array:23 [
  "pii" => "S1578219015000633"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.03.013"
  "estado" => "S300"
  "fechaPublicacion" => "2015-05-01"
  "aid" => "1070"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2015;106:331-2"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1367
    "formatos" => array:3 [
      "EPUB" => 43
      "HTML" => 884
      "PDF" => 440
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:18 [
      "pii" => "S0001731014004542"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2014.09.009"
      "estado" => "S300"
      "fechaPublicacion" => "2015-05-01"
      "aid" => "1070"
      "copyright" => "Elsevier España, S.L.U. y AEDV"
      "documento" => "simple-article"
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2015;106:331-2"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 2767
        "formatos" => array:3 [
          "EPUB" => 5
          "HTML" => 783
          "PDF" => 1979
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Telangiectasias verticalizadas y prurito en el t&#243;rax en un paciente con s&#237;ndrome de cava superior inicial secundario a un timoma maligno"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "331"
            "paginaFinal" => "332"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Vertically Orientated Telangiectasias and Pruritus on the Thorax of a Patient With Early Superior Vena Cava Syndrome Secondary to a Malignant Thymoma"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 662
                "Ancho" => 995
                "Tamanyo" => 85877
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Telangiectasias verticalizas en la piel de la cara anterior del t&#243;rax &#40;detalle&#41;&#46; La exploraci&#243;n no mostr&#243; vasos dilatados de mayor calibre&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "C&#46; Laguna"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Laguna"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015000633"
          "doi" => "10.1016/j.adengl.2015.03.013"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000633?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004542?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000004/v2_201505051016/S0001731014004542/v2_201505051016/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219015000645"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.03.014"
    "estado" => "S300"
    "fechaPublicacion" => "2015-05-01"
    "aid" => "1071"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:333-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1192
      "formatos" => array:3 [
        "EPUB" => 50
        "HTML" => 699
        "PDF" => 443
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Pseudoxanthoma Elasticum&#8211;like Papillary Dermal Elastolysis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "333"
          "paginaFinal" => "336"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Elast&#243;lisis de la dermis papilar similar a pseudoxantoma el&#225;stico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1313
              "Ancho" => 1750
              "Tamanyo" => 566340
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#44; Millimetric nonfollicular papules&#44; light brownish in color&#44; converge to form plaques with a cobblestone pattern&#46; B&#44; Light-brownish areas tending to converge&#59; multiple linear and branching vessels can be seen&#46; C&#44; Nearly total absence of elastic fibers in the papillary dermis&#59; in contrast&#44; elastic fibers &#40;black arrows&#41; can be seen in the reticular dermis &#40;orcein&#44; original magnification &#215;100&#41;&#46; D&#44; Melanophages &#40;red arrows&#41; dispersed in the papillary dermis &#40;hematoxilin-eosin &#215;400&#41;&#46; E&#44; Von Kossa staining revealed no calcifications of elastic fibers &#40;original magnification &#215;<span class="elsevierStyleHsp" style=""></span>100&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "I&#46; V&#225;zquez-Osorio, E&#46; Ros&#243;n, J&#46;M&#46; Su&#225;rez-Pe&#241;aranda, H&#46; V&#225;zquez-Veiga"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "V&#225;zquez-Osorio"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Ros&#243;n"
            ]
            2 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Su&#225;rez-Pe&#241;aranda"
            ]
            3 => array:2 [
              "nombre" => "H&#46;"
              "apellidos" => "V&#225;zquez-Veiga"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731014004554"
        "doi" => "10.1016/j.ad.2014.10.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004554?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000645?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000004/v2_201505051007/S1578219015000645/v2_201505051007/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219015000621"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.03.012"
    "estado" => "S300"
    "fechaPublicacion" => "2015-05-01"
    "aid" => "1066"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:329-31"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1532
      "formatos" => array:3 [
        "EPUB" => 53
        "HTML" => 1252
        "PDF" => 227
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Herpes Zoster in Children Vaccinated Against Varicella-Zoster Virus&#58; Experience in our Hospital"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "329"
          "paginaFinal" => "331"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Herpes z&#243;ster en ni&#241;os vacunados contra el virus varicela z&#243;ster&#58; experiencia en nuestro hospital"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 884
              "Ancho" => 1600
              "Tamanyo" => 182550
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical characteristics of the herpes zoster lesions in 4 of the patients in our series&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "D&#46; Caro-Guti&#233;rrez, J&#46;L&#46; L&#243;pez-Estebaranz, E&#46; Naz-Villalba, L&#46; Ayala-Bernaldo de Quiros"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Caro-Guti&#233;rrez"
            ]
            1 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "L&#243;pez-Estebaranz"
            ]
            2 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Naz-Villalba"
            ]
            3 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Ayala-Bernaldo de Quiros"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731014004505"
        "doi" => "10.1016/j.ad.2014.07.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004505?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000621?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000004/v2_201505051007/S1578219015000621/v2_201505051007/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Vertically Orientated Telangiectasias and Pruritus on the Thorax of a Patient With Early Superior Vena Cava Syndrome Secondary to a Malignant Thymoma"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "331"
        "paginaFinal" => "332"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "C&#46; Laguna"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Laguna"
            "email" => array:1 [
