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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 39-year-old woman came to the clinic with asymptomatic flesh-colored verruciform flat papules on her face that had first appeared 5 years earlier&#46; The patient had undergone a kidney transplant owing to lupus glomerulonephritis&#44; with chronic active rejection&#46; She was receiving 3 sessions of hemodialysis per week&#44; as well as meprednisone 4<span class="elsevierStyleHsp" style=""></span>mg&#47;d and tacrolimus 7<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Histopathology revealed enlarged keratinocytes with a pale blue cytoplasm in the upper layers of the epidermis&#46; These findings were compatible with epidermodysplasia verruciformis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Epidermodysplasia verruciformis is an uncommon disease&#46; It is characterized by susceptibility to human papillomavirus infection that predisposes to multiple skin tumors on areas exposed to sunlight&#46; The disease may be genetic in origin &#40;mutations in <span class="elsevierStyleItalic">EVER1&#47;TMC6&#44; EVER2&#47;TMC8&#44; RHOH&#44; MST1&#44; CORO1A</span>&#44; and <span class="elsevierStyleItalic">ECM1</span>&#41; or acquired &#40;iatrogenic or associated with HIV infection&#41;&#46; The most common skin manifestations are flat hypo- and hyperpigmented macules&#44; verruca-like papillomatous lesions&#44; seborrheic keratosis&#44; or reddish pityriasis versicolor&#46; The lesions may progress to various types of neoplasm&#44; the most frequent of which is squamous cell carcinoma&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In patients with iatrogenic acquired epidermodysplasia verruciformis&#44; immunosuppressive therapy should be modified if possible&#46;</p></span>"
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Vol. 114. Núm. 10.
Páginas T911 (noviembre - diciembre 2023)
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Vol. 114. Núm. 10.
Páginas T911 (noviembre - diciembre 2023)
Imágenes en Dermatología
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Acquired Epidermodysplasia Verruciformis in a Solid Organ Transplant Recipient
Epidermodisplasia verruciforme adquirida en una paciente trasplantada de órgano sólido
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A. di Prinzio
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, A.C. Torre, L.D. Mazzuoccolo
Servicio de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
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A. di Prinzio, A.C. Torre, L.D. Mazzuoccolo
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A 39-year-old woman came to the clinic with asymptomatic flesh-colored verruciform flat papules on her face that had first appeared 5 years earlier. The patient had undergone a kidney transplant owing to lupus glomerulonephritis, with chronic active rejection. She was receiving 3 sessions of hemodialysis per week, as well as meprednisone 4mg/d and tacrolimus 7mg/d.

Histopathology revealed enlarged keratinocytes with a pale blue cytoplasm in the upper layers of the epidermis. These findings were compatible with epidermodysplasia verruciformis (Fig. 1).

Figure 1
(0.14MB).

Epidermodysplasia verruciformis is an uncommon disease. It is characterized by susceptibility to human papillomavirus infection that predisposes to multiple skin tumors on areas exposed to sunlight. The disease may be genetic in origin (mutations in EVER1/TMC6, EVER2/TMC8, RHOH, MST1, CORO1A, and ECM1) or acquired (iatrogenic or associated with HIV infection). The most common skin manifestations are flat hypo- and hyperpigmented macules, verruca-like papillomatous lesions, seborrheic keratosis, or reddish pityriasis versicolor. The lesions may progress to various types of neoplasm, the most frequent of which is squamous cell carcinoma.

In patients with iatrogenic acquired epidermodysplasia verruciformis, immunosuppressive therapy should be modified if possible.

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