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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Granuloma faciale&#46; A&#46; Case 1&#58; erythematous-violaceous plaque on the right cheek&#46; B&#46; Hypoechoic&#44; heterogenous lesion in dermis and hypodermis&#44; measuring 4&#44;3&#8239;mm thick&#46; Note the subepidermal hypoechoic band &#40;22&#8239;MHz probe&#44; B-mode&#41;&#46; C&#46; Increased vascularity on color Doppler mode&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Granuloma faciale &#40;GF&#41; is a rare benign inflammatory dermatosis of unknown aetiology&#44; characterized by single or multiple red-brown or violaceous cutaneous nodules or plaques&#44; most frequently occurring on the face&#46; GF is considered a form of localized chronic fibrosing vasculitis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Diagnosis is commonly confirmed by skin biopsy&#44; although the histopathological diagnosis of GF may be challenging&#44; because precise histopathological criteria have not been defined&#46; Differential diagnosis is broad and includes inflammatory diseases&#44; malignancies and infections&#46; High resolution ultrasound &#40;HRU&#41; is being used increasingly in dermatology&#44; both for the diagnosis and monitoring of diverse inflammatory dermatoses and tumoral lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> We have not found publications about ultrasonographic features of GF&#46; We aimed to describe the ultrasonographic characteristics of GF in a series of patients&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Patients with biopsy-proven GF who consulted at a Spanish tertiary referral hospital between January 2016 and May 2018 were included&#46; Lesions were assessed using an Esaote MyLab Class C ultrasound machine with 18 and 22&#8239;MHz probes&#46; All the sonographic examinations were performed by following published guidelines for studying dermatologic lesions that include grayscale and color Doppler imaging&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> All patients gave oral and written consent for inclusion in the research and for publication of images&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Five patients &#40;six lesions&#41; &#40;four men and one woman&#41; with a median age of 67 years &#40;range&#44; 39-71&#41; and a biopsy-proven GF were included&#46; In three of patients the lesions were located on the face&#44; one on the scalp&#44; one on the ear and one on the umbilicus&#46; Most patients had undergone several treatments without clinical improvement &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; On ultrasonographic evaluation&#44; GF presented in all patients as a hypoechoic and heterogeneous lesion in dermis and hypodermis with an increased vascularity on color Doppler mode &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Fig&#46; 1&#8211;2</a>&#41;&#46; Almost all lesions &#40;5&#47;6&#41; were ill-defined&#46; In 5&#47;6&#8239;GF a marked subepidermal hypoechoic&#47;anechoic band was observed&#46; One lesion &#40;case 5&#44; nose&#41; presented a posterior enhancement&#46; There were no significant differences in ultrasound characteristics between facial and extrafacial GF &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Diagnosis of erythematous skin lesions occurring on the face can be challenging&#46; GF can be a highly disfiguring pathology&#44; and it is essential to perform the differential diagnosis with dermatosis of similar clinical appearance&#44; but different treatment such as sarcoidosis&#44; lupus vulgaris&#44; rosacea&#44; fungal infection&#44; mycobacteriosis&#44; discoid lupus erythematosus&#44; adverse reactions to fillers&#44; cutaneous lymphomas and pseudolymphomas&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">HRU is a rapid&#44; low-cost and safe technique&#46; It can be used for diagnosis&#44; follow-up&#44; monitoring response to treatment and to guide interventional procedures in dermatology&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Literature about ultrasonographic features of facial dermatoses is scarce&#46; We have not found previous reports of ultrasonographic descriptions of GF&#46; In our study facial and extrafacial granuloma faciale presented in most cases as a hypoechoic&#44; heterogenous and ill-defined lesion on dermis and hypodermis with increased vascularity on ultrasound examination&#46; A marked subepidermal hypoechoic band was also found in almost all cases&#44; and it may be secondary to cutaneous inflammation&#44; to the presence of a Grenz zone on histopathology &#40;a characteristic histopathologic feature of GF<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#41; or to photo-ageing&#44; as most lesions were located on sun-exposed skin&#46; Sonographic characteristics may allow to differentiate GF from subacute cutaneous lupus erythematosus as the latter shows thickening and hypoechogenicity of the dermis with a plateau shape&#44; and increased