleHsp" style=""></span>&#40;2&#46;0&#41; to 13&#46;1<span class="elsevierStyleHsp" style=""></span>&#40;15&#46;8&#41;&#44; from 37&#46;7<span class="elsevierStyleHsp" style=""></span>&#40;23&#46;0&#41; to 25&#46;8<span class="elsevierStyleHsp" style=""></span>&#40;20&#46;5&#41;&#44; and from 27&#46;2<span class="elsevierStyleHsp" style=""></span>&#40;18&#46;8&#41; to 20&#46;7<span class="elsevierStyleHsp" style=""></span>&#40;16&#46;2&#41;&#44; respectively&#46; <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> shows the differences between the 2 visits according to the grade of alopecia&#46; All of the differences evaluated were statistically significant with respect to the grade of alopecia&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Depending on the severity of alopecia&#44; differences were observed in the score on the HSS-29 scale between the first and second visits&#44; with an improvement in involvement of quality of life &#40;i&#46;e&#46;&#44; scores &#60;<span class="elsevierStyleHsp" style=""></span>20 in the HSS-29 scale in all its domains and for all grades of alopecia&#41;&#46; <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> shows the differences between the first and second evaluation&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">A statistically significant increase in the SF-12 scores was observed in the dimensions role-physical&#44; bodily pain&#44; general health&#44; vitality&#44; role-emotional&#44; social functioning&#44; and mental health at 6<span class="elsevierStyleHsp" style=""></span>months&#44; whereas the change in the physical dimension and physical functioning was not significant &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Sensitivity to Change</span><p id="par0085" class="elsevierStylePara elsevierViewall">In order to evaluate sensitivity to change&#44; we calculated the differences between the scores at 6<span class="elsevierStyleHsp" style=""></span>months and the baseline scores for all the dimensions on the HSS-29 and SF-12 scales and assessed the evaluations of the appearance of the patients&#8217; hair&#46; We then determined whether these differences were correlated or not&#44; that is&#44; whether one changed with the other&#46; The analysis was performed for the whole study population and by age group and grade of alopecia&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a> shows the correlation for the differences between the scales&#44; that is&#44; whether one changed with the other&#46; We observed that the differences between baseline and follow-up both for the overall HSS-29 index and for each of its dimensions were significantly correlated with the differences found for the dimensions of the SF-12&#46; The Pearson correlation coefficients ranged between &#8722;0&#46;1 and &#8722;0&#46;4&#44; and statistical significance in all cases was <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#46; The scatterplots for the correlation of differences are shown in Appendix BAnnex 3 &#40;Additional material&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Lastly&#44; <a class="elsevierStyleCrossRef" href="#tbl0030">Table 6</a> shows the differences between the appearance of the patients&#8217; hair and the HSS-29 score&#46; All of the correlations examined were statistically significant&#44; except for texture as assessed by the clinician compared with progress in the emotion dimension&#46; As the indices for the evaluation of the hair worsened&#44; the HSS-29 score decreased&#46; Both the physician&#8217;s and the patient&#8217;s evaluation revealed an improvement in the appearance of the hair in the categories volume&#44; density&#44; and texture&#46; For a score of 1&#8211;3 &#40;1 normal&#44; 3 very diminished&#41;&#44; the means perceived by the patients decreased from 2&#46;3 <span class="elsevierStyleHsp" style=""></span>&#40;0&#46;5&#41; to 1&#46;8 <span class="elsevierStyleHsp" style=""></span>&#40;0&#46;6&#41;&#44; from 2&#46;3<span class="elsevierStyleHsp" style=""></span>&#40;0&#46;5&#41; to 1&#46;8<span class="elsevierStyleHsp" style=""></span>&#40;0&#46;6&#41;&#44; and from 2&#46;0<span class="elsevierStyleHsp" style=""></span>&#40;0&#46;7&#41; to 1&#46;5<span class="elsevierStyleHsp" style=""></span>&#40;0&#46;6&#41; in volume&#44; density&#44; and texture&#44; respectively&#46; The means perceived by the physician decreased from 2&#46;0<span class="elsevierStyleHsp" style=""></span>&#40;0&#46;5&#41; to 1&#46;5<span class="elsevierStyleHsp" style=""></span>&#40;0&#46;6&#41;&#44; from 2&#46;1<span class="elsevierStyleHsp" style=""></span>&#40;0&#46;5&#41; to 1&#46;7<span class="elsevierStyleHsp" style=""></span>&#40;0&#46;5&#41;&#44; and from 1&#46;8<span class="elsevierStyleHsp" style=""></span>&#40;0&#46;6&#41; to 1&#46;3<span class="elsevierStyleHsp" style=""></span>&#40;0&#46;5&#41;&#46; All of the results were significant&#46; In approximate terms&#44; the higher the grade of alopecia&#44; the greater the improvement&#44; although data for grade<span class="elsevierStyleHsp" style=""></span>5 alopecia were not taken into consideration because there were only 3 patients in this group&#46; No statistically significant differences in patient progress were detected by age group&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Discussion</span><p id="par0100" class="elsevierStylePara elsevierViewall">Evaluation of the psychometric properties of an instrument is essential when determining quality of the measurements it generates&#46; When evaluating the accuracy of an instrument&#44; the key characteristics of a measurement are reliability&#44; validity&#44; sensitivity&#44; and feasibility&#46; Reliability refers to the ability to measure a variable in a constant manner&#59; validity refers to whether or not the instrument measures what it is intended to measure&#46; Not all reliable instruments are valid&#44; since an instrument may be reliable because it measures the variables in a constant manner but invalid if it does not appropriately measure the phenomenon it is intended to measure&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The validity of an instrument also depends on its sensitivity and feasibility&#46; Sensitivity shows the ability to detect changes in items or subjects evaluated after an intervention&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> It is associated with differences in the scores of a subject who has improved or worsened and scores that remained unchanged&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Lastly&#44; feasibility evaluates whether the questionnaire can actually be used in the field it is intended to be used in&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Both generic HRQOL questionnaires and dermatology-specific questionnaires have been used for the study of quality of life in many skin diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> In patients with alopecia&#44; Williamson et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> used an adapted version of the Dermatology Life Quality Index&#44; although this is not specific for measuring the effect of alopecia in women&#44; which is probably more intense than in men&#46; In the case of women with alopecia&#44; Schmidt et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> applied the Hairdex scale &#40;not available in Spanish&#41;&#44; and&#44; in Finland&#44; Hirsso et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> used the generic RAND<span class="elsevierStyleHsp" style=""></span>36 scale&#46; The Symptom Checklist-90-R&#44; which is specific to psychopathology&#44; has also been used as a complementary approach&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">HSS-29 is the only specific instrument available in Spanish for evaluation of HRQOL in women with alopecia<span class="elsevierStyleSup">2</span>&#46; In the present project&#44; we completed the validation of HSS-29&#46; Our data show that it is sensitive to change&#44; that is&#44; the score changes as the grade of female alopecia decreases&#46; Similarly&#44; the values obtained in the HSS-29 are significantly associated with the aspects evaluated using a generic HRQOL scale&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The correlations between the scales were statistically significant at both the baseline visit and at the follow-up visit&#46; Quality of life in all the dimensions of SF-12 worsened as the score on the HSS-29 and its subdimensions &#40;function&#44; emotions&#44; symptoms&#41; increased&#46; Thus&#44; the correlations are negative&#44; because in the case of HSS-29&#44; the score for each dimension is obtained by transforming the sum of all the responses on a linear scale of 0 &#40;no impact on quality of life&#41; to 100 &#40;maximum impact&#41;&#44; whereas on the SF-12&#44; a higher score indicates better quality of life&#46; Involvement in the emotion domain of the HSS-29&#44; with a mean score of 37&#46;7&#44; was higher than in the symptom and function domains&#46; This is consistent with the SF-12&#44; where role-emotional was the dimension most affected by alopecia&#46; The instrument seems to be very sensitive&#44; since&#44; compared with baseline&#44; the HSS-29 score at 6<span class="elsevierStyleHsp" style=""></span>months decreased both overall and in the individual dimensions&#44; for which the differences were statistically significant&#46; This aspect is relevant&#44; both in the validation of the test itself&#44; since sensitivity is an important psychometric property&#44; and in the evaluation of the efficacy of therapy&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Women with female androgenetic alopecia have a more negative perception of their health and psychosocial situation than women who do not experience hair abnormalities&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;13&#44;14</span></a> The condition may even be associated with depressive symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Van der Donk et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> reported that 50&#37; of women with alopecia had social problems and that 80&#37; felt that their daily life was affected to some extent&#46; In a study performed in Finnish women&#44; Hirsso et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> suggested that alopecia may even be associated with physical symptoms&#46; We found that the effect of female androgenetic alopecia on HRQOL was considerable&#44; particularly in the emotion domain&#58; the more severe the alopecia&#44; the more the patient was affected&#44; both overall and in the individual dimensions&#46; This impact is reflected in data obtained using the HSS-29 and the SF-12&#44; although the former was more sensitive to change&#46; The SF-12 focuses on physical limitations and emotional status independently of the cause&#44; and it may be for this reason that the HSS-29&#44; which focuses more on the impact of alopecia&#44; is more sensitive to changes in the condition of the hair&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">The validation project is particularly interesting because of its sample size &#40;983 women&#41;&#44; which is larger than that of other studies on quality of life in dermatology&#46; In addition&#44; the number of losses was relatively small &#40;12&#46;1&#37;&#41;&#46; Similarly&#44; questionnaires on quality of life translate concepts to numerical scales&#44; although this measurement could be completed with a qualitative evaluation&#46; A growing number of researchers now use such an approach&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a></p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conclusions</span><p id="par0130" class="elsevierStylePara elsevierViewall">Our data show that the Spanish version of HSS-29 is a useful tool for evaluating quality of life in women with female androgenetic alopecia and that it is considerably sensitive&#44; i&#46;e&#46;&#44; it is significantly able to detect changes in quality of life when objective conditions vary&#46; We also observed a correlation between the HSS-29 and SF-12 scales&#44; both at the baseline visit and during follow-up&#46; This same correlation was observed for differences in score between HSS-29 and differences in the evaluation of the appearance of the hair both by physicians and by patients&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Funding</span><p id="par0135" class="elsevierStylePara elsevierViewall">The project for the adaptation of the Spanish version of Hair Specific Skindex-29 was supported by a research grant from <span class="elsevierStyleGrantSponsor" id="gs0005">Laboratorio Reig Jofre</span>&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicts of interest</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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    "fechaRecibido" => "2019-05-03"
    "fechaAceptado" => "2019-06-30"
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          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1177557"
          "palabras" => array:4 [
            0 => "Scale validation"
            1 => "Female androgenetic alopecia"
            2 => "Health-related quality of life"
            3 => "Female-pattern hair loss"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabrasclave"
          "identificador" => "xpalclavsec1177558"
          "palabras" => array:4 [
            0 => "Validaci&#243;n de escalas"
            1 => "Alopecia femenina androg&#233;nica"
            2 => "Calidad de vida relacionada con la salud"
            3 => "Patr&#243;n femenino de alopecia"
          ]
        ]
      ]
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and objective</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Work has already been done on validating the cross-cultural adaptation of the hair-specific Skindex-29 questionnaire &#40;HSS-29&#41; into Spanish&#46; This questionnaire measures the impact of female-pattern hair loss on health-related quality of life &#40;HRQoL&#41;&#46; The aim of this study was to complete the validation process by testing the questionnaire&#8217;s sensitivity to change and assessing its correlation with the generic 12-item Short-Form Health Survey &#40;SF-12&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Patients who started treatment with a nutritional supplement that blocks the activity of 5 alpha-reductase were seen at 2 visits&#58; a baseline visit and a follow-up visit at 6 months&#46; At each visit&#44; hair loss severity was assessed by both investigators and patients via the Sinclair scale&#44; evaluation of hair condition&#44; and administration of HSS-29 and SF-12&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">In total&#44; 983 women with female-pattern hair loss participated in the study&#46; The mean &#40;SD&#41; HSS-29 score decreased from 25&#46;7 &#40;18&#46;7&#41; at baseline to 19&#46;3 &#40;15&#46;7&#41; at follow-up and significant changes were also observed in the functioning&#44; emotions&#44; and symptoms domains&#46; Changes in overall and subscale HSS-29 scores from baseline to follow-up were all significantly correlated with changes in SF-12 subscale scores&#46; The Pearson correlation coefficients ranged from -0&#46;1 to -0&#46;4 and were all significant at <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">The Spanish version of HSS-29 is sensitive to change&#44; as it detected changes in objective measurements of HRQoL&#46; Correlations between HSS-29 and SF-12 scores were also observed&#46;</p></span>"
