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1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Examination of a biopsy specimen from the center of the lesion revealed an epidermis with no significant histologic abnormalities and hyperpigmentation in the stratum basale&#46; Below the epidermis&#44; a fibrous band of superficial dermis acted as a border against a proliferation of small-caliber venous vessels running parallel to the epidermis that occupied the upper third of the reticular dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The vessels had oval lumina &#40;some of which were collapsed&#41; covered by a simple endothelium without atypia&#44; mitotic figures&#44; or intraluminal projections&#46; The dermis surrounding the vessels showed intense elastotic degeneration&#44; and the elastic fibers took the form of irregular arabesques with pointed ends &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The adnexa were displaced by the vascular proliferation&#46; All the vessels stained positive for the immunohistochemical marker CD34&#44; thus facilitating visualization of some vascular walls&#44; which were slightly collapsed&#44; with respect to the degenerated elastic fibers&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Acquired elastotic hemangioma&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course and Treatment</span><p id="par0030" class="elsevierStylePara elsevierViewall">The lesion was removed by simple excision&#44; with no signs of recurrence at 1 year&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Acquired elastotic hemangioma was first reported by Requena et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> in 2002&#46; This benign acquired vascular lesion grows in the form of a plaque that is not always angiomatous in appearance&#46; Consequently&#44; clinical opinions on the lesion are somewhat heterogeneous&#46; Given the clinical characteristics of the lesion in the case we report&#44; the various diagnoses proposed included neutrophilic dermatosis and granuloma annulare&#44; although the lesion was angiomatous in appearance&#44; thus indicating the possibility of Kaposi sarcoma or another type of hemangioma&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The lesion is found mainly on photoexposed areas and is composed of a proliferation of small-caliber vessels arranged in the form of a band running parallel to the epidermis&#44; from which it is separated by a homogeneous collagen band&#46; The vessels&#44; whose lumina may be open or collapsed&#44; can present a prominent endothelium&#44; without atypia&#44; mitosis&#44; or intraluminal projections&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#8211;5</span></a> The dermis always shows intense actinic damage&#44; and elastic fibers twisted in the form of arabesques are common&#46; The vessels stain positive for endothelial markers such as CD34 and CD31&#46; Positivity for podoplanin indicates that the vessels are lymphatic in origin&#44; although in the case we report&#44; there were&#44; at least focally&#44; vascular structures whose morphology was compatible with venous vessels &#40;consistent with the observations of Tong and Beer<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a>&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Once the vascular nature of the lesion has been confirmed&#44; 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Journal Information
Vol. 107. Issue 9.
Pages 771-772 (November 2016)
Visits
4894
Vol. 107. Issue 9.
Pages 771-772 (November 2016)
Case for Diagnosis
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Asymptomatic Erythematous-Purpuric Plaque on the Forearm
Placa eritematopurpúrica asintomática en antebrazo
Visits
4894
F.J. Torres Gómez
Corresponding author
javiertorresgomez@yahoo.es

Corresponding author.
, P. Fernández Machín, J. Neila Iglesias
Unidad de Anatomía Patológica, Agencia Sanitaria Bajo Guadalquivir, Hospital de Alta Resolución de Utrera, Utrera, Sevilla, Spain
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Clinical History

The patient was an asymptomatic 58-year-old woman with no history of interest who consulted for an erythematous-purpuric plaque measuring 2cm at its maximum diameter on the right forearm that had appeared 4 months previously.

Physical Examination

Physical examination revealed an erythematous-purpuric plaque with a rough surface, elastic consistency, and slightly irregular borders on the extensor aspect of the right forearm (Fig. 1).

Figure 1
(0.08MB).
Histopathology

Examination of a biopsy specimen from the center of the lesion revealed an epidermis with no significant histologic abnormalities and hyperpigmentation in the stratum basale. Below the epidermis, a fibrous band of superficial dermis acted as a border against a proliferation of small-caliber venous vessels running parallel to the epidermis that occupied the upper third of the reticular dermis (Fig. 2). The vessels had oval lumina (some of which were collapsed) covered by a simple endothelium without atypia, mitotic figures, or intraluminal projections. The dermis surrounding the vessels showed intense elastotic degeneration, and the elastic fibers took the form of irregular arabesques with pointed ends (Fig. 3). The adnexa were displaced by the vascular proliferation. All the vessels stained positive for the immunohistochemical marker CD34, thus facilitating visualization of some vascular walls, which were slightly collapsed, with respect to the degenerated elastic fibers.

