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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Over 113 new cases of basal cell carcinoma &#40;BCC&#41; are diagnosed per 100<span class="elsevierStyleHsp" style=""></span>000 inhabitants every year in Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> BCC is associated with significant morbidity and health care costs&#46; Patients who develop BCC at a younger age are more likely to have predisposing characteristics&#44; such as a sensitive skin type or a history of sunburn&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> They are thus an ideal population for the study of risk factors and for targeted preventive measures&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In order to analyze the clinical characteristics and risk factors associated with BCC in younger adults&#44; we reviewed all cases of BCC diagnosed in patients under 40 years of age at Hospital de Manacor in Mallorca&#44; Spain between 2010 and 2015&#46; Data were gathered from medical records and pathology reports&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Forty-one lesions were diagnosed over the 6-year period in 36 patients &#40;18 women and 18 men&#41;&#46; A diagnosis of BCC had not been suspected on the grounds of clinical records or pathology reports in 6 of the tumors &#40;14&#46;6&#37;&#41; before the histologic diagnosis&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> summarizes the clinical and histological characteristics of the 41 tumors&#44; treatment received&#44; follow-up times&#44; and incidence of second tumors&#46; Information on the presence of known risk factors for BCC is provided in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; Information on risk factors that was not available in the medical records was obtained through telephone interviews with the patients&#46; Five patients &#40;4 men and 1 woman&#41; were unlocatable and we were therefore only able to report on risk factors included in their medical records&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">BCC is a common disease in our setting&#46; The pathology laboratory at Hospital de Manacor&#44; which serves a population of approximately 150&#160;000 inhabitants in the eastern part of Mallorca&#44; diagnosed 1841 cases of BCC based on biopsy and surgical specimens in the 6 years analyzed &#40;306&#46;8 cases a year&#41;&#46; Just 2&#46;5&#37; of the cases corresponded to patients younger than 40 years&#46; This proportion is similar to that reported in a previous study in Catalonia&#44; Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> The low incidence of BCC in young patients could cause diagnostic delays due to a low index of suspicion&#46; In our series&#44; 6 of the 41 tumors &#40;14&#46;6&#37;&#41; had not been suspected clinically&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">As is usual with tumors of this type&#44; the most common location was the top of the head&#46; The most common subtype was nodular BCC &#40;73&#46;2&#37;&#41;&#44; contrasting with a recent report that early-onset BCC was associated with an aggressive histologic subtype&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Three of the BCCs in our series &#40;7&#46;3&#37;&#41; were associated with a sebaceous or epidermal nevus&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Four patients &#40;11&#46;1&#37;&#41; developed a second BCC during follow-up&#44; and 1 of these developed a third tumor&#46; Length of follow-up was highly variable&#44; and ranged from no follow-up in some cases to 5 years in others&#46; In a recent study&#44; 34&#37; of patients diagnosed with BCC before the age of 40 years had a second BCC at the 5-year follow-up&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">None of the patients had immunodeficiency or syndromes that predispose to BCC&#46; In relation to risk factors associated with pigmentary traits&#44; a majority of patients had Fitzpatrick skin type <span class="elsevierStyleSmallCaps">ii</span> or <span class="elsevierStyleSmallCaps">iii</span>&#44; which based on indirect data&#44; are the most common skin types seen in routine clinical practice in our setting&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Almost all the patients in the series had a history of sunburn and almost 20&#37; recalled blisters&#46; Intense and intermittent sun exposure in the early years of life is a well-known risk factor for BCC&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a> Occupational sun exposure&#44; whether intense &#40;builders&#44; agricultural workers&#41; or intermittent &#40;waiters&#44; couriers&#44; tourist guides&#41; was reported by 48&#37; of the patients&#46; This type of sun exposure tends to be more sustained over time&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Nine of the 31 patients we were able to locate by telephone &#40;7 women and 2 men&#41; had used tanning booths&#46; A clear association has been established between tanning booth use and early onset of skin cancer&#44; and adults under 40 years of age who have used a tanning booth at some point during their life have been found to have twice the risk of BCC as those who have never used one&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">9&#44;10</span></a> Unlike elsewhere in Europe&#44; frequency of tanning booth use has not been studied in Spain&#46; Apart from detecting a tendency towards a greater use of tanning booths among the women in our series&#44; we were unable to establish correlations between any of the other risk factors due to our small sample&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; BCC is a significant source of morbidity and health care costs in Spain&#46; Understanding the risk factors associated with BCC is essential for designing prevention strategies and favoring early diagnosis&#46; BCC is rare in patients under 40 years of age&#46; Nonetheless&#44; these patients have a higher prevalence of risk factors for this cancer&#44; some of which are avoidable&#46; Tanning booth use could be a major risk factor for BCC but there are no accurate data on its prevalence in Spain&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17-39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Sex</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Male&#47;female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#47;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Tumor site</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Head and neck&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;56&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Trunk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;29&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Upper limb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;12&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lower limb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Histologic subtype</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nodular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 &#40;73&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Superficial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;17&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Basal squamous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;4&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Desmoplastic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Multicomponent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;2&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Associated lesion<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Treatment</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34 &#40;82&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Imiquimod&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;17&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Follow-up&#44; mo</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mean&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Median&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0-60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Excision of other BCCs</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1406727.png"
              ]
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          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">The figures provided for age&#44; sex&#44; and follow-up time refer to the total number of patients &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>36&#41;&#46; The rest of the figures refer to the number of tumors &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>41&#41;&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Three cases&#58; 2 sebaceous nevi and 1 epidermal nevus&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical and Histological Characteristics&#44; Treatment&#44; Follow-up Time&#44; and Incidence of Second Tumors&#46;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Data are presented as number &#40;&#37;&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Syndrome associated with BCC or immunodeficiency</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Family history of BCC</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;25&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Fitzpatrick skin type</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">i</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;6&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">ii</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;45&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">iii</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;32&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">iv</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;16&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">History of sunburn</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Erythema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28 &#40;90&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Blisters&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;19&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Hair color</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Red&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;6&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Blonde&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;22&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Chestnut&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;41&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dark Brown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;29&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Eye color</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Green&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;25&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Blue&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;19&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Brown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17 &#40;54&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Use of tanning booths</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;29&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Occupational sun exposure</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Intense&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;29&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Partial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;19&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;51&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Smoking &#40;present or past&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;41&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">History of radiation therapy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1406726.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Percentages are based on the number of patients we were able to contact by telephone &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>31&#41;&#46;</p>"
            ]
          ]
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Journal Information
Vol. 108. Issue 4.
Pages 376-377 (May 2017)
Vol. 108. Issue 4.
Pages 376-377 (May 2017)
Case and Research Letter
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Basal Cell Carcinoma in Young Adults
Carcinoma basocelular en pacientes jóvenes
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J. Garcias-Ladaria
Corresponding author
jgarcila@gmail.com

