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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Examination of a 77-year-old man in the dermatology clinic revealed a 1&#46;5-cm light brown spot with eccentric pigmentation in the right pectoral region &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Diagnosis</span><p id="par0010" class="elsevierStylePara elsevierViewall">Dermoscopic examination showed erased areas containing white lines and atypical vascularization in the center and a characteristic fine reticular pattern at the periphery &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Comment</span><p id="par0015" class="elsevierStylePara elsevierViewall">Examination by confocal microscopy showed an epidermis with abundant dendritic cells and numerous junctional thickenings at the dermoepidermal junction &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The lesion was excised and histologic examination confirmed a diagnosis of extrafacial lentigo maligna &#40;LM&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Extrafacial LM is a lentiginous form of melanoma associated with chronic sun damage&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Its incidence is increasing in Spain for a number of reasons&#44; including longer life expectancy and improved clinical identification of these lesions and their dermoscopic features&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#8211;4</span></a> A clinical progression model with dermoscopic features &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41; based on confocal microscopy findings has been proposed for extrafacial LA&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;5</span></a> The first features observed are areas of reticular disruption&#44; followed by erased areas surrounded by pigment dots and triangular structures&#44; which progressively evolve to form angulated and zig-zag lines&#46; More advanced lesions show large erased areas with atypical vascularization and typically contain traces of a fine peripheral reticular pattern pointing to the melanocytic nature of the lesion&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The greatest diagnostic challenges are thus posed by early-stage lesions &#40;when the only finding is reticular disruption&#41; and advanced lesions &#40;when practically all structures have been erased&#41;&#46; Identification of advanced lesions is crucial&#46; We recommend paying special attention to atypical vascularization&#44; white lines&#44; and the characteristic traces of the reticular pattern at the periphery&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Funding</span><p id="par0030" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of Interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Vol. 114. Núm. 4.
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Vol. 114. Núm. 4.
Páginas T339-T340 (abril 2023)
Practical Dermoscopy
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Dermoscopic Features of Extrafacial Lentigo Maligna
Claves dermatoscópicas en lentigo maligno extrafacial
Visitas
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C. Sarró-Fuente
Autor para correspondencia
claudia.sarro@salud.madrid.org

Corresponding author.
, R. Gamo-Villegas, U. Floristán-Muruzábal
Servicio de Dermatología del Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain
Contenido relacionado
Actas Dermosifiliogr. 2023;114:339-4010.1016/j.ad.2022.03.034
C. Sarró-Fuente, R. Gamo-Villegas, U. Floristán-Muruzábal
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Examination of a 77-year-old man in the dermatology clinic revealed a 1.5-cm light brown spot with eccentric pigmentation in the right pectoral region (Fig. 1).

Figure 1.

Clinical image. Pale brown 1.5-cm spot with eccentric pigmentation.

(0.24MB).
Diagnosis

Dermoscopic examination showed erased areas containing white lines and atypical vascularization in the center and a characteristic fine reticular pattern at the periphery (Fig. 2).

Figure 2.

Dermoscopic image. Note the well-defined eccentric pigmentation (triangle), the characteristic reticular pattern at the periphery (white arrow), the structureless center with complete disruption of the reticular structure and white lines (asterisks), and the erythematous background with atypical vascularization (black arrows).

(0.08MB).
Comment

Examination by confocal microscopy showed an epidermis with abundant dendritic cells and numerous junctional thickenings at the dermoepidermal junction (Fig. 3). The lesion was excised and histologic examination confirmed a diagnosis of extrafacial lentigo maligna (LM).

Figure 3.

Confocal microscopy. A, Epidermis containing numerous dendritic cells. B, Junctural thickening and dendritic cells at the dermoepidermal junction.

(0.14MB).

Extrafacial LM is a lentiginous form of melanoma associated with chronic sun damage.1 Its incidence is increasing in Spain for a number of reasons, including longer life expectancy and improved clinical identification of these lesions and their dermoscopic features.2–4 A clinical progression model with dermoscopic features (Fig. 4) based on confocal microscopy findings has been proposed for extrafacial LA.2,5 The first features observed are areas of reticular disruption, followed by erased areas surrounded by pigment dots and triangular structures, which progressively evolve to form angulated and zig-zag lines. More advanced lesions show large erased areas with atypical vascularization and typically contain traces of a fine peripheral reticular pattern pointing to the melanocytic nature of the lesion.2

Figure 4.

Modified dermoscopic extrafacial lentigo maligna progression model adapted from Gamo-Villegas et al.2 A, Reticular disruption. B, Erased area and triangular structures. C, Angulated and zig-zag lines. D, Large areas.

(0.07MB).

The greatest diagnostic challenges are thus posed by early-stage lesions (when the only finding is reticular disruption) and advanced lesions (when practically all structures have been erased). Identification of advanced lesions is crucial. We recommend paying special attention to atypical vascularization, white lines, and the characteristic traces of the reticular pattern at the periphery.

Funding

None declared.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

References
[1]
N. Jaimes, A.A. Marghoob, H. Rabinovitz, R.P. Braun, A. Cameron, C. Rosendahl, et al.
Clinical and dermoscopic characteristics of melanomas on nonfacial chronically sun-damaged skin.
J Am Acad Dermatol, 72 (2015), pp. 1027-1035
[2]
R. Gamo-Villegas, A. Pampín-Franco, U. Floristán-Murúzabal, E. García-Zamora, F. Pinedo-Moraleda, J.L. López-Estebaranz.
Key dermoscopic signs in the diagnosis and progression of extrafacial lentigo maligna: evaluation of a series of 41 cases.
Australas J Dermatol, 60 (2019), pp. 288-293
[3]
Y.N. Lau, A.G. Affleck, C.J. Fleming.
Dermatoscopic features of extrafacial lentigo maligna.
Clin Exp Dermatol, 38 (2013), pp. 612-616
[4]
J. Keir.
Dermatoscopic features of cutaneous non-facial non-acral lentiginous growth pattern melanomas.
Dermatol Pract Concept, 4 (2014), pp. 77-82
[5]
P. Guitera, G. Pellacani, K.A. Crotty, R.A. Scolyer, L.X. Li, S. Bassoli, et al.
The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face.
J Invest Dermatol, 130 (2010), pp. 2080-2091
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