              0 => "cecipru&#64;comv&#46;es"
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; Hospital Llu&#237;s Alcany&#237;s&#44; X&#224;tiva&#44; Valencia&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Telangiectasias verticalizadas y prurito en el t&#243;rax en un paciente con s&#237;ndrome de cava superior inicial secundario a un timoma maligno"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 732
            "Ancho" => 976
            "Tamanyo" => 89941
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Computed tomography revealed a tumor in the anterior mediastinum &#40;MT&#41; with compression of the superior vena cava &#40;arrow&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Thymoma is the most common primary tumor of the anterior mediastinum&#46; Symptoms are due to compression by the tumor or to various paraneoplastic syndromes&#46; However&#44; 50&#37; of patients are asymptomatic at the time of diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> We describe the case of a patient who developed pruritus and telangiectasias on the trunk as the initial signs of a malignant thymoma&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 78-year-old man who was seen in outpatients for the progressive appearance of telangiectasias on the skin of the anterior chest wall over the previous 3 months&#46; He reported that he had previously had a skin rash in the area but that it had resolved by the time of consultation&#46; The patient complained of intense pruritus and malaise that even affected nighttime rest&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">He did not report chest pain or respiratory difficulty&#46; His past history included a bladder tumor that was in remission&#46; A chest x-ray and abdominal ultrasound performed 2 years earlier had shown no alterations&#46; Physical examination revealed telangiectasias in a vertical distribution&#44; most prominent on the left hemithorax&#44; with no other changes and no other dilated&#44; larger caliber vessels &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; There were no relevant findings on examination of the face and neck and no palpable masses or lymph nodes&#46; In view of the intensity of the symptoms reported by the patient&#44; cervical and thoracic computed tomography &#40;CT&#41; was requested to rule out an underlying lesion&#46; The CT revealed a retrosternal mass of 5<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2&#46;5<span class="elsevierStyleHsp" style=""></span>cm with enlarged perilesional and pericardial lymph nodes and compression of the superior vena cava &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The differential diagnosis included teratoma&#44; lymphoma&#44; and thymoma&#46; The patient did not report weight loss or night sweats&#44; and his general state of health was normal&#46; Cytology from a fine-needle aspiration biopsy was compatible with thymoma&#46; The patient was evaluated by the thoracic surgeons and the tumor was considered inoperable&#46; The final diagnosis was malignant sclerosing thymoma&#46; Studies of tumor spread excluded metastatic disease and there were no symptoms of paraneoplastic syndromes&#44; such as myasthenia gravis&#46; The patient started combined treatment with adriamycin and radiation therapy with a partial regression of the mass&#46; The telangiectases did not vary&#44; but the pruritus reported by the patient resolved with the treatment&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Thymoma is the most common tumor of the anterosuperior mediastinum&#46; It typically starts in the midline and spreads unilaterally&#46; Symptoms described by patients with thymoma can be due to the mass effect&#44; such as chest pain&#44; respiratory difficulty&#44; cough&#44; or superior vena cava syndrome&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#8211;3</span></a> This syndrome occurs when venous return from the upper part of the body is obstructed&#46; One of the earliest and most prominent signs of this syndrome is the appearance of numerous vertically orientated&#44; dilated and tortuous capillaries and venules&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> Other typical signs of superior vena cava syndrome are edema of the face and of the upper limbs&#44; cyanosis&#44; and visual changes due to papilledema&#46; Bruno et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> published a case caused by lymphoma in which the patient also presented a transient skin rash and telangiectases&#46; Other causes of telangiectases on the chest wall are chronic actinic damage and poikiloderma&#44; essential telangiectasia&#44; connective tissue diseases such as lupus&#44; dermatomyositis or scleroderma&#44; hyperestrogenic states such as cirrhosis and pregnancy&#44; and malignant causes such as intravascular B-cell lymphoma or skin metastases&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Other manifestations in patients with thymoma include a high prevalence of infections and immunological disturbances&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> Myasthenia gravis develops in at least 30&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> There have also been cases of red cell aplasia&#44; hypogammaglobulinemia&#44; endocrine disturbances&#44; chronic mucocutaneous candidiasis&#44; connective tissue diseases such as lupus or dermatomyositis&#44; and paraneoplastic pemphigus&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Surgery is the treatment of choice&#46; Patients with advanced invasive thymoma require treatment with radiation therapy and chemotherapy&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> Cases have been seen of invasive thymoma affecting the pleura and lung&#44; thoracic vertebrae&#44; thyroid gland&#44; central nervous system&#44; liver&#44; extrathoracic lymph nodes&#44; and overlying dermis&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">At no time did our patient present extracutaneous symptoms&#44; and it was the skin manifestations that led to the diagnosis of his serious underlying disease&#46; Thus&#44; in a patient with intense pruritus on the chest with no causative skin lesions and&#47;or vertically oriented telangiectasias of rapid onset&#44; we must exclude an intrathoracic space-occupying lesion&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Laguna C&#46; Telangiectasias verticalizadas y prurito en el t&#243;rax en un paciente con s&#237;ndrome de cava superior inicial secundario a un timoma maligno&#46; Actas Dermosifiliogr&#46; 2015&#59;106&#58;331&#8211;332&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 662
            "Ancho" => 995
            "Tamanyo" => 109423
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Telangiectasias on the left hemithorax&#46; Examination revealed no other alterations&#46; The rash described by the patient had resolved at the time of diagnosis&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 662
            "Ancho" => 995
            "Tamanyo" => 82800
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Detail of the vertically oriented telangiectasias on the skin of the anterior wall of the chest&#46; Examination revealed no dilated vessels of larger diameter&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 732