echogenicity of the upper hypodermis with a &#8220;foggy appearence&#8221;&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and from inflammatory complications of cosmetical fillers&#44; where the patient is occasionally reluctant to admit the procedure&#44; such as hyaluronic acid and pure silicone &#40;anechoic pseudocysts&#41;&#44; liquid silicone &#40;snowstorm appearance&#41;&#44; polymethylmethacrylate and calcium hydroxyapatite &#40;hyperechoic dots and bands&#44; respectively&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Also&#44; HRU may help to differentiate GF from primary cutaneous lymphomas &#40;PCLs&#41; occurring on the face such as primary cutaneous CD4<span class="elsevierStyleSup">&#43;</span> small&#47;medium T cell lymphoproliferative disorder&#44; primary cutaneous anaplastic large cell lymphoma&#44; primary cutaneous marginal zone lymphoma and primary cutaneous follicle center lymphoma&#44; among others&#46; In PCLs HRU reveals thickening of dermis with no evidence of necrosis&#44; calcification or posterior acoustic shadowing&#46; Papules of PCLs are seen as focal infiltrative lesions&#44; whilst nodules are seen as pseudonodules and nodules &#40;more frequently in B cell PCLs&#41;&#44; and plaques&#44; as hypoechoic&#44; diffusely infiltrative lesions &#40;more predominant in T cell PCLs&#41;&#46; On colour Doppler mode&#44; PCLs show hypervascularity&#44; although initial focal infiltrative lesions may be avascular&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Clinical and histopathological diagnosis of GF may be challenging&#46; We believe that knowing the sonographic characteristics of GF may help in the diagnosis of this disease&#46; Further studies describing ultrasonographic features of inflammatory dermatoses of the face are required&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors have nothing to disclose&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Morgado-Carrasco D&#44; Giavedoni P&#44; Mascar&#243; JM&#44; Iranzo P&#46; Caracter&#237;sticas ecogr&#225;ficas del granuloma facial y extrafacial&#46; Una serie de casos&#46; Actas Dermosifiliogr&#46; 2021&#59;112&#58;559&#8211;563&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2803
            "Ancho" => 1417
            "Tamanyo" => 405826
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Granuloma faciale&#46; A&#46; Case 1&#58; erythematous-violaceous plaque on the right cheek&#46; B&#46; Hypoechoic&#44; heterogenous lesion in dermis and hypodermis&#44; measuring 4&#44;3&#8239;mm thick&#46; Note the subepidermal hypoechoic band &#40;22&#8239;MHz probe&#44; B-mode&#41;&#46; C&#46; Increased vascularity on color Doppler mode&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2115
            "Ancho" => 1500
            "Tamanyo" => 397769
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        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Granuloma faciale&#46; A&#46; Case 3&#58; violaceous nodule on the umbilicus&#46; B&#46; Hypoechoic&#44; well-defined and heterogenous lesion in dermis and hypodermis&#44; measuring 6&#46;9&#8239;mm thick &#40;18&#8239;MHz probe&#44; B-mode&#41;&#46; C&#46; Marked increase in vascularization &#40;18&#8239;MHz probe&#44; color Doppler mode&#41;&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Table "
            "rol" => "short"
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        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">m&#44; male&#59; f&#44; female PSV&#44; Peak systolic velocity&#59; EDV&#44; end-diastolic velocity&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Case n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sex&#47;age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Time of evolution &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Anatomic location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Previous treatments&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Histological description&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ultrasound features &#40;B-mode &#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Doppler mode&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">m&#47;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">right cheek&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">topical corticosteroids&#44; hydroxycloroquine&#44; dapsone&#44; laser&#44; topical tacrolimus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presence of Grenz zone&#46; Dense inflammatory infiltrate constituted mainly by eosinophils&#44; few histiocytes&#44; lymphocytes and occasional plasma cells&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypoechoic&#44; heterogeneous and ill-defined lesion in dermis and hypodermis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increased vascularity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subepidermal hypoechoic band&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vessels in dermis up to 0&#46;63&#8239;mm