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                          0 => array:2 [ …2]
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                      "doi" => "10.1007/s00247-002-0838-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Radiol"
                        "fecha" => "2003"
                        "volumen" => "33"
                        "paginaInicial" => "99"
                        "paginaFinal" => "103"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Congenital vascular lesions&#58; clinical application of a new classification"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Pediatr Surg"
                        "fecha" => "1983"
                        "volumen" => "18"
                        "paginaInicial" => "894"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arteriovenous fistula&#58; results of management of congenital and acquired forms&#44; blood flow measurements&#44; and observations on proximal arterial degeneration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Surgery"
                        "fecha" => "1970"
                        "volumen" => "67"
                        "paginaInicial" => "40"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of deep venous anomalies in congenital vascular malformations of venous predominance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Vasc Surg"
                        "fecha" => "2000"
                        "volumen" => "31"
                        "paginaInicial" => "462"
                        "paginaFinal" => "471"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1996"
                        "volumen" => "87"
                        "paginaInicial" => "1181"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assignment of a locus for dominantly inherited venous malformations to chromosome 9p"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mol Genet"
                        "fecha" => "1994"
                        "volumen" => "3"
                        "paginaInicial" => "1583"
                        "paginaFinal" => "1587"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessels formation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/376070a0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "1995"
                        "volumen" => "376"
                        "paginaInicial" => "70"
                        "paginaFinal" => "74"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A gene for inherited cutaneous venous anomalies &#40;&#8220;glomangiomas&#8221;&#41; localizes to chromosome 1p21-22"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/302450"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "1999"
                        "volumen" => "65"
                        "paginaInicial" => "125"
                        "paginaFinal" => "133"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations in the gene encoding KRIT1&#44; a Krev-1&#47;rap1a binding protein&#44; cause cerebral cavernous malformations &#40;CCM1&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mol Genet"
                        "fecha" => "1999"
                        "volumen" => "8"
                        "paginaInicial" => "2325"
                        "paginaFinal" => "2333"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nature02320"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "2004"
                        "volumen" => "427"
                        "paginaInicial" => "640"
                        "paginaFinal" => "645"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PTEN&#58; one gene&#44; many syndromes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/humu.10257"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mutat"
                        "fecha" => "2003"
                        "volumen" => "22"
                        "paginaInicial" => "183"
                        "paginaFinal" => "198"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Port-wine stains&#58; a disease of altered neural modulation of blood vessels"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1986"
                        "volumen" => "122"
                        "paginaInicial" => "177"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ectatic blood vessels in port-wine stains lack innervation&#58; possible role in pathogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Plast Reconstr Surg"
                        "fecha" => "1991"
                        "volumen" => "87"
                        "paginaInicial" => "419"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S000293940900230X"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A computer simulation of the haemodynamic effects of intracranial arteriovenous malformation occlusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurol Res"
                        "fecha" => "1994"
                        "volumen" => "16"
                        "paginaInicial" => "345"
                        "paginaFinal" => "352"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epithelial and mesenchymal hamartomatous changes in a mature port-wine stain&#58; morphologic evidence for a multiple germ layer field defect"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2003.04.002"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2004"
                        "volumen" => "50"
                        "paginaInicial" => "608"
                        "paginaFinal" => "612"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0010782408001625"
                          "estado" => "S300"
                          "issn" => "00107824"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Understanding abnormalities in vascular specification and remodeling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/peds.2005-0132"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2005"
                        "volumen" => "116"
                        "paginaInicial" => "228"
                        "paginaFinal" => "230"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased expression of urinary matrix metalloproteinases parallels the extent and activity of vascular anomalies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1542/peds.2004-1518"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "2005"
                        "volumen" => "116"
                        "paginaInicial" => "38"
                        "paginaFinal" => "45"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Local and systemic expression of basic fibroblast growth factor in a patient with familial glomangioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2002"
                        "volumen" => "146"
                        "paginaInicial" => "518"
                        "paginaFinal" => "522"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coexpression of angiogenic factors in brain arteriovenous malformations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "2005"
                        "volumen" => "56"
                        "paginaInicial" => "158"
                        "paginaFinal" => "165"
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939411009196"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abnormal balance in the angiopoietintie2 system in human brain arteriovenous malformations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circ Res"
                        "fecha" => "2001"
                        "volumen" => "89"
                        "paginaInicial" => "111"
                        "paginaFinal" => "113"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Redondo P&#44; Mart&#237;nez-Cuesta A&#44; Garc&#237;a-Quetglas E&#44; Idoate A&#46; Active angiogenesis in an extensive arteriovenous vascular malformation&#58; a posible therapeutic target&#63; Arch Dermatol&#46; 2007&#46; In press&#46;"
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathology and pathogenesis of haemangiomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "An Sis Sanit Navar"
                        "fecha" => "2004"
                        "volumen" => "27"
                        "numero" => "Suppl 1"
                        "paginaInicial" => "27"
                        "paginaFinal" => "31"
                        "itemHostRev" => array:3 [
                          "pii" => "S0002937807019849"
                          "estado" => "S300"
                          "issn" => "00029378"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cellular markers that distinguish the phases of hemangioma during infancy and childhood"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI117241"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1994"
                        "volumen" => "93"
                        "paginaInicial" => "2357"
                        "paginaFinal" => "2364"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0886335010012150"
                          "estado" => "S300"
                          "issn" => "08863350"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nucha naevi and interscapular telangiectasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Paediatr Scand"
                        "fecha" => "1970"
                        "volumen" => "59"
                        "paginaInicial" => "416"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Portwine stains&#58; an assessment of 5 years of treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Otolaryngol Head Neck Surg"
                        "fecha" => "1996"
                        "volumen" => "122"
                        "paginaInicial" => "1174"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The nature and evolution of port wine stains&#58; a computer assisted study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "1980"
                        "volumen" => "74"
                        "paginaInicial" => "154"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neurocutaneous syndromes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Adolesc Med"
                        "fecha" => "2002"
                        "volumen" => "13"
                        "paginaInicial" => "495"
                        "paginaFinal" => "509"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S&#237;ndrome de Sturge Weber"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2001"
                        "volumen" => "117"
                        "paginaInicial" => "320"
                        "itemHostRev" => array:3 [
                          "pii" => "S0010782411001752"
                          "estado" => "S300"
                          "issn" => "00107824"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased fibronectin expression in Sturge-Weber syndrome fibroblasts and brain tissue"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1203/01.PDR.0000058921.54071.19"