Figure 2.

Hematoxylin-eosin, original magnification ×40.

(0.13MB).
Figure 3.

Hematoxylin-eosin, original magnification ×100.

(0.13MB).

What Is Your Diagnosis?

Diagnosis

Acquired elastotic hemangioma.

Clinical Course and Treatment

The lesion was removed by simple excision, with no signs of recurrence at 1 year.

Comment

Acquired elastotic hemangioma was first reported by Requena et al.1 in 2002. This benign acquired vascular lesion grows in the form of a plaque that is not always angiomatous in appearance. Consequently, clinical opinions on the lesion are somewhat heterogeneous. Given the clinical characteristics of the lesion in the case we report, the various diagnoses proposed included neutrophilic dermatosis and granuloma annulare, although the lesion was angiomatous in appearance, thus indicating the possibility of Kaposi sarcoma or another type of hemangioma.

The lesion is found mainly on photoexposed areas and is composed of a proliferation of small-caliber vessels arranged in the form of a band running parallel to the epidermis, from which it is separated by a homogeneous collagen band. The vessels, whose lumina may be open or collapsed, can present a prominent endothelium, without atypia, mitosis, or intraluminal projections.2–5 The dermis always shows intense actinic damage, and elastic fibers twisted in the form of arabesques are common. The vessels stain positive for endothelial markers such as CD34 and CD31. Positivity for podoplanin indicates that the vessels are lymphatic in origin, although in the case we report, there were, at least focally, vascular structures whose morphology was compatible with venous vessels (consistent with the observations of Tong and Beer6).

Once the vascular nature of the lesion has been confirmed, a differential diagnosis should be made with other conditions characterized by proliferation of small vessels. Histopathology rules out Kaposi sarcoma and other spindle-cell vascular tumors. In clinical terms, the lesion is not compatible with cherry hemangioma or hobnail hemangioma.

There continues to be some debate as to whether the lesion is hyperplastic or neoplastic, and the low number of cases reported in the literature contributes to this situation.

The treatment of choice is simple excision, with no relapses reported to date.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

References
[1]
L. Requena, H. Kutzner, T. Mentzel.
Acquired elastotic hemangioma: A clinicopathologic variant of hemangioma.
J Am Acad Dermatol, 47 (2002), pp. 371-376
[2]
E. Solís García, A. Moreno Torres, B. Rodríguez Enríquez, J. Sánchez Sánchez Vizcaíno, V. Haro Gabaldón.
Hemangioma elastótico adquirido. ¿Una entidad infradiagnosticada?.
Rev Esp Patol, 37 (2004), pp. 329-331
[3]
O. Sangüeza, L. Requena.
Pathology of vascular skin lesions.
Humana Press, (2003),
[4]
Ibarra de la Rosa J, Terrasa Sagrista F, Nadal Lladó C, Company Campins M. Hemangioma elastótico adquirido. A propósito de un caso y revisión de la literatura. X Congreso Virtual Hispanoamericano de Anatomía Patológica (en línea); 2007.
[5]
A. Martorell-Calatayud, N. Balmer, O. Sanmartín, J.L. Díaz-Recuero, O.P. Sangueza.
Definition of the features of acquired elastotic hemangioma reporting the clinical and histopathological characteristics of 14 patients.
J Cutan Pathol, 37 (2010), pp. 460-464
[6]
P. Tong, T.W. Beer.
Acquired elastotic hemangioma: Ten cases with immunohistochemistry refuting a lymphatic origin in most lesions.
J Cut Pathol, 37 (2010), pp. 1259-1260

Please cite this article as: Torres Gómez FJ, Fernández Machín P, Neila Iglesias J. Placa eritematopurpúrica asintomática en antebrazo. Actas Dermosifiliogr. 2016;107:771–772.

Copyright © 2016. Elsevier España, S.L.U. and AEDV
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