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Vol. 114. Núm. 2.
Páginas T147-T151 (febrero 2023)
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Vol. 114. Núm. 2.
Páginas T147-T151 (febrero 2023)
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[Translated article] Dactylitis Due to Subcutaneous Sarcoidosis as a Manifestation of Sarcoidosis
Dactilitis producida por sarcoidosis subcutánea como presentación de sarcoidosis
J. Marcoval
Autor para correspondencia

Corresponding author.
, C. Llobera-Ris, C. Moreno-Vílchez, C. Torrecilla-Vall-Llossera, J. Sánchez Sánchez, J. Molinero Caturla
Servicio de Dermatología, Hospital Universitari de Bellvitge, Universitat de Barcelona, IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain
Contenido relaccionado
Actas Dermosifiliogr. 2023;114:147-5110.1016/
J. Marcoval, C. Llobera-Ris, C. Moreno-Vílchez, C. Torrecilla-Vall-Llossera, J. Sánchez Sánchez, J. Molinero Caturla
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Dactylitis, or sausage fingers or toes, refers to the swelling of 1 or more digits. Sarcoid dactylitis is an uncommon form that tends to be caused by granulomatous bone involvement in the underlying phalanges. Sarcoid dactylitis can, however, clinically resemble subcutaneous sarcoidosis with finger or toe involvement. We describe 5 patients with dactylitis due to subcutaneous sarcoidosis of the fingers. In all cases, the proximal phalanges were involved; sarcoid dactylitis, by contrast, tends to affect the medial and distal phalanges. Differential diagnosis is important, as dactylitis due to bone involvement tends to be much more persistent and is generally seen in chronic forms of sarcoidosis.

Sarcoid dactylitis
Subcutaneous sarcoidosis

La dactilitis, o dedo en salchicha, se define como la inflamación de uno o varios dedos de las manos o de los pies. La dactilitis sarcoidea es una forma poco frecuente de dactilitis que suele ser debida a la afectación ósea granulomatosa a nivel de las falanges subyacentes. Sin embargo, una apariencia clínica similar puede deberse a la presencia de una sarcoidosis subcutánea en los dedos. Describimos 5 pacientes con dactilitis por una sarcoidosis subcutánea de los dedos. En nuestros pacientes las lesiones se localizaron en las falanges proximales, a diferencia de la dactilitis sarcoidea por afectación ósea, en la que suelen localizarse en las falanges medias y distales. Es importante el diagnóstico diferencial, puesto que la dactilitis por afectación ósea suele ser mucho más persistente y asociarse a formas crónicas de sarcoidosis.

Palabras clave:
Dactilitis sarcoidea
Sarcoidosis subcutánea
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Introduction and Objectives

Dactylitis or sausage finger is defined as inflammation of one or several fingers or toes.1 Although any inflammatory process involving the digits could be considered dactylitis, the term is reserved for a few well-defined entities. It is considered one of the differential clinical features of spondyloarthropathies and, in particular, psoriatic arthritis. However, it can manifest during the course of diseases including gout, sarcoidosis, tuberculosis, and syphilis.1,2

Sarcoid dactylitis is a rare manifestation of sarcoidosis. Most cases of sarcoid dactylitis are due to granulomatous involvement of the bone of the underlying phalanges.3 However, subcutaneous sarcoidosis of the digits can give rise to a similar clinical presentation. Below, we report cases of subcutaneous sarcoidosis of the digits with a clinical presentation resembling dactylitis due to underlying bone involvement.

Material and Methods

We reviewed diagnosed cases of subcutaneous sarcoidosis recorded in the database of specialized sarcoidosis consultations between 1988 and 2021 in a tertiary university hospital that provides care to approximately 1 000 000 people. Clinical histories of the patients were reviewed and clinical images were examined to detect cases that presented lesions on the fingers.


We identified 5 patients with subcutaneous sarcoidosis of the fingers over a period of 33 years: 3 women and 2 men, aged 45–75 years (Table 1).

Table 1.

General Characteristics of the Patients.

Case  Sex  Age  Time since onset, mo  Duration,mo  Dactylitis location  Other specific cutaneous sarcoidosis lesions  Radiological stage and extracutaneous involvement  ACE  Imaging studies  Treatment 
70  12  60  Proximal phalanges8 fingers  Subcutaneous, forearmsScar on elbow  1Hilar and mediastinal adenopathies  –    Prednisone 
63  24  36  Proximal phalanges6 fingers  Subcutaneous, forearms and kneesPapules on the kneesPlaques on the trunk  1Hilar lymphadenopathyHepatosplenic  0.71 (kat/L(n<0.87)  ECO: subcutaneous nodular lesions  PrednisoneHydroxychloroquine 
75  12  18  Proximal phalanges5 fingers  Subcutaneous, forearms and legsPapules on knees  0Conjunctival  64U/L (n<52)  Forearm radiograph without bone lesionsECO: subcutaneous nodular lesions  No treatment 
45  a  Proximal phalanxRight ring finger  Subcutaneous, forearms  1Hilar lymphadenopathyChoroidal granulomas  54U/L (n<52)  ECO: subcutaneous nodular lesions on fingers and forearms  a 
68  Proximal phalanges of fingers 2, 3, and 4 of each hand  –  No extracutaneous involvement detectedb  107U/L (n<52)  Radiography of hands, no bone lesionsECO: subcutaneous nodular lesions on fingers  No treatment 

Abbreviations: ACE, angiotensin-converting enzyme; ECO, echography; F, female; M, male.


Case 4: lost to follow-up due to change of address.


Case 5: subcutaneous sarcoidosis during treatment with atezolizumab.