                      "Revista" => array:7 [
                        "tituloSerie" => "Pediatr Res"
                        "fecha" => "2003"
                        "volumen" => "53"
                        "paginaInicial" => "762"
                        "paginaFinal" => "769"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0886335011010820"
                          "estado" => "S300"
                          "issn" => "08863350"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Location of port-wine stains and the likelihood of ophthalmic and&#47;or central nervous system complications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "1991"
                        "volumen" => "87"
                        "paginaInicial" => "323"
                        "paginaFinal" => "327"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939411007719"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sturge-Weber syndrome&#58; age of onset of seizures and glaucoma and the prognosis for affected children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Child Neurol"
                        "fecha" => "1995"
                        "volumen" => "10"
                        "paginaInicial" => "49"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ciliochoroidal effusion syndrome secondary to Sturge-Weber syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Jpn J Ophthalmol"
                        "fecha" => "2003"
                        "volumen" => "47"
                        "paginaInicial" => "233"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Outcome of infants with unilateral Sturge-Weber syndrome and early onset seizures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dev Med Child Neurol"
                        "fecha" => "2000"
                        "volumen" => "42"
                        "paginaInicial" => "756"
                        "paginaFinal" => "759"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib46"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sturge-Weber syndrome revisited&#46; Evaluation of encephalic morphological changes with computerized tomography and magnetic resonance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Med Port"
                        "fecha" => "2003"
                        "volumen" => "16"
                        "paginaInicial" => "141"
                        "paginaFinal" => "148"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib47"
              "etiqueta" => "47&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early single photon emission computed tomography in Sturge-Weber syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "1997"
                        "volumen" => "63"
                        "paginaInicial" => "616"
                        "paginaFinal" => "621"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0010782409005393"
                          "estado" => "S300"
                          "issn" => "00107824"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib48"
              "etiqueta" => "48&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cobb syndrome&#58; case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Child Neurol"
                        "fecha" => "2002"
                        "volumen" => "17"
                        "paginaInicial" => "847"
                        "paginaFinal" => "849"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib49"
              "etiqueta" => "49&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paradominant inheritance may explain familial occurrence of cutis marmorata telangiectatica congenita"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "51750"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatology"
                        "fecha" => "2001"
                        "volumen" => "203"
                        "paginaInicial" => "208"
                        "paginaFinal" => "211"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib50"
              "etiqueta" => "50&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutis marmorata telangiect&#225;tica cong&#233;nita&#46; Revisi&#243;n de 28 casos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "1999"
                        "volumen" => "90"
                        "paginaInicial" => "433"
                        "paginaFinal" => "438"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib51"
              "etiqueta" => "51&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutis marmorata telangiectatica congenita&#58; clinical findings in 85 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2000"
                        "volumen" => "17"
                        "paginaInicial" => "100"
                        "paginaFinal" => "104"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0010782408003284"
                          "estado" => "S300"
                          "issn" => "00107824"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib52"
              "etiqueta" => "52&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutis marmorata telangiectatica congenita associated with bilateral congenital retinal detachment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Retina"
                        "fecha" => "1990"
                        "volumen" => "10"
                        "paginaInicial" => "135"
                        "paginaFinal" => "139"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib53"
              "etiqueta" => "53&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutis marmorata telangiectatica congenita and extensive mongolian spots&#58; type 5 phacomatosis pigmentovascularis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2003"
                        "volumen" => "148"
                        "paginaInicial" => "342"
                        "paginaFinal" => "345"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib54"
              "etiqueta" => "54&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phakomatosis pigmentovascularis II A and II B&#58; clinical findings in 24 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol"
                        "fecha" => "2003"
                        "volumen" => "30"
                        "paginaInicial" => "381"
                        "paginaFinal" => "388"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib55"
              "etiqueta" => "55&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary disorders of the lymphatic vessels&#46; A unified concept"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Pediatr Surg"
                        "fecha" => "1989"
                        "volumen" => "24"
                        "paginaInicial" => "233"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib56"
              "etiqueta" => "56&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystic hygroma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "titulo" => "The surgery of infancy and childhood"
                        "fecha" => "1953"
                        "editorial" => "WB Saunders"
                        "editorialLocalizacion" => "Philadelphia"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib57"
              "etiqueta" => "57&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystic hygroma of the head and neck"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Surg Obstet Gynecol"
                        "fecha" => "1950"
                        "volumen" => "58"
                        "paginaInicial" => "41"
                        "paginaFinal" => "47"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib58"
              "etiqueta" => "58&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystic hygroma-lymphoma&#58; a rare&#44; still unclear entity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1288/00005537-198910001-00001"
                      "Revista" => array:7 [
                        "tituloSerie" => "Laryngoscope"
                        "fecha" => "1989"
                        "volumen" => "99"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0010782409001280"
                          "estado" => "S300"
                          "issn" => "00107824"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib59"
              "etiqueta" => "59&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystic hygroma of the neck"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Plast Surg"
                        "fecha" => "1964"
                        "volumen" => "17"
                        "paginaInicial" => "225"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib60"
              "etiqueta" => "60&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystic hygroma in children&#58; report of 126 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Pediatr Surg"
                        "fecha" => "1974"
                        "volumen" => "9"
                        "paginaInicial" => "191"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib61"
              "etiqueta" => "61&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Skeletal changes associated with vascular malformations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Plast Reconstr Surg"
                        "fecha" => "1984"
                        "volumen" => "76"
                        "paginaInicial" => "789"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib62"
              "etiqueta" => "62&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Massive osteolysis &#40;acute spontaneous absorption of bone&#44; phantom bone&#44; disappearing bone&#41;&#58; its relations to hemangiomatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Bone Joint Surg"
                        "fecha" => "1955"
                        "volumen" => "37"
                        "paginaInicial" => "986"
                        "paginaFinal" => "1004"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib63"
              "etiqueta" => "63&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Heterogenicidad del s&#237;ndrome de Gorham-Stout&#58; asociaci&#243;n a malformaciones linf&#225;ticas venosas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2003"
                        "volumen" => "58"
                        "paginaInicial" => "599"
                        "paginaFinal" => "603"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib64"
              "etiqueta" => "64&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The lymphatic system in human embryos&#44; with a consideration of the morphology of the system as a whole"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Am J Anat"
                        "fecha" => "1909"
                        "volumen" => "9"
                        "paginaInicial" => "43"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib65"
