array:25 [
  "pii" => "S1578219021002985"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2020.02.002"
  "estado" => "S300"
  "fechaPublicacion" => "2021-11-01"
  "aid" => "2704"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2021"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2021;112:949-51"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S0001731021002398"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2020.02.017"
      "estado" => "S300"
      "fechaPublicacion" => "2021-11-01"
      "aid" => "2704"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2021;112:949-51"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Heterotopia salival"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "949"
            "paginaFinal" => "951"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Heterotopic Salivary Gland Tissue"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 1921
                "Ancho" => 2500
                "Tamanyo" => 262852
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio ecogr&#225;fico con lesi&#243;n subcut&#225;nea hipoecoica bien definida&#44; no encapsulada&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "P&#46; Chicharro, P&#46; Rodr&#237;guez-Jim&#233;nez, J&#46; Fraga, M&#46; Llamas-Velasco"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "P&#46;"
                "apellidos" => "Chicharro"
              ]
              1 => array:2 [
                "nombre" => "P&#46;"
                "apellidos" => "Rodr&#237;guez-Jim&#233;nez"
              ]
              2 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Fraga"
              ]
              3 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Llamas-Velasco"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219021002985"
          "doi" => "10.1016/j.adengl.2020.02.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002985?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021002398?idApp=UINPBA000044"
      "url" => "/00017310/0000011200000010/v1_202111020534/S0001731021002398/v1_202111020534/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S1578219021002614"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2021.09.010"
    "estado" => "S300"
    "fechaPublicacion" => "2021-11-01"
    "aid" => "2662"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2021;112:951-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Comet Sign in Dermatitis Due to <span class="elsevierStyleItalic">Pyemotes</span> Species"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "951"
          "paginaFinal" => "952"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Signo de la cometa en la dermatitis por <span class="elsevierStyleItalic">Pyemotes</span>"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 282
              "Ancho" => 750
              "Tamanyo" => 19970
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multiple lesions exhibiting the comet sign on the leg of Patient 1&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Pulido P&#233;rez, M&#46; Berg&#243;n-Send&#237;n, I&#46; Hern&#225;ndez-Arag&#252;&#233;s, R&#46; Su&#225;rez-Fern&#225;ndez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Pulido P&#233;rez"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Berg&#243;n-Send&#237;n"
            ]
            2 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Hern&#225;ndez-Arag&#252;&#233;s"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Su&#225;rez-Fern&#225;ndez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731021001800"
        "doi" => "10.1016/j.ad.2020.02.013"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021001800?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002614?idApp=UINPBA000044"
    "url" => "/15782190/0000011200000010/v1_202111080506/S1578219021002614/v1_202111080506/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S1578219021002778"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2021.10.009"
    "estado" => "S300"
    "fechaPublicacion" => "2021-11-01"
    "aid" => "2701"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2021;112:943-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Risk Factors for Melanoma in a Latin American Population&#58; A Case-Control Study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "943"
          "paginaFinal" => "949"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Factores de riesgo para melanoma en una poblaci&#243;n latinoamericana&#58; estudio de casos y controles"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L&#46;M&#46; Aguirre, A&#46;M&#46; Mu&#241;oz, M&#46;S&#46; Aluma-Tenorio, N&#46; Jaimes"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "L&#46;M&#46;"
              "apellidos" => "Aguirre"
            ]
            1 => array:2 [
              "nombre" => "A&#46;M&#46;"
              "apellidos" => "Mu&#241;oz"
            ]
            2 => array:2 [
              "nombre" => "M&#46;S&#46;"
              "apellidos" => "Aluma-Tenorio"
            ]
            3 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Jaimes"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731021002362"
        "doi" => "10.1016/j.ad.2020.09.012"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021002362?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002778?idApp=UINPBA000044"
    "url" => "/15782190/0000011200000010/v1_202111080506/S1578219021002778/v1_202111080506/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
    "titulo" => "Heterotopic Salivary Gland Tissue"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "949"
        "paginaFinal" => "951"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "P&#46; Chicharro, P&#46; Rodr&#237;guez-Jim&#233;nez, J&#46; Fraga, M&#46; Llamas-Velasco"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "P&#46;"
            "apellidos" => "Chicharro"
            "email" => array:1 [
              0 => "somniem@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Rodr&#237;guez-Jim&#233;nez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Fraga"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Llamas-Velasco"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitario de La Princesa&#44; Madrid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Universitario de La Princesa&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Heterotopia salival"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1921
            "Ancho" => 2500
            "Tamanyo" => 262852
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Ultrasound study with well-defined nonencapsulated&#44; hypoechoic subcutaneous lesion&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Salivary gland heterotopia or choristoma consists of the presence of salivary gland tissue outside the major and minor salivary glands&#46; It is a rare disease&#44; usually congenital&#44; secondary to the persistence and abnormal development of vestigial structures<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 53-year-old woman with no past history of interest reported the appearance in childhood of a nodular lesion in the right lower anterior cervical region that had been growing slowly and gradually&#46; The lesion occasionally exuded a clear&#44; odorless liquid&#44; frequently in association with eating&#46; The examination revealed a soft nodule measuring 9&#160;mm in diameter&#44; with overlying light-brown skin&#44; located on the right sternoclavicular joint&#46; It was associated with a small central orifice with no active draining on pressing &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A and B&#41;&#46; Ultrasound revealed a well-defined nonencapsulated hypoechoic subcutaneous lesion with no clear fistular tracts and with no vascularization in the Doppler study &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The lesion was excised and the histopathology study revealed aggregates of salivary gland tissue made up of mucous and serous glands&#44; accompanied by a discrete ductal excretory component&#44; located in the subcutaneous cell tissue &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#44;B&#41;&#46; It presented isolated foci of lymphocytic inflammatory infiltrate&#46; These findings led to a diagnosis of salivary gland heterotopia&#46; The patient remained asymptomatic during follow-up&#44; with no signs of recurrence&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Salivary gland heterotopia is a rare disease&#44; associated with abnormal development of the branchial apparatus&#44; and only small series or isolated cases have been reported in the literature&#46; The pathogenesis is unknown but the most widely accepted hypothesis suggests that it is due to defective closure of the precervical sinus within the branchial apparatus&#46; It usually manifests at birth or in early childhood as a nodular&#44; cystic&#44; or fistulized lesion that is asymptomatic except for the occasional secretion of a fluid similar to saliva&#44; predominantly located on the lower anterior part of the sternocleidomastoid muscle&#44; with a predilection for the right side<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; Other reported locations are the