array:25 [
  "pii" => "S0001731022009279"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2022.11.002"
  "estado" => "S300"
  "fechaPublicacion" => "2023-01-01"
  "aid" => "3281"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2023;114:T74"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0001731022007669"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2022.03.020"
    "estado" => "S300"
    "fechaPublicacion" => "2023-01-01"
    "aid" => "3179"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2023;114:75-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
      "titulo" => "Cambios histopatol&#243;gicos secundarios a terapia diana en melanoma"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "75"
          "paginaFinal" => "77"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Histopathologic Changes Secondary to Targeted Therapy in Melanoma"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1255
              "Ancho" => 1255
              "Tamanyo" => 541599
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cortes histol&#243;gicos de ganglio linf&#225;tico tras terapia diana con dabrafenib y trametinib&#46; A&#46; M&#250;ltiples melan&#243;fagos sobre un fondo de fibrosis en la parte superior y necrosis intensa en la parte inferior &#40;hematoxilina y eosina&#44; &#215;10&#41;&#46; B&#46; Melan&#243;fagos y CTV con mucha melanina intracitoplasm&#225;tica&#44; haciendo necesario el uso de t&#233;cnicas adicionales como el marcador nuclear SOX10 para evaluar el porcentaje de CTV y&#44; por tanto&#44; el tipo de respuesta patol&#243;gica &#40;hematoxilina y eosina&#44; &#215;20&#41;&#46; C&#46; Melan&#243;fagos a la izquierda con melanina intracitoplasm&#225;tica &#40;marcados con verde&#41;&#44; y a la derecha CTV aisladas &#40;marcadas con rojo&#41; &#40;hematoxilina y eosina &#215;100&#41;&#46; D&#46; Captaci&#243;n nuclear para las CTV &#40;marcadas con rojo&#41; y captaci&#243;n citoplasm&#225;tica de los melan&#243;fagos sin tinci&#243;n nuclear &#40;marcados con verde&#41; &#40;inmunohistoqu&#237;mica para SOX10&#44; &#215;100&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "I&#46; Navarro Navarro, D&#46; Jim&#233;nez Gallo, M&#46;T&#46; Fern&#225;ndez Morano, I&#46; Villegas Romero, M&#46;I&#46; Catalina Fern&#225;ndez, M&#46; Linares Barrios"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Navarro Navarro"
            ]
            1 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Jim&#233;nez Gallo"
            ]
            2 => array:2 [
              "nombre" => "M&#46;T&#46;"
              "apellidos" => "Fern&#225;ndez Morano"
            ]
            3 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Villegas Romero"
            ]
            4 => array:2 [
              "nombre" => "M&#46;I&#46;"
              "apellidos" => "Catalina Fern&#225;ndez"
            ]
            5 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Linares Barrios"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022007669?idApp=UINPBA000044"
    "url" => "/00017310/0000011400000001/v1_202301060625/S0001731022007669/v1_202301060625/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0001731022003003"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2022.03.007"
    "estado" => "S300"
    "fechaPublicacion" => "2023-01-01"
    "aid" => "3016"
    "copyright" => "AEDV"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2023;114:74"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Im&#225;genes en Dermatolog&#237;a</span>"
      "titulo" => "Placas anulares en el prepucio y el escroto en el contexto de una s&#237;filis secundaria reinfecci&#243;n"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "74"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Annular Plaques on the Foreskin and Scrotum in the Context of Secondary Reinfection Syphilis"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:6 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 401
              "Ancho" => 1255
              "Tamanyo" => 115061
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Ruiz-Mesa, M&#46; Blanco-Calvo, A&#46; Martin-Gorgojo"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Ruiz-Mesa"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Blanco-Calvo"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Martin-Gorgojo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022003003?idApp=UINPBA000044"
    "url" => "/00017310/0000011400000001/v1_202301060625/S0001731022003003/v1_202301060625/es/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:19 [
      "pii" => "S0001731022003003"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2022.03.007"
      "estado" => "S300"
      "fechaPublicacion" => "2023-01-01"
      "aid" => "3016"
      "copyright" => "AEDV"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "sco"
      "cita" => "Actas Dermosifiliogr. 2023;114:74"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Im&#225;genes en Dermatolog&#237;a</span>"
        "titulo" => "Placas anulares en el prepucio y el escroto en el contexto de una s&#237;filis secundaria reinfecci&#243;n"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:1 [
            "paginaInicial" => "74"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Annular Plaques on the Foreskin and Scrotum in the Context of Secondary Reinfection Syphilis"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:6 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 401
                "Ancho" => 1255
                "Tamanyo" => 115061
              ]
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "P&#46; Ruiz-Mesa, M&#46; Blanco-Calvo, A&#46; Martin-Gorgojo"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "P&#46;"
                "apellidos" => "Ruiz-Mesa"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Blanco-Calvo"
              ]
              2 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Martin-Gorgojo"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022003003?idApp=UINPBA000044"
      "url" => "/00017310/0000011400000001/v1_202301060625/S0001731022003003/v1_202301060625/es/main.assets"
    ]
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Images in Dermatology</span>"
    "titulo" => " Annular Plaques on the Foreskin and Scrotum in the Context of Secondary Reinfection Syphilis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:1 [
        "paginaInicial" => "T74"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "P&#46; Ruiz-Mesa, M&#46; Blanco-Calvo, A&#46; Martin-Gorgojo"
        "autores" => array:3 [
          0 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Ruiz-Mesa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Blanco-Calvo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Martin-Gorgojo"
            "email" => array:1 [
              0 => "alejandromartingorgojo@aedv.es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Centro de Atenci&#243;n Primaria Antonio Guti&#233;rrez&#44; Unidad Docente de Atenci&#243;n Primaria de Le&#243;n&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de ITS&#47;Dermatolog&#237;a&#44; Secci&#243;n de Especialidades M&#233;dicas&#44; Ayuntamiento de Madrid&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Placas anulares en el prepucio y el escroto en el contexto de una s&#237;filis secundaria reinfecci&#243;n"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:6 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 401
            "Ancho" => 1256
            "Tamanyo" => 105105
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 40-year-old cis-gender homosexual male patient with a history of HIV infection &#40;undetectable viral load&#44; CD4 count within the normal range&#44; receiving dolutegravir&#47;lamivudine&#41; and 2 episodes of secondary syphilis in the past&#44; attended the clinic for assessment of a desquamative&#44; asymptomatic&#44; erythematous plaque with an annular pattern on the foreskin &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Given the circinate appearance of the lesion&#44; he was treated with antifungal and anti-inflammatory cream and screened for venereal infections&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">At the follow-up visit&#44; the lesion on the foreskin had not improved&#44; and new asymptomatic lesions were identified on the scrotum &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41; and on the dorsum of the tongue &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; Serology revealed immunoglobulin G and M against <span class="elsevierStyleItalic">Treponema pallidum</span>&#44; with a rapid plasma reagin titer of 1&#58;32&#46; The other screening tests did not reveal additional findings&#46; Given the diagnosis of secondary reinfection syphilis &#40;supported by the positive rapid plasma reagin results with a 1&#47;1 titer 3 months earlier&#41;&#44; we administered a single intramuscular dose of benzylpenicillin G benzathine &#40;2&#46;4 million IU&#41;&#46; The lesions had improved 1 week after treatment&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The incidence of syphilis is growing&#44; and clinical presentation can be diverse&#46; Cases of reinfection are less well characterized and may present with more subtle cutaneous findings&#44; as in the present case&#46; We report a case of psoriasiform and annular syphilis&#46; The low frequency of this form of syphilis led us to varied differential diagnoses&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0020" class="elsevierStylePara elsevierViewall">No funding was received for the present study&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:1 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Funding"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:1 [
      0 => array:6 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 401
            "Ancho" => 1256
            "Tamanyo" => 105105
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000011400000001/v1_202301060625/S0001731022009279/v1_202301060625/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "83194"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Im&#225;genes en Dermatolog&#237;a"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011400000001/v1_202301060625/S0001731022009279/v1_202301060625/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022009279?idApp=UINPBA000044"
]
Compartir
Información de la revista
Vol. 114. Núm. 1.
Páginas T74 (enero 2022)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 114. Núm. 1.
Páginas T74 (enero 2022)
Images in Dermatology
Open Access
Annular Plaques on the Foreskin and Scrotum in the Context of Secondary Reinfection Syphilis
Placas anulares en el prepucio y el escroto en el contexto de una sífilis secundaria reinfección
Visitas
2653
P. Ruiz-Mesaa, M. Blanco-Calvob, A. Martin-Gorgojob,
Autor para correspondencia
alejandromartingorgojo@aedv.es