              "etiqueta" => "65&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1995"
                        "volumen" => "92"
                        "paginaInicial" => "3566"
                        "paginaFinal" => "3570"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0886335008004264"
                          "estado" => "S300"
                          "issn" => "08863350"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib66"
              "etiqueta" => "66&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hemangioma in the zygoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Plast Surg"
                        "fecha" => "1982"
                        "volumen" => "3"
                        "paginaInicial" => "330"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib67"
              "etiqueta" => "67&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Venous malformations of skeletal muscle"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.PRS.0000033021.60657.74"
                      "Revista" => array:6 [
                        "tituloSerie" => "Plast Reconstr Surg"
                        "fecha" => "2002"
                        "volumen" => "110"
                        "paginaInicial" => "1625"
                        "paginaFinal" => "1635"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib68"
              "etiqueta" => "68&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extensive pure venous malformations in the upper or lower limb&#44; a review of 27 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1997"
                        "volumen" => "36"
                        "paginaInicial" => "219"
                        "paginaFinal" => "225"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib69"
              "etiqueta" => "69&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infants with Kasabach-Merritt syndrome do not have &#171;true&#187; hemangiomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "1997"
                        "volumen" => "130"
                        "paginaInicial" => "631"
                        "paginaFinal" => "640"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib70"
              "etiqueta" => "70&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multifocal lymphangioendotheliomatosis with thrombocytopenia&#46; A newly recognized clinicopathological entity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.140.5.599"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2004"
                        "volumen" => "140"
                        "paginaInicial" => "599"
                        "paginaFinal" => "606"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib71"
              "etiqueta" => "71&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vascular endothelial growth factor receptor-3 &#40;VEGF-R3&#41;&#58; a marker of vascular tumors with presumed lymphatic differentiation&#44; including Kaposi&#39;s sarcoma&#44; kaposiform and Dabska-type hemangioendotheliomas&#44; and a subset of angiosarcomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/modpathol.3880033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mod Pathol"
                        "fecha" => "2000"
                        "volumen" => "13"
                        "paginaInicial" => "180"
                        "paginaFinal" => "185"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            71 => array:3 [
              "identificador" => "bib72"
              "etiqueta" => "72&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glomus tumor of the mediastinum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Thorac Surg"
                        "fecha" => "1949"
                        "volumen" => "18"
                        "paginaInicial" => "417"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939411009317"
                          "estado" => "S300"
                          "issn" => "00029394"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
              "identificador" => "bib73"
              "etiqueta" => "73&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple glomus tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "1977"
                        "volumen" => "4"
                        "paginaInicial" => "244"
                        "paginaFinal" => "257"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0010782409004867"
                          "estado" => "S300"
                          "issn" => "00107824"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            73 => array:3 [
              "identificador" => "bib74"
              "etiqueta" => "74&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hereditary multiple glomangiomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Plast Surg"
                        "fecha" => "1998"
                        "volumen" => "51"
                        "paginaInicial" => "32"
                        "paginaFinal" => "37"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            74 => array:3 [
              "identificador" => "bib75"
              "etiqueta" => "75&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glomuvenous malformation &#40;glomangioma&#41; and venous malformation&#46; Distinct clinicopathologic and genetic entibies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archderm.140.8.971"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2004"
                        "volumen" => "140"
                        "paginaInicial" => "971"
                        "paginaFinal" => "976"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            75 => array:3 [
              "identificador" => "bib76"
              "etiqueta" => "76&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blue rubber bleb nevus syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "1986"
                        "volumen" => "3"
                        "paginaInicial" => "304"
                        "paginaFinal" => "310"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            76 => array:3 [
              "identificador" => "bib77"
              "etiqueta" => "77&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blue rubber bleb nevus syndrome&#58; CT diagnosis of intussusception"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Radiol"
                        "fecha" => "1990"
                        "volumen" => "154"
                        "paginaInicial" => "105"
                        "paginaFinal" => "106"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            77 => array:3 [
              "identificador" => "bib78"
              "etiqueta" => "78&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blue rubber bleb nevus syndrome&#58; a clinical spectrum with correlation between cutaneous and gastrointestinal manifestations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gastroenterol Hepatol"
                        "fecha" => "2003"
                        "volumen" => "18"
                        "paginaInicial" => "1000"
                        "paginaFinal" => "1002"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            78 => array:3 [
              "identificador" => "bib79"
              "etiqueta" => "79&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An association between autosomal dominant cerebral cavernomas and a distinctive hyperkeratotic cutaneous vascular malformation in 4 families"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Neurol"
                        "fecha" => "1999"
                        "volumen" => "45"
                        "paginaInicial" => "250"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            79 => array:3 [
              "identificador" => "bib80"
              "etiqueta" => "80&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial cerebral cavernous angioma&#58; a gene localized to a 15-cM interval on chromosome 7q"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Neurol"
                        "fecha" => "1996"
                        "volumen" => "39"
                        "paginaInicial" => "311"
                        "paginaFinal" => "314"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            80 => array:3 [
              "identificador" => "bib81"
              "etiqueta" => "81&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of congenital arteriovenous malformations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Surgery"
                        "fecha" => "1983"
                        "volumen" => "94"
                        "paginaInicial" => "740"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            81 => array:3 [
              "identificador" => "bib82"
              "etiqueta" => "82&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arteriovenous fistulae of the internal iliac vessels"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Cardiovasc Surg"
                        "fecha" => "1984"
                        "volumen" => "25"
                        "paginaInicial" => "165"
                        "paginaFinal" => "172"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            82 => array:3 [
              "identificador" => "bib83"
              "etiqueta" => "83&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arteriovenous malformation of the head and neck&#58; natural history and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Plast Reconstr Surg"
                        "fecha" => "1988"
                        "volumen" => "102"
                        "paginaInicial" => "643"
                        "paginaFinal" => "654"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            83 => array:3 [
              "identificador" => "bib84"
              "etiqueta" => "84&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Klippel-Trenaunay syndrome&#58; spectrum and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0025-6196(11)63615-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "1998"
                        "volumen" => "73"
                        "paginaInicial" => "28"
                        "paginaFinal" => "36"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            84 => array:3 [
              "identificador" => "bib85"
              "etiqueta" => "85&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Klippel and Trenaunay&#39;s syndrome&#46; 768 operated cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Surg"
                        "fecha" => "1985"
                        "volumen" => "201"
                        "paginaInicial" => "365"
                        "paginaFinal" => "373"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            85 => array:3 [
              "identificador" => "bib86"
