Publish in this journal
Journal Information
Vol. 110. Issue 3.
Pages 227-231 (April 2019)
Share
Share
Download PDF
More article options
ePub
Visits
7
Vol. 110. Issue 3.
Pages 227-231 (April 2019)
Original Article
DOI: 10.1016/j.adengl.2018.06.027
A Retrospective Study of Systemic Treatment of Severe Atopic Dermatitis With Azathioprine: Effectiveness and Tolerance in 11 Pediatric Patients
Estudio retrospectivo del tratamiento sistémico de la dermatitis atópica grave con azatioprina. Eficacia y tolerancia en 11 pacientes pediátricos
Visits
7
L. Noguera-Morel, N. Knöpfel, A. Torrelo, A. Hernández-Martín
Corresponding author
ahernandez@aedv.es

Corresponding author.
Departamento de Dermatología, Hospital Infantil Universitario Niño Jesús, Madrid, España
This item has received
7
Visits
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Tables (2)
Table 1. Demographic Data and Drug-Related Variables.
Table 2. Summary of Data From Studies on Atopic Dermatitis Treated With Azathioprine in Children.
Show moreShow less
Abstract
Background

Atopic dermatitis (AD) is a chronic inflammatory skin disease that typically affects children. Severe forms may have a profound effect on patients’ quality of life. Some forms are resistant to conventional treatment and require the use of systemic immunosuppressants such as azathioprine (AZA) to adequately manage the disease.

Objective

To evaluate the effectiveness and tolerance of AZA in children with severe AD.

Patients and methods

We performed a retrospective study of children with severe AD treated with AZA between January 2007 and May 2017.

Results

We reviewed the cases of 11 patients (6 boys and 5 girls) with a mean age of 13 years (range, 8-18 years). The mean (SD) age at start of treatment was 10.9 (2.2) years (95% CI 8.6-13.1). The mean initial dosage of AZA was 1.8 (0.2) mg/kg/d. We evaluated treatment response after 4 weeks, 12 to 16 weeks, and 6 months. Mean treatment duration was 10.8 (5.7) months. Treatment had to be suspended in 2 patients because of adverse effects. Seven of the 9 remaining patients presented complete or almost complete clearance of the AD after 6 months of treatment.

Conclusion

In our experience, AZA is well tolerated and may be considered as a treatment option in children with severe AD resistant to conventional treatment.

Keywords:
Azathioprine
Atopic dermatitis
Atopic eczema
Immunosuppressants
Children
Resumen
Antecedentes

La dermatitis atópica (DA) es una enfermedad inflamatoria crónica de la piel típicamente infantil cuyas formas graves pueden afectar intensamente la calidad de vida del paciente. Existen formas refractarias al tratamiento convencional en las que es preciso emplear inmunosupresores sistémicos como la azatioprina (AZA) para alcanzar un buen control de la enfermedad.

Objetivo

Evaluar la eficacia y la tolerancia de la AZA en niños con DA grave.

Pacientes y métodos

Se realizó una revisión retrospectiva de niños con DA grave tratados con AZA entre enero de 2007 y mayo de 2017.

Resultados

Se revisaron 11 pacientes (6 varones, 5 mujeres) con una edad promedio de 13 años (rango 8-18 años). La edad media±DE al inicio del tratamiento fue de 10,9±2,2 años (IC 95% 8,6-13,1). La media de la dosis inicial de AZA fue de 1,8±0,2mg/kg/d. Evaluamos la respuesta al tratamiento de nuestros pacientes a las 4 semanas, entre la semana 12 y la 16, y a partir de los 6 meses. La media del tratamiento fue de 10,8±5,7 meses. Dos pacientes tuvieron que suspender el tratamiento por efectos adversos. Siete de los 9 pacientes restantes presentaron un aclaramiento completo o casi completo de la DA a los 6 meses de tratamiento.

Conclusión

En nuestra experiencia, la AZA es bien tolerada y puede ser considerada como una opción terapéutica en los niños con DA grave refractaria a tratamientos convencionales.

Palabras clave:
Azatioprina
Dermatitis atópica
Eccema atópico
Inmunosupresores
Niños

Article

These are the options to access the full texts of the publication Actas Dermo-Sifiliográficas (English Edition)
Member
If you are a member of the AEDV:
Go to the members area of the website of the AEDV, (https://aedv.es/backend/login) and login.
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 22,50 €

Comprar ahora
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Email
Idiomas
Actas Dermo-Sifiliográficas (English Edition)

Subscribe to our newsletter

Article options
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1258])
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1258])
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1258])
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1258])
  • Additional material
Tools
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1258])
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1258])
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1258])
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1258])
Supplemental materials
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.