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Vol. 104. Issue 4.
Pages 285-298 (May 2013)
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Vol. 104. Issue 4.
Pages 285-298 (May 2013)
Review
DOI: 10.1016/j.adengl.2012.03.027
Cutaneous Alerts in Systemic Malignancy: Part I
Alertas cutáneas en malignidades sistémicas (parte I)
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M. Yuste-Chaves
Corresponding author
manuelayuste@hotmail.com

Corresponding author.
, P. Unamuno-Pérez
Servicio de Dermatología, Hospital Universitario de Salamanca, Salamanca, Spain
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Tables (8)
Table 1. Nature of Paraneoplastic Syndrome.
Table 2. Possible Cutaneous Signs of an Internal Malignancy.
Table 3. Conditions Involving Facial Reddening, Swelling or Flushing Potentially Associated With an Internal Malignancy.
Table 4. Hyperpigmentation as a Sign of Possible Internal Malignancy.
Table 5. Skin Disorders With Annular Lesions Potentially Associated With an Internal Malignancy.
Table 6. Conditions Involving Erythematosquamous and Hyperkeratotic Lesions as Potential Signs of an Internal Malignancy.
Table 7. Conditions Involving Skin Thickening and Hardening Potentially Associated With an Internal Malignancy.
Table 8. Vascular Lesions Potentially Associated With an Internal Malignancy.
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Abstract

The aim of this review is to familiarize dermatologists and clinicians in general with cutaneous signs and symptoms that can help lead to an early diagnosis of an underlying malignancy. Because the skin is one of the most accessible organs, it should never be overlooked in systemic disease. Examination of the skin has the advantage of revealing important information about the patient's condition without requiring the use of invasive techniques.

In the literature, most discussions of cutaneous manifestations of internal malignancy refer to classic paraneoplastic syndromes, but a wide variety of skin conditions, while not strictly paraneoplastic, can, in certain contexts, indicate the presence of malignancy or an increased risk of developing cancer later in life.

In this review, various skin conditions that can signal malignancy or increased cancer risk are presented in randomly ordered groups based on clinical morphology.

Conditions with multiple signs and symptoms have been classified on the basis of their most characteristic feature.

Keywords:
Cutaneous alerts
Neoplasia
Cutaneous paraneoplastic syndromes
Resumen

El objetivo de esta revisión es alertar al dermatólogo y a los clínicos en general de los signos y síntomas cutáneos que pueden contribuir al diagnóstico precoz de una neoplasia subyacente. Puesto que la piel es uno de los órganos más accesible, nunca debe ser ignorada en las enfermedades sistémicas. Posee la ventaja de que su exploración no requiere técnicas agresivas y nos revela datos importantes de la situación del paciente.

Habitualmente se abordan los síndromes paraneoplásicos clásicos, pero hay una gran variedad de procesos cutáneos no estrictamente paraneoplásicos, que en un determinado contexto sugieren la presencia de una malignidad o bien tienen más riesgo de desarrollarla a lo largo de la vida.

Se ha optado por enumerar las distintas dermatosis agrupándolas por su morfología clínica, siguiendo un orden aleatorio.

Varios de los procesos comparten signos y síntomas múltiples por lo que se ha recurrido al más notorio para incluirlo en un determinado grupo.

Palabras clave:
Alertas cutáneas
Neoplasia
Síndromes paraneoplásicos cutáneos

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