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Imágenes en Dermatología
Acquired Epidermodysplasia Verruciformis in a Solid Organ Transplant Recipient
Epidermodisplasia verruciforme adquirida en una paciente trasplantada de órgano sólido
A. di Prinzio
Autor para correspondencia
, A.C. Torre, L.D. Mazzuoccolo
Servicio de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 39-year-old woman came to the clinic with asymptomatic flesh-colored verruciform flat papules on her face that had first appeared 5 years earlier&#46; The patient had undergone a kidney transplant owing to lupus glomerulonephritis&#44; with chronic active rejection&#46; She was receiving 3 sessions of hemodialysis per week&#44; as well as meprednisone 4<span class="elsevierStyleHsp" style=""></span>mg&#47;d and tacrolimus 7<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Histopathology revealed enlarged keratinocytes with a pale blue cytoplasm in the upper layers of the epidermis&#46; These findings were compatible with epidermodysplasia verruciformis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Epidermodysplasia verruciformis is an uncommon disease&#46; It is characterized by susceptibility to human papillomavirus infection that predisposes to multiple skin tumors on areas exposed to sunlight&#46; The disease may be genetic in origin &#40;mutations in <span class="elsevierStyleItalic">EVER1&#47;TMC6&#44; EVER2&#47;TMC8&#44; RHOH&#44; MST1&#44; CORO1A</span>&#44; and <span class="elsevierStyleItalic">ECM1</span>&#41; or acquired &#40;iatrogenic or associated with HIV infection&#41;&#46; The most common skin manifestations are flat hypo- and hyperpigmented macules&#44; verruca-like papillomatous lesions&#44; seborrheic keratosis&#44; or reddish pityriasis versicolor&#46; The lesions may progress to various types of neoplasm&#44; the most frequent of which is squamous cell carcinoma&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In patients with iatrogenic acquired epidermodysplasia verruciformis&#44; immunosuppressive therapy should be modified if possible&#46;</p></span>"
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ISSN: 00017310
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