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1</a>&#41;&#46; The tumor measured approximately 4<span class="elsevierStyleHsp" style=""></span>cm in its largest diameter and 3<span class="elsevierStyleHsp" style=""></span>cm in height&#46; There were no palpable locoregional lymph nodes&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Additional Tests</span><p id="par0015" class="elsevierStylePara elsevierViewall">The lesion was completely excised and the defect was closed using a full-thickness skin graft&#46; Histopathology revealed the presence of tumor nodules in the dermis&#46; The nodules were composed of monomorphic mononuclear cells&#44; spindle-shaped cells&#44; and multinucleated osteoclast-like giant cells&#44; with no cellular atypia &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The number of mitoses was 3 per 10 high-power fields and the Ki-67 index was 21&#37;&#46; Immunohistochemistry was positive for CD68 &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; and negative for S100 and pancytokeratins&#46; No vascular invasion was detected&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">&#191;What Is Your Diagnosis&#63;</span></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Soft tissue giant cell tumor of low malignant potential &#40;STGCTLMP&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course and Treatment</span><p id="par0030" class="elsevierStylePara elsevierViewall">The patient has attended follow-up in the dermatology unit for 2 years and has presented no local recurrence or lymph-node or distant metastases&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">STGCTLMP is a rare neoplasm that presents in middle-aged men and women as an asymptomatic&#44; well-defined tumor&#46; Around 80 cases with similar characteristics have been reported&#44; the majority located on the upper and lower limbs&#44; in contrast to our patient&#44; in whom the tumor was in the frontal region&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#8211;5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Although STGCTLMP was initially included as a malignant soft tissue giant cell tumor&#44; Folpe et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> subsequently proposed the term <span class="elsevierStyleItalic">soft tissue giant cell tumor of low malignant potential</span> as&#44; in contrast to the former tumors&#44; this neoplasm only presents mild or moderate atypia and an indolent clinical course&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">They are considered to be the soft tissue analogy to giant cell tumors of bone&#44; due to their histological and immunohistochemical similarity&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> Microscopically&#44; STGCTLMP presents a monomorphic proliferation of mononuclear cells and osteoclast-like multinucleated giant cells distributed uniformly through the tumor&#44; as was observed in our case&#46; These tumors can present metaplastic bone formation peripherally and vascular invasion&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The histological diagnosis is confirmed on immunohistochemistry&#46; CD68&#44; which is also expressed in epithelial and mesenchymal tumors such as atypical fibroxanthoma&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> is detected in the cytoplasm of the multinucleated cells&#46; Tartrate-resistant acid phosphatase and smooth muscle actin are also positive&#44; but CD45&#44; protein S100&#44; desmin&#44; and lysozyme are negative&#44; producing an immunophenotypic profile identical to that of giant cell tumors of bone&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> Additional tests demonstrate the extraosseus situation&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The differential diagnosis should include mesenchymal tumors rich in osteoclast-like giant cells&#44; such as the giant cell variant of malignant fibrous histiocytoma&#44; plexiform fibrohistiocytic tumor&#44; and extraskeletal osteosarcoma&#59; these tumors have a more aggressive course&#46; STGCTLMP must also be differentiated from atypical fibroxanthoma&#44; an uncommon dermal tumor of uncertain histogenesis&#44; considered by the majority of authors to be superficial variant of malignant fibrous histiocytoma&#44; but with a better prognosis&#46; This tumor typically presents as a solitary nodule in sun-exposed areas in elderly adults&#46; Histologically&#44; there is a predominance of spindle-shaped cells with large vesicular nuclei&#44; associated with a variable number of giant cells&#44; some of which are multinucleated&#44; and polygonal cells with abundant eosinophilic cytoplasm&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> Other lesions rich in multinucleated giant cells include giant cell tumors of the tendon sheath and benign cutaneous fibrous histiocytoma&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The prognosis is favorable if resection is complete&#44; but local recurrence can occur after incomplete resection&#44; as is seen with its osseous form&#46; Lymph-node and lung metastases are very rare&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">We have reported a new case of STGCTLMP&#44; a rare lesion that must be included in the differential diagnosis of soft tissue tumors rich in giant cells&#44; as its clinical behavior&#44; prognosis&#44; and treatment differ significantly&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Journal Information
Vol. 107. Issue 10.
Pages 851-852 (December 2016)
Visits
5521
Vol. 107. Issue 10.
Pages 851-852 (December 2016)
Case for Diagnosis
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A Slow-Growing Tumor on the Forehead
Tumor de lento crecimiento en región frontal
Visits
5521
A. Almodovar-Reala,
Corresponding author
anamariaalmodovar@gmail.com

Corresponding author.
, J. Aneiros-Fernándezb, R. Ruiz-Villaverdec
a Unidad de Gestión Clínica de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario San Cecilio, Granada, Spain
b Unidad de Gestión Clínica de Anatomía Patológica, Hospital Universitario San Cecilio, Granada, Spain
c Unidad de Gestión Clínica de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Virgen de las Nieves, Granada, Spain
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Medical History

A man aged 80 years, with no past medical history of interest, consulted for an exophytic tumor that had arisen a year earlier in the frontal region and had grown progressively to its current size. There were no associated symptoms and the patient did not recall any history of trauma.

Physical Examination

On physical examination, a single, well-defined exophytic tumor with a cylindric polypoid morphology and a fibrinous and friable surface was observed in the left lateral frontal region (Fig. 1). The tumor measured approximately 4cm in its largest diameter and 3cm in height. There were no palpable locoregional lymph nodes.

Figure 1.

Clinical image.

