array:23 [
  "pii" => "S1578219009701076"
  "issn" => "15782190"
  "doi" => "10.1016/S1578-2190(09)70107-6"
  "estado" => "S300"
  "fechaPublicacion" => "2009-08-01"
  "aid" => "70107"
  "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
  "copyrightAnyo" => "2009"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "Actas Dermosifiliogr. 2009;100:499-502"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2373
    "formatos" => array:3 [
      "EPUB" => 38
      "HTML" => 1440
      "PDF" => 895
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219009701088"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(09)70108-8"
    "estado" => "S300"
    "fechaPublicacion" => "2009-08-01"
    "aid" => "70108"
    "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2009;100:503-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3813
      "formatos" => array:3 [
        "EPUB" => 31
        "HTML" => 1443
        "PDF" => 2339
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Traction Folliculitis&#58; 6 Cases Caused by Different Types of Hairstyles That Pull on the Hair"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "503"
          "paginaFinal" => "506"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Foliculitis por Tracci&#243;n&#58; Seis Casos Producidos por Diferentes Tipos de Peinado Tirante"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "F&#46; Urbina, E&#46; Sudy, M&#46; Barrios"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Urbina"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Sudy"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Barrios"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701088?idApp=UINPBA000044"
    "url" => "/15782190/0000010000000006/v1_201304241459/S1578219009701088/v1_201304241459/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219009701064"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(09)70106-4"
    "estado" => "S300"
    "fechaPublicacion" => "2009-08-01"
    "aid" => "70106"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2009;100:493-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2451
      "formatos" => array:3 [
        "EPUB" => 39
        "HTML" => 1535
        "PDF" => 877
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Characteristics of Patients With Hand Dermatitis Referred to the Contact Dermatitis Unit of a Tertiary Hospital and Impact of Patch Testing on Diagnosis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "493"
          "paginaFinal" => "498"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Perfil de los Pacientes con Dermatosis en las Manos Remitidos a la Unidad de Contacto de un Hospital Terciario e Impacto de las Pruebas Epicut&#225;neas en el Diagn&#243;stico"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46;M&#46; Carrascosa, F&#46; Benvenuti, C&#46; Rodr&#237;guez, C&#46; Ferr&#225;ndiz"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Carrascosa"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Benvenuti"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Rodr&#237;guez"
            ]
            3 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Ferr&#225;ndiz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701064?idApp=UINPBA000044"
    "url" => "/15782190/0000010000000006/v1_201304241459/S1578219009701064/v1_201304241459/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
    "titulo" => "Necrobiotic Xanthogranuloma&#58; Efficacy of Surgery in 2 Patients"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "499"
        "paginaFinal" => "502"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "P&#46; Gacto, F&#46; Barrera, J&#46;J&#46; Pereyra, P&#46; Fern&#225;ndez-Ortega"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "P&#46;"
            "apellidos" => "Gacto"
            "email" => array:1 [
              0 => "purigacto&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "F&#46;"
            "apellidos" => "Barrera"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;J&#46;"
            "apellidos" => "Pereyra"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Fern&#225;ndez-Ortega"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Cirug&#237;a Pl&#225;stica&#44; Hospitales Universitarios Virgen del Roc&#237;o&#44; Sevilla&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospitales Universitarios Virgen del Roc&#237;o&#44; Sevilla&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence&#58; Servicio de Cirug&#237;a Pl&#225;stica&#44; 5&#46;<span class="elsevierStyleSup"><span class="elsevierStyleUnderline">a</span></span> Planta&#44; Hospital de Rehabilitaci&#243;n y Traumatolog&#237;a&#44; Hospitales Universitarios Virgen del Roc&#237;o&#44; Avd&#46; Manuel Siurot&#44; s&#47;n&#44; 41013 Sevilla&#44; Spain&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Necrobiotic Xanthogranuloma&#58; Efficacy of Surgery in 2 Patients"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaAceptado" => "2008-10-06"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec84525"
          "palabras" => array:3 [
            0 => "necrobiotic xanthogranuloma"
            1 => "ocular complications"
            2 => "surgery"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec84526"
          "palabras" => array:3 [
            0 => "xantogranuloma necrobi&#243;tico"
            1 => "complicaciones oculares"
            2 => "tratamiento quir&#250;rgico"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Necrobiotic xanthogranuloma is a rare disease characterized by indurated nodules and yellowish-red plaques in the dermis or subdermal tissues particularly in the periorbital region&#59; the lesions are often ulcerated&#46; This disease is frequently associated with hematological disorders such as monoclonal gammopathy and lymphoproliferative disorders&#46; Its pathogenesis is unknown and the small number of cases makes long-term studies difficult&#46; We present 2 cases of periorbital lesions in which the biopsies established a diagnosis of necrobiotic xanthogranuloma&#46; Both patients were treated with corticosteroids and cyclophosphamide&#44; with no improvement&#46; The lesions were excised and the periorbital regions were reconstructed with skin grafts&#46; After 1 year of follow-up there are no signs of recurrence&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El xantogranuloma necrobi&#243;tico es una enfermedad poco frecuente que se caracteriza