            "Ancho" => 976
            "Tamanyo" => 89941
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Computed tomography revealed a tumor in the anterior mediastinum &#40;MT&#41; with compression of the superior vena cava &#40;arrow&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumours of the mediastinum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;V&#46; Duwe"
                            1 => "D&#46;H&#46; Sterman"
                            2 => "A&#46;I&#46; Musani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.128.4.2893"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "paginaInicial" => "2893"
                        "paginaFinal" => "2909"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16236967"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thymoma presenting as chest pain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Meghani"
                            1 => "M&#46;N&#46; Siddique"
                            2 => "M&#46; Sicart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MAJ.0b013e31824ab427"
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Med Sci"
                        "fecha" => "2012"
                        "volumen" => "344"
                        "paginaInicial" => "413"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23095443"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thymic neoplasms&#58; A clinical update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Mikhail"
                            1 => "Y&#46; Mekhaiel"
                            2 => "T&#46; Mekhail"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11912-012-0246-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Oncol Rep"
                        "fecha" => "2012"
                        "volumen" => "14"
                        "paginaInicial" => "350"
                        "paginaFinal" => "358"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22639107"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermatologic features of the superior vena cava syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;V&#46; Hirschmann"
                            1 => "G&#46;J&#46; Raugi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1992"
                        "volumen" => "128"
                        "paginaInicial" => "953"
                        "paginaFinal" => "956"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1626963"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Superior vena cava syndrome and telangiectasia in a man with lymphoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;F&#46; Bruno"
                            1 => "M&#46; Donoff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1503/cmaj.070628"
                      "Revista" => array:6 [
                        "tituloSerie" => "CMAJ"
                        "fecha" => "2007"
                        "volumen" => "177"
                        "paginaInicial" => "1177"
                        "paginaFinal" => "1179"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17984468"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High prevalence of infections and autoimmunity in patients with thymoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Holbro"
                            1 => "A&#46; Jauch"
                            2 => "D&#46; Lardinois"
                            3 => "A&#46; Tzankov"
                            4 => "S&#46; Dirnhofer"
                            5 => "C&#46; Hess"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.humimm.2011.12.022"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hum Immunol"
                        "fecha" => "2012"
                        "volumen" => "73"
                        "paginaInicial" => "287"
                        "paginaFinal" => "290"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22261388"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673609609181"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thymoma and paraneoplastic myasthenia gravis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Marx"
                            1 => "N&#46; Willcox"
                            2 => "M&#46;I&#46; Leite"
                            3 => "W&#46;Y&#46; Chuang"
                            4 => "B&#46; Schalke"
                            5 => "W&#46; Nix"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/08916930903555935"
                      "Revista" => array:7 [
                        "tituloSerie" => "Autoimmunity"
                        "fecha" => "2010"
                        "volumen" => "43"
                        "numero" => "5-6"
                        "paginaInicial" => "413"
                        "paginaFinal" => "427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20380583"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A unique paraneoplastic syndrome presenting in a patient with unresectable thymoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Lally"
                            1 => "V&#46;J&#46; Venning"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Acad Dermatol Venereol"
                        "fecha" => "2007"
                        "volumen" => "21"
                        "paginaInicial" => "434"
                        "paginaFinal" => "435"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An extraordinary case of subcutaneous invasive thymoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Herde"
                            1 => "T&#46; Gambichler"
                            2 => "K&#46; Hoffmann"
                            3 => "P&#46; Altmeyer"
                            4 => "M&#46; St&#252;cker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2002"
                        "volumen" => "16"
                        "paginaInicial" => "537"
                        "paginaFinal" => "538"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12428860"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1473309911701967"
                          "estado" => "S300"
                          "issn" => "14733099"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000004/v2_201505051007/S1578219015000633/v2_201505051007/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000004/v2_201505051007/S1578219015000633/v2_201505051007/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000633?idApp=UINPBA000044"
]
Compartir
Información de la revista
Vol. 106. Núm. 4.
Páginas 331-332 (mayo 2015)
Vol. 106. Núm. 4.
Páginas 331-332 (mayo 2015)
Case and Research Letter
Acceso a texto completo
Vertically Orientated Telangiectasias and Pruritus on the Thorax of a Patient With Early Superior Vena Cava Syndrome Secondary to a Malignant Thymoma
Telangiectasias verticalizadas y prurito en el tórax en un paciente con síndrome de cava superior inicial secundario a un timoma maligno
Visitas
6825
C. Laguna
Departamento de Dermatología, Hospital Lluís Alcanyís, Xàtiva, Valencia, Spain
Este artículo ha recibido
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Figuras (3)
Mostrar másMostrar menos
Texto completo