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          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background and objective"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Materials and methods"
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          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivo</span><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Previamente se hab&#237;a iniciado el proceso metodol&#243;gico para la validaci&#243;n transcultural al idioma espa&#241;ol de la escala Hair Specific Skindex-29 &#40;HSS-29&#41;&#44; que mide el impacto de la alopecia androg&#233;nica femenina sobre la calidad de vida relacionada con la salud &#40;CVRS&#41;&#46; Para finalizar el proceso&#44; el objetivo del estudio fue completar la validaci&#243;n a trav&#233;s de la determinaci&#243;n de su sensibilidad al cambio y su correlaci&#243;n con una escala generalista de CVRS &#40;SF-12&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todo</span><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Se establecieron dos visitas&#44; una basal y tras seis meses de tratamiento con suplemento alimenticio con actividad inhibidora de la enzima 5-alfa reductasa&#46; En cada visita&#44; investigadores y pacientes valoraron la gravedad de la alopecia mediante la escala Sinclair&#44; el estado de la apariencia del cabello&#44; y se administraron las escalas HSS-29&#44; SF-12&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Participaron 983 mujeres con alopecia androg&#233;nica&#46; La media de puntuaci&#243;n en la escala HSS-29 cambi&#243; de 27&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;7 en la visita basal a 19&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#44;7 en la de seguimiento&#44; y sus dimensiones funcional&#44; emocional y sintom&#225;tica tambi&#233;n cambiaron significativamente&#46; Tanto las diferencias entre basal y seguimiento en el &#237;ndice HSS-29 global como en cada una de sus dimensiones se correlacionaron significativamente con las diferencias encontradas en las dimensiones de SF-12&#46; Los coeficientes de correlaci&#243;n de Pearson oscilaron entre -0&#44;1 y -0&#44;4 y en todos los casos el grado de significaci&#243;n fue p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">La versi&#243;n en espa&#241;ol de la escala HSS-29 posee sensibilidad&#44; es decir detecta cambios relacionados con la calidad de vida cuando las condiciones objetivas var&#237;an&#46; Igualmente&#44; se observ&#243; una correlaci&#243;n entre las escalas HSS-29 y SF-12&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Los miembros del grupo de validaci&#243;n Hair Specific Skindex-29 se indican en el <a class="elsevierStyleCrossRef" href="#sec0075">Appendix A</a>&#46;</p>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Please cite this article as&#58; Guerra-Tapia A&#44; et al&#46; Fase final de la validaci&#243;n transcultural al espa&#732;nol de la escala <span class="elsevierStyleItalic">Hair Specific Skindex-29</span>&#58; sensibilidad al cambio y correlaci&#243;n con la escala SF-12&#46; Actas Dermosifiliogr&#46; 2019&#59;110&#58;819&#8211;829&#46;</p>"
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            "apendice" => "<p id="par0145" class="elsevierStylePara elsevierViewall">Members of the Hair Specific Skindex-29 Validation Group</p> <p id="par0150" class="elsevierStylePara elsevierViewall">Juan Ferrando Barbera&#44; Agust&#237;n Buend&#237;a Eisman&#44; Aurora Guerra Tapia&#44; Ana Garayalde Perurena&#44; Yolanda Ju&#225;rez Casado&#44; Dolores Otero Tejero&#44; David Carlos Camacho Nu&#241;ez&#44; H&#233;ctor Juan Morales Moreno&#44; Priti Mohan Melwani&#44; Anna Vilanova Mateu&#44; Loida Galvany Rossell&#44; Paloma del Valle Calder&#243;n Andr&#233;s&#44; Rosa Izu Belloso&#44; Marta Ballestero Diez&#44; Ana Isabel Bernal Ruiz&#44; Miren Urcelay Mendiaraz&#44; Manuel Almagro S&#225;nchez&#44; Antoni Mas Ferra&#44; Miguel Servera Llaneras&#44; Laura Asumendi Redondo&#44; Mar&#237;a Rueda G&#243;mez-Calcerrada&#44; Mercedes Hospital Gil&#44; Cristina P&#233;rez Mortet&#44; Mar&#237;a Loreto Crego Di&#233;guez&#44; N&#233;stor Santana Molina&#44; Margarita Puerto Castrill&#243;n&#44; Rafael Aguayo Ortiz&#44; Esperanza Mart&#237;nez Ruiz&#44; Antonio Javier Gonz&#225;lez Rodr&#237;guez&#44; Eugenia Agut Busquet&#44; Mireia Sabat Santandreu&#44; Walter Espinosa Delgado&#44; Roberto Marengo Otero&#44; Mercedes Pico Valima&#241;a&#44; Isabel Nieto Montesinos&#44; Laura Cuesta Montero&#44; Alfredo Daniel Agullo P&#233;rez&#44; Teresa Ojeda Vila&#44; Carolina Vila Sava&#44; Manuel Pe&#241;a Blanco&#44; Eva Balb&#237;n Carrero&#44; Manuel Claros Romero&#44; Ver&#243;nica D&#237;az Fern&#225;ndez&#44; Marina Rodr&#237;guez Martin&#44; Blas Alexis G&#243;mez Dorado&#44; Mar&#237;a Carmen Goday Maso&#44; Servando Eugenio Marron Moya&#44; Mar&#237;a del Carmen V&#225;zquez Bayo&#44; Mar&#237;a Teresa Arguisjuela Hermida&#44; Kristyna Vorlicka&#44; Guillermo Enrique Solano L&#243;pez Morel&#44; Silvia Gallego &#193;lvarez&#44; Olga Gonz&#225;lez Valle&#44; Mar&#237;a Concepci&#243;n Fuente L&#225;zaro&#44; Antonia Reyes Ram&#237;rez&#44; Jes&#250;s Manuel Borbujo Mart&#237;nez&#44; Mar&#237;a Teresa de Pedro Herrero&#44; Teresa Efigenia L&#225;zaro Cantalejo&#44; Rosa Ballester S&#225;nchez&#44; Patricia Garc&#237;a Morras&#44; Sergio Hern&#225;ndez Ostiz&#44; Rosa Mar&#237;a Ortega del Olmo&#44; Salvador Arias Santiago&#44; Amaia de Mariscal Polo&#44; Clara Mart&#237;n Callizo&#44; Nayra Patricia Merino de Paz&#44; Carmen Ruiz Dom&#233;nech&#44; Juan Manuel Verdeguer Miralles&#44; Fernando Javier Allegue Gallego&#44; Francisco Jos&#233; de Le&#243;n Marrero&#44; Marisa C&#225;ceres Cwiek&#44; Marta Lamoca Martin&#44; Luis Miguel Valladares Narganes&#44; Jos&#233; Carlos San Martin Mu&#241;iz&#44; Mar&#237;a Covadonga Mart&#237;nez Gonz&#225;lez&#44; Manuel S&#225;nchez Rega&#241;a&#44; Maite Robles Portillo&#44; Vicente Aneri Mas&#44; Javier Garc&#237;a Navarro&#44; Mar&#237;a Carmen Diaz Sarrio&#44; Jos&#233; Luis Garc&#237;a Fern&#225;ndez&#44; Yolanda Carames Varela&#44; Miriam Sidro Sarto&#44; Mar&#237;a Teresa Mart&#237;n-Urda D&#237;ez-Canseco&#44; Basilio Narv&#225;ez Moreno&#44; Mario Le&#243;n Gil&#44; Marina del Hoyo Gonz&#225;lez&#44; Rebeca Sonali Lax&#44; Mar&#237;a Teresa Fern&#225;ndez&#44; Mar&#237;a Dolores Garc&#237;a Plata&#44; Elena Gonz&#225;lez Guerra&#44; Jos&#233; Manuel Pazos Campos&#44; Luis Pastor Llord&#44; Susana del Canto Gonz&#225;lez&#44; Antonio Martorell Calatayud&#44; Vicente Manuel Leis Dosil&#44; Mar&#237;a Elisa Garc&#237;a&#44; Guadalupe Fern&#225;ndez Buezo&#44; Emili Masferrer Niub&#243;&#44; Carmen Mart&#237;nez Peinado&#44; Josep Pujol Montcus&#237;&#46;</p>"
            "etiqueta" => "Appendix A"
            "identificador" => "sec0075"
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            "apendice" => "<p id="par0160" class="elsevierStylePara elsevierViewall">The following are Supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix B"
            "titulo" => "Supplementary data"
            "identificador" => "sec0085"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hair-Specific Skindex-29 and severity of alopecia&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Total score and score by dimension according to the severity of alopecia &#40;Sinclair scale&#41; at the baseline visit&#46; Involvement in the function&#44; emotion&#44; and symptom dimensions of the Hair-Specific Skindex-29 scale and overall involvement increase with the severity of alopecia&#46;</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">t</span> test&#47;ANOVA between the score on the function dimension and grade of severity&#58; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#46; <span class="elsevierStyleItalic">t</span> test&#47;ANOVA between the emotion dimension and grade of severity&#58; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#46; <span class="elsevierStyleItalic">t</span> test&#47;ANOVA between the symptom dimension and grade of severity&#58; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#46; <span class="elsevierStyleItalic">t</span> test&#47;ANOVA between the overall score and grade of severity&#58; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#46; ANOVA indicates analysis of variance&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Hair Specific Skindex-29&#46;</span>&#58; Differences in score between the first and second visit for each grade of alopecia&#46; The presence of negative differences indicates a reduced impact on quality of life at the second visit&#46;</p> <p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Difference at 6<span class="elsevierStyleHsp" style=""></span>months from baseline in the function dimension&#58; <span class="elsevierStyleItalic">t</span> test&#47;ANOVA <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#46; Difference at 6<span class="elsevierStyleHsp" style=""></span>months from baseline in the emotion dimension&#58; <span class="elsevierStyleItalic">t</span> test&#47;ANOVA <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01478&#46; Difference at 6<span class="elsevierStyleHsp" style=""></span>months from baseline in the symptom dimension&#58; <span class="elsevierStyleItalic">t</span> test&#47;ANOVA <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0009&#46; Difference at 6<span class="elsevierStyleHsp" style=""></span>months from baseline in the Hair Specific Skindex-29 global&#58; <span class="elsevierStyleItalic">t</span> test&#47;ANOVA <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&#46;</p>"
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;3&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;3&#93;<span class="elsevierStyleItalic">Sinclair alopecia scale</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Grade I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">231&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Grade II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">364&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Grade III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">263&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Grade IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Grade V&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;<a class="elsevierStyleCrossRefs" href="#bib0005">1&#8211;3&#93;</a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;<a class="elsevierStyleCrossRefs" href="#bib0005">1&#8211;3&#93;</a><span class="elsevierStyleItalic">Appearance of hair</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Normal volume&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Reduced volume&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">510&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Very reduced volume&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">330&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Normal density&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Reduced density&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">513&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Very reduced density&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">340&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Normal texture&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">187&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Reduced texture&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">457&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Very reduced texture&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">258&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No&#46; Missing&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Median&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">IQR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;8&#93; <span class="elsevierStyleItalic">HSS-29</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Function dimension&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;99&#8211;20&#46;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Emotion dimension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">977&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#46;32&#8211;39&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#46;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Symptom dimension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">976&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;09&#8211;28&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hair Specific Skindex-29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">977&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;42&#8211;28&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;8&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;8&#93;<span class="elsevierStyleItalic">SF-12</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Physical dimension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">877&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">106&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#46;82&#8211;46&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mental dimension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">877&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">106&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#46;53&#8211;42&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Physical functioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">943&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;84&#8211;47&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Role-physical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">935&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;32&#8211;27&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bodily pain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">923&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#46;99&#8211;50&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>General health&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#91;0&#44;1&#8211;11&#93; Pearson Correlation Coefficients</th></tr><tr title="table-row"><th