Case report
Necrobiotic Xanthogranuloma: Efficacy of Surgery in 2 Patients
Necrobiotic Xanthogranuloma: Efficacy of Surgery in 2 Patients
P. Gactoa,
, F. Barreraa, J.J. Pereyrab, P. Fernández-Ortegaa
Corresponding author
purigacto@gmail.com
Correspondence: Servicio de Cirugía Plástica, 5.a Planta, Hospital de Rehabilitación y Traumatología, Hospitales Universitarios Virgen del Rocío, Avd. Manuel Siurot, s/n, 41013 Sevilla, Spain.
Correspondence: Servicio de Cirugía Plástica, 5.a Planta, Hospital de Rehabilitación y Traumatología, Hospitales Universitarios Virgen del Rocío, Avd. Manuel Siurot, s/n, 41013 Sevilla, Spain.
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"apellidos" => "Fernández-Ortega" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Cirugía Plástica, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Cirugía Plástica, 5.<span class="elsevierStyleSup"><span class="elsevierStyleUnderline">a</span></span> Planta, Hospital de Rehabilitación y Traumatología, Hospitales Universitarios Virgen del Rocío, Avd. Manuel Siurot, s/n, 41013 Sevilla, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Necrobiotic Xanthogranuloma: Efficacy of Surgery in 2 Patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-10-06" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84525" "palabras" => array:3 [ 0 => "necrobiotic xanthogranuloma" 1 => "ocular complications" 2 => "surgery" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84526" "palabras" => array:3 [ 0 => "xantogranuloma necrobiótico" 1 => "complicaciones oculares" 2 => "tratamiento quirúrgico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Necrobiotic xanthogranuloma is a rare disease characterized by indurated nodules and yellowish-red plaques in the dermis or subdermal tissues particularly in the periorbital region; the lesions are often ulcerated. This disease is frequently associated with hematological disorders such as monoclonal gammopathy and lymphoproliferative disorders. Its pathogenesis is unknown and the small number of cases makes long-term studies difficult. We present 2 cases of periorbital lesions in which the biopsies established a diagnosis of necrobiotic xanthogranuloma. Both patients were treated with corticosteroids and cyclophosphamide, with no improvement. The lesions were excised and the periorbital regions were reconstructed with skin grafts. After 1 year of follow-up there are no signs of recurrence.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El xantogranuloma necrobiótico es una enfermedad poco frecuente que se caracteriza por la presencia de nódulos indurados y placas rojo-amarillentas en los tejidos dérmicos o subdérmicos, a menudo ulceradas, que asientan preferentemente en la región periorbitaria. Suele asociarse con alteraciones hematológicas como gammapatía monoclonal y trastornos linfoproliferativos. Su patogenia es desconocida y el escaso número de casos existentes hace difícil la publicación de estudios a largo plazo. Presentamos dos casos de lesiones periorbitarias cuyas biopsias establecieron el diagnóstico de xantogranuloma necrobiótico. Los pacientes se sometieron a tratamiento con corticoides y ciclofosfamida sin mejoría. Las lesiones fueron tratadas quirúrgicamente mediante escisión y reconstrucción con injertos de piel. Tras un año de seguimiento no hay evidencias de recurrencia de la enfermedad.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 7 | 14 |
| 2024 October | 56 | 50 | 106 |
| 2024 September | 50 | 26 | 76 |
| 2024 August | 78 | 49 | 127 |
| 2024 July | 53 | 40 | 93 |
| 2024 June | 63 | 41 | 104 |
| 2024 May | 55 | 29 | 84 |
| 2024 April | 48 | 35 | 83 |
| 2024 March | 48 | 41 | 89 |
| 2024 February | 51 | 42 | 93 |
| 2024 January | 41 | 43 | 84 |
| 2023 December | 51 | 41 | 92 |
| 2023 November | 65 | 42 | 107 |
| 2023 October | 44 | 37 | 81 |