mandibular region&#44; the middle ear&#44; the sella turcica&#44; the parathyroid glands&#44; the mediastinum&#44; and the rectum<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;8</span></a>&#46; Although rare&#44; bilateral presentation is also possible<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46; Histology shows mucous and&#47;or serous salivary gland structures&#44; often with an associated ductal component &#40;dilated&#44; collapsed&#44; or absent&#41; and chronic periductal inflammation&#46; Its association with other congenital anomalies is very rare<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Surgical treatment is indicated for diagnostic purposes and to prevent inflammatory processes and potential neoplastic degeneration&#46; In fact&#44; in the largest series available in the literature&#44; with 24 cases of salivary gland heterotopia&#44; associated malignant tumors were found in 6 cases &#40;3 mucoepidermoid tumors&#44; 2 acinar cell carcinomas&#44; and 1 adenocarcinoma&#41;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46; While malignancy in a heterotopic area must be considered in cases of salivary gland carcinoma outside the salivary glands&#44; metastatic dissemination should also be ruled out<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;9&#44;10</span></a>&#46; While no data exist in the literature&#44; ultrasound may be particularly useful in the differential diagnosis with other more common diseases and in preoperative planning&#46; Based on our case and the literature&#44; in the event of a nodular lesion in a typical location&#44; with secretion and with ultrasound showing no characteristics of a cystic lesion&#44; we must include salivary gland heterotopia in the differential diagnosis&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of Interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Chicharro P&#44; Rodr&#237;guez-Jim&#233;nez P&#44; Fraga J&#44; Llamas-Velasco M&#46; Heterotopia salival&#46; Actas Dermosifiliogr&#46; 2021&#59;112&#58;949&#8211;951&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 844
            "Ancho" => 1510
            "Tamanyo" => 170989
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Right supraclavicular nodular lesion&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1921
            "Ancho" => 2500
            "Tamanyo" => 262852
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Ultrasound study with well-defined nonencapsulated&#44; hypoechoic subcutaneous lesion&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 837
            "Ancho" => 1500
            "Tamanyo" => 339256
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In subcutaneous cellular tissue&#44; aggregates of salivary gland tissue made up of mucous and serous glands&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Heterotopic salivary gland tissue in the lower neck"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;A&#46; Youngs"
                            1 => "H&#46;H&#46; Scofield"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Path"
                        "fecha" => "1967"
                        "volumen" => "83"
                        "paginaInicial" => "550"
                        "paginaFinal" => "556"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6024732"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Heterotopic salivary gland tissue in the neck"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Haemel"
                            1 => "D&#46;R&#46; Gnepp"
                            2 => "J&#46; Carlsten"
                            3 => "L&#46; Robinson-Bostom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2007.11.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "paginaInicial" => "251"
                        "paginaFinal" => "256"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18222321"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Salivary gland heterotopia in the bone tissue of the mandible"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46;V&#46; Afanas&#8217;ev"
                            1 => "V&#46;S&#46; Starodubtsev"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Stomatologiia &#40;Mosk&#41;"
                        "fecha" => "1995"
                        "volumen" => "74"
                        "paginaInicial" => "69"
                        "paginaFinal" => "70"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Salivary gland choristoma of the middle ear"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Enoz"
                            1 => "Y&#46; Suoglu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Laryngoscope"
                        "fecha" => "2006"
                        "volumen" => "116"
                        "paginaInicial" => "1033"
                        "paginaFinal" => "1034"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Symptomatic salivary-rest cyst of the sella turcica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;B&#46; Tatter"
                            1 => "M&#46;A&#46; Edgar"
                            2 => "A&#46; Klibanski"
                            3 => "B&#46; Swearingen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neurochir &#40;Wien&#41;"
                        "fecha" => "1995"
                        "volumen" => "135"
                        "paginaInicial" => "150"
                        "paginaFinal" => "153"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Salivary heterotopia of the parathyroid gland&#58; A report of two cases and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;C&#46; Edwards"
                            1 => "T&#46; Bhuiya"
                            2 => "L&#46;B&#46; Kahn"
                            3 => "J&#46;E&#46; Fantasia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.tripleo.2004.08.023"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod"
                        "fecha" => "2005"
                        "volumen" => "99"
                        "paginaInicial" => "590"
                        "paginaFinal" => "593"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15829882"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mixed tumor of the mediastinum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;A&#46; Feigin"
                            1 => "B&#46; Robinson"
                            2 => "A&#46; Marchevsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Pathol Lab Med"
                        "fecha" => "1986"
                        "volumen" => "110"
                        "paginaInicial" => "80"
                        "paginaFinal" => "81"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ectopic salivary gland tissue in submucosa of rectum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Weitzner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF02554758"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dis Colon Rectum"
                        "fecha" => "1983"
                        "volumen" => "26"
                        "paginaInicial" => "814"
                        "paginaFinal" => "817"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6641465"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neck masses secondary to heterotopic salivary gland tissue&#58; A 25-year experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Daniel"
                            1 => "W&#46;F&#46; McGuirt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjoto.2004.08.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Otolaryngol"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "96"
                        "paginaFinal" => "100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15742261"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A review of heterotopia and associated salivary gland neoplasms of the head and neck"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Ferlito"
                            1 => "G&#46; Bertino"
                            2 => "A&#46; Rinaldo"
                            3 => "G&#46;M&#46; Mannara"
                            4 => "K&#46;O&#46; Devaney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1017/s0022215100143841"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Laryngol Otol"
                        "fecha" => "1999"
                        "volumen" => "113"
                        "paginaInicial" => "299"
                        "paginaFinal" => "303"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10474661"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000011200000010/v1_202111080506/S1578219021002985/v1_202111080506/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011200000010/v1_202111080506/S1578219021002985/v1_202111080506/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219021002985?idApp=UINPBA000044"
]
Compartir
Información de la revista
Vol. 112. Núm. 10.
Páginas 949-951 (noviembre - diciembre 2021)
Vol. 112. Núm. 10.
Páginas 949-951 (noviembre - diciembre 2021)
Case and Research Letters
Open Access
Heterotopic Salivary Gland Tissue
Heterotopia salival
Visitas
4446
P. Chicharroa,
Autor para correspondencia
somniem@gmail.com