class="td-with-role" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">877&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">877&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">943&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">935&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">923&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">945&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">939&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">933&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">929&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">939&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Function dimension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;23660&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;51743&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;31827&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;39444&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;33643&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;30199&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;35628&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;46863&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;55672&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;47292&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">877&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">877&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">943&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">935&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">923&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">945&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">939&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">933&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">929&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">939&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Emotion dimension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;16057&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;52011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;23709&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;32116&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;25731&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;30144&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;39339&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;41062&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;45253&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;48458&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
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                  """
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Coefficients for the Correlation Between the Hair-Specific Skindex-29 &#40;HSS-29&#41; and 12-Item Short-Form Health Survey at Baseline&#58; Pearson Coefficients for the Correlation Between Both Instruments&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Paired <span class="elsevierStyleItalic">t</span> Test<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#91;0&#44;1&#8211;5&#93; <span class="elsevierStyleItalic">Hair Specific Skindex 29</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hair Specific Skindex-29&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">19&#46;3 &#40;15&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">18&#46;29-20&#46;31&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hair Specific Skindex-29&#46; Baseline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Function dimension&#46; Baseline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">19&#46;3 &#40;21&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17&#46;99-20&#46;63&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">P</span> &#60; &#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Emotion dimension&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">25&#46;8 &#40;20&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">24&#46;49-27&#46;12&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Emotion dimension&#46; Baseline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">37&#46;8 &#40;23&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">36&#46;32-39&#46;21&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">P</span> &#60; &#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Symptom dimension&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">938&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">20&#46;7 &#40;16&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">19&#46;66-21&#46;74&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Symptom dimension&#46; Baseline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">27&#46;2 &#40;18&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">26&#46;09-28&#46;46&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">P</span> &#60; &#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#91;0&#44;1&#8211;5&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="5" align="left" valign="\n
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                  \t\t\t\t">&#91;0&#44;1&#8211;5&#93; <span class="elsevierStyleItalic">12-Item Short-Form Health Survey</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Physical dimension&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">855&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Physical dimension&#46; Baseline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">877&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">46&#46;2 &#40;6&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">45&#46;82&#8211;46&#46;67&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">P</span> &#60; &#46;<span class="elsevierStyleBold">34</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mental dimension&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">855&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">43&#46;8 &#40;7&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">43&#46;30&#8211;44&#46;34&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mental dimension&#46; Baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">877&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">42&#46;1 &#40;8&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Physical functioning&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">937&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">47&#46;5 &#40;8&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">46&#46;98&#8211;48&#46;02&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Physical functioning&#46; Baseline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">943&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">47&#46;3 &#40;8&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">46&#46;84&#8211;47&#46;87&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Role-physical&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Role-physical&#46; Baseline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">P</span> &#60; &#46;<span class="elsevierStyleBold">01</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bodily pain&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">912&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#46;0 &#40;5&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;58&#8211;51&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bodily pain&#46; Baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">923&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;4 &#40;6&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#46;99&#8211;50&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">P</span> &#60; &#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>General health&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">936&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;0 &#40;7&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#46;56-50&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>General health&#46; Baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">945&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;6 &#40;7&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;16&#8211;49&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">P</span> &#60; &#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Vitality&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">929&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#46;5 &#40;10&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;81&#8211;52&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Vitality&#46; Baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">939&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;2 &#40;9&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#46;63&#8211;50&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">P</span> &#60; &#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Role-emotional&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">933&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;7 &#40;4&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;45&#8211;20&#46;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Role-emotional&#46; Baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">933&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;3 &#40;4&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;06&#8211;20&#46;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">P</span> &#60; &#46;<span class="elsevierStyleBold">01</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Social functioning&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">897&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#46;9 &#40;9&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#46;36&#8211;55&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Social functioning&#46; Baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">929&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;7 &#40;9&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;05&#8211;54&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">P</span> &#60; &#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mental health&#46; Follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">926&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;4 &#40;9&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;85&#8211;54&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mental health&#46; Baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">939&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#46;1 &#40;9&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;51&#8211;51&#46;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">P</span> &#60; &#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#91;0&#44;1&#8211;5&#93; Pearson Correlation Coefficients</th></tr><tr title="table-row"><th class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#91;0&#44;1&#8211;5&#93; Prob &#62; &#124;r&#124; Assuming H0&#58; Rho<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0</th></tr><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#91;0&#44;1&#8211;5&#93; No&#46; of Observations</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Difference in the Function Dimension<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Difference in the Emotion Dimension<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Difference in the Symptom Dimension<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Difference in Overall HSS-29<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difference physical dimension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span> &#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">772&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">772&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">771&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">772&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difference mental dimension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span> &#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">772&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">772&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">771&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">772&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difference physical functioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span> &#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">905&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">905&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">904&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">905&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difference role-physical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span> &#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">894&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">894&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">893&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">894&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difference bodily pain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; <span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">864&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">864&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">863&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">864&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difference general health&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span> &#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">905&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">905&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">904&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">905&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difference vitality&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span> &#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">894&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">894&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">893&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">894&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difference role-emotional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span> &#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">891&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">891&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">890&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">891&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difference social functioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span> &#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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Journal Information
Vol. 110. Issue 10.
Pages 819-829 (December 2019)
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4518
Vol. 110. Issue 10.
Pages 819-829 (December 2019)
Original Article
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Final Phase in the Validation of the Cross-Cultural Adaptation of the Hair-Specific Skindex-29 Questionnaire Into Spanish: Sensitivity to Change and Correlation With the 12-Item Short-Form Health Survey
Fase final de la validación transcultural al español de la escala
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4518
A. Guerra-Tapiaa,
Corresponding author
aurora@auroraguerra.com