Thymoma is the most common primary tumor of the anterior mediastinum. Symptoms are due to compression by the tumor or to various paraneoplastic syndromes. However, 50% of patients are asymptomatic at the time of diagnosis.1 We describe the case of a patient who developed pruritus and telangiectasias on the trunk as the initial signs of a malignant thymoma.

The patient was a 78-year-old man who was seen in outpatients for the progressive appearance of telangiectasias on the skin of the anterior chest wall over the previous 3 months. He reported that he had previously had a skin rash in the area but that it had resolved by the time of consultation. The patient complained of intense pruritus and malaise that even affected nighttime rest.

He did not report chest pain or respiratory difficulty. His past history included a bladder tumor that was in remission. A chest x-ray and abdominal ultrasound performed 2 years earlier had shown no alterations. Physical examination revealed telangiectasias in a vertical distribution, most prominent on the left hemithorax, with no other changes and no other dilated, larger caliber vessels (Figs. 1 and 2). There were no relevant findings on examination of the face and neck and no palpable masses or lymph nodes. In view of the intensity of the symptoms reported by the patient, cervical and thoracic computed tomography (CT) was requested to rule out an underlying lesion. The CT revealed a retrosternal mass of 5×2.5cm with enlarged perilesional and pericardial lymph nodes and compression of the superior vena cava (Fig. 3). The differential diagnosis included teratoma, lymphoma, and thymoma. The patient did not report weight loss or night sweats, and his general state of health was normal. Cytology from a fine-needle aspiration biopsy was compatible with thymoma. The patient was evaluated by the thoracic surgeons and the tumor was considered inoperable. The final diagnosis was malignant sclerosing thymoma. Studies of tumor spread excluded metastatic disease and there were no symptoms of paraneoplastic syndromes, such as myasthenia gravis. The patient started combined treatment with adriamycin and radiation therapy with a partial regression of the mass. The telangiectases did not vary, but the pruritus reported by the patient resolved with the treatment.

Figure 1.

Telangiectasias on the left hemithorax. Examination revealed no other alterations. The rash described by the patient had resolved at the time of diagnosis.

(0.1MB).
Figure 2.