por la presencia de n&#243;dulos indurados y placas rojo-amarillentas en los tejidos d&#233;rmicos o subd&#233;rmicos&#44; a menudo ulceradas&#44; que asientan preferentemente en la regi&#243;n periorbitaria&#46; Suele asociarse con alteraciones hematol&#243;gicas como gammapat&#237;a monoclonal y trastornos linfoproliferativos&#46; Su patogenia es desconocida y el escaso n&#250;mero de casos existentes hace dif&#237;cil la publicaci&#243;n de estudios a largo plazo&#46; Presentamos dos casos de lesiones periorbitarias cuyas biopsias establecieron el diagn&#243;stico de xantogranuloma necrobi&#243;tico&#46; Los pacientes se sometieron a tratamiento con corticoides y ciclofosfamida sin mejor&#237;a&#46; Las lesiones fueron tratadas quir&#250;rgicamente mediante escisi&#243;n y reconstrucci&#243;n con injertos de piel&#46; Tras un a&#241;o de seguimiento no hay evidencias de recurrencia de la enfermedad&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:16 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Necrobiotic xanthogranuloma with paraproteinemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Kossard"
                            1 => "R&#46;K&#46; Winkelmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1980"
                        "volumen" => "3"
                        "paginaInicial" => "257"
                        "paginaFinal" => "270"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7451693"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Necrobiotic xanthogranuloma with scleroderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;G&#46; Russo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cutis"
                        "fecha" => "2002"
                        "volumen" => "70"
                        "paginaInicial" => "311"
                        "paginaFinal" => "316"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12502118"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Necrobiotic xanthogranuloma associated with a benign monoclonal gammopathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;E&#46; Burdick"
                            1 => "J&#46; S&#225;nchez"
                            2 => "G&#46;W&#46; Elgart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cutis"
                        "fecha" => "2003"
                        "volumen" => "72"
                        "paginaInicial" => "47"
                        "paginaFinal" => "50"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12889715"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recombinant interferon alfa-2b treatment of necrobiotic xanthogranuloma with paraproteinemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;Y&#46; Venencie"
                            1 => "P&#46; Le Bras"
                            2 => "N&#46;D&#46; Toan"
                            3 => "G&#46; Tchernia"
                            4 => "J&#46;F&#46; Delfraissy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1995"
                        "volumen" => "32"
                        "paginaInicial" => "666"
                        "paginaFinal" => "667"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7896960"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Monoclonal gammapathies and associated skin disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;S&#46; Daoud"
                            1 => "J&#46;A&#46; Lust"
                            2 => "R&#46;A&#46; Kyle"
                            3 => "M&#46;R&#46; Pittelkow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1999"
                        "volumen" => "40"
                        "paginaInicial" => "507"
                        "paginaFinal" => "535"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10188670"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Necrobiotic xanthogranuloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;A&#46; Mehregan"
                            1 => "R&#46;K&#46; Winkelmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1992"
                        "volumen" => "128"
                        "paginaInicial" => "94"
                        "paginaFinal" => "100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1739294"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Necrobiotic xanthogranuloma&#58; long-term outcome of ocular and systemic involvement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Ugurlu"
                            1 => "G&#46;B&#46; Bartley"
                            2 => "L&#46;E&#46; Gibson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ophthalmol"
                        "fecha" => "2000"
                        "volumen" => "129"
                        "paginaInicial" => "651"
                        "paginaFinal" => "657"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10844059"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recalcitrant necrobiotic xanthogranuloma responding to pulsed high-dose oral dexamethasone plus maintenance therapy with oral prednisolone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;A&#46; Chave"
                            1 => "M&#46;M&#46; Chowdhury"
                            2 => "P&#46;J&#46; Holt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2001"
                        "volumen" => "144"
                        "paginaInicial" => "158"
                        "paginaFinal" => "161"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11167699"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510707024091"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Necrobiotic xanthogranuloma with paraproteinemia&#58; a review of 22 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;C&#46; Finan"
                            1 => "R&#46;K&#46; Winkelmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Medicine"
                        "fecha" => "1984"
                        "volumen" => "65"
                        "paginaInicial" => "376"
                        "paginaFinal" => "388"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3097454"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Necrobiotic xanthogranuloma with paraproteinaemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Flann"
                            1 => "E&#46;M&#46; Wain"
                            2 => "S&#46; Halpern"
                            3 => "V&#46; Andrews"