              "etiqueta" => "86&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Asimetr&#237;a de extremidades inferiores con manchas &#171;en vino de Oporto&#187;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2004"
                        "volumen" => "60"
                        "paginaInicial" => "589"
                        "paginaFinal" => "590"
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939411005812"
                          "estado" => "S300"
                          "issn" => "00029394"
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                  ]
                ]
              ]
            ]
            86 => array:3 [
              "identificador" => "bib87"
              "etiqueta" => "87&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Capillary malformation-arteriovenous malformation&#44; a new clinical and genetic disorder caused by RASA1 mutations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/379793"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2003"
                        "volumen" => "73"
                        "paginaInicial" => "1240"
                        "paginaFinal" => "1249"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002939411009196"
                          "estado" => "S300"
                          "issn" => "00029394"
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                  ]
                ]
              ]
            ]
            87 => array:3 [
              "identificador" => "bib88"
              "etiqueta" => "88&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification and molecular characterization of a de novo supernumerary ring chromosome 18 in a patient with Klippel-Trenaunay syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1529-8817.2004.00095.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Hum Genet"
                        "fecha" => "2004"
                        "volumen" => "68"
                        "paginaInicial" => "353"
                        "paginaFinal" => "361"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            88 => array:3 [
              "identificador" => "bib89"
              "etiqueta" => "89&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Klippel-Trenaunay syndrome&#58; the importance of &#8220;geographic stains&#8221; in identifying lymphatic disease and risk of complications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2003.12.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2004"
                        "volumen" => "51"
                        "paginaInicial" => "391"
                        "paginaFinal" => "398"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            89 => array:3 [
              "identificador" => "bib90"
              "etiqueta" => "90&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New techniques for the evaluation and therapeutic planning of patients with Klippel-Trenaunay syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2006.08.057"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2007"
                        "volumen" => "56"
                        "paginaInicial" => "242"
                        "paginaFinal" => "249"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            90 => array:3 [
              "identificador" => "bib91"
              "etiqueta" => "91&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A rare vascular malformation&#44; Klippel-Trenaunay syndrome&#46; Report of a case with deep vein agenesis and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Cardiovasc Surg &#40;Torino&#41;"
                        "fecha" => "2003"
                        "volumen" => "44"
                        "paginaInicial" => "95"
                        "paginaFinal" => "100"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            91 => array:3 [
              "identificador" => "bib92"
              "etiqueta" => "92&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Klippel-Trenaunay syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "1998"
                        "volumen" => "79"
                        "paginaInicial" => "319"
                        "paginaFinal" => "326"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            92 => array:3 [
              "identificador" => "bib93"
              "etiqueta" => "93&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Klippel-Trenaunay syndrome&#58; the risks and benefits of vascular interventions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surgery"
                        "fecha" => "1991"
                        "volumen" => "110"
                        "paginaInicial" => "469"
                        "paginaFinal" => "479"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            93 => array:3 [
              "identificador" => "bib94"
              "etiqueta" => "94&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Klippel-Trenaunay syndrome&#58; clinical features&#44; complications and management in children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Surg"
                        "fecha" => "1995"
                        "volumen" => "82"
                        "paginaInicial" => "757"
                        "paginaFinal" => "761"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            94 => array:3 [
              "identificador" => "bib95"
              "etiqueta" => "95&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Klippel-Trenaunay syndrome&#58; clinical&#44; radiological&#44; and hemodynamic features and management"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Surg"
                        "fecha" => "1985"
                        "volumen" => "72"
                        "paginaInicial" => "232"
                        "paginaFinal" => "236"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            95 => array:3 [
              "identificador" => "bib96"
              "etiqueta" => "96&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S&#237;ndrome de Klippel-Trenaunay"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Piel"
                        "fecha" => "2005"
                        "volumen" => "20"
                        "paginaInicial" => "373"
                        "paginaFinal" => "382"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            96 => array:3 [
              "identificador" => "bib97"
              "etiqueta" => "97&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Proteus syndrome"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Pediatr"
                        "fecha" => "1983"
                        "volumen" => "140"
                        "paginaInicial" => "5"
                        "paginaFinal" => "12"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            97 => array:3 [
              "identificador" => "bib98"
              "etiqueta" => "98&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proteus syndrome and hamartoses with overgrowth"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dysmorphol Clin Genet"
                        "fecha" => "1990"
                        "volumen" => "4"
                        "paginaInicial" => "87"
                        "paginaFinal" => "102"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            98 => array:3 [
              "identificador" => "bib99"
              "etiqueta" => "99&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Overgrowth syndromes"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2000"
                        "editorial" => "Oxford University Press"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            99 => array:3 [
              "identificador" => "bib100"
              "etiqueta" => "100&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spindle cell hemangioendothelioma&#46; An analysis of 78 cases with reassessment of its pathogenesis and biologic behavior"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Surg Pathol"
                        "fecha" => "1996"
                        "volumen" => "20"
                        "paginaInicial" => "1196"
                        "paginaFinal" => "1204"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            100 => array:3 [
              "identificador" => "bib101"
              "etiqueta" => "101&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S&#237;ndrome de Mafucci"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2002"
                        "volumen" => "93"
                        "paginaInicial" => "321"
                        "paginaFinal" => "324"
                        "itemHostRev" => array:3 [ …3]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            101 => array:3 [
              "identificador" => "bib102"
              "etiqueta" => "102&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Maffucci&#39;s syndrome&#58; two case reports with a literature review"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1993"
                        "volumen" => "29"
                        "paginaInicial" => "894"
                        "paginaFinal" => "899"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            102 => array:3 [
              "identificador" => "bib103"
              "etiqueta" => "103&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hemodynamic observations in a newborn with Parkes-Weber syndrome"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Pediatr"
                        "fecha" => "1999"
                        "volumen" => "134"
                        "paginaInicial" => "513"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            103 => array:3 [
              "identificador" => "bib104"
              "etiqueta" => "104&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Parkes Weber or Klippel-Trenaunay syndrome&#63; Non-invasive diagnosis with MR projection angiography"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00330-004-2274-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Radiol"
                        "fecha" => "2004"
                        "volumen" => "14"
                        "paginaInicial" => "2025"
                        "paginaFinal" => "2029"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            104 => array:3 [
              "identificador" => "bib105"
              "etiqueta" => "105&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vasculogenesis&#44; angiogenesis&#44; hemangiomas&#44; and vascular malformations"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Med Gen"
                        "fecha" => "2002"
                        "volumen" => "108"
                        "paginaInicial" => "265"
                        "paginaFinal" => "274"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
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Información de la revista
Vol. 98. Núm. 3.