Corresponding author.
, F.J. Morales-Morato, M. Cuadrado Rosón, V. Rocamora
Servicio de Dermatología, Hospital de Manacor, Manacor, Islas Baleares, Spain
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Tables (2)
Table 1. Clinical and Histological Characteristics, Treatment, Follow-up Time, and Incidence of Second Tumors.a
Table 2. Presence of Known Risk Factors for Basal Cell Carcinoma (BCC).a
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To the Editor:

Over 113 new cases of basal cell carcinoma (BCC) are diagnosed per 100000 inhabitants every year in Spain.1 BCC is associated with significant morbidity and health care costs. Patients who develop BCC at a younger age are more likely to have predisposing characteristics, such as a sensitive skin type or a history of sunburn.2 They are thus an ideal population for the study of risk factors and for targeted preventive measures.

In order to analyze the clinical characteristics and risk factors associated with BCC in younger adults, we reviewed all cases of BCC diagnosed in patients under 40 years of age at Hospital de Manacor in Mallorca, Spain between 2010 and 2015. Data were gathered from medical records and pathology reports.

Forty-one lesions were diagnosed over the 6-year period in 36 patients (18 women and 18 men). A diagnosis of BCC had not been suspected on the grounds of clinical records or pathology reports in 6 of the tumors (14.6%) before the histologic diagnosis. Table 1 summarizes the clinical and histological characteristics of the 41 tumors, treatment received, follow-up times, and incidence of second tumors. Information on the presence of known risk factors for BCC is provided in Table 2. Information on risk factors that was not available in the medical records was obtained through telephone interviews with the patients. Five patients (4 men and 1 woman) were unlocatable and we were therefore only able to report on risk factors included in their medical records.

Table 1.

Clinical and Histological Characteristics, Treatment, Follow-up Time, and Incidence of Second Tumors.a

Age at first diagnosis, y
Mean  32.9 
Median  33 
Range  17-39 
Sex
Male/female  18/18 
Tumor site
Head and neck  23 (56.1) 
Trunk  12 (29.3) 
Upper limb  5 (12.2) 
Lower limb  1 (2.4) 
Histologic subtype
Nodular  30 (73.2) 
Superficial  7 (17.1) 
Basal squamous  2 (4.9) 
Desmoplastic  1 (2.4) 
Multicomponent  1 (2.4) 
Associated lesionb  3 (7.3) 
Treatment
Surgery  34 (82.9) 
Imiquimod  7 (17.1) 
Follow-up, mo
Mean  23.8 
Median  19 
Range  0-60 
Excision of other BCCs  4 (11.1) 

Data are presented as number (%) of patients unless otherwise specified.

a

The figures provided for age, sex, and follow-up time refer to the total number of patients (n=36). The rest of the figures refer to the number of tumors (n=41).

b

Three cases: 2 sebaceous nevi and 1 epidermal nevus.