                            4 => "S&#46; Whittaker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2230.2005.02042.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2006"
                        "volumen" => "31"
                        "paginaInicial" => "248"
                        "paginaFinal" => "251"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16487104"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Necrobiotic xanthogranuloma presenting as a solitary tumor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Stork"
                            1 => "D&#46; Kodetov&#225;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "2000"
                        "volumen" => "5"
                        "paginaInicial" => "453"
                        "paginaFinal" => "456"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6318588"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510711017718"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Necrobiotic xanthogranuloma with cutaneous and cerebral manifestations&#46; Case report and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46;C&#46; Shah"
                            1 => "S&#46;I&#46; Poonnoose"
                            2 => "R&#46; George"
                            3 => "M&#46; Jacob"
                            4 => "V&#46; Rajshekhar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.2004.100.6.1111"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "2004"
                        "volumen" => "100"
                        "paginaInicial" => "1111"
                        "paginaFinal" => "1114"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15200133"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Xantogranuloma necrobi&#243;tico sin paraproteinemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Mahiques"
                            1 => "T&#46; Mart&#237;nez-Mench&#243;n"
                            2 => "J&#46; Pardo"
                            3 => "G&#46; Pitarch"
                            4 => "A&#46; Mart&#237;nez-Aparicio"
                            5 => "J&#46;M&#46; Fortea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2004"
                        "volumen" => "95"
                        "paginaInicial" => "508"
                        "paginaFinal" => "510"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiation therapy for ocular necrobiotic xanthogranuloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;H&#46; Char"
                            1 => "P&#46;E&#46; Leboit"
                            2 => "B&#46;M&#46; Ljung"
                            3 => "W&#46; Wara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Ophthalmol"
                        "fecha" => "1987"
                        "volumen" => "105"
                        "paginaInicial" => "174"
                        "paginaFinal" => "175"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3813945"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interferon Alpha-2a monotherapy for necrobiotic xanthogranuloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Georgiou"
                            1 => "A&#46; Monastirli"
                            2 => "N&#46; Kapranos"
                            3 => "E&#46; Pasmatzi"
                            4 => "T&#46;H&#46; Sakkis"
                            5 => "D&#46; Tsambaos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "1999"
                        "volumen" => "79"
                        "paginaInicial" => "484"
                        "paginaFinal" => "485"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10598773"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1590865809001960"
                          "estado" => "S300"
                          "issn" => "15908658"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Xantogranuloma necrobi&#243;tico con paraproteinemia asociado a liquen escleroatr&#243;fico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Ju&#225;rez"
                            1 => "S&#46; Espa&#241;a"
                            2 => "M&#46; Lueiro"
                            3 => "M&#46;L&#46; Fern&#225;ndez-D&#237;az"
                            4 => "F&#46; Bal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2006"
                        "volumen" => "97"
                        "paginaInicial" => "603"
                        "paginaFinal" => "608"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17173768"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010000000006/v1_201304241459/S1578219009701076/v1_201304241459/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6183"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010000000006/v1_201304241459/S1578219009701076/v1_201304241459/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219009701076?idApp=UINPBA000044"
]
Share
Journal Information
Vol. 100. Issue 6.
Pages 499-502 (August 2009)
Share
Share
Download PDF
More article options
Vol. 100. Issue 6.
Pages 499-502 (August 2009)
Case report
Full text access
Necrobiotic Xanthogranuloma: Efficacy of Surgery in 2 Patients
Necrobiotic Xanthogranuloma: Efficacy of Surgery in 2 Patients
Visits
5947
P. Gactoa,
Corresponding author
purigacto@gmail.com

Correspondence: Servicio de Cirugía Plástica, 5.a Planta, Hospital de Rehabilitación y Traumatología, Hospitales Universitarios Virgen del Rocío, Avd. Manuel Siurot, s/n, 41013 Sevilla, Spain.
, F. Barreraa, J.J. Pereyrab, P. Fernández-Ortegaa
a Servicio de Cirugía Plástica, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain
b Servicio de Dermatología, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics
Abstract

Necrobiotic xanthogranuloma is a rare disease characterized by indurated nodules and yellowish-red plaques in the dermis or subdermal tissues particularly in the periorbital region; the lesions are often ulcerated. This disease is frequently associated with hematological disorders such as monoclonal gammopathy and lymphoproliferative disorders. Its pathogenesis is unknown and the small number of cases makes long-term studies difficult. We present 2 cases of periorbital lesions in which the biopsies established a diagnosis of necrobiotic xanthogranuloma. Both patients were treated with corticosteroids and cyclophosphamide, with no improvement. The lesions were excised and the periorbital regions were reconstructed with skin grafts. After 1 year of follow-up there are no signs of recurrence.