Páginas 141-158 (abril 2007)
Vol. 98. Núm. 3.
Páginas 141-158 (abril 2007)
Review article
Acceso a texto completo
Vascular Malformations (I). Concept, Classification, Pathogenesis and Clinical Features
Malformaciones Vasculares (I). Concepto, Clasificación, Fisiopatogenia y Manifestaciones Clínicas
Visitas
18690
P. Redondo
Autor para correspondencia
predondo@unav.es

Correspondence: Departamento de Dermatología. Clínica Universitaria de Navarra. 31080 Pamplona. Spain.
Departamento de Dermatología, Clínica Universitaria de Navarra, Pamplona, Spain
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Abstract

Vascular malformations are anomalies always present at birth that, contrary to hemangiomas, never regress and may grow during lifetime. Clinical presentation of vascular malformations is extremely variable and ranges from asymptomatic spots of mere aesthetic concern to lesions with high blood flow or located in critical sites that may be life-threatening. Given the low incidence of these disorders it is difficult to establish therapeutic guidelines. In addition to a correct classification of vascular anomalies, it is necessary a multidisciplinary approach for the follow-up and management of these patients. The first part of this review focuses on the different classifications of vascular anomalies, maintaining as reference the one proposed by the International Society for the Study of Vascular Anomalies (ISSVA). Additionally, clinical features of the different subtypes of vascular anomalies as well as their association in certain syndromes are reviewed.

Key words:
vascular malformation
Klippel-Trenaunay
venous
lymphatic
arteriovenous
Resumen

Las malformaciones vasculares son anomalías presentes siempre en el nacimiento que, al contrario que los hemangiomas, nunca desaparecen y pueden crecer durante toda la vida. La presentación clínica de las malformaciones vasculares es extremadamente variable y va desde manchas asintomáticas con repercusión meramente estética, hasta lesiones de alto flujo o localizaciones peculiares que pueden incluso poner en peligro la vida del enfermo. También al tratarse de enfermedades relativamente raras es difícil alcanzar la suficiente experiencia en su manejo para establecer pautas contrastadas de tratamiento. Además de una correcta clasificación de las anomalías vasculares, es necesario un enfoque multidisciplinar respecto del seguimiento y las posibilidades terapéuticas de estos pacientes. En la primera parte de esta revisión se abordan las diferentes clasificaciones de las malformaciones vaculares, manteniendo como referencia la sugerida por la ISSVA (International Society for the Study of Vascular Anomalies). Además se incide en las características clínicas de los diferentes subtipos de malformaciones vasculares así como sus asociaciones en determinados complejos sindrómicos.

Palabras clave:
malformación vascular
Klippel-Trenaunay
venosa
linfática
arterio-venosa
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References
[1.]
A.L. Bruckner, I.J. Frieden.
Hemangiomas of infancy.
J Am Acad Dermatol, 48 (2003), pp. 477-493
[2.]
K.G. Chiller, D. Passaro, I.J. Frieden.
Hemangiomas of infancy. Clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex.
Arch Dermatol, 138 (2002), pp. 1567-1576
[3.]
O. Enjolras, J.B. Mulliken, L. Boon, M. Wassef, H.P. Kozakewich, P.E. Burrows.
Noninvoluting congenital hemangioma: a rare cutaneous anomaly.
Plast Reconstr Surg, 107 (2001), pp. 1647-1654
[4.]
O. Konez, P.E. Burrows.
Magnetic resonance of vascular anomalies.
Magn Reson Imagin Clin N Am, 10 (2002), pp. 363-388
[5.]
J.B. Mulliken, J. Glowacki.
Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics.
Plast Reconstr Surg, 69 (1982), pp. 412
[6.]
J.L. Hand, I.J. Frieden.
Vascular birthmarks of infancy: resolving nosologic confusion.
Am J Med Genet, 108 (2002), pp. 257-264
[7.]
J.Q. Ly, T.G. Sanders, J.W. San Diego.
Hemangioma of the triceps muscle.
AJR Am J Roentgenol, 181 (2003), pp. 544
[8.]
P.-H. Kuo, Y.-C. Chang, J.-H. Liou, J.-M. Lee.
Mediastinal cavernous haemangioma in a patient with Klippel-Trenaunay syndrome.
Thorax, 58 (2003), pp. 183-184
[9.]
J.B. Mulliken.
Vascular malformations of the head and neck.
Vascular birthmarks: Hemangiomas and vascular malformations,
[10.]
S. Belov.
Classification of congenital vascular defects.
Int Angiol, 9 (1990), pp. 141-146
[11.]
St. Belov DA, Loose J, Weber, editors. Vascular malformations. Einhorn Presse Verlag. Periodica Angiologica; 1989. p25-7.
[12.]
M. Waner, J.Y. Suen.
A classification of congenital vascular lesions.
Hemangiomas and vascular malformations of the head and neck, pp. 1-12
[13.]
S. Puig, H. Aref, V. Chigot, B. Bonin, F. Brunelle.
Classification of venous malformations in children and implications for sclerotherapy.
Pediatr Radiol, 33 (2003), pp. 99-103
[14.]
M.C. Finn, J. Glowacki, J.B. Mulliken.
Congenital vascular lesions: clinical application of a new classification.
J Pediatr Surg, 18 (1983), pp. 894
[15.]
Y. Sako, R. Varco.
Arteriovenous fistula: results of management of congenital and acquired forms, blood flow measurements, and observations on proximal arterial degeneration.
Surgery, 67 (1970), pp. 40
[16.]
S. Eifert, J.L. Villavicencio, T.C. Kao, B.M. Taute, N.M. Rich.
Prevalence of deep venous anomalies in congenital vascular malformations of venous predominance.
J Vasc Surg, 31 (2000), pp. 462-471
[17.]
M. Vikkula, L. Boon, K.L. Carraway 3rd, J.T. Calvert, A.J. Diamonti, B. Goumnerov, et al.
Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2.
Cell, 87 (1996), pp. 1181
[18.]
L.M. Boon, J.B. Mulliken, M. Vikkula, H. Watkins, J. Seidman, B.R. Olsen, et al.
Assignment of a locus for dominantly inherited venous malformations to chromosome 9p.
Hum Mol Genet, 3 (1994), pp. 1583-1587
[19.]
T.N. Sato, Y. Tozawa, U. Deutsch, K. Wolburg-Buchholz, Y. Fujiwara, M. Gendron-Maguire, et al.
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessels formation.
