Case and Research Letter
Secondary Syphilis-Induced Anetoderma
Anetoderma inducida por sífilis secundaria
J. Barbosa
, A.L. João, A. João, C. Fernandes
Autor para correspondencia
Dermatology and Venereology Department, Hospital de Santo António dos Capuchos, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal
Leído
2479
Vecesse ha leído el artículo
790
Total PDF
1689
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S0001731023007494" "issn" => "00017310" "doi" => "10.1016/j.ad.2022.11.021" "estado" => "S300" "fechaPublicacion" => "2024-09-01" "aid" => "3667" "copyright" => "AEDV" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2024;115:838-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S0001731024005106" "issn" => "00017310" "doi" => "10.1016/j.ad.2024.06.003" "estado" => "S300" "fechaPublicacion" => "2024-09-01" "aid" => "3992" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2024;115:T838-T840" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => " Anetodermia inducida por sífilis secundaria" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "T838" "paginaFinal" => "T840" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Secondary Syphilis-Induced Anetoderma" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1304 "Ancho" => 1309 "Tamanyo" => 339951 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Numerosas pápulas, placas y nódulos eritematosos-violáceos infiltrados, con distribución simétrica en cara, cuello, tronco y brazos (A, B). La tinción de hematoxilina y eosina (100×) muestra un infiltrado denso granulomatoso perivascular y perianexial con células plasmáticas e histiocitos en dermis superficial y profunda (C); la inmunotinción para T. Pallidum (100×) resalta de forma robusta la presencia de espiroquetas perivasculares e intraepidérmicas (D).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Barbosa, A.L. João, A. João, C. Fernandes" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Barbosa" ] 1 => array:2 [ "nombre" => "A.L." "apellidos" => "João" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "João" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Fernandes" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005106?idApp=UINPBA000044" "url" => "/00017310/0000011500000008/v1_202409020432/S0001731024005106/v1_202409020432/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0001731024005787" "issn" => "00017310" "doi" => "10.1016/j.ad.2023.03.020" "estado" => "S300" "fechaPublicacion" => "2024-09-01" "aid" => "4012" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2024;115:T834-T837" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => " Seborrhuca: Vindication of a Pattern?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "T834" "paginaFinal" => "T837" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Seborruca: ¿reivindicación de un patrón?" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1822 "Ancho" => 995 "Tamanyo" => 345934 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Three examples of seborrhucas showing typical features commonly shared by warts and SK (H&E x20). Many whorls can be seen in B.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Aróstegui Aguilar, N. Martínez Campayo, D. Cassarino, A. Fernandez-Flores" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Aróstegui Aguilar" ] 1 => array:2 [ "nombre" => "N." "apellidos" => "Martínez Campayo" ] 2 => array:2 [ "nombre" => "D." "apellidos" => "Cassarino" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Fernandez-Flores" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005787?idApp=UINPBA000044" "url" => "/00017310/0000011500000008/v1_202409020432/S0001731024005787/v1_202409020432/en/main.assets" ] "asociados" => array:1 [ 0 => array:18 [ "pii" => "S0001731024005106" "issn" => "00017310" "doi" => "10.1016/j.ad.2024.06.003" "estado" => "S300" "fechaPublicacion" => "2024-09-01" "aid" => "3992" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2024;115:T838-T840" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => " Anetodermia inducida por sífilis secundaria" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "T838" "paginaFinal" => "T840" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Secondary Syphilis-Induced Anetoderma" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1304 "Ancho" => 1309 "Tamanyo" => 339951 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Numerosas pápulas, placas y nódulos eritematosos-violáceos infiltrados, con distribución simétrica en cara, cuello, tronco y brazos (A, B). La tinción de hematoxilina y eosina (100×) muestra un infiltrado denso granulomatoso perivascular y perianexial con células plasmáticas e histiocitos en dermis superficial y profunda (C); la inmunotinción para T. Pallidum (100×) resalta de forma robusta la presencia de espiroquetas perivasculares e intraepidérmicas (D).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Barbosa, A.L. João, A. João, C. Fernandes" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Barbosa" ] 1 => array:2 [ "nombre" => "A.L." "apellidos" => "João" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "João" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Fernandes" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731024005106?idApp=UINPBA000044" "url" => "/00017310/0000011500000008/v1_202409020432/S0001731024005106/v1_202409020432/es/main.assets" ] ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Secondary Syphilis-Induced Anetoderma" "tieneTextoCompleto" => true "saludo" => "To the Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "838" "paginaFinal" => "840" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Barbosa, A.L. João, A. João, C. Fernandes" "autores" => array:4 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Barbosa" "email" => array:1 [ 0 => "joanafabarbosa@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "A.L." "apellidos" => "João" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "João" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Fernandes" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Dermatology and Venereology Department, Hospital de Santo António dos Capuchos, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Anetoderma inducida por sífilis secundaria" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 707 "Ancho" => 940 "Tamanyo" => 275462 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nearly complete loss of elastic fibers in the layers of the papillary and reticular dermis (Orcein stain, 100×).