Key words:
necrobiotic xanthogranuloma
ocular complications
surgery
Resumen

El xantogranuloma necrobiótico es una enfermedad poco frecuente que se caracteriza por la presencia de nódulos indurados y placas rojo-amarillentas en los tejidos dérmicos o subdérmicos, a menudo ulceradas, que asientan preferentemente en la región periorbitaria. Suele asociarse con alteraciones hematológicas como gammapatía monoclonal y trastornos linfoproliferativos. Su patogenia es desconocida y el escaso número de casos existentes hace difícil la publicación de estudios a largo plazo. Presentamos dos casos de lesiones periorbitarias cuyas biopsias establecieron el diagnóstico de xantogranuloma necrobiótico. Los pacientes se sometieron a tratamiento con corticoides y ciclofosfamida sin mejoría. Las lesiones fueron tratadas quirúrgicamente mediante escisión y reconstrucción con injertos de piel. Tras un año de seguimiento no hay evidencias de recurrencia de la enfermedad.

Palabras clave:
xantogranuloma necrobiótico
complicaciones oculares
tratamiento quirúrgico
Full text is only aviable in PDF
References
[1.]
S. Kossard, R.K. Winkelmann.
Necrobiotic xanthogranuloma with paraproteinemia.
J Am Acad Dermatol, 3 (1980), pp. 257-270
[2.]
G.G. Russo.
Necrobiotic xanthogranuloma with scleroderma.
Cutis, 70 (2002), pp. 311-316
[3.]
A.E. Burdick, J. Sánchez, G.W. Elgart.
Necrobiotic xanthogranuloma associated with a benign monoclonal gammopathy.
Cutis, 72 (2003), pp. 47-50
[4.]
P.Y. Venencie, P. Le Bras, N.D. Toan, G. Tchernia, J.F. Delfraissy.
Recombinant interferon alfa-2b treatment of necrobiotic xanthogranuloma with paraproteinemia.
J Am Acad Dermatol, 32 (1995), pp. 666-667
[5.]
M.S. Daoud, J.A. Lust, R.A. Kyle, M.R. Pittelkow.
Monoclonal gammapathies and associated skin disorders.
J Am Acad Dermatol, 40 (1999), pp. 507-535
[6.]
D.A. Mehregan, R.K. Winkelmann.
Necrobiotic xanthogranuloma.
Arch Dermatol, 128 (1992), pp. 94-100
[7.]
S. Ugurlu, G.B. Bartley, L.E. Gibson.
Necrobiotic xanthogranuloma: long-term outcome of ocular and systemic involvement.
Am J Ophthalmol, 129 (2000), pp. 651-657
[8.]
T.A. Chave, M.M. Chowdhury, P.J. Holt.
Recalcitrant necrobiotic xanthogranuloma responding to pulsed high-dose oral dexamethasone plus maintenance therapy with oral prednisolone.
Br J Dermatol, 144 (2001), pp. 158-161
[9.]
M.C. Finan, R.K. Winkelmann.
Necrobiotic xanthogranuloma with paraproteinemia: a review of 22 cases.
Medicine, 65 (1984), pp. 376-388
[10.]
S. Flann, E.M. Wain, S. Halpern, V. Andrews, S. Whittaker.
Necrobiotic xanthogranuloma with paraproteinaemia.
Clin Exp Dermatol, 31 (2006), pp. 248-251
[11.]
J. Stork, D. Kodetová.
Necrobiotic xanthogranuloma presenting as a solitary tumor.
Am J Dermatopathol, 5 (2000), pp. 453-456
[12.]
K.C. Shah, S.I. Poonnoose, R. George, M. Jacob, V. Rajshekhar.
Necrobiotic xanthogranuloma with cutaneous and cerebral manifestations. Case report and review of the literature.
J Neurosurg, 100 (2004), pp. 1111-1114
[13.]
L. Mahiques, T. Martínez-Menchón, J. Pardo, G. Pitarch, A. Martínez-Aparicio, J.M. Fortea.
Xantogranuloma necrobiótico sin paraproteinemia.
Actas Dermosifiliogr, 95 (2004), pp. 508-510
[14.]
D.H. Char, P.E. Leboit, B.M. Ljung, W. Wara.
Radiation therapy for ocular necrobiotic xanthogranuloma.
Arch Ophthalmol, 105 (1987), pp. 174-175
[15.]
S. Georgiou, A. Monastirli, N. Kapranos, E. Pasmatzi, T.H. Sakkis, D. Tsambaos.
Interferon Alpha-2a monotherapy for necrobiotic xanthogranuloma.
Acta Derm Venereol, 79 (1999), pp. 484-485
[16.]
Y. Juárez, S. España, M. Lueiro, M.L. Fernández-Díaz, F. Bal.
Xantogranuloma necrobiótico con paraproteinemia asociado a liquen escleroatrófico.
Actas Dermosifiliogr, 97 (2006), pp. 603-608
Copyright © 2009. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
Download PDF
Idiomas
Actas Dermo-Sifiliográficas
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?