array:24 [
  "pii" => "S0001731023007494"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2022.11.021"
  "estado" => "S300"
  "fechaPublicacion" => "2024-09-01"
  "aid" => "3667"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2023"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2024;115:838-40"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0001731024005106"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2024.06.003"
    "estado" => "S300"
    "fechaPublicacion" => "2024-09-01"
    "aid" => "3992"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2024;115:T838-T840"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
      "titulo" => " Anetodermia inducida por s&#237;filis secundaria"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "T838"
          "paginaFinal" => "T840"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Secondary Syphilis-Induced Anetoderma"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1304
              "Ancho" => 1309
              "Tamanyo" => 339951
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Numerosas p&#225;pulas&#44; placas y n&#243;dulos eritematosos-viol&#225;ceos infiltrados&#44; con distribuci&#243;n sim&#233;trica en cara&#44; cuello&#44; tronco y brazos &#40;A&#44; B&#41;&#46; La tinci&#243;n de hematoxilina y eosina &#40;100&#215;&#41; muestra un infiltrado denso granulomatoso perivascular y perianexial con c&#233;lulas plasm&#225;ticas e histiocitos en dermis superficial y profunda &#40;C&#41;&#59; la inmunotinci&#243;n para T&#46; Pallidum &#40;100&#215;&#41; resalta de forma robusta la presencia de espiroquetas perivasculares e intraepid&#233;rmicas &#40;D&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Barbosa, A&#46;L&#46; Jo&#227;o, A&#46; Jo&#227;o, C&#46; Fernandes"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Barbosa"
            ]
            1 => array:2 [
              "nombre" => "A&#46;L&#46;"
              "apellidos" => "Jo&#227;o"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Jo&#227;o"
            ]
            3 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Fernandes"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005106?idApp=UINPBA000044"
    "url" => "/00017310/0000011500000008/v1_202409020432/S0001731024005106/v1_202409020432/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0001731024005787"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2023.03.020"
    "estado" => "S300"
    "fechaPublicacion" => "2024-09-01"
    "aid" => "4012"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2024;115:T834-T837"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => " Seborrhuca&#58; Vindication of a Pattern&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "T834"
          "paginaFinal" => "T837"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Seborruca&#58; &#191;reivindicaci&#243;n de un patr&#243;n&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1822
              "Ancho" => 995
              "Tamanyo" => 345934
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Three examples of seborrhucas showing typical features commonly shared by warts and SK &#40;H&#38;E x20&#41;&#46; Many whorls can be seen in B&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Ar&#243;stegui Aguilar, N&#46; Mart&#237;nez Campayo, D&#46; Cassarino, A&#46; Fernandez-Flores"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Ar&#243;stegui Aguilar"
            ]
            1 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Mart&#237;nez Campayo"
            ]
            2 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Cassarino"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Fernandez-Flores"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005787?idApp=UINPBA000044"
    "url" => "/00017310/0000011500000008/v1_202409020432/S0001731024005787/v1_202409020432/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:18 [
      "pii" => "S0001731024005106"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2024.06.003"
      "estado" => "S300"
      "fechaPublicacion" => "2024-09-01"
      "aid" => "3992"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2024;115:T838-T840"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => " Anetodermia inducida por s&#237;filis secundaria"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "T838"
            "paginaFinal" => "T840"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Secondary Syphilis-Induced Anetoderma"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1304
                "Ancho" => 1309
                "Tamanyo" => 339951
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Numerosas p&#225;pulas&#44; placas y n&#243;dulos eritematosos-viol&#225;ceos infiltrados&#44; con distribuci&#243;n sim&#233;trica en cara&#44; cuello&#44; tronco y brazos &#40;A&#44; B&#41;&#46; La tinci&#243;n de hematoxilina y eosina &#40;100&#215;&#41; muestra un infiltrado denso granulomatoso perivascular y perianexial con c&#233;lulas plasm&#225;ticas e histiocitos en dermis superficial y profunda &#40;C&#41;&#59; la inmunotinci&#243;n para T&#46; Pallidum &#40;100&#215;&#41; resalta de forma robusta la presencia de espiroquetas perivasculares e intraepid&#233;rmicas &#40;D&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46; Barbosa, A&#46;L&#46; Jo&#227;o, A&#46; Jo&#227;o, C&#46; Fernandes"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Barbosa"
              ]
              1 => array:2 [
                "nombre" => "A&#46;L&#46;"
                "apellidos" => "Jo&#227;o"
              ]
              2 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Jo&#227;o"
              ]
              3 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Fernandes"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005106?idApp=UINPBA000044"
      "url" => "/00017310/0000011500000008/v1_202409020432/S0001731024005106/v1_202409020432/es/main.assets"
    ]
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Secondary Syphilis-Induced Anetoderma"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "838"
        "paginaFinal" => "840"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46; Barbosa, A&#46;L&#46; Jo&#227;o, A&#46; Jo&#227;o, C&#46; Fernandes"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "J&#46;"
            "apellidos" => "Barbosa"
            "email" => array:1 [
              0 => "joanafabarbosa@gmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "A&#46;L&#46;"
            "apellidos" => "Jo&#227;o"
          ]
          2 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Jo&#227;o"
          ]
          3 => array:2 [
            "nombre" => "C&#46;"