Corresponding author.
a Centro de Atención Primaria Antonio Gutiérrez, Unidad Docente de Atención Primaria de León, Spain
b Servicio de ITS/Dermatología, Sección de Especialidades Médicas, Ayuntamiento de Madrid, Madrid, Spain
Contenido relacionado
P. Ruiz-Mesa, M. Blanco-Calvo, A. Martin-Gorgojo
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Texto completo
Descargar PDF
Estadísticas
Figuras (1)
Texto completo

A 40-year-old cis-gender homosexual male patient with a history of HIV infection (undetectable viral load, CD4 count within the normal range, receiving dolutegravir/lamivudine) and 2 episodes of secondary syphilis in the past, attended the clinic for assessment of a desquamative, asymptomatic, erythematous plaque with an annular pattern on the foreskin (Fig. 1A). Given the circinate appearance of the lesion, he was treated with antifungal and anti-inflammatory cream and screened for venereal infections.

Figure 1
(0.1MB).

At the follow-up visit, the lesion on the foreskin had not improved, and new asymptomatic lesions were identified on the scrotum (Fig. 1B) and on the dorsum of the tongue (Fig. 1C). Serology revealed immunoglobulin G and M against Treponema pallidum, with a rapid plasma reagin titer of 1:32. The other screening tests did not reveal additional findings. Given the diagnosis of secondary reinfection syphilis (supported by the positive rapid plasma reagin results with a 1/1 titer 3 months earlier), we administered a single intramuscular dose of benzylpenicillin G benzathine (2.4 million IU). The lesions had improved 1 week after treatment.

The incidence of syphilis is growing, and clinical presentation can be diverse. Cases of reinfection are less well characterized and may present with more subtle cutaneous findings, as in the present case. We report a case of psoriasiform and annular syphilis. The low frequency of this form of syphilis led us to varied differential diagnoses.

Funding

No funding was received for the present study.

Copyright © 2022. AEDV
Descargar PDF
Idiomas
Actas Dermo-Sifiliográficas
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?