Poliosis secundaria al tratamiento con ipilimumab

doi:10.1016/j.medcli.2013.07.005

Medicina Clínica

Volume 142, Issue 5, 4 March 2014, Page 234

https://doi.org/10.1016/j.medcli.2013.07.005 Get rights and content

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Adverse Hair Reactions to New Targeted Therapies for Cancer
2019, Actas Dermo-Sifiliograficas
Citation Excerpt :
In the case of ipilimumab, the onset of vitiligo-like hypopigmentation is common (particularly in patients with melanoma), and in initial studies, up to 14% of patients experienced hypopigmentation of hair of the scalp, eyebrows, or eye lashes.18,19 Subsequently, there have been 2 reports of poliosis with this class of drugs, 1 with ipilimumab20 and the other with pembrolizumab.21 However, the reverse effect seems more frequent with PD-1/PD-L1 inhibitors, as a series of 14 patients was recently published of scalp repigmentation after receiving treatment with 1 of these PD-1/PD-L1 agents for nonsmall cell lung cancer (Fig. 3).22
The advent of immune targeted therapies for cancer has radically changed the treatment and prognosis of many cancers. These drugs are called targeted therapies because they target specific pathophysiological mechanisms of cancer. This paradigm shift in cancer treatment, however, has resulted in new adverse dermatologic effects involving both the skin and its appendages. In the case of hair, targeted drugs can cause immune alterations and changes in hair growth, color, and shape. Because most targeted therapies are new, there is no single document describing all these adverse effects. We performed an exhaustive review of the literature to characterize adverse hair effects associated with the use of targeted therapies.
Las nuevas terapias inmunológicas dirigidas contra el cáncer han supuesto un cambio radical en el tratamiento y el pronóstico de muchas neoplasias. Estos medicamentos se dirigen de manera mucho más específica contra los mecanismos fisiopatogénicos del cáncer, por lo que adquieren el sobrenombre de «terapias diana». Este cambio de paradigma ha supuesto la aparición de nuevos efectos adversos dermatológicos, que afectan tanto la piel como sus anejos. Los efectos adversos en el pelo pueden manifestarse en alteraciones de su ciclo, forma, color o inmunología. Debido a que son tratamientos nuevos en su mayoría y no existe un documento que englobe todos estos efectos adversos, hemos realizado una exhaustiva revisión bibliográfica para caracterizar de manera concreta cuáles son los efectos adversos tricológicos que pueden inducir cada uno de estos fármacos.

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Imagen de la semanaPoliosis secundaria al tratamiento con ipilimumabIpilimumab-induced poliosis

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Poliosis secundaria al tratamiento con ipilimumabIpilimumab-induced poliosis