Corresponding author.
, A. Buendía-Eismanb, J. Ferrando Barberac, en representación del grupo de validación Hair Specific Skindex 29 1
a Servicio de Dermatología, Hospital Universitario 12 de Octubre, Facultad de Medicina, Universidad Complutense, Madrid, Spain
b Facultad de Medicina, Universidad de Granada, Granada, Spain
c Servicio de Dermatología, Hospital Clínico, Facultad de Medicina, Universidad de Barcelona, Barcelona, Spain
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Figures (2)
Tables (6)
Table 1. Patient Characteristics by Age, Sinclair Grade, and Appearance of Hair at Baseline.
Table 2. Scores on the Hair-Specific Skindex-29 (HSS-29) and 12-Item Short Form Health Survey (SF-12) Scales: Baseline Visit.
Table 3. Coefficients for the Correlation Between the Hair-Specific Skindex-29 (HSS-29) and 12-Item Short-Form Health Survey at Baseline: Pearson Coefficients for the Correlation Between Both Instruments.
Table 4. Scores on the Hair Specific Skindex 29 and 12-Item Short-Form Health Survey Scales at Baseline and During Follow-up.
Table 5. Sensitivity to Change: Correlation Between Hair-Specific Skindex 29 (HSS-29) and 12-Item Short-Form Health Survey.
Table 6. Sensitivity to Change. Correlation Between Hair Specific Skindex 29 and the Evaluation of the Appearance of the Hair.
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Additional material (1)
Abstract
Background and objective