in diameter&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">m&#47;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">topical corticosteroids&#44; doxycycline&#44; topical tacrolimus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presence of Grenz zone&#46; Dense perivascular and perianexial inflammatory infiltrate constituted by histiocytes&#44; lymphocytes&#44; plasma cells and occasional eosinophils&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypoechoic&#44; heterogeneous and ill-defined lesion in dermis and hypodermis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increased vascularity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subepidermal anechoic band&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vessels in dermis up to 1&#46;4&#8239;mm in diameter &#40;PSV 9&#46;2&#8239;cm&#47;sec&#44; EDV 2&#46;7&#8239;cm&#47;sec&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">m&#47;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">topical and intralesional corticosteroids&#44; topical tacrolimus&#44; hydroxycloroquine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presence of Grenz zone&#46; Dense lymphoplasmocytic inflammatory infiltrates in dermis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypoechoic&#44; heterogeneous and ill-defined lesion in dermis and hypodermis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increased vascularity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vessels in dermis up to 0&#46;8&#8239;mm in diameter&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Umbilicus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">topical and intralesional corticosteroids&#44; topical tacrolimus&#44; hydroxycloroquine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presence of Grenz zone&#46; Dense lymphoplasmocytic inflammatory infiltrates in dermis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypoechoic&#44; heterogeneous and well-defined lesion in dermis and hypodermis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increased vascularity&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subepidermal hypoechoic band&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vessels in dermis up to 1&#46;4&#8239;mm in diameter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">f&#47;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">nose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">none&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presence of Grenz zone&#46; Perivascular and interstitial inflammatory infiltrate constituted mainly by histiocytes&#44; neutrophils&#44; eosinophils and occasional plasma cells&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypoechoic&#44; heterogeneous and ill-defined lesion in dermis and hypodermis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increased vascularity&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Subepidermal anechoic band&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vessels in dermis up to 0&#46;96&#8239;mm in diameter &#40;PSV 17&#46;6&#8239;cm&#47;sec&#44; EDV 7&#46;2&#8239;cm&#47;sec&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">m&#47;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">nose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Imiquimod&#44; cryotherapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dense inflammatory infiltrate constituted mainly by eosinophils&#44; histiocytes&#44; neutrophils and plasma cells&#46; Papillary dermal Fibrosis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypoechoic and ill-defined lesion in dermis and hypodermis with posterior enhancement&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Increased vascularity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vesselsin dermis up to 0&#46;66&#8239;mm in diameter &#40;PSV 16&#46;3&#8239;cm&#47;sec&#44; EDV 5&#46;9&#8239;cm&#47;sec&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2608379.png"
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Characteristics of patients with granuloma faciale&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
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                  "host" => array:1 [
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                  "contribucion" => array:1 [
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            7 => array:3 [
              "identificador" => "bib0040"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
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Vol. 112. Núm. 6.
Páginas 559-563 (junio 2021)
Vol. 112. Núm. 6.
Páginas 559-563 (junio 2021)
Case and Research Letters
Open Access
Ultrasound Features of Facial and Extrafacial Granuloma Facial. A Caso Series
Características ecográficas del granuloma facial y extrafacial. Una serie de casos
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D. Morgado-Carrasco, P. Giavedoni
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giavedonip@gmail.com