Corresponding author.
, P. Rodríguez-Jiméneza, J. Fragab, M. Llamas-Velascoa
a Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, Spain
b Servicio de Anatomía Patológica, Hospital Universitario de La Princesa, Madrid, Spain
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Figuras (3)
Mostrar másMostrar menos
Texto completo
To the Editor:

Salivary gland heterotopia or choristoma consists of the presence of salivary gland tissue outside the major and minor salivary glands. It is a rare disease, usually congenital, secondary to the persistence and abnormal development of vestigial structures1,2.

A 53-year-old woman with no past history of interest reported the appearance in childhood of a nodular lesion in the right lower anterior cervical region that had been growing slowly and gradually. The lesion occasionally exuded a clear, odorless liquid, frequently in association with eating. The examination revealed a soft nodule measuring 9 mm in diameter, with overlying light-brown skin, located on the right sternoclavicular joint. It was associated with a small central orifice with no active draining on pressing (Fig. 1A and B). Ultrasound revealed a well-defined nonencapsulated hypoechoic subcutaneous lesion with no clear fistular tracts and with no vascularization in the Doppler study (Fig. 2). The lesion was excised and the histopathology study revealed aggregates of salivary gland tissue made up of mucous and serous glands, accompanied by a discrete ductal excretory component, located in the subcutaneous cell tissue (Fig. 3A,B). It presented isolated foci of lymphocytic inflammatory infiltrate. These findings led to a diagnosis of salivary gland heterotopia. The patient remained asymptomatic during follow-up, with no signs of recurrence.