            "apellidos" => "Fernandes"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Dermatology and Venereology Department&#44; Hospital de Santo Ant&#243;nio dos Capuchos&#44; Centro Hospitalar Universit&#225;rio de Lisboa Central&#44; Lisbon&#44; Portugal"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Anetoderma inducida por s&#237;filis secundaria"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 707
            "Ancho" => 940
            "Tamanyo" => 275462
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nearly complete loss of elastic fibers in the layers of the papillary and reticular dermis &#40;Orcein stain&#44; 100&#215;&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Anetoderma is a rare&#44; benign disorder characterized microscopically by the loss of mid-dermal elastic fibers&#44; resulting in well-circumscribed&#44; skin-colored or gray-white atrophic macules or patches with a &#8220;sac-like&#8221; appearance&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Anetoderma is classically divided into primary &#40;idiopathic&#41; and secondary anetoderma&#44; with the former occurring in areas of previously normal skin and the latter developing at the site of a previous dermatosis&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Secondary anetoderma has been associated with a broad spectrum of autoimmune&#44; infectious&#44; neoplastic and inflammatory dermatosis&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">An otherwise healthy 35-year-old Indian man presented with a two-month history of multiple disseminated asymptomatic skin lesions&#46; He had sex with women and reported multiple sex partners in the previous six months&#46; No drug or medication use was elicited&#46; He also denied any constitutional symptoms such as fever&#44; malaise&#44; or weight loss&#46; On physical examination&#44; there were multiple well-defined erythematous-violaceous&#44; infiltrated&#44; papules&#44; plaques and nodules&#44; symmetrically distributed on the face&#44; neck&#44; trunk and arms &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#44; B&#41;&#46; Palmoplantar region and mucous membranes were not affected&#46; Examination was otherwise unremarkable&#44; without evidence of lymphadenopathy&#46; Laboratory workup revealed a positive venereal disease research laboratory &#40;VDRL&#41; test result with a titer of 1&#58;16 and a positive treponema pallidum hemagglutination &#40;TPHA&#41;&#46; Complete blood count and comprehensive metabolic panel were within reference range&#46; Screening of other sexually transmitted diseases including human immunodeficiency virus &#40;HIV&#41;&#44; hepatitis C and hepatitis B virus was negative&#46; Skin biopsy of an infiltrated erythematous plaque of the trunk was performed&#46; Routine histopathological examination revealed a dense perivascular and periadnexal granulomatous infiltrate with plasma cells and histiocytes located in the superficial and deep dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; Immunostaining using a polyclonal antibody for Treponema pallidum revealed the presence of multiple perivascular and intraepidermal spirochetes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46; Clinical&#44; laboratory and histopathologic findings were thus compatible with the diagnosis of secondary syphilis&#46; The patient was treated with a single dose of 2&#46;4 million units of intramuscular benzathine penicillin G and clinical improvement was observed&#46; However&#44; six months later the patient presented to the clinic with asymptomatic&#44; atrophic&#44; wrinkled&#44; skin-colored papules and plaques on the same locations that were previously affected by the syphilitic rash &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; VDRL and viral serologies were negative&#46; Skin biopsy was performed and histopathological examination with elastic tissue staining revealed a significant reduction of elastic fibers and a mild superficial perivascular lymphocytic infiltrate &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; As such&#44; clinical and histopathological findings confirmed the diagnosis of anetoderma due to secondary syphilis&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Clinical manifestations of secondary syphilis can be varied and often represent a diagnostic challenge&#46; The most commonly observed clinical presentation &#40;80&#37;&#41; is a generalized&#44; non-pruritic papulosquamous eruption that typically affects palms and soles&#44; accompanied by flu-like symptoms and generalized lymphadenopathy&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> However&#44; a broad spectrum of cutaneous manifestations has been described in literature&#44; frequently leading to misdiagnosis and&#44; for that reason&#44; secondary syphilis has been known as the &#8220;great imitator&#8221;&#46; Notably&#44; papulonodular presentation of secondary syphilis is uncommon&#44; with no more than 30 reported cases&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> In our patient&#44; differential diagnosis included cutaneous lymphoma&#44; subacute cutaneous lupus erythematous&#44; Sweet syndrome and cutaneous sarcoidosis&#46; Those were excluded by clinical history&#44; laboratory investigations and routine histopathology&#46; At the time of diagnosis of syphilis&#44; there was no other dermatologic process that could be the cause of anetoderma&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Usually&#44; after appropriate treatment with penicillin&#44; syphilitic lesions resolve without scarring&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Secondary anetoderma due to syphilis has been poorly mentioned in literature&#46; It may present in all stages of the disease&#44; although it seems to be more common on the secondary stage and in HIV-infected patients&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Even though there are multiple diseases that can evolve to anetoderma&#44; its pathophysiology is still not fully understood&#46; The decrease in elastic tissue may be due to either defective elastin synthesis&#44; uncontrolled production of elastolytic enzymes&#44; loss of elastolytic enzyme inhibitors&#44; elastophagocytosis or degeneration of elastic fibers secondary to local ischemia induced by microthrombosis in dermal vessels&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> In addition&#44; demonstration of fragmented elastic fibers present within macrophages by electron microscopic examination suggests that granulomatous diseases could evolve to anetoderma&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Our case supports this hypothesis&#44; since it presented with a granulomatous pattern in histopathological examination of syphilitic skin lesions&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">There is no satisfactory treatment available for established anetoderma lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Cryotherapy&#44; intralesional steroids and resurfacing laser have been used with variable success&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Since the problem was solely cosmetic in nature&#44; our patient declined any treatment attempt&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; the present case highlights the occurrence of anetoderma after adequately treated papulonodular secondary syphilis and should further alert dermatologists for this rare potential association&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0040" class="elsevierStylePara elsevierViewall">No funding has been received for the completion of this article&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interests</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:3 [