Work has already been done on validating the cross-cultural adaptation of the hair-specific Skindex-29 questionnaire (HSS-29) into Spanish. This questionnaire measures the impact of female-pattern hair loss on health-related quality of life (HRQoL). The aim of this study was to complete the validation process by testing the questionnaire’s sensitivity to change and assessing its correlation with the generic 12-item Short-Form Health Survey (SF-12).

Materials and methods

Patients who started treatment with a nutritional supplement that blocks the activity of 5 alpha-reductase were seen at 2 visits: a baseline visit and a follow-up visit at 6 months. At each visit, hair loss severity was assessed by both investigators and patients via the Sinclair scale, evaluation of hair condition, and administration of HSS-29 and SF-12.

Results

In total, 983 women with female-pattern hair loss participated in the study. The mean (SD) HSS-29 score decreased from 25.7 (18.7) at baseline to 19.3 (15.7) at follow-up and significant changes were also observed in the functioning, emotions, and symptoms domains. Changes in overall and subscale HSS-29 scores from baseline to follow-up were all significantly correlated with changes in SF-12 subscale scores. The Pearson correlation coefficients ranged from -0.1 to -0.4 and were all significant at P<.001.

Conclusions

The Spanish version of HSS-29 is sensitive to change, as it detected changes in objective measurements of HRQoL. Correlations between HSS-29 and SF-12 scores were also observed.

Keywords:
Scale validation
Female androgenetic alopecia
Health-related quality of life
Female-pattern hair loss
Palabrasclave:
Validación de escalas
Alopecia femenina androgénica
Calidad de vida relacionada con la salud
Patrón femenino de alopecia
Resumen
Antecedentes y objetivo

Previamente se había iniciado el proceso metodológico para la validación transcultural al idioma español de la escala Hair Specific Skindex-29 (HSS-29), que mide el impacto de la alopecia androgénica femenina sobre la calidad de vida relacionada con la salud (CVRS). Para finalizar el proceso, el objetivo del estudio fue completar la validación a través de la determinación de su sensibilidad al cambio y su correlación con una escala generalista de CVRS (SF-12).

Material y método

Se establecieron dos visitas, una basal y tras seis meses de tratamiento con suplemento alimenticio con actividad inhibidora de la enzima 5-alfa reductasa. En cada visita, investigadores y pacientes valoraron la gravedad de la alopecia mediante la escala Sinclair, el estado de la apariencia del cabello, y se administraron las escalas HSS-29, SF-12.

Resultados

Participaron 983 mujeres con alopecia androgénica. La media de puntuación en la escala HSS-29 cambió de 27,5±18,7 en la visita basal a 19,3±15,7 en la de seguimiento, y sus dimensiones funcional, emocional y sintomática también cambiaron significativamente. Tanto las diferencias entre basal y seguimiento en el índice HSS-29 global como en cada una de sus dimensiones se correlacionaron significativamente con las diferencias encontradas en las dimensiones de SF-12. Los coeficientes de correlación de Pearson oscilaron entre -0,1 y -0,4 y en todos los casos el grado de significación fue p<0,001.

Conclusiones

La versión en español de la escala HSS-29 posee sensibilidad, es decir detecta cambios relacionados con la calidad de vida cuando las condiciones objetivas varían. Igualmente, se observó una correlación entre las escalas HSS-29 y SF-12.

Full Text
Introduction

During the years 2016 and 2018, a Spanish group carried out a cross-cultural validation of the Spanish-language version of the Hair-Specific Skindex-29 (HSS-29) scale, which was based on the Skindex-29 scale1 for measuring the impact of female androgenetic alopecia on health-related quality of life (HRQOL).

This result was an adapted functional Spanish-language version of the HSS-29 scale. The process was described, and the results were published in Actas Dermosifiliográficas in 2018.2

In order to finalize the validation process and complete all of its phases, it was decided to evaluate sensitivity to change and its correlation with the generic 12-Item Short-Form Health Survey (SF-12).3

Material and MethodsPopulation

The study sample included 983 women from 101 dermatology clinics in the different Spanish autonomous communities. The women consulted for female androgenetic alopecia and participated voluntarily after receiving appropriate information. They started treatment with dietary supplements containing 5-α-reductase enzyme inhibitor and had not received treatment with supplements in the previous 3 months.

Instruments

Quality of life was evaluated using HSS-29 (Appendix B1. Additional Material) and SF-12 (Appendix B2. Additional Material). The HSS-29 questionnaire is a self-administered tool that makes it possible to evaluate HRQOL in patients with alopecia. It was based on the Skindex-29 scale and is composed of 29 items distributed over 3dimensions or domains: symptoms (7items), function (12items), and emotions (10items). The questionnaire takes a mean of 5minutes to complete, and each item is answered based on a Likert-type scale ranging from 0 (never) to 5 (all the time). The dimensions are scored by transforming the sum of all the responses to a linear scale ranging from 0 (no impact) to 100 (maximum impact).

The SF-12 questionnaire contains 12items covering 8 HRQOL domains: physical dimension, mental dimension, physical functioning, role-physical, bodily pain, general health, role-emotional, social functioning, and mental health. Reference guidelines are available for the Spanish version of SF-12 (version 2).4

Furthermore, the patient and the clinician were asked their opinion on the volume, density, and texture of the hair.

Design

Patients attended 2 visits, one at baseline and the other after 6months of treatment. At the baseline visit, patients initiated treatment with 5-α-reductase enzyme inhibitor dietary supplements, which they continued to take for 6months. They completed both questionnaires at each visit, and the investigators evaluated the severity of alopecia using the Sinclair scale. Both the patient and the clinician evaluated the volume, density, and texture of the hair as better, worse, or no change.

The project for cross-cultural adaptation to Spanish began in 2016, according to the protocol approved by the Ethics Committee of Hospital 12 de Octubre on December 20 (No. 16/392). The second phase was carried out between January and October 2018.

Data Analysis

First, a descriptive analysis of the data was performed using a frequency table for nominal variables and measures of central tendency and dispersion for continuous variables. Data for continuous variables were presented with their 95%CI.

Comparisons between groups and quantitative variables were made using the t test (2groups) or 1-way analysis of variance (≥3 groups). If either of these tests could not be applied, the Mann-Whitney test (2groups) or the Kruskal-Wallis test (≥3 groups) was used. Where necessary, tests for paired data were applied. Continuous variables were compared using the Fisher correlation coefficient in the case of absolutely continuous variables or the Spearman test in the case of those that were not. All calculations were made using SAS Version 9.4.

ResultsBaseline Visit

Table 1 shows the characteristics of the patients included in the study. The study population comprised 983 women with a mean age of 50 (16.3) years and mainly (83.6%) grade 1–3 alopecia according to the Sinclair scale. Table 2 shows the total score and the score by dimensions on the HSS-29 scale. The grade of alopecia is shown in Fig. 1. Emotion was the most affected domain, with a mean score of 37.7 (95%CI, 36.3–39.2); the score was lower in the symptom and function domains, with a mean of 27.2 (95% CI, 26.0–28.4) and 19.3 (95%CI, 17.9–20.6), respectively. We found that involvement was more pronounced as alopecia became more severe, both in the overall score and in the various dimensions. No significant differences were detected for age group with respect to the score on the scale as a whole or in its individual dimensions. The baseline SF-12 score is also shown in Table 2. The domain with the greatest impact on quality of life was role-emotional, with a mean score of 20.3 (95%CI, 20.0–20.6). As in the HSS-29, involvement was more pronounced as alopecia became worse in all the scores recorded for the SF-12.

Table 1.

Patient Characteristics by Age, Sinclair Grade, and Appearance of Hair at Baseline.

