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1</a>&#41;&#44; and there were violaceous macular lesions with a necrotic appearance on the pads of the fingers &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#46;&#41;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Histopathology</span><p id="par0015" class="elsevierStylePara elsevierViewall">Biopsy of one of the nodules revealed a medium-sized vessel in the superficial subcutaneous tissue&#44; with an occlusive intraluminal thrombus&#46; There was a mixed inflammatory infiltrate in the vessel wall and the adjacent fat &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#41;&#44; and a granulomatous reaction with multinucleated giant cells at the periphery of the thrombus &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41;&#46; Orcein staining revealed elastic fibers throughout the full thickness of the vessel wall&#44; confirming it to be a vein &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>C&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Additional Tests</span><p id="par0020" class="elsevierStylePara elsevierViewall">Capillaroscopy was normal&#46; Laboratory tests &#40;blood and urine&#44; basic biochemistry&#44; viral serology&#44; tumor markers&#44; tests for hypercoagulability&#44; and screening for autoimmune disease and cyroglobulins&#41; were negative or normal and echocardiography was unremarkable&#46; Arteriography was requested&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">&#191;What Is Your Diagnosis&#63;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Thromboangiitis obliterans &#40;Buerger disease&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Course and Treatment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Arteriography of the upper limbs revealed occlusion of both ulnar arteries&#59; 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pain at rest&#44; ischemic ulcers&#44; or gangrene&#41;&#44; absence of connective tissue disease&#44; hypercoagulability or diabetes mellitus&#44; the exclusion a proximal source of emboli by echocardiography&#44; and a compatible arteriography&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Arteriography is characterized by segmental lesions with abrupt arterial occlusion&#44; gradual tapering &#40;mouse tail&#41; of the lumen&#44; and collateral circulation with &#8216;corkscrew&#8217; morphology&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Cessation of smoking is the only means of slowing the progression of the disease and avoiding amputation&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Even the use of nicotine patches or gum may be sufficient to maintain disease activity&#46; The goal of treatment in refractory cases is to relieve intractable pain and avoid amputation by debridement and the administration of analgesics&#44; 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Información de la revista
Vol. 104. Núm. 8.
Páginas 717-718 (octubre 2013)
Visitas
8078
Vol. 104. Núm. 8.
Páginas 717-718 (octubre 2013)
Case for Diagnosis
Acceso a texto completo
Smoker With Raynaud Phenomenon and Painful Nodules on the Legs
Fumador con fenómeno de Raynaud y nódulos dolorosos en las piernas
Visitas
8078
M.U. Floristána,
Autor para correspondencia
uxuafloristan@hotmail.com

Corresponding author.
, R. Almodovarb, F.J. Salamancac
a Unidad de Dermatología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain
b Unidad de Reumatología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain
c Unidad de Anatomía Patológica, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain
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Medical History

A 44-year-old man who smoked 20 cigarettes per day was referred from the rheumatology department, where he had been under investigation for arthritis and Raynaud phenomenon, which affected the fingers of both hands and the toes of the right foot. This condition had developed several months earlier after the appearance of painful migratory lesions on the lower limbs.

Physical Examination

On examination, erythematous nodules were observed in a linear distribution on both ankles (Fig. 1), and there were violaceous macular lesions with a necrotic appearance on the pads of the fingers (Fig. 2.)

Figure 1
(0.07MB).
Figure 2
(0.05MB).
Histopathology

Biopsy of one of the nodules revealed a medium-sized vessel in the superficial subcutaneous tissue, with an occlusive intraluminal thrombus. There was a mixed inflammatory infiltrate in the vessel wall and the adjacent fat (Fig. 3A), and a granulomatous reaction with multinucleated giant cells at the periphery of the thrombus (Fig. 3B). Orcein staining revealed elastic fibers throughout the full thickness of the vessel wall, confirming it to be a vein (Fig. 3C).

Figure 3.

A, Hematoxylin-eosin, original magnification ×100. B, Hematoxylin-eosin, original magnification ×400. C, Orcein stain, original magnification ×400.

(0.26MB).
Additional Tests

Capillaroscopy was normal. Laboratory tests (blood and urine, basic biochemistry, viral serology, tumor markers, tests for hypercoagulability, and screening for autoimmune disease and cyroglobulins) were negative or normal and echocardiography was unremarkable. Arteriography was requested.