        0 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Funding"
        ]
        1 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflict of interests"
        ]
        2 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1737
            "Ancho" => 1740
            "Tamanyo" => 532136
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multiple erythematous-violaceous&#44; infiltrated&#44; papules&#44; plaques and nodules&#44; symmetrically distributed on the face&#44; neck&#44; trunk and arms &#40;A&#44; B&#41;&#46; Hematoxylin &#38; eosin stain &#40;100&#215;&#41; shows a dense perivascular and periadnexal granulomatous infiltrate with plasma cells and histiocytes in the superficial and deep dermis &#40;C&#41;&#59; The T&#46; pallidum immunostain &#40;100&#215;&#41; robustly highlights perivascular and intraepidermal spirochetes &#40;D&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 663
            "Ancho" => 1007
            "Tamanyo" => 121556
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multiple atrophic&#44; wrinkled&#44; skin-colored papules and plaques on the neck and armpit&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 707
            "Ancho" => 940
            "Tamanyo" => 275462
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nearly complete loss of elastic fibers in the layers of the papillary and reticular dermis &#40;Orcein stain&#44; 100&#215;&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anetoderma&#58; a case report and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;P&#46; Kineston"
                            1 => "Y&#46; Xia"
                            2 => "G&#46;W&#46; Turiansky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cutis"
                        "fecha" => "2008"
                        "volumen" => "81"
                        "paginaInicial" => "501"
                        "paginaFinal" => "506"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anetoderma due to secondary syphilis&#58; report of two cases and discussion of the histopathological findings"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;V&#46; Veasey"
                            1 => "R&#46;F&#46; Lellis"
                            2 => "R&#46;L&#46; Porto"
                            3 => "G&#46;M&#46; Mattei"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0956462417713586"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J STD AIDS"
                        "fecha" => "2017"
                        "volumen" => "28"
                        "paginaInicial" => "1456"
                        "paginaFinal" => "1460"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28571518"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nodular secondary syphilis in an immunocompetent woman&#58; case report and literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;H&#46; Son"
                            1 => "S&#46;Y&#46; Park"
                            2 => "B&#46;Y&#46; Chung"
                            3 => "H&#46;O&#46; Kim"
                            4 => "H&#46;J&#46; Cho"
                            5 => "C&#46;W&#46; Park"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Sin"
                        "fecha" => "2018"
                        "volumen" => "36"
                        "paginaInicial" => "36"
                        "paginaFinal" => "41"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Secondary anetoderma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; de Faria Melo"
                            1 => "I&#46; de Faria Melo"
                            2 => "G&#46;F&#46; Escobar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jamadermatol.2021.0440"
                      "Revista" => array:4 [
                        "tituloSerie" => "JAMA Dermatol"
                        "fecha" => "2021"
                        "volumen" => "157"
                        "paginaInicial" => "860"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Generalized anetoderma&#58; an unusual manifestation of secondary syphilis treated with injection penicillin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;Y&#46; Patel"
                            1 => "K&#46;B&#46; Patel"
                            2 => "H&#46;J&#46; Prajapati"
                            3 => "P&#46;P&#46; Desai"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/ijstd.IJSTD_81_19"
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Sex Transm Dis AIDS"
                        "fecha" => "2021"
                        "volumen" => "42"
                        "paginaInicial" => "166"
                        "paginaFinal" => "168"
                        "itemHostRev" => array:3 [
                          "pii" => "S1876285920300589"
                          "estado" => "S300"
                          "issn" => "18762859"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000011500000008/v1_202409020432/S0001731023007494/v1_202409020432/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6160"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Cartas cient&#237;fico-cl&#237;nicas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011500000008/v1_202409020432/S0001731023007494/v1_202409020432/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023007494?idApp=UINPBA000044"
]
Compartir
Información de la revista
Vol. 115. Núm. 8.
Páginas 838-840 (septiembre 2024)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 115. Núm. 8.
Páginas 838-840 (septiembre 2024)
Case and Research Letter
Acceso a texto completo
Secondary Syphilis-Induced Anetoderma
Anetoderma inducida por sífilis secundaria
Visitas
2475
J. Barbosa
Autor para correspondencia
joanafabarbosa@gmail.com

