array:24 [
  "pii" => "S1578219015002371"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2015.09.002"
  "estado" => "S300"
  "fechaPublicacion" => "2015-10-01"
  "aid" => "1174"
  "copyright" => "Elsevier España, S.L.U. and AEDV"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2015;106:687-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 827
    "formatos" => array:3 [
      "EPUB" => 54
      "HTML" => 340
      "PDF" => 433
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S0001731015002045"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2015.01.016"
      "estado" => "S300"
      "fechaPublicacion" => "2015-10-01"
      "aid" => "1174"
      "copyright" => "Elsevier España, S.L.U. and AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2015;106:687-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 781
        "formatos" => array:3 [
          "EPUB" => 47
          "HTML" => 320
          "PDF" => 414
        ]
      ]
      "en" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
        "titulo" => "Psoriatic Cheilitis&#58; A Report of 2 Cases Treated Successfully With Topical Tacrolimus and a Review of the Literature"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "687"
            "paginaFinal" => "689"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Queilitis psori&#225;sica&#58; Un reporte de 2 casos tratados con &#233;xito con tacrolimus t&#243;pico y revisi&#243;n de la literatura"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figure 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 542
                "Ancho" => 1500
                "Tamanyo" => 132517
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Whitish scales on the vermilion borders of both lips in patient 2 before treatment&#46; &#40;b&#41; Mounds of parakeratosis and hypogranulosis&#44; acanthosis&#44; and dilated&#44; vertically elongated papillary vessels &#40;hematoxylin-eosin&#44; original magnification &#215;20&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Z&#46; Apalla, E&#46; Sotiriou, A&#46; Trigoni, D&#46; Ioannides"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Z&#46;"
                "apellidos" => "Apalla"
              ]
              1 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Sotiriou"
              ]
              2 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Trigoni"
              ]
              3 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Ioannides"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219015002371"
          "doi" => "10.1016/j.adengl.2015.09.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002371?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002045?idApp=UINPBA000044"
      "url" => "/00017310/0000010600000008/v1_201510020746/S0001731015002045/v1_201510020746/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219015002139"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.015"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1177"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:689-91"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1230
      "formatos" => array:3 [
        "EPUB" => 43
        "HTML" => 805
        "PDF" => 382
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Use of the Burow Triangle or Wedge-shaped Resection During the Repair of Infraorbital Defects"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "689"
          "paginaFinal" => "691"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Uso del tri&#225;ngulo de Burow o escisi&#243;n en &#171;V&#187; para la reparaci&#243;n de defectos infraorbitarios"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1151
              "Ancho" => 1150
              "Tamanyo" => 241338
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Case 1&#46; Surgical resection of a malignant tumor leaving a defect in the infraorbital region&#46; Closure using a Burow triangle or wedge-shaped resection&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L&#46;M&#46; Molinari, D&#46; Ferrario, G&#46;N&#46; Galimberti"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "L&#46;M&#46;"
              "apellidos" => "Molinari"
            ]
            1 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Ferrario"
            ]
            2 => array:2 [
              "nombre" => "G&#46;N&#46;"
              "apellidos" => "Galimberti"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015002070"
        "doi" => "10.1016/j.ad.2014.12.026"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002070?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002139?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002139/v1_201510011018/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219015002097"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2015.07.011"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "1173"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2015;106:685-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1036
      "formatos" => array:3 [
        "EPUB" => 54
        "HTML" => 608
        "PDF" => 374
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Diffuse Systemic Large B-Cell Lymphoma With Secondary Skin Involvement"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "685"
          "paginaFinal" => "687"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Linfoma B difuso de c&#233;lulas grandes sist&#233;mico con afectaci&#243;n cut&#225;nea secundaria"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1263
              "Ancho" => 1682
              "Tamanyo" => 314385
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Indurated erythematous-violaceous plaque&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Lloret-Ruiz, P&#46; Mol&#233;s-Poveda, N&#46; Barrado-Sol&#237;s, E&#46; Gimeno-Carpio"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Lloret-Ruiz"
            ]
            1 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Mol&#233;s-Poveda"
            ]
            2 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Barrado-Sol&#237;s"
            ]