Figure 1.

Right supraclavicular nodular lesion.

(0.16MB).
Figure 2.

Ultrasound study with well-defined nonencapsulated, hypoechoic subcutaneous lesion.

(0.25MB).
Figure 3.

In subcutaneous cellular tissue, aggregates of salivary gland tissue made up of mucous and serous glands.

(0.32MB).

Salivary gland heterotopia is a rare disease, associated with abnormal development of the branchial apparatus, and only small series or isolated cases have been reported in the literature. The pathogenesis is unknown but the most widely accepted hypothesis suggests that it is due to defective closure of the precervical sinus within the branchial apparatus. It usually manifests at birth or in early childhood as a nodular, cystic, or fistulized lesion that is asymptomatic except for the occasional secretion of a fluid similar to saliva, predominantly located on the lower anterior part of the sternocleidomastoid muscle, with a predilection for the right side1,2. Other reported locations are the mandibular region, the middle ear, the sella turcica, the parathyroid glands, the mediastinum, and the rectum3–8. Although rare, bilateral presentation is also possible2. Histology shows mucous and/or serous salivary gland structures, often with an associated ductal component (dilated, collapsed, or absent) and chronic periductal inflammation. Its association with other congenital anomalies is very rare2.

Surgical treatment is indicated for diagnostic purposes and to prevent inflammatory processes and potential neoplastic degeneration. In fact, in the largest series available in the literature, with 24 cases of salivary gland heterotopia, associated malignant tumors were found in 6 cases (3 mucoepidermoid tumors, 2 acinar cell carcinomas, and 1 adenocarcinoma)9. While malignancy in a heterotopic area must be considered in cases of salivary gland carcinoma outside the salivary glands, metastatic dissemination should also be ruled out2,9,10. While no data exist in the literature, ultrasound may be particularly useful in the differential diagnosis with other more common diseases and in preoperative planning. Based on our case and the literature, in the event of a nodular lesion in a typical location, with secretion and with ultrasound showing no characteristics of a cystic lesion, we must include salivary gland heterotopia in the differential diagnosis.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

References
[1]
L.A. Youngs, H.H. Scofield.
Heterotopic salivary gland tissue in the lower neck.
Arch Path, 83 (1967), pp. 550-556
[2]
A. Haemel, D.R. Gnepp, J. Carlsten, L. Robinson-Bostom.
Heterotopic salivary gland tissue in the neck.
J Am Acad Dermatol, 58 (2008), pp. 251-256
[3]
V.V. Afanas’ev, V.S. Starodubtsev.
Salivary gland heterotopia in the bone tissue of the mandible.
Stomatologiia (Mosk), 74 (1995), pp. 69-70
[4]
M. Enoz, Y. Suoglu.
Salivary gland choristoma of the middle ear.
Laryngoscope, 116 (2006), pp. 1033-1034
[5]
S.B. Tatter, M.A. Edgar, A. Klibanski, B. Swearingen.
Symptomatic salivary-rest cyst of the sella turcica.
Acta Neurochir (Wien), 135 (1995), pp. 150-153
[6]
P.C. Edwards, T. Bhuiya, L.B. Kahn, J.E. Fantasia.
Salivary heterotopia of the parathyroid gland: A report of two cases and review of the literature.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 99 (2005), pp. 590-593
[7]
G.A. Feigin, B. Robinson, A. Marchevsky.
Mixed tumor of the mediastinum.
Arch Pathol Lab Med, 110 (1986), pp. 80-81
[8]
S. Weitzner.
Ectopic salivary gland tissue in submucosa of rectum.
Dis Colon Rectum, 26 (1983), pp. 814-817
[9]
E. Daniel, W.F. McGuirt.
Neck masses secondary to heterotopic salivary gland tissue: A 25-year experience.
Am J Otolaryngol, 26 (2005), pp. 96-100
[10]
A. Ferlito, G. Bertino, A. Rinaldo, G.M. Mannara, K.O. Devaney.
A review of heterotopia and associated salivary gland neoplasms of the head and neck.
J Laryngol Otol, 113 (1999), pp. 299-303

Please cite this article as: Chicharro P, Rodríguez-Jiménez P, Fraga J, Llamas-Velasco M. Heterotopia salival. Actas Dermosifiliogr. 2021;112:949–951.

Copyright © 2021. AEDV
Descargar PDF
Idiomas
Actas Dermo-Sifiliográficas
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?