¿What Is Your Diagnosis?

Diagnosis

Thromboangiitis obliterans (Buerger disease).

Clinical Course and Treatment

Arteriography of the upper limbs revealed occlusion of both ulnar arteries; the palmar arch arising from the radial arteries was incomplete and there was a near total absence of distal vasculature. The arterial study revealed no involvement above the elbow. The patient stopped smoking and the lesions gradually improved.

Comment

Thromboangiitis obliterans is a segmental, nonatherosclerotic, occlusive inflammatory vascular disease of the small and medium-sized arteries and veins of the extremities. This disease primarily affects young male smokers and is most prevalent in Asian and Eastern Europe populations.1

Though its pathogenesis is unclear, tobacco use is central to the initiation and progression of the disease. Thromboangiitis obliterans is considered a smoking-related autoimmune process that affects genetically predisposed patients.2

Clinical manifestations are due to distal ischemia, and the main symptom is pain at rest. The disease presents as painful digital ulcers accompanied by cyanosis and coldness, which can progress to gangrene and require amputation of the affected limb. Some cases, including the one described here, are suggestive of a connective tissue disease, as they initiate with arthritis and Raynaud phenomenon.3 Raynaud phenomenon and/or migratory thrombophlebitis of superficial veins occur in 40% of patients. Although rare, the visceral arteries (mesenteric, coronary, retinal, cerebral, pulmonary, or renal) may be affected.4

Biopsy, which will reveal an inflammatory occlusive thrombus, is rarely indicated. The biopsy is most likely to be diagnostic in the acute phase of the disease and in a vessel from an area of superficial thrombophlebitis,1 as occurred in the present case.

In cases with no pathognomonic signs or symptoms, the diagnosis is one of exclusion.1 Although no clear consensus has been reached, a number of diagnostic criteria have been proposed: young male smoker (under 45 years of age) with signs and symptoms of distal ischemia of the extremities (intermittent claudication, pain at rest, ischemic ulcers, or gangrene), absence of connective tissue disease, hypercoagulability or diabetes mellitus, the exclusion a proximal source of emboli by echocardiography, and a compatible arteriography.5 Arteriography is characterized by segmental lesions with abrupt arterial occlusion, gradual tapering (mouse tail) of the lumen, and collateral circulation with ‘corkscrew’ morphology.

Cessation of smoking is the only means of slowing the progression of the disease and avoiding amputation.1 Even the use of nicotine patches or gum may be sufficient to maintain disease activity. The goal of treatment in refractory cases is to relieve intractable pain and avoid amputation by debridement and the administration of analgesics, antiplatelet drugs, and antibiotics. Alternative approaches include prostaglandin infusion, sympathectomy, revascularization (a very limited technique due to poor distal beds), and the administration of immunosuppressants and vascular endothelial growth factor analogs. The response is variable.6

References
[1]
J.W. Olin.
Thromboangiitis obliterans (Buerger's disease).
N Engl J Med, 343 (2000), pp. 864-869
[2]
R. Dellalibera-Joviliano, E.E. Joviliano, J.S. Silva, P.R. Evora.
Activation of cytokines corroborate with development of inflammation and autoimmunity in thromboangiitis obliterans patients.
Clin Exp Immunol, 170 (2012), pp. 28-35
[3]
X. Puechal, J.N. Fiessinger.
Thromboangiitis obliterans or Buerger's disease: Challenges for the rheumatologist.
Rheumatology (Oxford), 46 (2007), pp. 192-199
[4]
R. Goiriz-Valdés, J. Fernández-Herrera.
Buerger's disease (thromboangiitis obliterans).
Actas Dermosifiliogr, 96 (2005), pp. 553-562
[5]
J.W. Olin, A. Shih.
Thromboangiitis obliterans (Buerger's disease).
Curr Opin Rheumatol, 18 (2006), pp. 18-24
[6]
P.T. Dargon, G.J. Landry.
Buerger's disease.
Ann Vasc Surg, 26 (2012), pp. 871-880

Please cite this article as: Floristán M, et al. Fumador con fenómeno de Raynaud y nódulos dolorosos en las piernas. Actas Dermosifiliogr. 2013;104:717–8.

Copyright © 2013. Elsevier España, S.L. and AEDV
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