Nature, 376 (1995), pp. 70-74
[20.]
L.M. Boon, P. Brouillard, A. Irrthum, L. Karttunen, M.L. Warman, R. Rudolph, et al.
A gene for inherited cutaneous venous anomalies (“glomangiomas”) localizes to chromosome 1p21-22.
Am J Hum Genet, 65 (1999), pp. 125-133
[21.]
T. Sahoo, E.W. Johnson, J.W. Thomas, P.M. Kuehl, T.L. Jones, C.G. Dokken, et al.
Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1).
Hum Mol Genet, 8 (1999), pp. 2325-2333
[22.]
X.L. Tian, R. Kadaba, S.A. You, M. Liu, A.A. Timur, L. Yang, et al.
Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome.
Nature, 427 (2004), pp. 640-645
[23.]
C. Eng.
PTEN: one gene, many syndromes.
Hum Mutat, 22 (2003), pp. 183-198
[24.]
B.R. Smoller, S. Rosen.
Port-wine stains: a disease of altered neural modulation of blood vessels.
Arch Dermatol, 122 (1986), pp. 177
[25.]
M. Rydy, M. Malm, J. Jernbeck, C. Dalsgaard.
Ectatic blood vessels in port-wine stains lack innervation: possible role in pathogenesis.
Plast Reconstr Surg, 87 (1991), pp. 419
[26.]
E. Ornstein, W.B. Blesser, W.L. Young, J. Pile-Spellman.
A computer simulation of the haemodynamic effects of intracranial arteriovenous malformation occlusion.
Neurol Res, 16 (1994), pp. 345-352
[27.]
I. Sánchez-Carpintero, M.C. Mihm, A. Mizeracki, M. Waner, P.E. North.
Epithelial and mesenchymal hamartomatous changes in a mature port-wine stain: morphologic evidence for a multiple germ layer field defect.
J Am Acad Dermatol, 50 (2004), pp. 608-612
[28.]
J.M. Enciso, K.K. Hirschi.
Understanding abnormalities in vascular specification and remodeling.
Pediatrics, 116 (2005), pp. 228-230
[29.]
J. Marler, S.J. Fishman, S.M. Kilroy, J. Fang, J. Upton, J.B. Mulliken, et al.
Increased expression of urinary matrix metalloproteinases parallels the extent and activity of vascular anomalies.
Pediatrics, 116 (2005), pp. 38-45
[30.]
N. Kapur, P. Lambiase, R.D. Rakhit, J. Pearce, G. Orchard, E. Calonje, et al.
Local and systemic expression of basic fibroblast growth factor in a patient with familial glomangioma.
Br J Dermatol, 146 (2002), pp. 518-522
[31.]
T. Hashimoto, Y. Wu, M.T. Lawton, G.Y. Yang, N.M. Barbaro, W.L. Young.
Coexpression of angiogenic factors in brain arteriovenous malformations.
Neurosurgery, 56 (2005), pp. 158-165
[32.]
T. Hashimoto, T. Lam, N.J. Boudreau, A.W. Bollen, M.T. Lawton, W.L. Young.
Abnormal balance in the angiopoietintie2 system in human brain arteriovenous malformations.
Circ Res, 89 (2001), pp. 111-113
[33.]
Redondo P, Martínez-Cuesta A, García-Quetglas E, Idoate A. Active angiogenesis in an extensive arteriovenous vascular malformation: a posible therapeutic target? Arch Dermatol. 2007. In press.
[34.]
J. Soto.
Pathology and pathogenesis of haemangiomas.
An Sis Sanit Navar, 27 (2004), pp. 27-31
[35.]
K. Takahashi, J.B. Mulliken, H.P. Kozakewich, R.A. Rogers, J. Folkman, R.A. Ezekowitz.
Cellular markers that distinguish the phases of hemangioma during infancy and childhood.
J Clin Invest, 93 (1994), pp. 2357-2364
[36.]
J. Oster, A. Nielson.
Nucha naevi and interscapular telangiectasis.
Acta Paediatr Scand, 59 (1970), pp. 416
[37.]
S. Orten, M. Waner, S. Flock, P. Roberson, J. Kincannon.
Portwine stains: an assessment of 5 years of treatment.
Arch Otolaryngol Head Neck Surg, 122 (1996), pp. 1174
[38.]
S.H. Barsky, S. Rosen, D.E. Geer, J. Noe.
The nature and evolution of port wine stains: a computer assisted study.
J Invest Dermatol, 74 (1980), pp. 154
[39.]
D. Dahan, G.M. Fenichel, R. El-Said.
Neurocutaneous syndromes.
Adolesc Med, 13 (2002), pp. 495-509
[40.]
E.M. Alonso, J. Sánchez, J.J. Lalanza.
Síndrome de Sturge Weber.
Med Clin (Barc), 117 (2001), pp. 320
[41.]
A.M. Comi, P. Hunt, M.P. Vawter, C.A. Pardo, K.G. Becker, J. Pevsner.
Increased fibronectin expression in Sturge-Weber syndrome fibroblasts and brain tissue.
[42.]
B. Tallman, O.T. Tan, J.G. Morelli, J. Piepenbrink, T.J. Stafford, S. Trainor, et al.
Location of port-wine stains and the likelihood of ophthalmic and/or central nervous system complications.
Pediatrics, 87 (1991), pp. 323-327
[43.]
E. Sujansky, S. Conradi.
Sturge-Weber syndrome: age of onset of seizures and glaucoma and the prognosis for affected children.
J Child Neurol, 10 (1995), pp. 49-58
[44.]
N. Ikeda, T. Ikeda, M. Nagata, O. Mimura.
Ciliochoroidal effusion syndrome secondary to Sturge-Weber syndrome.
Jpn J Ophthalmol, 47 (2003), pp. 233
[45.]
U. Kramer, E. Kahana, Z. Shorer, B. Ben-Zeev.
Outcome of infants with unilateral Sturge-Weber syndrome and early onset seizures.
Dev Med Child Neurol, 42 (2000), pp. 756-759
[46.]
P.F. Vilela.
Sturge-Weber syndrome revisited. Evaluation of encephalic morphological changes with computerized tomography and magnetic resonance.
Acta Med Port, 16 (2003), pp. 141-148
[47.]
F. Pinton, C. Chiron, O. Enjolras, J. Motte, A. Syrota, O. Dulac.
Early single photon emission computed tomography in Sturge-Weber syndrome.
J Neurol Neurosurg Psychiatry, 63 (1997), pp. 616-621
[48.]
