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Vol. 110. Issue 4.
Pages 262-272 (May 2019)
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Vol. 110. Issue 4.
Pages 262-272 (May 2019)
Review
DOI: 10.1016/j.adengl.2019.04.001
Vitamin D and the Skin: A Review for Dermatologists
Vitamina D y la piel. Una revisión para dermatólogos
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F.J. Navarro-Triviñoa,
Corresponding author
fntmed@gmail.com

Corresponding author.
, S. Arias-Santiagob, Y. Gilaberte-Calzadac
a Unidad de Dermatología Médico-Quirúrgica y Venereología, Hospital Comarcal Alcalá la Real, Jaén, Spain
b Unidad de Gestión Clínica de Dermatología y Venereología, Hospital Universitario Virgen de las Nieves, Granada, Spain
c Servicio de Dermatología, Hospital Universitario Miguel Servet, IIS Aragón, Zaragoza, Spain
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Tables (9)
Table 1. Foods Rich in Vitamin D.
Table 2. Risk Factors Associated with Low Vitamin D Levels.
Table 3. Functions of Vitamin D in the Body.
Table 4. Indications for Vitamin D Supplementation During Corticosteroid Therapy.
Table 5. Vitamin D Formulations Available in Spain.
Table 6. Vitamin D Supplement Dosages According to 25(OH)D Serum Levels as Specified in the Summary of Product Characteristics.
Table 7. Skin Diseases Related to Alterations in Vitamin Levels D.
Table 8. Vitamin D Supplementation in Skin Diseases: Grades of Recommendation and Levels of Evidence.
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Abstract

In recent years, the growing interest in the role played by vitamin D in skin disease has given rise to the publication of many studies of the relationship between this vitamin and certain skin conditions. As dermatologists, we need to understand, among other aspects, how vitamin D is synthesized and the main sources in humans, as well as plasma levels and the factors that can modify them. Of particular interest are the latest discoveries about the role of vitamin D in skin diseases such as lupus erythematosus, ichthyosis, atopic dermatitis, hidradenitis suppurativa, acne, alopecia areata, androgenetic alopecia, melanoma, and nonmelanoma skin cancer. Also of interest is the importance of vitamin D as adjuvant therapy in patients on long-term treatment with corticosteroids. In this review, we provide an overview of the most important and most recent information regarding the relationship between vitamin D and skin disease and discuss the importance of assessing individual vitamin D status and correcting deficiencies.

Keywords:
Vitamin D
Lupus erythematosus
Ichthyosis
Atopic dermatitis
Hidradenitis suppurativa
Acne
Alopecia
Melanoma
Resumen

El papel de la vitamina D en enfermedades cutáneas ha cobrado interés en los últimos años. La relación entre esta vitamina y algunas dermatosis ha supuesto la publicación de múltiples trabajos al respecto. Como dermatólogos, conocer sus principales fuentes, síntesis, niveles plasmáticos y algunos de los factores modificadores son varios de los aspectos a recordar. Asimismo, es preciso resaltar los últimos descubrimientos sobre el papel de la vitamina D en las diferentes enfermedades dermatológicas, como el lupus eritematoso, la ictiosis, la dermatitis atópica, la hidrosadenitis supurativa, el acné, la alopecia areata y androgenética, el melanoma y el cáncer cutáneo no melanoma, así como la relevancia como terapia adyuvante en pacientes en tratamiento crónico con corticoides. Acercamos al lector la información más relevante y reciente de la relación entre la vitamina D y las enfermedades de la piel, así como la importancia de conocer los niveles de esta vitamina.

Palabras clave:
Vitamina D
Lupus eritematoso
Ictiosis
Dermatitis atópica
Hidrosadenitis supurativa
Acné
Alopecia
Melanoma

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