Corresponding author.
, A.L. João, A. João, C. Fernandes
Dermatology and Venereology Department, Hospital de Santo António dos Capuchos, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal
Contenido relacionado
Actas Dermosifiliogr. 2024;115:T838-T84010.1016/j.ad.2024.06.003
J. Barbosa, A.L. João, A. João, C. Fernandes
Este artículo ha recibido
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Figuras (3)
Mostrar másMostrar menos
Texto completo
To the Editor:

Anetoderma is a rare, benign disorder characterized microscopically by the loss of mid-dermal elastic fibers, resulting in well-circumscribed, skin-colored or gray-white atrophic macules or patches with a “sac-like” appearance.1 Anetoderma is classically divided into primary (idiopathic) and secondary anetoderma, with the former occurring in areas of previously normal skin and the latter developing at the site of a previous dermatosis.2 Secondary anetoderma has been associated with a broad spectrum of autoimmune, infectious, neoplastic and inflammatory dermatosis.1

An otherwise healthy 35-year-old Indian man presented with a two-month history of multiple disseminated asymptomatic skin lesions. He had sex with women and reported multiple sex partners in the previous six months. No drug or medication use was elicited. He also denied any constitutional symptoms such as fever, malaise, or weight loss. On physical examination, there were multiple well-defined erythematous-violaceous, infiltrated, papules, plaques and nodules, symmetrically distributed on the face, neck, trunk and arms (Fig. 1A, B). Palmoplantar region and mucous membranes were not affected. Examination was otherwise unremarkable, without evidence of lymphadenopathy. Laboratory workup revealed a positive venereal disease research laboratory (VDRL) test result with a titer of 1:16 and a positive treponema pallidum hemagglutination (TPHA). Complete blood count and comprehensive metabolic panel were within reference range. Screening of other sexually transmitted diseases including human immunodeficiency virus (HIV), hepatitis C and hepatitis B virus was negative. Skin biopsy of an infiltrated erythematous plaque of the trunk was performed. Routine histopathological examination revealed a dense perivascular and periadnexal granulomatous infiltrate with plasma cells and histiocytes located in the superficial and deep dermis (Fig. 1C). Immunostaining using a polyclonal antibody for Treponema pallidum revealed the presence of multiple perivascular and intraepidermal spirochetes (Fig. 1D). Clinical, laboratory and histopathologic findings were thus compatible with the diagnosis of secondary syphilis. The patient was treated with a single dose of 2.4 million units of intramuscular benzathine penicillin G and clinical improvement was observed. However, six months later the patient presented to the clinic with asymptomatic, atrophic, wrinkled, skin-colored papules and plaques on the same locations that were previously affected by the syphilitic rash (Fig. 2). VDRL and viral serologies were negative. Skin biopsy was performed and histopathological examination with elastic tissue staining revealed a significant reduction of elastic fibers and a mild superficial perivascular lymphocytic infiltrate (Fig. 3). As such, clinical and histopathological findings confirmed the diagnosis of anetoderma due to secondary syphilis.