  No. 
Patients included  983   
[0,1–3]Age
0-44 y  358  36.4 
45-65 y  383  39.0 
> 65 7  188  19.1 
Unknown  54  5.5 
[0,1–3]
[0,1–3]Sinclair alopecia scale
Grade I  231  23.5 
Grade II  364  37.0 
Grade III  263  26.7 
Grade IV  66  6.7 
Grade V  0.3 
Unknown  56  5.7 
[0,1–3]
[0,1–3]Appearance of hair
Normal volume  62  6.9 
Reduced volume  510  56.5 
Very reduced volume  330  36.6 
Normal density  50  5.5 
Reduced density  513  5.8 
Very reduced density  340  37.7 
Normal texture  187  20.7 
Reduced texture  457  50.7 
Very reduced texture  258  28.6 
Table 2.

Scores on the Hair-Specific Skindex-29 (HSS-29) and 12-Item Short Form Health Survey (SF-12) Scales: Baseline Visit.

  No.  No. Missing  Mean  SD  95% CI  Median  IQR 
[0,1–8] HSS-29
Function dimension  977  19.31  20.97  17.99–20.63  12.50  29.17 
Emotion dimension  977  37.77  23.06  36.32–39.21  35.00  32.50 
Symptom dimension  976  27.28  18.85  26.09–28.46  25.00  25.00 
Hair Specific Skindex-29  977  27.59  18.71  26.42–28.77  24.14  25.80 
[0,1–8]
[0,1–8]SF-12
Physical dimension  877  106  46.24  6.38  45.82–46.67  47.90  10.05 
Mental dimension  877  106  42.08  8.18  41.53–42.62  43.00  11.05 
Physical functioning  943  40  47.35  8.06  46.84–47.87  54.41  15.87 
Role-physical  935  48  27.54  3.46  27.32–27.76  29.79  4.25 
Bodily pain  923  60  50.42  6.61  49.99–50.85  55.38  6.72 
General health  945  38  48.64  7.58  48.16–49.13  46.74  8.31 
Vitality  939  44  50.25  9.77  49.63–50.88  51.73  16.03 
Role-emotional  933  50  20.34  4.39  20.06–20.63  23.22  5.17 
Social functioning  929  54  53.67  9.55  53.05–54.28  54.42  17.67 
Mental health  939  44  51.13  9.69  50.51–51.75  54.16  14.59 

Abbreviation: IQR, interquartile range.

The score for the dimensions of the HSS-29 scale ranges from 0 (no impact) to 100 (maximum impact). Each item on the SF-12 scale evaluates different aspects on a scale of 0 (no quality of life) to 100 (maximum quality of life).

Figure 1.

Hair-Specific Skindex-29 and severity of alopecia.

Total score and score by dimension according to the severity of alopecia (Sinclair scale) at the baseline visit. Involvement in the function, emotion, and symptom dimensions of the Hair-Specific Skindex-29 scale and overall involvement increase with the severity of alopecia.

t test/ANOVA between the score on the function dimension and grade of severity: P<.001. t test/ANOVA between the emotion dimension and grade of severity: P<.001. t test/ANOVA between the symptom dimension and grade of severity: P<.001. t test/ANOVA between the overall score and grade of severity: P<.001. ANOVA indicates analysis of variance.

(0.25MB).

The correlation between both scales at baseline is presented in Table 3. All of the correlations studied using Pearson coefficients were negative and statistically significant (P< .001). A higher score in the HSS-29 and all its subdimensions (function, emotion, and symptoms) was associated with a lower score, i.e., reduced HRQOL, in all of the dimensions of the SF-12 scale. Similarly, the mean scores on the SF-12 decreased as severity in the HSS-29 increased in its classified form. When the study population was stratified by age group and severity of alopecia, we observed the same negative correlation in all the groups, except in patients with grade 5 alopecia. No analysis was performed for this subgroup, since it only included 3women.

Table 3.

Coefficients for the Correlation Between the Hair-Specific Skindex-29 (HSS-29) and 12-Item Short-Form Health Survey at Baseline: Pearson Coefficients for the Correlation Between Both Instruments.

[0,1–11] Pearson Correlation Coefficients
[0,1–11]Prob > |r| assuming H0: Rho=0
[0,1–11]Number of Observations
  Physical Dimension  Mental Dimension  Physical Functioning  Role-Physical  Bodily Pain  General Health  Vitality  Role-Emotional  Social Functioning  Mental Health 
HSS-29  −0.24003  −0.55938  −0.31839  −0.40848  −0.34350  −0.33711  −0.41408  −0.48271  −0.54738  −0.51527 
  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001 
  877  877  943  935  923  945  939  933  929  939 
Function dimension  −0.23660  −0.51743  −0.31827  −0.39444  −0.33643  −0.30199  −0.35628  −0.46863  −0.55672  −0.47292 
  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001 
  877  877  943  935  923  945  939  933  929  939 
Emotion dimension  −0.16057  −0.52011  −0.23709  −0.32116  −0.25731  −0.30144  −0.39339  −0.41062  −0.45253  −0.48458 
  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001 
  877  877  943  935  923  945  939  933  929  939 
Symptom dimension  −0.25844  −0.39918  −0.29281  −0.36953  −0.31984  −0.28697  −0.33661  −0.37542  −0.40267  −0.37324 
  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001  <0.0001 
  876  876  942  934  922  944  938  932  928  938 
Follow-up Visit

Of the 983 patients included in the initial project, 967 (98.3%) were evaluated at 6months. Compared with the baseline score, the global score on the HSS-29 scale at 6months decreased overall and in the scores for the individual dimensions, in which the differences were statistically significant (Table 4). The mean score on the overall scale fell from 27.5(18.7) at baseline to 19.3(15.7) at the follow-up visit. Significant changes were also observed for the function, emotion, and symptom dimensions, from 19.3(2.0) to 13.1(15.8), from 37.7(23.0) to 25.8(20.5), and from 27.2(18.8) to 20.7(16.2), respectively. Fig. 2 shows the differences between the 2 visits according to the grade of alopecia. All of the differences evaluated were statistically significant with respect to the grade of alopecia.

Table 4.

Scores on the Hair Specific Skindex 29 and 12-Item Short-Form Health Survey Scales at Baseline and During Follow-up.

  Mean (SD)  95% CI  Paired t Testa 
[0,1–5] Hair Specific Skindex 29
Hair Specific Skindex-29. Follow-up  939  19.3 (15.8)  18.29-20.31   
Hair Specific Skindex-29. Baseline  977  27.6 (18.7)  26.42-28.77  P < .001 
Function dimension. Follow-up  937  13.2 (15.9)  12.15-14.18   
Function dimension. Baseline  977  19.3 (21.0)  17.99-20.63  P < .001 
Emotion dimension. Follow-up  936  25.8 (20.5)  24.49-27.12   
Emotion dimension. Baseline  977  37.8 (23.1)  36.32-39.21  P < .001 
Symptom dimension. Follow-up  938  20.7 (16.2)  19.66-21.74   
Symptom dimension. Baseline  976  27.2 (18.8)  26.09-28.46  P < .001 
[0,1–5]
[0,1–5] 12-Item Short-Form Health Survey
Physical dimension. Follow-up  855  46.3 (6.1)  45.93–46.75   
Physical dimension. Baseline  877  46.2 (6.3)  45.82–46.67  P < .34 
Mental dimension. Follow-up  855  43.8 (7.9)  43.30–44.34   
Mental dimension. Baseline  877  42.1 (8.1)  41.53–42.62  P < .001 
Physical functioning. Follow-up  937  47.5 (8.1)  46.98–48.02   
Physical functioning. Baseline  943  47.3 (8.0)  46.84–47.87  P < .37 
Role-physical. Follow-up  935  27.7 (3.3)  27.53–27.96   
Role-physical. Baseline  935  27.5 (3.4)  27.32–27.76  P < .01 
Bodily pain. Follow-up  912  51.0 (5.9)  50.58–51.36   
Bodily pain. Baseline  923  50.4 (6.6)  49.99–50.85  P < .001 
General health. Follow-up  936  50.0 (7.6)  49.56-50.54   
General health. Baseline  945  48.6 (7.5)  48.16–49.13  P < .001 
Vitality. Follow-up  929  51.5 (10.4)  50.81–52.15   
Vitality. Baseline  939  50.2 (9.7)  49.63–50.88  P < .001 
Role-emotional. Follow-up  933  20.7 (4.1)  20.45–20.98   
Role-emotional. Baseline  933  20.3 (4.3)  20.06–20.63  P < .01 
Social functioning. Follow-up  897  54.9 (9.0)  54.36–55.54   
Social functioning. Baseline  929  53.7 (9.5)  53.05–54.28  P < .001 
Mental health. Follow-up  926  53.4 (9.2)  52.85–54.05   
Mental health. Baseline  939  51.1 (9.6)  50.51–51.75  P < .001 
a

Follow-up visit at 6 months compared with baseline.