All patients consulted for their skin lesions. Four patients had lesions predominantly on the forearms, while in the remaining patient the lesions were limited to the fingers (Fig. 1). The time since lesion appearance ranged from 3 to 24 months. The lesions were not painful and persisted for 8–60 months in the 4 patients who were followed up until resolution (Table 1).

Figure 1.

A, Case 1. Dactylitis in the proximal phalanges of the first, second, and third fingers of the left hand. B, Case 2. Dactylitis in the proximal phalanges of 3 fingers of each hand. C, Case 3. Dactylitis in the proximal phalanges of the left middle finger and the right index finger. D, Case 4. Dactylitis in the proximal phalanx of the right ring finger. E, Case 5. Dactylitis in the proximal phalanges of the index, middle, and ring fingers of each hand.


None of the patients had systemic symptoms at the time of diagnosis. In all cases biopsy of the lesions revealed sarcoid granulomatous infiltration in the subcutaneous cellular tissue (in the forearms in 3 cases and the fingers in 2 cases).

Extracutaneous lesions consisted of bilateral hilar adenopathies in 3 cases, as revealed by chest radiography. Conjunctival granulomas were detected in another case without intrathoracic involvement. The remaining patient developed dactylitis lesions during the course of atezolizumab treatment for disseminated endometrial carcinoma, but showed no signs of extracutaneous involvement. Angiotensin converting enzyme (ACE) levels were elevated in 3 of the 4 cases in which they were determined.


Dactylitis can be acute, characterized by painful inflammation of the finger, or can manifest as a chronic form, which tends to be more persistent and less painful.2 The distinct forms of dactylitis also differ in terms of the affected tissue and the type of involvement. The most frequent forms are dactylitis due to spondyloarthritis, especially psoriatic arthritis, which causes painful diffuse inflammation of the fingers and toes.1,2 Studies using ultrasound and nuclear magnetic resonance have established that this form is due to tenosynovitis of the flexors.1,2 Tenosynovitis that arises during the course of gout is also a common cause of dactylitis. Pyogenic (usually streptococcal) infection of the soft parts of the finger also manifests as acute dactylitis. Another less frequent form is tuberculous dactylitis, which is caused by tuberculous osteomyelitis of the short tubular bones of the hands or feet.1,2 Syphilitic dactylitis is a manifestation of congenital syphilis that is characterized by radiological findings similar to those of tuberculous dactylitis, although the involvement is usually bilateral and symmetrical.

Sarcoid dactylitis1,2 is an uncommon manifestation of sarcoidosis that is seen in 0.2% of patients. It is defined as the presence of swelling in the fingers or toes in patients with sarcoidosis, mainly affecting the middle and, less frequently, distal phalanges.3,4 Radiologically, sarcoid dactylitis is characterized by trabecular alterations with a honeycomb or lattice pattern, which may or may not be associated with cystic formations and periosteal reaction.5 Histologically, osseous lesions are characterized by noncaseating granulomas that invade the phalanges and surrounding soft tissue. This form of sarcoid dactylitis due to granulomatous bone involvement is very persistent, and is associated with lupus pernio and chronic forms of sarcoidosis.6

In addition to sarcoid dactylitis due to granulomatous involvement of the bone of the underlying phalanges, the term dactylitis has also been applied to patients with subcutaneous sarcoidosis affecting the fingers.7,8 These patients can exhibit a similar clinical presentation. However, in subcutaneous sarcoidosis the proximal phalanges are more frequently affected than the middle and distal phalanges,7 as in all our patients. Another significant difference is that subcutaneous sarcoidosis of the fingers appears at the onset of the systemic disease, and therefore its recognition can enable early diagnosis of systemic sarcoidosis, avoiding the need for invasive examinations.9–12 Because it is a form of subcutaneous sarcoidosis, it could be assumed that it has similar prognostic significance regarding the course of systemic sarcoidosis. Some studies have proposed that subcutaneous sarcoidosis is associated with acute forms of sarcoidosis.9–12 In agreement with those findings, none of our patients developed complications typical of chronic sarcoidosis, such as bone lesions or pulmonary fibrosis.

In 4 of our 5 patients, dactylitis was associated with subcutaneous sarcoid lesions in other locations. Therefore, when sarcoid dactylitis is suspected, the remaining extremities should be examined for subcutaneous nodular lesions, especially the forearms.13 As in the case described by Curcó et al.,7 we did not detect underlying bone lesions in any of our patients.

Treatment of sarcoid dactylitis due to underlying bone involvement usually requires high-dose oral corticosteroids combined with antimalarials and methotrexate, or even the use of anti-TNF (tumor necrosis factor) drugs such as infliximab or adalimumab.3,14 In our patients, digital lesions did not require specific treatment. Two of our patients received systemic treatment, indicated for extracutaneous involvement: oral corticosteroids in one case and oral corticosteroids plus hydroxychloroquine in the other. The digital lesions remained partially controlled until complete resolution (after 60 and 36 months, respectively). In the remaining 2 patients for whom clinical follow-up data were available, the digital lesions remitted spontaneously without requiring any treatment, with a total lesion duration of 8 and 18 months, respectively.

Although the clinical appearance may be similar, sarcoid dactylitis due to granulomatous infiltration of the underlying phalanges must be distinguished from sarcoid dactylitis due to subcutaneous involvement, owing to the differences in clinical course and prognostic significance. Ultrasound can be a fundamental tool for differential diagnosis.15

Dactylitis due to subcutaneous sarcoidosis is usually present at the onset of systemic sarcoidosis, usually affects the proximal phalanges, and is often accompanied by subcutaneous sarcoidosis in other locations, especially the forearms. It is necessary to rule out the presence of underlying bony lesions in cases of persistent dactylitis involving the middle and distal phalanges.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

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