| 2023 September | 28 | 24 | 52 |
| 2023 August | 24 | 24 | 48 |
| 2023 July | 43 | 50 | 93 |
| 2023 June | 43 | 28 | 71 |
| 2023 May | 40 | 25 | 65 |
| 2023 April | 24 | 17 | 41 |
| 2023 March | 19 | 34 | 53 |
| 2023 February | 24 | 25 | 49 |
| 2023 January | 35 | 36 | 71 |
| 2022 December | 33 | 43 | 76 |
| 2022 November | 13 | 26 | 39 |
| 2022 October | 21 | 18 | 39 |
| 2022 September | 14 | 44 | 58 |
| 2022 August | 12 | 33 | 45 |
| 2022 July | 16 | 32 | 48 |
| 2022 June | 8 | 19 | 27 |
| 2022 May | 28 | 43 | 71 |
| 2022 April | 37 | 45 | 82 |
| 2022 March | 34 | 74 | 108 |
| 2022 February | 20 | 31 | 51 |
| 2022 January | 25 | 49 | 74 |
| 2021 December | 18 | 44 | 62 |
| 2021 November | 27 | 43 | 70 |
| 2021 October | 27 | 55 | 82 |
| 2021 September | 33 | 46 | 79 |
| 2021 August | 19 | 24 | 43 |
| 2021 July | 23 | 30 | 53 |
| 2021 June | 15 | 21 | 36 |
| 2021 May | 16 | 18 | 34 |
| 2021 April | 69 | 58 | 127 |
| 2021 March | 51 | 17 | 68 |
| 2021 February | 56 | 19 | 75 |
| 2021 January | 24 | 14 | 38 |
| 2020 December | 29 | 5 | 34 |
| 2020 November | 24 | 14 | 38 |
| 2020 October | 7 | 8 | 15 |
| 2020 September | 21 | 18 | 39 |
| 2020 August | 29 | 15 | 44 |
| 2020 July | 12 | 7 | 19 |
| 2020 June | 28 | 26 | 54 |
| 2020 May | 13 | 18 | 31 |
| 2020 April | 20 | 16 | 36 |
| 2020 March | 20 | 16 | 36 |
| 2020 February | 1 | 7 | 8 |
| 2020 January | 0 | 13 | 13 |
| 2019 December | 0 | 12 | 12 |
| 2019 November | 0 | 3 | 3 |
| 2019 October | 0 | 1 | 1 |
| 2019 September | 0 | 5 | 5 |
| 2019 August | 0 | 3 | 3 |
| 2019 July | 0 | 10 | 10 |
| 2019 June | 0 | 6 | 6 |
| 2019 May | 2 | 46 | 48 |
| 2019 April | 0 | 36 | 36 |
| 2019 March | 0 | 11 | 11 |
| 2019 February | 0 | 8 | 8 |
| 2018 December | 0 | 2 | 2 |
| 2018 October | 0 | 4 | 4 |
| 2018 August | 0 | 6 | 6 |
| 2018 July | 0 | 7 | 7 |
| 2018 June | 0 | 1 | 1 |
| 2018 April | 0 | 1 | 1 |
| 2018 March | 0 | 5 | 5 |
| 2018 February | 6 | 2 | 8 |
| 2018 January | 12 | 6 | 18 |
| 2017 December | 13 | 11 | 24 |
| 2017 November | 15 | 5 | 20 |
| 2017 October | 10 | 9 | 19 |
| 2017 September | 12 | 7 | 19 |
| 2017 August | 14 | 18 | 32 |
| 2017 July | 9 | 4 | 13 |
| 2017 June | 25 | 16 | 41 |
| 2017 May | 14 | 14 | 28 |
| 2017 April | 26 | 10 | 36 |
| 2017 March | 26 | 9 | 35 |
| 2017 February | 12 | 14 | 26 |
| 2017 January | 15 | 16 | 31 |
| 2016 December | 16 | 14 | 30 |
| 2016 November | 12 | 9 | 21 |
| 2016 October | 24 | 11 | 35 |
| 2016 September | 21 | 6 | 27 |
| 2016 August | 24 | 9 | 33 |
| 2016 July | 22 | 6 | 28 |
| 2016 June | 14 | 4 | 18 |
| 2016 May | 11 | 0 | 11 |
| 2016 April | 9 | 4 | 13 |
| 2016 March | 6 | 0 | 6 |
| 2016 February | 8 | 2 | 10 |
| 2016 January | 5 | 1 | 6 |
| 2015 December | 10 | 0 | 10 |
| 2015 November | 11 | 8 | 19 |
| 2015 October | 10 | 6 | 16 |
| 2015 September | 5 | 5 | 10 |
| 2015 August | 14 | 5 | 19 |
| 2015 July | 34 | 8 | 42 |
| 2015 June | 25 | 9 | 34 |
| 2015 May | 76 | 14 | 90 |
| 2015 April | 47 | 11 | 58 |
| 2015 March | 31 | 7 | 38 |
| 2015 February | 21 | 14 | 35 |
| 2015 January | 21 | 18 | 39 |
| 2014 December | 18 | 6 | 24 |
| 2014 November | 17 | 4 | 21 |
| 2014 October | 32 | 12 | 44 |
| 2014 September | 30 | 10 | 40 |
| 2014 August | 36 | 11 | 47 |
| 2014 July | 45 | 16 | 61 |
| 2014 June | 35 | 14 | 49 |
| 2014 May | 55 | 14 | 69 |
| 2014 April | 48 | 13 | 61 |
| 2014 March | 49 | 21 | 70 |
| 2014 February | 27 | 16 | 43 |
| 2014 January | 32 | 16 | 48 |
| 2013 December | 46 | 18 | 64 |
| 2013 November | 33 | 20 | 53 |
| 2013 October | 25 | 17 | 42 |
| 2013 September | 23 | 15 | 38 |
| 2013 August | 20 | 18 | 38 |
| 2013 July | 42 | 39 | 81 |
| 2013 June | 20 | 34 | 54 |
| 2013 May | 25 | 22 | 47 |
| 2013 April | 33 | 29 | 62 |
| 2013 March | 31 | 23 | 54 |
| 2013 February | 20 | 9 | 29 |
| 2013 January | 10 | 3 | 13 |
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