            3 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Gimeno-Carpio"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731015002033"
        "doi" => "10.1016/j.ad.2015.02.012"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731015002033?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002097?idApp=UINPBA000044"
    "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002097/v1_201510011018/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Psoriatic Cheilitis&#58; A Report of 2 Cases Treated Successfully With Topical Tacrolimus and a Review of the Literature"
    "tieneTextoCompleto" => true
    "saludo" => "Dear Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "687"
        "paginaFinal" => "689"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Z&#46; Apalla, E&#46; Sotiriou, A&#46; Trigoni, D&#46; Ioannides"
        "autores" => array:4 [
          0 => array:3 [
            "nombre" => "Z&#46;"
            "apellidos" => "Apalla"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "E&#46;"
            "apellidos" => "Sotiriou"
            "email" => array:1 [
              0 => "elenasotiriou&#64;yahoo&#46;gr"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Trigoni"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Ioannides"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "State Clinic&#44; Hospital of Skin and Venereal Diseases&#44; Thessaloniki&#44; Greece"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "First Dermatology Department&#44; Aristotle University of Thessaloniki&#44; Greece"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Queilitis psori&#225;sica&#58; Un reporte de 2 casos tratados con &#233;xito con tacrolimus t&#243;pico y revisi&#243;n de la literatura"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 904
            "Ancho" => 2500
            "Tamanyo" => 258717
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Whitish scales on the vermilion borders of both lips in patient 2 before treatment&#46; &#40;b&#41; Mounds of parakeratosis and hypogranulosis&#44; acanthosis&#44; and dilated&#44; vertically elongated papillary vessels &#40;hematoxylin-eosin&#44; original magnification &#215;20&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Psoriasis is a chronic inflammatory skin disease that typically affects the extremities&#44; trunk&#44; scalp&#44; and nails&#46; Psoriatic cheilitis as an exclusive presentation is very rare&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> and to our knowledge&#44; only 5 cases have been reported to date&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#8211;6</span></a> The absence of cutaneous lesions causes diagnostic difficulties that can result in misdiagnosis and inadequate treatment&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the cases of 2 young adults who presented with psoriasis of the vermilion of the lips as the only disease manifestation&#46; Response to topical tacrolimus 0&#46;1&#37; treatment was good in both cases&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The first case involved a 28-year-old white woman referred to our clinic with a 3-month history of scaly plaques on the vermilion of her lips and a clinical diagnosis of contact cheilitis&#46; Clinical examination revealed an erythematous fissured plaque over the entire upper and lower lip surface&#44; covered by thick white-yellowish scales &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Full body examination did not reveal any evidence of intraoral or cutaneous involvement&#46; Apart from a 10-year history of Hashimoto thyroiditis&#44; the patient&#39;s medical history was unremarkable&#46; However&#44; she did mention that her brother had psoriasis&#46; Contact cheilitis was excluded following negative patch tests&#46; Subsequent biopsy and histological examination confirmed the clinical suspicion of psoriasis&#46; The patient received initial treatment with salicylic acid 5&#37; ointment twice daily for 5 days&#44; followed by a 1-month course of topical tacrolimus 0&#46;1&#37; twice daily&#44; resulting in adequate control of disease activity &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; The patient is currently on maintenance treatment with twice-weekly application of tacrolimus 0&#46;1&#37; ointment&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The second case involved a 20-year-old white man referred to our clinic for further assessment of a 2-year history of recurrent erosive cheilitis&#44; characterized by fissures and white-yellowish scales on the vermilion borders of both lips &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#46; Intraoral and cutaneous lesions were absent&#46; The patient reported exacerbations&#44; particularly during winter&#46; His medical history was unremarkable&#59; there was&#44; however&#44; a positive family history of psoriasis &#40;his mother&#41;&#46; After excluding contact cheilitis by patch testing&#44; we performed a lip biopsy&#46; Histopathology showed mounds of parakeratosis and hypogranulosis&#44; acanthosis&#44; and dilated and vertically elongated papillary vessels &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#44; leading to a diagnosis of psoriatic cheilitis&#46; The patient was started on salicylic acid 5&#37; twice daily for 3 days&#44; followed by topical tacrolimus 0&#46;1&#37; twice daily for the next month&#46; The treatment resulted in the gradual remission of lesions&#44; but discontinuation led to a flare-up&#44; which was managed with the same regimen&#46; To avoid recurrences the patient was advised to use tacrolimus 0&#46;1&#37; twice weekly&#44; with excellent results&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Perioral psoriasis is an unusual presentation of psoriasis&#46; It is clinically characterized by cracking and scaling of the lips and can have a profound emotional&#44; social&#44; and physical impact on patients&#8217; lives&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;4</span></a> In the vast majority of the cases&#44; coexistence of typical psoriatic lesions elsewhere on the body facilitates diagnosis&#46; To the best of our