Table 2.

Presence of Known Risk Factors for Basal Cell Carcinoma (BCC).a

Syndrome associated with BCC or immunodeficiency  0 (0) 
Family history of BCC  8 (25.8) 
Fitzpatrick skin type
i  2 (6.5) 
ii  14 (45.1) 
iii  10 (32.3) 
iv  5 (16.1) 
History of sunburn
Erythema  28 (90.3) 
Blisters  6 (19.4) 
Hair color
Red  2 (6.5) 
Blonde  7 (22.6) 
Chestnut  13 (41.9) 
Dark Brown  9 (29.0) 
Eye color
Green  8 (25.8) 
Blue  6 (19.4) 
Brown  17 (54.8) 
Use of tanning booths  9 (29.0) 
Occupational sun exposure
Intense  9 (29.0) 
Partial  6 (19.4) 
None  16 (51.6) 
Smoking (present or past)  13 (41.9) 
History of radiation therapy  0 (0) 

Data are presented as number (%).

a

Percentages are based on the number of patients we were able to contact by telephone (n=31).

BCC is a common disease in our setting. The pathology laboratory at Hospital de Manacor, which serves a population of approximately 150 000 inhabitants in the eastern part of Mallorca, diagnosed 1841 cases of BCC based on biopsy and surgical specimens in the 6 years analyzed (306.8 cases a year). Just 2.5% of the cases corresponded to patients younger than 40 years. This proportion is similar to that reported in a previous study in Catalonia, Spain.3 The low incidence of BCC in young patients could cause diagnostic delays due to a low index of suspicion. In our series, 6 of the 41 tumors (14.6%) had not been suspected clinically.

As is usual with tumors of this type, the most common location was the top of the head. The most common subtype was nodular BCC (73.2%), contrasting with a recent report that early-onset BCC was associated with an aggressive histologic subtype.4 Three of the BCCs in our series (7.3%) were associated with a sebaceous or epidermal nevus.

Four patients (11.1%) developed a second BCC during follow-up, and 1 of these developed a third tumor. Length of follow-up was highly variable, and ranged from no follow-up in some cases to 5 years in others. In a recent study, 34% of patients diagnosed with BCC before the age of 40 years had a second BCC at the 5-year follow-up.5

None of the patients had immunodeficiency or syndromes that predispose to BCC. In relation to risk factors associated with pigmentary traits, a majority of patients had Fitzpatrick skin type ii or iii, which based on indirect data, are the most common skin types seen in routine clinical practice in our setting.6 Almost all the patients in the series had a history of sunburn and almost 20% recalled blisters. Intense and intermittent sun exposure in the early years of life is a well-known risk factor for BCC.7,8 Occupational sun exposure, whether intense (builders, agricultural workers) or intermittent (waiters, couriers, tourist guides) was reported by 48% of the patients. This type of sun exposure tends to be more sustained over time.

Nine of the 31 patients we were able to locate by telephone (7 women and 2 men) had used tanning booths. A clear association has been established between tanning booth use and early onset of skin cancer, and adults under 40 years of age who have used a tanning booth at some point during their life have been found to have twice the risk of BCC as those who have never used one.9,10 Unlike elsewhere in Europe, frequency of tanning booth use has not been studied in Spain. Apart from detecting a tendency towards a greater use of tanning booths among the women in our series, we were unable to establish correlations between any of the other risk factors due to our small sample.

In conclusion, BCC is a significant source of morbidity and health care costs in Spain. Understanding the risk factors associated with BCC is essential for designing prevention strategies and favoring early diagnosis. BCC is rare in patients under 40 years of age. Nonetheless, these patients have a higher prevalence of risk factors for this cancer, some of which are avoidable. Tanning booth use could be a major risk factor for BCC but there are no accurate data on its prevalence in Spain.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

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Please cite this article as: Garcias-Ladaria J, Morales-Morato FJ, Rosón MC, Rocamora V. Carcinoma basocelular en pacientes jóvenes. Actas Dermosifiliogr. 2017;108:376–377.

Copyright © 2016. Elsevier España, S.L.U. and AEDV
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