I. Pascual-Castroviejo, R. Frutos, J. Viano, S.I. Pascual-Pascual, P. González.
Cobb syndrome: case report.
J Child Neurol, 17 (2002), pp. 847-849
[49.]
R. Danarti, R. Happle, A. Konig.
Paradominant inheritance may explain familial occurrence of cutis marmorata telangiectatica congenita.
Dermatology, 203 (2001), pp. 208-211
[50.]
E. Nagore, A. Torrelo, A. Zambrano.
Cutis marmorata telangiectática congénita. Revisión de 28 casos.
Actas Dermosifiliogr, 90 (1999), pp. 433-438
[51.]
D.B. Amitai, S. Fichman, P. Merlob, Y. Morad, M. Lapidoth, A. Metzker.
Cutis marmorata telangiectatica congenita: clinical findings in 85 patients.
Pediatr Dermatol, 17 (2000), pp. 100-104
[52.]
J.A. Shields, C.L. Shields, H.P. Koller, J.L. Federman, P. Koblenzer, L.S. Barbera.
Cutis marmorata telangiectatica congenita associated with bilateral congenital retinal detachment.
Retina, 10 (1990), pp. 135-139
[53.]
A. Torrelo, A. Zambrano, R. Happle.
Cutis marmorata telangiectatica congenita and extensive mongolian spots: type 5 phacomatosis pigmentovascularis.
Br J Dermatol, 148 (2003), pp. 342-345
[54.]
H. Vidaurri-de la Cruz, L. Tamayo-Sánchez, C. Durán-McKinster, L. Orozco-Covarrubias Mde, R. Ruiz-Maldonado.
Phakomatosis pigmentovascularis II A and II B: clinical findings in 24 patients.
J Dermatol, 30 (2003), pp. 381-388
[55.]
C. Levine.
Primary disorders of the lymphatic vessels. A unified concept.
J Pediatr Surg, 24 (1989), pp. 233
[56.]
R.E. Gross.
Cystic hygroma.
The surgery of infancy and childhood, WB Saunders, (1953),
[57.]
G.E. Ward, J.W. Hendrick, R.G. Chambers.
Cystic hygroma of the head and neck.
Surg Obstet Gynecol, 58 (1950), pp. 41-47
[58.]
T.L. Kennedy.
Cystic hygroma-lymphoma: a rare, still unclear entity.
[59.]
I.W. Broomhead.
Cystic hygroma of the neck.
Br J Plast Surg, 17 (1964), pp. 225
[60.]
T.N. Nihn, T.X. Nihn.
Cystic hygroma in children: report of 126 cases.
J Pediatr Surg, 9 (1974), pp. 191
[61.]
J.B. Boyd, J.B. Mulliken, L.B. Kaban, J. Upton, J.E. Murray.
Skeletal changes associated with vascular malformations.
Plast Reconstr Surg, 76 (1984), pp. 789
[62.]
L.W. Gorham, A.P. Stout.
Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone): its relations to hemangiomatosis.
J Bone Joint Surg, 37 (1955), pp. 986-1004
[63.]
I. Somoza, M. Díaz, L. Matínez, Z. Ros, J.C. López-Gutiérrez.
Heterogenicidad del síndrome de Gorham-Stout: asociación a malformaciones linfáticas venosas.
An Pediatr (Barc), 58 (2003), pp. 599-603
[64.]
F.R. Sabin.
The lymphatic system in human embryos, with a consideration of the morphology of the system as a whole.
Am J Anat, 9 (1909), pp. 43
[65.]
A. Kaipainen, J. Korhonen, T. Mustonen, V.W. van Hinsbergh, G.H. Fang, D. Dumont, et al.
Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.
Proc Natl Acad Sci USA, 92 (1995), pp. 3566-3570
[66.]
G.H. Schmidt.
Hemangioma in the zygoma.
Ann Plast Surg, 3 (1982), pp. 330
[67.]
K.D. Hein, J.B. Mulliken, H.P. Kozakewich, J. Upton, P.E. Burrows.
Venous malformations of skeletal muscle.
Plast Reconstr Surg, 110 (2002), pp. 1625-1635
[68.]
O. Enjolras, D. Ciabrini, E. Mazoyer, C. Laurian, D. Herbreteau.
Extensive pure venous malformations in the upper or lower limb, a review of 27 cases.
J Am Acad Dermatol, 36 (1997), pp. 219-225
[69.]
O. Enjolras, M. Wassef, E. Mazoyer, I.J. Frieden, P.N. Rieu, L. Drouet, et al.
Infants with Kasabach-Merritt syndrome do not have «true» hemangiomas.
J Pediatr, 130 (1997), pp. 631-640
[70.]
P.E. North, T. Khan, M.R. Cordisco, S.S. Dadras, M. Detmar, I.J. Frieden.
Multifocal lymphangioendotheliomatosis with thrombocytopenia. A newly recognized clinicopathological entity.
Arch Dermatol, 140 (2004), pp. 599-606
[71.]
A.L. Folpe, T. Veikkola, R. Valtola, S.W. Weiss.
Vascular endothelial growth factor receptor-3 (VEGF-R3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas.
Mod Pathol, 13 (2000), pp. 180-185
[72.]
G.V. Brindley.
Glomus tumor of the mediastinum.
J Thorac Surg, 18 (1949), pp. 417-420
[73.]
M.C. Pepper, R. Laubenheiner, D.J. Cripps.
Multiple glomus tumors.
J Cutan Pathol, 4 (1977), pp. 244-257
[74.]
A. Iqbal, G.C. Cormack, G. Scerri.
Hereditary multiple glomangiomas.
Br J Plast Surg, 51 (1998), pp. 32-37
[75.]
L.M. Boon, J.B. Mulliken, O. Enjolras, M. Vikkula.
Glomuvenous malformation (glomangioma) and venous malformation. Distinct clinicopathologic and genetic entibies.
Arch Dermatol, 140 (2004), pp. 971-976
[76.]
A.P. Oranje.
Blue rubber bleb nevus syndrome.
Pediatr Dermatol, 3 (1986), pp. 304-310
[77.]
R.T. Tyrell, B.R. Baumgartner, K.A. Montemayor.
Blue rubber bleb nevus syndrome: CT diagnosis of intussusception.
Am J Radiol, 154 (1990), pp. 105-106
[78.]
C.H. Wong, Y.M. Tan, W.C. Chow, P.H. Tan, W.K. Wong.
Blue rubber bleb nevus syndrome: a clinical spectrum with correlation between cutaneous and gastrointestinal manifestations.