knowledge&#44; exclusive lip involvement is very uncommon&#44; with only 5 cases reported in the literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#8211;6</span></a> In 2 of these cases&#44; involvement of the vermilion of the lips preceded cutaneous manifestations by at least 2 months&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;6</span></a> Brenner et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> reported a case of psoriatic cheilitis triggered by protruding teeth as a result of Koebner phenomenon&#59; the condition was resolved by replacing the teeth with a nonirritating prosthesis&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> summarizes the main epidemiological and clinical characteristics of all the cases reported to date&#44; including ours&#46; Perioral psoriasis as a single site of involvement can pose significant diagnostic difficulties&#46; Due to a lack of specific diagnostic criteria&#44; it has been suggested that a chronic course&#44; with resistance to treatment and frequent recurrences&#44; should raise the suspicion of psoriatic cheilitis&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> A positive family history and HLA typing have also been described as important in supporting the a diagnosis of perioral psoriasis&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Therapeutic modalities such as topical steroids and tacrolimus alone or in combination with calcipotriol have produced adequate response in patients with perioral psoriasis&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#8211;6&#44;8</span></a> Tacrolimus&#44; a calcineurin-inhibitor with anti-inflammatory properties&#44; lacks the well-known adverse effects associated with steroids&#46; Yamamoto and Nishioka<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> reported a case in which topical tacrolimus ointment was used to treat psoriasis of the vermilion of the lips&#44; with very promising results&#46; Moreover&#44; this treatment combined with salicylic acid gel has been shown to increase the penetration and absorption of the drug&#44; enhancing therapeutic action&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; we have described 2 new cases of psoriatic cheilitis with exclusive lip involvement treated successfully with topical tacrolimus 0&#46;1&#37; in combination with salicylic acid&#44; indicating their possible therapeutic role in this troublesome localization&#46; We suggest that psoriasis should be considered in cases of refractory long-standing eczema-like cheilitis&#44; even in the absence of a positive family or personal history of psoriasis&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 740
            "Ancho" => 2503
            "Tamanyo" => 152374
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Thick white-yellowish scales strongly attached to the lips of patient &#35;1 before treatment&#46; &#40;b&#41; Resolution of lesions after treatment with topical tacrolimus&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 904
            "Ancho" => 2500
            "Tamanyo" => 258717
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Whitish scales on the vermilion borders of both lips in patient 2 before treatment&#46; &#40;b&#41; Mounds of parakeratosis and hypogranulosis&#44; acanthosis&#44; and dilated&#44; vertically elongated papillary vessels &#40;hematoxylin-eosin&#44; original magnification &#215;20&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>&#58; CR&#44; complete response&#59; F&#44; female&#59; M&#44; male&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Skin lesions at presentation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Oral lesions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Exclusive lip involvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Tosti et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Steroid cream&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Rahman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Triamcinolone acetonide ointment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sehgal et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Tacrolimus<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>calcipotriol<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>betamethasone dipropionate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Ersoy-Evans et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fluticasone propionate 0&#46;005&#37; ointment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Baz et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mometasone furoate 0&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Current cases</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Tacrolimus<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>salicylic acid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Tacrolimus<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>salicylic acid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab908838.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Summary of cases of psoriatic cheilitis reported in the literature&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral psoriasis&#58; report of a case and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Sklavounou"
                            1 => "G&#46; Laskaris"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatologica"
                        "fecha" => "1990"
                        "volumen" => "180"
                        "paginaInicial" => "157"
                        "paginaFinal" => "159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2187720"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guess what&#33; Psoriasis of the lips"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Tosti"
                            1 => "C&#46; Misciali"
                            2 => "N&#46; Cameli"
                            3 => "C&#46; Vincenzi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2001"
                        "volumen" => "11"
                        "paginaInicial" => "589"