Figure 2.

Hair Specific Skindex-29.: Differences in score between the first and second visit for each grade of alopecia. The presence of negative differences indicates a reduced impact on quality of life at the second visit.

Difference at 6months from baseline in the function dimension: t test/ANOVA P<.001. Difference at 6months from baseline in the emotion dimension: t test/ANOVA P<.01478. Difference at 6months from baseline in the symptom dimension: t test/ANOVA P<.0009. Difference at 6months from baseline in the Hair Specific Skindex-29 global: t test/ANOVA P<.0001.

(0.25MB).

Depending on the severity of alopecia, differences were observed in the score on the HSS-29 scale between the first and second visits, with an improvement in involvement of quality of life (i.e., scores <20 in the HSS-29 scale in all its domains and for all grades of alopecia). Fig. 2 shows the differences between the first and second evaluation.

A statistically significant increase in the SF-12 scores was observed in the dimensions role-physical, bodily pain, general health, vitality, role-emotional, social functioning, and mental health at 6months, whereas the change in the physical dimension and physical functioning was not significant (Table 4).

Sensitivity to Change

In order to evaluate sensitivity to change, we calculated the differences between the scores at 6months and the baseline scores for all the dimensions on the HSS-29 and SF-12 scales and assessed the evaluations of the appearance of the patients’ hair. We then determined whether these differences were correlated or not, that is, whether one changed with the other. The analysis was performed for the whole study population and by age group and grade of alopecia.

Table 5 shows the correlation for the differences between the scales, that is, whether one changed with the other. We observed that the differences between baseline and follow-up both for the overall HSS-29 index and for each of its dimensions were significantly correlated with the differences found for the dimensions of the SF-12. The Pearson correlation coefficients ranged between −0.1 and −0.4, and statistical significance in all cases was P<.001. The scatterplots for the correlation of differences are shown in Appendix BAnnex 3 (Additional material).

Table 5.

Sensitivity to Change: Correlation Between Hair-Specific Skindex 29 (HSS-29) and 12-Item Short-Form Health Survey.

[0,1–5] Pearson Correlation Coefficients
[0,1–5] Prob > |r| Assuming H0: Rho=0
[0,1–5] No. of Observations
  Difference in the Function Dimensiona  Difference in the Emotion Dimensiona  Difference in the Symptom Dimensiona  Difference in Overall HSS-29a 
Difference physical dimension  −0.18  −0.14  −0.21  −0.20 
  <.0001  < .0001  <.0001  <.0001 
  772  772  771  772 
Difference mental dimension  −0.41  −0.40  −0.32  −0.44 
  <.0001  < .0001  <.0001  <.0001 
  772  772  771  772 
Difference physical functioning  −0.20  −0.17  −0.23  −0.22 
  <.0001  < .0001  <.0001  <.0001 
  905  905  904  905 
Difference role-physical  −0.28  −0.23  −0.25  −0.29 
  <.0001  < .0001  <.0001  <.0001 
  894  894  893  894 
Difference bodily pain  −0.26  −0.19  −0.22  −0.26 
  <.0001  < .0001  <.0001  <.0001 
  864  864  863  864 
Difference general health  −0.25  −0.26  −0.26  −0.29 
  <.0001  < .0001  <.0001  <.0001 
  905  905  904  905 
Difference vitality  −0.23  −0.27  −0.22  −0.28 
  <.0001  < .0001  <.0001  <.0001 
  894  894  893  894 
Difference role-emotional  −0.34  −0.31  −0.29  −0.37 
  <.0001  < .0001  <.0001  <.0001 
  891  891  890  891 
Difference social functioning  −0.43  −0.32  −0.30  −0.41 
  <.0001  < .0001  <.0001  <.0001 
  854  854  853  854 
Difference mental health  −0.34  −0.34  −0.28  −0.37 
  <.0001  < .0001  <.0001  <.0001 
  891  891  890  891 

Pearson correlation coefficients between the HSS-29 and SF-12 scales, evaluated based on the differences in the score between the baseline visit and the follow-up visit for each item studied.

a

Differences in the score at the baseline visit and the follow-up visit.

Lastly, Table 6 shows the differences between the appearance of the patients’ hair and the HSS-29 score. All of the correlations examined were statistically significant, except for texture as assessed by the clinician compared with progress in the emotion dimension. As the indices for the evaluation of the hair worsened, the HSS-29 score decreased. Both the physician’s and the patient’s evaluation revealed an improvement in the appearance of the hair in the categories volume, density, and texture. For a score of 1–3 (1 normal, 3 very diminished), the means perceived by the patients decreased from 2.3 (0.5) to 1.8 (0.6), from 2.3(0.5) to 1.8(0.6), and from 2.0(0.7) to 1.5(0.6) in volume, density, and texture, respectively. The means perceived by the physician decreased from 2.0(0.5) to 1.5(0.6), from 2.1(0.5) to 1.7(0.5), and from 1.8(0.6) to 1.3(0.5). All of the results were significant. In approximate terms, the higher the grade of alopecia, the greater the improvement, although data for grade5 alopecia were not taken into consideration because there were only 3 patients in this group. No statistically significant differences in patient progress were detected by age group.

Table 6.

Sensitivity to Change. Correlation Between Hair Specific Skindex 29 and the Evaluation of the Appearance of the Hair.

[0,1–5] Pearson Correlation Coefficients
[0,1–5] Prob > |r| Assuming H0: Rho=0
[0,1–5] No. of Observations
  Difference in the Function Dimensiona  Difference in the Emotion Dimensiona  Difference in the Symptom Dimensiona  Difference in Overall HSS-29a 
Volume. Patient. Difference between baseline and follow-up  −0.22603  −0.31208  −0.21855  −0.29747 
  <0.0001  <0.0001  <0.0001  <0.0001 
  861  861  860  861 
Density. Patient. Difference between baseline and follow-up  −0.29644  −0.34290  −0.29573  −0.35695 
  <0.0001  <0.0001  <0.0001  <0.0001 
  862  862  861  862 
Texture. Patient. Difference between baseline and follow-up  −0.24214  −0.27862  −0.20991  −0.28001 
  <0.0001  <0.0001  <0.0001  <0.0001 
  859  859  858  859 
Volume. Physician. Difference between baseline and follow-up  −0.14387  −0.12736  −0.18275  −0.16639 
  <0.0001  0.0003  <0.0001  <0.0001 
  815  815  814  815 
Density. Physician. Difference between baseline and follow-up  −0.17044  −0.15101  −0.16342  −0.18756 
  <0.0001  <0.0001  <0.0001  <0.0001 
  814  814  813  814 
Texture. Physician. Difference between baseline and follow-up  −0.08975  −0.05517  −0.14394  −0.10544 
  0.0104  0.1158  <0.0001  0.0026 
  814  814  813  814 

Correlation between the differences observed by the physician and the patient in density, volume, and texture of the patient’s hair at the baseline and follow-up visits and differences in the Hair-Specific Skindex-29 score between the baseline and follow-up visits.

a

Differences between the score at the baseline visit and the follow-up visit.