Corresponding author.
, J.M. Mascaró, P. Iranzo
Departamento de Dermatología, Hospital Clínic de Barcelona, Universidad de Barcelona, Barcelona, Spain
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Table 1. Characteristics of patients with granuloma faciale.
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Dear Editor:

Granuloma faciale (GF) is a rare benign inflammatory dermatosis of unknown aetiology, characterized by single or multiple red-brown or violaceous cutaneous nodules or plaques, most frequently occurring on the face. GF is considered a form of localized chronic fibrosing vasculitis.1 Diagnosis is commonly confirmed by skin biopsy, although the histopathological diagnosis of GF may be challenging, because precise histopathological criteria have not been defined. Differential diagnosis is broad and includes inflammatory diseases, malignancies and infections. High resolution ultrasound (HRU) is being used increasingly in dermatology, both for the diagnosis and monitoring of diverse inflammatory dermatoses and tumoral lesions.2 We have not found publications about ultrasonographic features of GF. We aimed to describe the ultrasonographic characteristics of GF in a series of patients.

Patients with biopsy-proven GF who consulted at a Spanish tertiary referral hospital between January 2016 and May 2018 were included. Lesions were assessed using an Esaote MyLab Class C ultrasound machine with 18 and 22 MHz probes. All the sonographic examinations were performed by following published guidelines for studying dermatologic lesions that include grayscale and color Doppler imaging.3 All patients gave oral and written consent for inclusion in the research and for publication of images.

Five patients (six lesions) (four men and one woman) with a median age of 67 years (range, 39-71) and a biopsy-proven GF were included. In three of patients the lesions were located on the face, one on the scalp, one on the ear and one on the umbilicus. Most patients had undergone several treatments without clinical improvement (Table 1). On ultrasonographic evaluation, GF presented in all patients as a hypoechoic and heterogeneous lesion in dermis and hypodermis with an increased vascularity on color Doppler mode (Fig. 1–2). Almost all lesions (5/6) were ill-defined. In 5/6 GF a marked subepidermal hypoechoic/anechoic band was observed. One lesion (case 5, nose) presented a posterior enhancement. There were no significant differences in ultrasound characteristics between facial and extrafacial GF (Table 1).

Table 1.

Characteristics of patients with granuloma faciale.

Case n  Sex/age (years)  Time of evolution (years)  Anatomic location  Previous treatments  Histological description  Ultrasound features (B-mode )  Doppler mode 
m/39  right cheek  topical corticosteroids, hydroxycloroquine, dapsone, laser, topical tacrolimus  Presence of Grenz zone. Dense inflammatory infiltrate constituted mainly by eosinophils, few histiocytes, lymphocytes and occasional plasma cells.  Hypoechoic, heterogeneous and ill-defined lesion in dermis and hypodermis.  Increased vascularity 
            Subepidermal hypoechoic band  Vessels in dermis up to 0.63 mm in diameter. 
m/59  scalp  topical corticosteroids, doxycycline, topical tacrolimus  Presence of Grenz zone. Dense perivascular and perianexial inflammatory infiltrate constituted by histiocytes, lymphocytes, plasma cells and occasional eosinophils.  Hypoechoic, heterogeneous and ill-defined lesion in dermis and hypodermis.  Increased vascularity 
            Subepidermal anechoic band  Vessels in dermis up to 1.4 mm in diameter (PSV 9.2 cm/sec, EDV 2.7 cm/sec). 
m/67  12  Ear  topical and intralesional corticosteroids, topical tacrolimus, hydroxycloroquine  Presence of Grenz zone. Dense lymphoplasmocytic inflammatory infiltrates in dermis.  Hypoechoic, heterogeneous and ill-defined lesion in dermis and hypodermis.  Increased vascularity 
              Vessels in dermis up to 0.8 mm in diameter. 
      Umbilicus  topical and intralesional corticosteroids, topical tacrolimus, hydroxycloroquine  Presence of Grenz zone. Dense lymphoplasmocytic inflammatory infiltrates in dermis.  Hypoechoic, heterogeneous and well-defined lesion in dermis and hypodermis.  Increased vascularity. 
            Subepidermal hypoechoic band  Vessels in dermis up to 1.4 mm in diameter 
f/68  nose  none  Presence of Grenz zone. Perivascular and interstitial inflammatory infiltrate constituted mainly by histiocytes, neutrophils, eosinophils and occasional plasma cells.  Hypoechoic, heterogeneous and ill-defined lesion in dermis and hypodermis  Increased vascularity. 
            Subepidermal anechoic band  Vessels in dermis up to 0.96 mm in diameter (PSV 17.6 cm/sec, EDV 7.2 cm/sec). 
m/71  13  nose  Imiquimod, cryotherapy  Dense inflammatory infiltrate constituted mainly by eosinophils, histiocytes, neutrophils and plasma cells. Papillary dermal Fibrosis.  Hypoechoic and ill-defined lesion in dermis and hypodermis with posterior enhancement.  Increased vascularity 
              Vesselsin dermis up to 0.66 mm in diameter (PSV 16.3 cm/sec, EDV 5.9 cm/sec). 

m, male; f, female PSV, Peak systolic velocity; EDV, end-diastolic velocity.