                        "paginaFinal" => "590"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11701417"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Perioral psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;A&#46; Rahman"
                            1 => "M&#46; Fikree"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2000"
                        "volumen" => "14"
                        "paginaInicial" => "521"
                        "paginaFinal" => "522"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11444285"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exclusive plaque psoriasis of the lips&#58; efficacy of combination therapy of topical tacrolimus&#44; calcipotriol&#44; and betamethasone dipropionate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "V&#46;N&#46; Sehgal"
                            1 => "S&#46; Sehgal"
                            2 => "P&#46; Verma"
                            3 => "N&#46; Singh"
                            4 => "F&#46; Rasool"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Skin Med"
                        "fecha" => "2012"
                        "volumen" => "10"
                        "paginaInicial" => "183"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasis of the lips&#58; a rare entity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Ersoy-Evans"
                            1 => "L&#46; Nuralina"
                            2 => "G&#46; Erkin"
                            3 => "O&#46; Ozkaya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2006.01824.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2007"
                        "volumen" => "21"
                        "paginaInicial" => "142"
                        "paginaFinal" => "143"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17207203"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Isolated lip involvement in psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46; Baz"
                            1 => "A&#46;C&#46; Yazici"
                            2 => "A&#46; Usta"
                            3 => "G&#46; Ikizoglu"
                            4 => "D&#46;D&#46; Apa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2230.2007.02445.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Dermatol"
                        "fecha" => "2007"
                        "volumen" => "32"
                        "paginaInicial" => "578"
                        "paginaFinal" => "579"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17501965"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasis of the lips&#58; the unusual K&#246;bner phenomenon caused by protruding upper teeth"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Brenner"
                            1 => "R&#46; Lipitz"
                            2 => "B&#46; Llie"
                            3 => "A&#46; Krakowski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatologica"
                        "fecha" => "1982"
                        "volumen" => "164"
                        "paginaInicial" => "413"
                        "paginaFinal" => "416"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7117646"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasis of the lips"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46; Mart&#237;"
                            1 => "I&#46; Pinazo"
                            2 => "A&#46; Revert"
                            3 => "E&#46; Jord&#225;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3315/jdcr.2009.1036"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol Case Rep"
                        "fecha" => "2009"
                        "volumen" => "3"
                        "paginaInicial" => "50"
                        "paginaFinal" => "52"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21886732"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Successful treatment with topical tacrolimus for oral psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Yamamoto"
                            1 => "K&#46; Nishioka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1468-3083.2006.01630.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2006"
                        "volumen" => "20"
                        "paginaInicial" => "1137"
                        "paginaFinal" => "1138"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16987275"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tacrolimus ointment for the treatment of psoriasis on the face and intertriginous areas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;K&#46; Freeman"
                            1 => "G&#46;J&#46; Linowski"
                            2 => "C&#46; Brady"
                            3 => "L&#46; Lind"
                            4 => "P&#46; Vanveldhuisen"
                            5 => "G&#46; Singer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1067/mjd.2003.169"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2003"
                        "volumen" => "48"
                        "paginaInicial" => "564"
                        "paginaFinal" => "568"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12664020"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010600000008/v1_201510011018/S1578219015002371/v1_201510011018/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6157"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case and Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010600000008/v1_201510011018/S1578219015002371/v1_201510011018/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015002371?idApp=UINPBA000044"
]
Compartir
Información de la revista
Vol. 106. Núm. 8.
Páginas 687-689 (octubre 2015)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 106. Núm. 8.
Páginas 687-689 (octubre 2015)
Case and Research Letter
Acceso a texto completo
Psoriatic Cheilitis: A Report of 2 Cases Treated Successfully With Topical Tacrolimus and a Review of the Literature
Queilitis psoriásica: Un reporte de 2 casos tratados con éxito con tacrolimus tópico y revisión de la literatura
Visitas
6013
Z. Apallab, E. Sotirioub,
Autor para correspondencia
elenasotiriou@yahoo.gr