Detail of the vertically oriented telangiectasias on the skin of the anterior wall of the chest. Examination revealed no dilated vessels of larger diameter.

(0.08MB).
Figure 3.

Computed tomography revealed a tumor in the anterior mediastinum (MT) with compression of the superior vena cava (arrow).

(0.09MB).

Thymoma is the most common tumor of the anterosuperior mediastinum. It typically starts in the midline and spreads unilaterally. Symptoms described by patients with thymoma can be due to the mass effect, such as chest pain, respiratory difficulty, cough, or superior vena cava syndrome.1–3 This syndrome occurs when venous return from the upper part of the body is obstructed. One of the earliest and most prominent signs of this syndrome is the appearance of numerous vertically orientated, dilated and tortuous capillaries and venules.4 Other typical signs of superior vena cava syndrome are edema of the face and of the upper limbs, cyanosis, and visual changes due to papilledema. Bruno et al.5 published a case caused by lymphoma in which the patient also presented a transient skin rash and telangiectases. Other causes of telangiectases on the chest wall are chronic actinic damage and poikiloderma, essential telangiectasia, connective tissue diseases such as lupus, dermatomyositis or scleroderma, hyperestrogenic states such as cirrhosis and pregnancy, and malignant causes such as intravascular B-cell lymphoma or skin metastases.

Other manifestations in patients with thymoma include a high prevalence of infections and immunological disturbances.6 Myasthenia gravis develops in at least 30% of patients.7 There have also been cases of red cell aplasia, hypogammaglobulinemia, endocrine disturbances, chronic mucocutaneous candidiasis, connective tissue diseases such as lupus or dermatomyositis, and paraneoplastic pemphigus.8

Surgery is the treatment of choice. Patients with advanced invasive thymoma require treatment with radiation therapy and chemotherapy.3 Cases have been seen of invasive thymoma affecting the pleura and lung, thoracic vertebrae, thyroid gland, central nervous system, liver, extrathoracic lymph nodes, and overlying dermis.9

At no time did our patient present extracutaneous symptoms, and it was the skin manifestations that led to the diagnosis of his serious underlying disease. Thus, in a patient with intense pruritus on the chest with no causative skin lesions and/or vertically oriented telangiectasias of rapid onset, we must exclude an intrathoracic space-occupying lesion.

References
[1]
B.V. Duwe, D.H. Sterman, A.I. Musani.
Tumours of the mediastinum.
Chest, 128 (2005), pp. 2893-2909
[2]
M. Meghani, M.N. Siddique, M. Sicart.
Thymoma presenting as chest pain.
Am J Med Sci, 344 (2012), pp. 413
[3]
M. Mikhail, Y. Mekhaiel, T. Mekhail.
Thymic neoplasms: A clinical update.
Curr Oncol Rep, 14 (2012), pp. 350-358
[4]
J.V. Hirschmann, G.J. Raugi.
Dermatologic features of the superior vena cava syndrome.
Arch Dermatol, 128 (1992), pp. 953-956
[5]
T.F. Bruno, M. Donoff.
Superior vena cava syndrome and telangiectasia in a man with lymphoma.
CMAJ, 177 (2007), pp. 1177-1179
[6]
A. Holbro, A. Jauch, D. Lardinois, A. Tzankov, S. Dirnhofer, C. Hess.
High prevalence of infections and autoimmunity in patients with thymoma.
Hum Immunol, 73 (2012), pp. 287-290
[7]
A. Marx, N. Willcox, M.I. Leite, W.Y. Chuang, B. Schalke, W. Nix, et al.
Thymoma and paraneoplastic myasthenia gravis.
Autoimmunity, 43 (2010), pp. 413-427
[8]
A. Lally, V.J. Venning.
A unique paraneoplastic syndrome presenting in a patient with unresectable thymoma.
Eur Acad Dermatol Venereol, 21 (2007), pp. 434-435
[9]
M. Herde, T. Gambichler, K. Hoffmann, P. Altmeyer, M. Stücker.
An extraordinary case of subcutaneous invasive thymoma.
J Eur Acad Dermatol Venereol, 16 (2002), pp. 537-538

Please cite this article as: Laguna C. Telangiectasias verticalizadas y prurito en el tórax en un paciente con síndrome de cava superior inicial secundario a un timoma maligno. Actas Dermosifiliogr. 2015;106:331–332.

Copyright © 2014. Elsevier España, S.L.U. and AEDV
Descargar PDF
Idiomas
Actas Dermo-Sifiliográficas
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?