Case ReportMalignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: A case report and review of the literature
Section snippets
Case report
A 52-year-old Caucasian female, who was previously healthy, was referred to the Cleveland clinic with the diagnosis of progressive acanthosis nigricans. In June 2004, she noted brownish discoloration of the skin on the neck, bilateral axillary region and groins followed by the appearance of velvety patchy lesions on the hyperpigmented area, then, a few weeks, later similar skin changes appeared under the breasts, a warty thickening of nipples was also noted, then she developed coarse thickening
Discussion
Our case represents the first occurrence of malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat in a patient with ovarian cancer.
Ovarian cancer is the 4th leading cause of female cancer-related death in the United States, most cases are asymptomatic at early stages and are not diagnosed until the tumor has progressed to advanced stages.
Malignant acanthosis nigricans (MAN) is a well-known paraneoplastic dermatosis. Although its exact incidence is unknown, in one study, it
Conclusion
MAN is a rare paraneoplastic dermatosis that can precede the diagnosis of the underlying cancer. The mechanism of development of malignant acanthosis nigricans has yet to be determined. The neoplasms associated with malignant acanthosis nigricans are typically aggressive in nature, mandating an extensive search for the underlying malignancy once the diagnosis of MAN is suspected, including clinical, laboratory and radiological investigations. Some authors even suggested consideration of
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