(0.08MB).
Additional Tests

The lesion was completely excised and the defect was closed using a full-thickness skin graft. Histopathology revealed the presence of tumor nodules in the dermis. The nodules were composed of monomorphic mononuclear cells, spindle-shaped cells, and multinucleated osteoclast-like giant cells, with no cellular atypia (Fig. 2). The number of mitoses was 3 per 10 high-power fields and the Ki-67 index was 21%. Immunohistochemistry was positive for CD68 (Fig. 3) and negative for S100 and pancytokeratins. No vascular invasion was detected.

Figure 2.

Hematoxylin and eosin, original magnification ×20.

(0.22MB).
Figure 3.

Immunohistochemistry, original magnification ×20.

(0.23MB).

¿What Is Your Diagnosis?

Diagnosis

Soft tissue giant cell tumor of low malignant potential (STGCTLMP).

Clinical Course and Treatment

The patient has attended follow-up in the dermatology unit for 2 years and has presented no local recurrence or lymph-node or distant metastases.

Comment

STGCTLMP is a rare neoplasm that presents in middle-aged men and women as an asymptomatic, well-defined tumor. Around 80 cases with similar characteristics have been reported, the majority located on the upper and lower limbs, in contrast to our patient, in whom the tumor was in the frontal region.1–5

Although STGCTLMP was initially included as a malignant soft tissue giant cell tumor, Folpe et al.2 subsequently proposed the term soft tissue giant cell tumor of low malignant potential as, in contrast to the former tumors, this neoplasm only presents mild or moderate atypia and an indolent clinical course.

They are considered to be the soft tissue analogy to giant cell tumors of bone, due to their histological and immunohistochemical similarity.2 Microscopically, STGCTLMP presents a monomorphic proliferation of mononuclear cells and osteoclast-like multinucleated giant cells distributed uniformly through the tumor, as was observed in our case. These tumors can present metaplastic bone formation peripherally and vascular invasion.3

The histological diagnosis is confirmed on immunohistochemistry. CD68, which is also expressed in epithelial and mesenchymal tumors such as atypical fibroxanthoma,6 is detected in the cytoplasm of the multinucleated cells. Tartrate-resistant acid phosphatase and smooth muscle actin are also positive, but CD45, protein S100, desmin, and lysozyme are negative, producing an immunophenotypic profile identical to that of giant cell tumors of bone.2 Additional tests demonstrate the extraosseus situation.3

The differential diagnosis should include mesenchymal tumors rich in osteoclast-like giant cells, such as the giant cell variant of malignant fibrous histiocytoma, plexiform fibrohistiocytic tumor, and extraskeletal osteosarcoma; these tumors have a more aggressive course. STGCTLMP must also be differentiated from atypical fibroxanthoma, an uncommon dermal tumor of uncertain histogenesis, considered by the majority of authors to be superficial variant of malignant fibrous histiocytoma, but with a better prognosis. This tumor typically presents as a solitary nodule in sun-exposed areas in elderly adults. Histologically, there is a predominance of spindle-shaped cells with large vesicular nuclei, associated with a variable number of giant cells, some of which are multinucleated, and polygonal cells with abundant eosinophilic cytoplasm.7 Other lesions rich in multinucleated giant cells include giant cell tumors of the tendon sheath and benign cutaneous fibrous histiocytoma.1

The prognosis is favorable if resection is complete, but local recurrence can occur after incomplete resection, as is seen with its osseous form. Lymph-node and lung metastases are very rare.4

We have reported a new case of STGCTLMP, a rare lesion that must be included in the differential diagnosis of soft tissue tumors rich in giant cells, as its clinical behavior, prognosis, and treatment differ significantly.

Conflicts of interest

The authors declare that they have no conflicts of interest.

References
[1]
A.M. Oliveira, A.P. Dei Tos, C.D. Fletcher, A.G. Nascimento.
Primary giant cell tumor of soft tissues: A study of 22 cases.
Am J Surg Pathol, 24 (2000), pp. 248-256
[2]
A.L. Folpe, R.J. Morris, S.W. Weiss.
Soft tissue giant cell tumor of low malignant potential: A proposal for the reclassification of malignant giant cell tumor of soft parts.
Mod Pathol, 12 (1999), pp. 894-902
[3]
J.L. Rodríguez-Peralto, F. Lopez-Barea, J. Fernández-Delgado.
Primary giant cell tumor of soft tissues similar to bone giant cell tumor: A case report and literature review.
Pathol Int, 51 (2001), pp. 60-63
[4]
J.X. O’Connell, B.M. Wehrli, G.P. Nielsen, A.E. Rosenberg.
Giant cell tumors of soft tissue: A clinicopathologic study of 18 benign and malignant tumors.
Am J Surg Pathol, 24 (2000), pp. 386-395
[5]
V. Boneschi, A. Parafioriti, E. Armiraglio, F. Gaiani, L. Brambilla.
Primary giant cell tumor of soft tissue of the groin - a case of 46 years duration.
J Cutan Pathol, 36 (2009), pp. S20-S24
[6]
L. Fuertes, C. Santonja, H. Kutzner, L. Requena.
Immunohistochemistry in dermatopathology: A review of the most commonly used antibodies (part II) [Article in English, Spanish].
Actas Dermosifiliogr, 104 (2013), pp. 181-203
[7]
E. Gómez de la Fuente, M. Sols, F. Pinedo, J.G. Álvarez-Fernández, F.J. Vicente, E. Naz, et al.
Atypical fibroxanthoma. Clinical/pathological study of 10 cases [Article in Spanish].
Actas Dermosifiliogr, 96 (2005), pp. 153-158

Please cite this article as: Almodovar-Real A, Aneiros-Fernández J, Ruiz-Villaverde R. Tumor de lento crecimiento en región frontal. Actas Dermosifiliogr. 2016;107:851–852.

Copyright © 2016. Elsevier España, S.L.U. and AEDV
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