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Vol. 110. Num. 3.
Pages 181-256 (April 2019)
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Vol. 110. Num. 3.
Pages 181-256 (April 2019)
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DOI: 10.1016/j.adengl.2019.02.017
Adverse Hair Reactions to New Targeted Therapies for Cancer
Reacciones capilares de las nuevas terapias diana dirigidas contra el cáncer
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J.F. Mir-Bonaféa,
Corresponding author
jmirb@santpau.cat

Corresponding author.
, D. Saceda-Corralob, S. Vañó-Galvánb
a Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
b Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, Spain
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Table 1. Main Molecular Targets for Targeted Cancer Therapy and the Corresponding Agents.
Table 2. The 10 Drugs With Highest Incidence of Alopecia and Their Mechanism of Action.
Table 3. Summary of the Main and Secondary Capillary Reactions of Targeted Cancer Therapy by Pharmacological Class.
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Abstract

The advent of immune targeted therapies for cancer has radically changed the treatment and prognosis of many cancers. These drugs are called targeted therapies because they target specific pathophysiological mechanisms of cancer. This paradigm shift in cancer treatment, however, has resulted in new adverse dermatologic effects involving both the skin and its appendages. In the case of hair, targeted drugs can cause immune alterations and changes in hair growth, color, and shape. Because most targeted therapies are new, there is no single document describing all these adverse effects. We performed an exhaustive review of the literature to characterize adverse hair effects associated with the use of targeted therapies.

Keywords:
Cancer treatment
Trichology
Hair
Alopecia
Targeted therapies
Hair reactions
Resumen

Las nuevas terapias inmunológicas dirigidas contra el cáncer han supuesto un cambio radical en el tratamiento y el pronóstico de muchas neoplasias. Estos medicamentos se dirigen de manera mucho más específica contra los mecanismos fisiopatogénicos del cáncer, por lo que adquieren el sobrenombre de «terapias diana». Este cambio de paradigma ha supuesto la aparición de nuevos efectos adversos dermatológicos, que afectan tanto la piel como sus anejos. Los efectos adversos en el pelo pueden manifestarse en alteraciones de su ciclo, forma, color o inmunología. Debido a que son tratamientos nuevos en su mayoría y no existe un documento que englobe todos estos efectos adversos, hemos realizado una exhaustiva revisión bibliográfica para caracterizar de manera concreta cuáles son los efectos adversos tricológicos que pueden inducir cada uno de estos fármacos.

Palabras clave:
Tratamiento oncológico
Tricología
Pelo
Alopecia
Terapias diana
Alteraciones capilares

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