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Anetoderma is a rare, benign disorder characterized microscopically by the loss of mid-dermal elastic fibers, resulting in well-circumscribed, skin-colored or gray-white atrophic macules or patches with a “sac-like” appearance.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Anetoderma is classically divided into primary (idiopathic) and secondary anetoderma, with the former occurring in areas of previously normal skin and the latter developing at the site of a previous dermatosis.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Secondary anetoderma has been associated with a broad spectrum of autoimmune, infectious, neoplastic and inflammatory dermatosis.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">An otherwise healthy 35-year-old Indian man presented with a two-month history of multiple disseminated asymptomatic skin lesions. He had sex with women and reported multiple sex partners in the previous six months. No drug or medication use was elicited. He also denied any constitutional symptoms such as fever, malaise, or weight loss. On physical examination, there were multiple well-defined erythematous-violaceous, infiltrated, papules, plaques and nodules, symmetrically distributed on the face, neck, trunk and arms (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A, B). Palmoplantar region and mucous membranes were not affected. Examination was otherwise unremarkable, without evidence of lymphadenopathy. Laboratory workup revealed a positive venereal disease research laboratory (VDRL) test result with a titer of 1:16 and a positive treponema pallidum hemagglutination (TPHA). Complete blood count and comprehensive metabolic panel were within reference range. Screening of other sexually transmitted diseases including human immunodeficiency virus (HIV), hepatitis C and hepatitis B virus was negative. Skin biopsy of an infiltrated erythematous plaque of the trunk was performed. Routine histopathological examination revealed a dense perivascular and periadnexal granulomatous infiltrate with plasma cells and histiocytes located in the superficial and deep dermis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C). Immunostaining using a polyclonal antibody for Treponema pallidum revealed the presence of multiple perivascular and intraepidermal spirochetes (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D). Clinical, laboratory and histopathologic findings were thus compatible with the diagnosis of secondary syphilis. The patient was treated with a single dose of 2.4 million units of intramuscular benzathine penicillin G and clinical improvement was observed. However, six months later the patient presented to the clinic with asymptomatic, atrophic, wrinkled, skin-colored papules and plaques on the same locations that were previously affected by the syphilitic rash (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). VDRL and viral serologies were negative. Skin biopsy was performed and histopathological examination with elastic tissue staining revealed a significant reduction of elastic fibers and a mild superficial perivascular lymphocytic infiltrate (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). As such, clinical and histopathological findings confirmed the diagnosis of anetoderma due to secondary syphilis.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Clinical manifestations of secondary syphilis can be varied and often represent a diagnostic challenge. The most commonly observed clinical presentation (80%) is a generalized, non-pruritic papulosquamous eruption that typically affects palms and soles, accompanied by flu-like symptoms and generalized lymphadenopathy.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> However, a broad spectrum of cutaneous manifestations has been described in literature, frequently leading to misdiagnosis and, for that reason, secondary syphilis has been known as the “great imitator”. Notably, papulonodular presentation of secondary syphilis is uncommon, with no more than 30 reported cases.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> In our patient, differential diagnosis included cutaneous lymphoma, subacute cutaneous lupus erythematous, Sweet syndrome and cutaneous sarcoidosis. Those were excluded by clinical history, laboratory investigations and routine histopathology. At the time of diagnosis of syphilis, there was no other dermatologic process that could be the cause of anetoderma.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Usually, after appropriate treatment with penicillin, syphilitic lesions resolve without scarring.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Secondary anetoderma due to syphilis has been poorly mentioned in literature. It may present in all stages of the disease, although it seems to be more common on the secondary stage and in HIV-infected patients.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Even though there are multiple diseases that can evolve to anetoderma, its pathophysiology is still not fully understood. The decrease in elastic tissue may be due to either defective elastin synthesis, uncontrolled production of elastolytic enzymes, loss of elastolytic enzyme inhibitors, elastophagocytosis or degeneration of elastic fibers secondary to local ischemia induced by microthrombosis in dermal vessels.