Figure 1.

Multiple erythematous-violaceous, infiltrated, papules, plaques and nodules, symmetrically distributed on the face, neck, trunk and arms (A, B). Hematoxylin & eosin stain (100×) shows a dense perivascular and periadnexal granulomatous infiltrate with plasma cells and histiocytes in the superficial and deep dermis (C); The T. pallidum immunostain (100×) robustly highlights perivascular and intraepidermal spirochetes (D).

(0.51MB).
Figure 2.

Multiple atrophic, wrinkled, skin-colored papules and plaques on the neck and armpit.

(0.12MB).
Figure 3.

Nearly complete loss of elastic fibers in the layers of the papillary and reticular dermis (Orcein stain, 100×).

(0.26MB).

Clinical manifestations of secondary syphilis can be varied and often represent a diagnostic challenge. The most commonly observed clinical presentation (80%) is a generalized, non-pruritic papulosquamous eruption that typically affects palms and soles, accompanied by flu-like symptoms and generalized lymphadenopathy.3 However, a broad spectrum of cutaneous manifestations has been described in literature, frequently leading to misdiagnosis and, for that reason, secondary syphilis has been known as the “great imitator”. Notably, papulonodular presentation of secondary syphilis is uncommon, with no more than 30 reported cases.3 In our patient, differential diagnosis included cutaneous lymphoma, subacute cutaneous lupus erythematous, Sweet syndrome and cutaneous sarcoidosis. Those were excluded by clinical history, laboratory investigations and routine histopathology. At the time of diagnosis of syphilis, there was no other dermatologic process that could be the cause of anetoderma.

Usually, after appropriate treatment with penicillin, syphilitic lesions resolve without scarring.4 Secondary anetoderma due to syphilis has been poorly mentioned in literature. It may present in all stages of the disease, although it seems to be more common on the secondary stage and in HIV-infected patients.4 Even though there are multiple diseases that can evolve to anetoderma, its pathophysiology is still not fully understood. The decrease in elastic tissue may be due to either defective elastin synthesis, uncontrolled production of elastolytic enzymes, loss of elastolytic enzyme inhibitors, elastophagocytosis or degeneration of elastic fibers secondary to local ischemia induced by microthrombosis in dermal vessels.5 In addition, demonstration of fragmented elastic fibers present within macrophages by electron microscopic examination suggests that granulomatous diseases could evolve to anetoderma.2 Our case supports this hypothesis, since it presented with a granulomatous pattern in histopathological examination of syphilitic skin lesions.

There is no satisfactory treatment available for established anetoderma lesions.5 Cryotherapy, intralesional steroids and resurfacing laser have been used with variable success.5 Since the problem was solely cosmetic in nature, our patient declined any treatment attempt.

In conclusion, the present case highlights the occurrence of anetoderma after adequately treated papulonodular secondary syphilis and should further alert dermatologists for this rare potential association.

Funding

No funding has been received for the completion of this article.

Conflict of interests

The authors declare that they have no conflict of interest.

References
[1]
D.P. Kineston, Y. Xia, G.W. Turiansky.
Anetoderma: a case report and review of the literature.
Cutis, 81 (2008), pp. 501-506
[2]
J.V. Veasey, R.F. Lellis, R.L. Porto, G.M. Mattei.
Anetoderma due to secondary syphilis: report of two cases and discussion of the histopathological findings.
Int J STD AIDS, 28 (2017), pp. 1456-1460
[3]
J.H. Son, S.Y. Park, B.Y. Chung, H.O. Kim, H.J. Cho, C.W. Park.
Nodular secondary syphilis in an immunocompetent woman: case report and literature review.
Dermatol Sin, 36 (2018), pp. 36-41
[4]
M. de Faria Melo, I. de Faria Melo, G.F. Escobar.
Secondary anetoderma.
JAMA Dermatol, 157 (2021), pp. 860
[5]
A.Y. Patel, K.B. Patel, H.J. Prajapati, P.P. Desai.
Generalized anetoderma: an unusual manifestation of secondary syphilis treated with injection penicillin.
Indian J Sex Transm Dis AIDS, 42 (2021), pp. 166-168
Copyright © 2023. AEDV
Descargar PDF
Idiomas
Actas Dermo-Sifiliográficas
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?