Corresponding author.
, A. Trigonia, D. Ioannidesb
a State Clinic, Hospital of Skin and Venereal Diseases, Thessaloniki, Greece
b First Dermatology Department, Aristotle University of Thessaloniki, Greece
Este artículo ha recibido
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Figuras (2)
Tablas (1)
Table 1. Summary of cases of psoriatic cheilitis reported in the literature.
Texto completo
Dear Editor,

Psoriasis is a chronic inflammatory skin disease that typically affects the extremities, trunk, scalp, and nails. Psoriatic cheilitis as an exclusive presentation is very rare,1 and to our knowledge, only 5 cases have been reported to date.2–6 The absence of cutaneous lesions causes diagnostic difficulties that can result in misdiagnosis and inadequate treatment.

We report the cases of 2 young adults who presented with psoriasis of the vermilion of the lips as the only disease manifestation. Response to topical tacrolimus 0.1% treatment was good in both cases.

The first case involved a 28-year-old white woman referred to our clinic with a 3-month history of scaly plaques on the vermilion of her lips and a clinical diagnosis of contact cheilitis. Clinical examination revealed an erythematous fissured plaque over the entire upper and lower lip surface, covered by thick white-yellowish scales (Fig. 1A). Full body examination did not reveal any evidence of intraoral or cutaneous involvement. Apart from a 10-year history of Hashimoto thyroiditis, the patient's medical history was unremarkable. However, she did mention that her brother had psoriasis. Contact cheilitis was excluded following negative patch tests. Subsequent biopsy and histological examination confirmed the clinical suspicion of psoriasis. The patient received initial treatment with salicylic acid 5% ointment twice daily for 5 days, followed by a 1-month course of topical tacrolimus 0.1% twice daily, resulting in adequate control of disease activity (Fig. 1B). The patient is currently on maintenance treatment with twice-weekly application of tacrolimus 0.1% ointment.

Figure 1.

(a) Thick white-yellowish scales strongly attached to the lips of patient #1 before treatment. (b) Resolution of lesions after treatment with topical tacrolimus.

(0.15MB).

The second case involved a 20-year-old white man referred to our clinic for further assessment of a 2-year history of recurrent erosive cheilitis, characterized by fissures and white-yellowish scales on the vermilion borders of both lips (Fig. 2A). Intraoral and cutaneous lesions were absent. The patient reported exacerbations, particularly during winter. His medical history was unremarkable; there was, however, a positive family history of psoriasis (his mother). After excluding contact cheilitis by patch testing, we performed a lip biopsy. Histopathology showed mounds of parakeratosis and hypogranulosis, acanthosis, and dilated and vertically elongated papillary vessels (Fig. 2B), leading to a diagnosis of psoriatic cheilitis. The patient was started on salicylic acid 5% twice daily for 3 days, followed by topical tacrolimus 0.1% twice daily for the next month. The treatment resulted in the gradual remission of lesions, but discontinuation led to a flare-up, which was managed with the same regimen. To avoid recurrences the patient was advised to use tacrolimus 0.1% twice weekly, with excellent results.

Figure 2.

(a) Whitish scales on the vermilion borders of both lips in patient 2 before treatment. (b) Mounds of parakeratosis and hypogranulosis, acanthosis, and dilated, vertically elongated papillary vessels (hematoxylin-eosin, original magnification ×20).

(0.25MB).

Perioral psoriasis is an unusual presentation of psoriasis. It is clinically characterized by cracking and scaling of the lips and can have a profound emotional, social, and physical impact on patients’ lives.1,4 In the vast majority of the cases, coexistence of typical psoriatic lesions elsewhere on the body facilitates diagnosis. To the best of our knowledge, exclusive lip involvement is very uncommon, with only 5 cases reported in the literature.2–6 In 2 of these cases, involvement of the vermilion of the lips preceded cutaneous manifestations by at least 2 months.5,6 Brenner et al.7 reported a case of psoriatic cheilitis triggered by protruding teeth as a result of Koebner phenomenon; the condition was resolved by replacing the teeth with a nonirritating prosthesis. Table 1 summarizes the main epidemiological and clinical characteristics of all the cases reported to date, including ours. Perioral psoriasis as a single site of involvement can pose significant diagnostic difficulties. Due to a lack of specific diagnostic criteria, it has been suggested that a chronic course, with resistance to treatment and frequent recurrences, should raise the suspicion of psoriatic cheilitis.1 A positive family history and HLA typing have also been described as important in supporting the a diagnosis of perioral psoriasis.