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> In addition, demonstration of fragmented elastic fibers present within macrophages by electron microscopic examination suggests that granulomatous diseases could evolve to anetoderma.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Our case supports this hypothesis, since it presented with a granulomatous pattern in histopathological examination of syphilitic skin lesions.</p><p id="par0025" class="elsevierStylePara elsevierViewall">There is no satisfactory treatment available for established anetoderma lesions.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Cryotherapy, intralesional steroids and resurfacing laser have been used with variable success.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Since the problem was solely cosmetic in nature, our patient declined any treatment attempt.</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion, the present case highlights the occurrence of anetoderma after adequately treated papulonodular secondary syphilis and should further alert dermatologists for this rare potential association.</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0040" class="elsevierStylePara elsevierViewall">No funding has been received for the completion of this article.</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interests</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interests" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1737 "Ancho" => 1740 "Tamanyo" => 532136 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Multiple erythematous-violaceous, infiltrated, papules, plaques and nodules, symmetrically distributed on the face, neck, trunk and arms (A, B). Hematoxylin & eosin stain (100×) shows a dense perivascular and periadnexal granulomatous infiltrate with plasma cells and histiocytes in the superficial and deep dermis (C); The T. pallidum immunostain (100×) robustly highlights perivascular and intraepidermal spirochetes (D).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 663 "Ancho" => 1007 "Tamanyo" => 121556 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Multiple atrophic, wrinkled, skin-colored papules and plaques on the neck and armpit.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 707 "Ancho" => 940 "Tamanyo" => 275462 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nearly complete loss of elastic fibers in the layers of the papillary and reticular dermis (Orcein stain, 100×).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anetoderma: a case report and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.P. Kineston" 1 => "Y. Xia" 2 => "G.W. Turiansky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cutis" "fecha" => "2008" "volumen" => "81" "paginaInicial" => "501" "paginaFinal" => "506" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anetoderma due to secondary syphilis: report of two cases and discussion of the histopathological findings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.V. Veasey" 1 => "R.F. Lellis" 2 => "R.L. Porto" 3 => "G.M. Mattei" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0956462417713586" "Revista" => array:6 [ "tituloSerie" => "Int J STD AIDS" "fecha" => "2017" "volumen" => "28" "paginaInicial" => "1456" "paginaFinal" => "1460" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28571518" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nodular secondary syphilis in an immunocompetent woman: case report and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.H. Son" 1 => "S.Y. Park" 2 => "B.Y. Chung" 3 => "H.O. Kim" 4 => "H.J. Cho" 5 => "C.W. Park" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatol Sin" "fecha" => "2018" "volumen" => "36" "paginaInicial" => "36" "paginaFinal" => "41" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Secondary anetoderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. de Faria Melo" 1 => "I. de Faria Melo" 2 => "G.F. Escobar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamadermatol.2021.0440" "Revista" => array:4 [ "tituloSerie" => "JAMA Dermatol" "fecha" => "2021" "volumen" => "157" "paginaInicial" => "860" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Generalized anetoderma: an unusual manifestation of secondary syphilis treated with injection penicillin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.Y. Patel" 1 => "K.B. Patel" 2 => "H.J. Prajapati" 3 => "P.P. Desai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/ijstd.IJSTD_81_19" "Revista" => array:6 [ "tituloSerie" => "Indian J Sex Transm Dis AIDS" "fecha" => "2021" "volumen" => "42" "paginaInicial" => "166" "paginaFinal" => "168" "itemHostRev" => array:3 [ "pii" => "S1876285920300589" "estado" => "S300" "issn" => "18762859" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00017310/0000011500000008/v1_202409020432/S0001731023007494/v1_202409020432/en/main.assets" "Apartado" => array:4 [ "identificador" => "6160" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Cartas científico-clínicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011500000008/v1_202409020432/S0001731023007494/v1_202409020432/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023007494?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 14 | 11 | 25 |
| 2024 Octubre | 138 | 69 | 207 |
| 2024 Septiembre | 165 | 62 | 227 |
| 2024 Agosto | 182 | 79 | 261 |
| 2024 Julio | 179 | 56 | 235 |
| 2024 Junio | 153 | 51 | 204 |
| 2024 Mayo | 138 | 59 | 197 |
| 2024 Abril | 122 | 44 | 166 |
| 2024 Marzo | 130 | 44 | 174 |
| 2024 Febrero | 77 | 50 | 127 |
| 2024 Enero | 127 | 57 | 184 |
| 2023 Diciembre | 85 | 51 | 136 |
| 2023 Noviembre | 89 | 62 | 151 |
| 2023 Octubre | 90 | 95 | 185 |
Mostrar todo