Discussion

Evaluation of the psychometric properties of an instrument is essential when determining quality of the measurements it generates. When evaluating the accuracy of an instrument, the key characteristics of a measurement are reliability, validity, sensitivity, and feasibility. Reliability refers to the ability to measure a variable in a constant manner; validity refers to whether or not the instrument measures what it is intended to measure. Not all reliable instruments are valid, since an instrument may be reliable because it measures the variables in a constant manner but invalid if it does not appropriately measure the phenomenon it is intended to measure.5 The validity of an instrument also depends on its sensitivity and feasibility. Sensitivity shows the ability to detect changes in items or subjects evaluated after an intervention.6 It is associated with differences in the scores of a subject who has improved or worsened and scores that remained unchanged.7 Lastly, feasibility evaluates whether the questionnaire can actually be used in the field it is intended to be used in.

Both generic HRQOL questionnaires and dermatology-specific questionnaires have been used for the study of quality of life in many skin diseases.8 In patients with alopecia, Williamson et al.9 used an adapted version of the Dermatology Life Quality Index, although this is not specific for measuring the effect of alopecia in women, which is probably more intense than in men. In the case of women with alopecia, Schmidt et al.10 applied the Hairdex scale (not available in Spanish), and, in Finland, Hirsso et al.11 used the generic RAND36 scale. The Symptom Checklist-90-R, which is specific to psychopathology, has also been used as a complementary approach.12

HSS-29 is the only specific instrument available in Spanish for evaluation of HRQOL in women with alopecia2. In the present project, we completed the validation of HSS-29. Our data show that it is sensitive to change, that is, the score changes as the grade of female alopecia decreases. Similarly, the values obtained in the HSS-29 are significantly associated with the aspects evaluated using a generic HRQOL scale.

The correlations between the scales were statistically significant at both the baseline visit and at the follow-up visit. Quality of life in all the dimensions of SF-12 worsened as the score on the HSS-29 and its subdimensions (function, emotions, symptoms) increased. Thus, the correlations are negative, because in the case of HSS-29, the score for each dimension is obtained by transforming the sum of all the responses on a linear scale of 0 (no impact on quality of life) to 100 (maximum impact), whereas on the SF-12, a higher score indicates better quality of life. Involvement in the emotion domain of the HSS-29, with a mean score of 37.7, was higher than in the symptom and function domains. This is consistent with the SF-12, where role-emotional was the dimension most affected by alopecia. The instrument seems to be very sensitive, since, compared with baseline, the HSS-29 score at 6months decreased both overall and in the individual dimensions, for which the differences were statistically significant. This aspect is relevant, both in the validation of the test itself, since sensitivity is an important psychometric property, and in the evaluation of the efficacy of therapy.

Women with female androgenetic alopecia have a more negative perception of their health and psychosocial situation than women who do not experience hair abnormalities.10,13,14 The condition may even be associated with depressive symptoms.15 Van der Donk et al.16 reported that 50% of women with alopecia had social problems and that 80% felt that their daily life was affected to some extent. In a study performed in Finnish women, Hirsso et al.11 suggested that alopecia may even be associated with physical symptoms. We found that the effect of female androgenetic alopecia on HRQOL was considerable, particularly in the emotion domain: the more severe the alopecia, the more the patient was affected, both overall and in the individual dimensions. This impact is reflected in data obtained using the HSS-29 and the SF-12, although the former was more sensitive to change. The SF-12 focuses on physical limitations and emotional status independently of the cause, and it may be for this reason that the HSS-29, which focuses more on the impact of alopecia, is more sensitive to changes in the condition of the hair.

The validation project is particularly interesting because of its sample size (983 women), which is larger than that of other studies on quality of life in dermatology. In addition, the number of losses was relatively small (12.1%). Similarly, questionnaires on quality of life translate concepts to numerical scales, although this measurement could be completed with a qualitative evaluation. A growing number of researchers now use such an approach.17

Conclusions

Our data show that the Spanish version of HSS-29 is a useful tool for evaluating quality of life in women with female androgenetic alopecia and that it is considerably sensitive, i.e., it is significantly able to detect changes in quality of life when objective conditions vary. We also observed a correlation between the HSS-29 and SF-12 scales, both at the baseline visit and during follow-up. This same correlation was observed for differences in score between HSS-29 and differences in the evaluation of the appearance of the hair both by physicians and by patients.

Funding

The project for the adaptation of the Spanish version of Hair Specific Skindex-29 was supported by a research grant from Laboratorio Reig Jofre.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Appendix A

Members of the Hair Specific Skindex-29 Validation Group

Juan Ferrando Barbera, Agustín Buendía Eisman, Aurora Guerra Tapia, Ana Garayalde Perurena, Yolanda Juárez Casado, Dolores Otero Tejero, David Carlos Camacho Nuñez, Héctor Juan Morales Moreno, Priti Mohan Melwani, Anna Vilanova Mateu, Loida Galvany Rossell, Paloma del Valle Calderón Andrés, Rosa Izu Belloso, Marta Ballestero Diez, Ana Isabel Bernal Ruiz, Miren Urcelay Mendiaraz, Manuel Almagro Sánchez, Antoni Mas Ferra, Miguel Servera Llaneras, Laura Asumendi Redondo, María Rueda Gómez-Calcerrada, Mercedes Hospital Gil, Cristina Pérez Mortet, María Loreto Crego Diéguez, Néstor Santana Molina, Margarita Puerto Castrillón, Rafael Aguayo Ortiz, Esperanza Martínez Ruiz, Antonio Javier González Rodríguez, Eugenia Agut Busquet, Mireia Sabat Santandreu, Walter Espinosa Delgado, Roberto Marengo Otero, Mercedes Pico Valimaña, Isabel Nieto Montesinos, Laura Cuesta Montero, Alfredo Daniel Agullo Pérez, Teresa Ojeda Vila, Carolina Vila Sava, Manuel Peña Blanco, Eva Balbín Carrero, Manuel Claros Romero, Verónica Díaz Fernández, Marina Rodríguez Martin, Blas Alexis Gómez Dorado, María Carmen Goday Maso, Servando Eugenio Marron Moya, María del Carmen Vázquez Bayo, María Teresa Arguisjuela Hermida, Kristyna Vorlicka, Guillermo Enrique Solano López Morel, Silvia Gallego Álvarez, Olga González Valle, María Concepción Fuente Lázaro, Antonia Reyes Ramírez, Jesús Manuel Borbujo Martínez, María Teresa de Pedro Herrero, Teresa Efigenia Lázaro Cantalejo, Rosa Ballester Sánchez, Patricia García Morras, Sergio Hernández Ostiz, Rosa María Ortega del Olmo, Salvador Arias Santiago, Amaia de Mariscal Polo, Clara Martín Callizo, Nayra Patricia Merino de Paz, Carmen Ruiz Doménech, Juan Manuel Verdeguer Miralles, Fernando Javier Allegue Gallego, Francisco José de León Marrero, Marisa Cáceres Cwiek, Marta Lamoca Martin, Luis Miguel Valladares Narganes, José Carlos San Martin Muñiz, María Covadonga Martínez González, Manuel Sánchez Regaña, Maite Robles Portillo, Vicente Aneri Mas, Javier García Navarro, María Carmen Diaz Sarrio, José Luis García Fernández, Yolanda Carames Varela, Miriam Sidro Sarto, María Teresa Martín-Urda Díez-Canseco, Basilio Narváez Moreno, Mario León Gil, Marina del Hoyo González, Rebeca Sonali Lax, María Teresa Fernández, María Dolores García Plata, Elena González Guerra, José Manuel Pazos Campos, Luis Pastor Llord, Susana del Canto González, Antonio Martorell Calatayud, Vicente Manuel Leis Dosil, María Elisa García, Guadalupe Fernández Buezo, Emili Masferrer Niubó, Carmen Martínez Peinado, Josep Pujol Montcusí.

Appendix B
Supplementary data

The following are Supplementary data to this article:

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Los miembros del grupo de validación Hair Specific Skindex-29 se indican en el Appendix A.

Please cite this article as: Guerra-Tapia A, et al. Fase final de la validación transcultural al espa˜nol de la escala Hair Specific Skindex-29: sensibilidad al cambio y correlación con la escala SF-12. Actas Dermosifiliogr. 2019;110:819–829.

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