Table 1.

Summary of cases of psoriatic cheilitis reported in the literature.

  Sex  Age, y  Skin lesions at presentation  Oral lesions  Treatment  Outcome  Exclusive lip involvement 
Tosti et al.2  24  No  No  Steroid cream  CR  Yes 
Rahman et al.3  20  No  No  Triamcinolone acetonide ointment  CR  Yes 
Sehgal et al.4  16  No  No  Tacrolimus+calcipotriol+betamethasone dipropionate  CR  Yes 
Ersoy-Evans et al.5  19  No  No  Fluticasone propionate 0.005% ointment  CR  No 
Baz et al.6  22  No  No  Mometasone furoate 0.1%  CR  No 
Current cases20  No  No  Tacrolimus+salicylic acid  CR  Yes 
28  No  No  Tacrolimus+salicylic acid  CR  Yes 

Abbreviations: CR, complete response; F, female; M, male.

Therapeutic modalities such as topical steroids and tacrolimus alone or in combination with calcipotriol have produced adequate response in patients with perioral psoriasis.2–6,8 Tacrolimus, a calcineurin-inhibitor with anti-inflammatory properties, lacks the well-known adverse effects associated with steroids. Yamamoto and Nishioka9 reported a case in which topical tacrolimus ointment was used to treat psoriasis of the vermilion of the lips, with very promising results. Moreover, this treatment combined with salicylic acid gel has been shown to increase the penetration and absorption of the drug, enhancing therapeutic action.10

In conclusion, we have described 2 new cases of psoriatic cheilitis with exclusive lip involvement treated successfully with topical tacrolimus 0.1% in combination with salicylic acid, indicating their possible therapeutic role in this troublesome localization. We suggest that psoriasis should be considered in cases of refractory long-standing eczema-like cheilitis, even in the absence of a positive family or personal history of psoriasis.

References
[1]
A. Sklavounou, G. Laskaris.
Oral psoriasis: report of a case and review of the literature.
Dermatologica, 180 (1990), pp. 157-159
[2]
A. Tosti, C. Misciali, N. Cameli, C. Vincenzi.
Guess what! Psoriasis of the lips.
Eur J Dermatol, 11 (2001), pp. 589-590
[3]
M.A. Rahman, M. Fikree.
Perioral psoriasis.
J Eur Acad Dermatol Venereol, 14 (2000), pp. 521-522
[4]
V.N. Sehgal, S. Sehgal, P. Verma, N. Singh, F. Rasool.
Exclusive plaque psoriasis of the lips: efficacy of combination therapy of topical tacrolimus, calcipotriol, and betamethasone dipropionate.
J Skin Med, 10 (2012), pp. 183
[5]
S. Ersoy-Evans, L. Nuralina, G. Erkin, O. Ozkaya.
Psoriasis of the lips: a rare entity.
J Eur Acad Dermatol Venereol, 21 (2007), pp. 142-143
[6]
K. Baz, A.C. Yazici, A. Usta, G. Ikizoglu, D.D. Apa.
Isolated lip involvement in psoriasis.
Clin Exp Dermatol, 32 (2007), pp. 578-579
[7]
S. Brenner, R. Lipitz, B. Llie, A. Krakowski.
Psoriasis of the lips: the unusual Köbner phenomenon caused by protruding upper teeth.
Dermatologica, 164 (1982), pp. 413-416
[8]
N. Martí, I. Pinazo, A. Revert, E. Jordá.
Psoriasis of the lips.
J Dermatol Case Rep, 3 (2009), pp. 50-52
[9]
T. Yamamoto, K. Nishioka.
Successful treatment with topical tacrolimus for oral psoriasis.
J Eur Acad Dermatol Venereol, 20 (2006), pp. 1137-1138
[10]
A.K. Freeman, G.J. Linowski, C. Brady, L. Lind, P. Vanveldhuisen, G. Singer, et al.
Tacrolimus ointment for the treatment of psoriasis on the face and intertriginous areas.
J Am Acad Dermatol, 48 (2003), pp. 564-568
Copyright © 2014. Elsevier España, S.L.U. and AEDV
Descargar PDF
Idiomas
Actas Dermo-Sifiliográficas
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?