Figure 1.

Granuloma faciale. A. Case 1: erythematous-violaceous plaque on the right cheek. B. Hypoechoic, heterogenous lesion in dermis and hypodermis, measuring 4,3 mm thick. Note the subepidermal hypoechoic band (22 MHz probe, B-mode). C. Increased vascularity on color Doppler mode.

(0.39MB).
Figure 2.

Granuloma faciale. A. Case 3: violaceous nodule on the umbilicus. B. Hypoechoic, well-defined and heterogenous lesion in dermis and hypodermis, measuring 6.9 mm thick (18 MHz probe, B-mode). C. Marked increase in vascularization (18 MHz probe, color Doppler mode).

(0.38MB).

Diagnosis of erythematous skin lesions occurring on the face can be challenging. GF can be a highly disfiguring pathology, and it is essential to perform the differential diagnosis with dermatosis of similar clinical appearance, but different treatment such as sarcoidosis, lupus vulgaris, rosacea, fungal infection, mycobacteriosis, discoid lupus erythematosus, adverse reactions to fillers, cutaneous lymphomas and pseudolymphomas.1

HRU is a rapid, low-cost and safe technique. It can be used for diagnosis, follow-up, monitoring response to treatment and to guide interventional procedures in dermatology.4 Literature about ultrasonographic features of facial dermatoses is scarce. We have not found previous reports of ultrasonographic descriptions of GF. In our study facial and extrafacial granuloma faciale presented in most cases as a hypoechoic, heterogenous and ill-defined lesion on dermis and hypodermis with increased vascularity on ultrasound examination. A marked subepidermal hypoechoic band was also found in almost all cases, and it may be secondary to cutaneous inflammation, to the presence of a Grenz zone on histopathology (a characteristic histopathologic feature of GF5) or to photo-ageing, as most lesions were located on sun-exposed skin. Sonographic characteristics may allow to differentiate GF from subacute cutaneous lupus erythematosus as the latter shows thickening and hypoechogenicity of the dermis with a plateau shape, and increased echogenicity of the upper hypodermis with a “foggy appearence”,6 and from inflammatory complications of cosmetical fillers, where the patient is occasionally reluctant to admit the procedure, such as hyaluronic acid and pure silicone (anechoic pseudocysts), liquid silicone (snowstorm appearance), polymethylmethacrylate and calcium hydroxyapatite (hyperechoic dots and bands, respectively).7 Also, HRU may help to differentiate GF from primary cutaneous lymphomas (PCLs) occurring on the face such as primary cutaneous CD4+ small/medium T cell lymphoproliferative disorder, primary cutaneous anaplastic large cell lymphoma, primary cutaneous marginal zone lymphoma and primary cutaneous follicle center lymphoma, among others. In PCLs HRU reveals thickening of dermis with no evidence of necrosis, calcification or posterior acoustic shadowing. Papules of PCLs are seen as focal infiltrative lesions, whilst nodules are seen as pseudonodules and nodules (more frequently in B cell PCLs), and plaques, as hypoechoic, diffusely infiltrative lesions (more predominant in T cell PCLs). On colour Doppler mode, PCLs show hypervascularity, although initial focal infiltrative lesions may be avascular.8

Clinical and histopathological diagnosis of GF may be challenging. We believe that knowing the sonographic characteristics of GF may help in the diagnosis of this disease. Further studies describing ultrasonographic features of inflammatory dermatoses of the face are required.

Conflicts of interest

The authors have nothing to disclose.

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Please cite this article as: Morgado-Carrasco D, Giavedoni P, Mascaró JM, Iranzo P. Características ecográficas del granuloma facial y extrafacial. Una serie de casos. Actas Dermosifiliogr. 2021;112:559–563.

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