J Gastroenterol Hepatol, 18 (2003), pp. 1000-1002
[79.]
P. Labauge, O. Enjolras, J.J. Bonerandi, S. Laberge, Dandyrand, J.M. Joujoux, et al.
An association between autosomal dominant cerebral cavernomas and a distinctive hyperkeratotic cutaneous vascular malformation in 4 families.
Ann Neurol, 45 (1999), pp. 250-254
[80.]
A. Gil-Nagel, J. Dubovsky, K.J. Wilcox, J.M. Stewart, V.E. Anderson, I.E. Leppik, et al.
Familial cerebral cavernous angioma: a gene localized to a 15-cM interval on chromosome 7q.
Ann Neurol, 39 (1996), pp. 311-314
[81.]
M.W. Flye, B.P. Jordan, M.Z. Schwartz.
Management of congenital arteriovenous malformations.
Surgery, 94 (1983), pp. 740
[82.]
J. Natali, P. Jue-Denis, E. Kieffer, M. Benhamou, J.F. Tricot, J.J. Merland, et al.
Arteriovenous fistulae of the internal iliac vessels.
J Cardiovasc Surg, 25 (1984), pp. 165-172
[83.]
M.P. Kohout, M. Hansen, J.J. Pribaz, J.B. Mulliken.
Arteriovenous malformation of the head and neck: natural history and management.
Plast Reconstr Surg, 102 (1988), pp. 643-654
[84.]
A.G. Jacob, D.J. Driscoll, W.J. Shaughnessy, A.W. Stanson, R.P. Clay, P. Gloviczki, et al.
Klippel-Trenaunay syndrome: spectrum and management.
Mayo Clin Proc, 73 (1998), pp. 28-36
[85.]
M. Servelle.
Klippel and Trenaunay's syndrome. 768 operated cases.
Ann Surg, 201 (1985), pp. 365-373
[86.]
M. Bastida, R. Iturbe.
Asimetría de extremidades inferiores con manchas «en vino de Oporto».
An Pediatr (Barc), 60 (2004), pp. 589-590
[87.]
I. Enrola, L.M. Boon, J.B. Mulliken, P.E. Burrows, A. Dompmartin, S. Watanabe, et al.
Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations.
Am J Hum Genet, 73 (2003), pp. 1240-1249
[88.]
A.A. Timar, A. Sadgephour, M. Graf, S. Schwartz, E.D. Libby, D.J. Driscoll, et al.
Identification and molecular characterization of a de novo supernumerary ring chromosome 18 in a patient with Klippel-Trenaunay syndrome.
Ann Hum Genet, 68 (2004), pp. 353-361
[89.]
C. Maari, I.J. Frieden.
Klippel-Trenaunay syndrome: the importance of “geographic stains” in identifying lymphatic disease and risk of complications.
J Am Acad Dermatol, 51 (2004), pp. 391-398
[90.]
G. Bastarrika, P. Redondo, A. Sierra, D. Cano, A. Martínez-Cuesta, J.C. López-Gutiérrez, et al.
New techniques for the evaluation and therapeutic planning of patients with Klippel-Trenaunay syndrome.
J Am Acad Dermatol, 56 (2007), pp. 242-249
[91.]
R. Dogan, O. Faruk Dogan, M. Oc, D. Akata, B. Gumus, F. Balkanci.
A rare vascular malformation, Klippel-Trenaunay syndrome. Report of a case with deep vein agenesis and review of the literature.
J Cardiovasc Surg (Torino), 44 (2003), pp. 95-100
[92.]
S.A. Berry, C. Peterson, W. Mize, K. Bloom, C. Zachary, P. Blasco, et al.
Klippel-Trenaunay syndrome.
Am J Med Genet, 79 (1998), pp. 319-326
[93.]
P. Gloviczki, A.W. Stanson, G.B. Stickler, C.M. Johnson, B.J. Toomey, N.B. Meland, et al.
Klippel-Trenaunay syndrome: the risks and benefits of vascular interventions.
Surgery, 110 (1991), pp. 469-479
[94.]
M. Samuel, L. Spitz.
Klippel-Trenaunay syndrome: clinical features, complications and management in children.
Br J Surg, 82 (1995), pp. 757-761
[95.]
P.A. Baskerville, J.S. Akroyd, M.L. Thomas, N.L. Browse.
The Klippel-Trenaunay syndrome: clinical, radiological, and hemodynamic features and management.
Br J Surg, 72 (1985), pp. 232-236
[96.]
A. Bauza, P. Redondo.
Síndrome de Klippel-Trenaunay.
Piel, 20 (2005), pp. 373-382
[97.]
H.R. Wiedemann, G.R. Burgio, P. Aldenhoff, J. Kunze, H.J. Kaufmann, E. Schirg.
The Proteus syndrome.
Eur J Pediatr, 140 (1983), pp. 5-12
[98.]
G.S. Hotamisligil.
Proteus syndrome and hamartoses with overgrowth.
Dysmorphol Clin Genet, 4 (1990), pp. 87-102
[99.]
M.M. Cohen Jr, G. Neri, R. Wesberg.
Overgrowth syndromes.
Oxford University Press, (2000),
[100.]
P. Perkins, S.W. Weiss.
Spindle cell hemangioendothelioma. An analysis of 78 cases with reassessment of its pathogenesis and biologic behavior.
Am J Surg Pathol, 20 (1996), pp. 1196-1204
[101.]
J.C. Moreno, F. Valverde, I. Medina, J. Marchal.
Síndrome de Mafucci.
Actas Dermosifiliogr, 93 (2002), pp. 321-324
[102.]
R.P. Kaplan, J.T. Wang, D.M. Amron, L. Kaplan.
Maffucci's syndrome: two case reports with a literature review.
J Am Acad Dermatol, 29 (1993), pp. 894-899
[103.]
T.M. Berger, J.H. Caduff.
Hemodynamic observations in a newborn with Parkes-Weber syndrome.
J Pediatr, 134 (1999), pp. 513
[104.]
S. Ziyeh, J. Spreer, J. Rossier, R. Strecker, A. Hochmuth, M. Schumacher, et al.
Parkes Weber or Klippel-Trenaunay syndrome? Non-invasive diagnosis with MR projection angiography.
Eur Radiol, 14 (2004), pp. 2025-2029
[105.]
M.M. Cohen Jr.
Vasculogenesis, angiogenesis, hemangiomas, and vascular malformations.
Am J Med Gen, 108 (2002), pp. 265-274
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