array:23 [
  "pii" => "S1578219010707320"
  "issn" => "15782190"
  "doi" => "10.1016/S1578-2190(10)70732-0"
  "estado" => "S300"
  "fechaPublicacion" => "2010-12-01"
  "aid" => "70732"
  "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
  "copyrightAnyo" => "2010"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2010;101:853-7"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2043
    "formatos" => array:3 [
      "EPUB" => 40
      "HTML" => 1232
      "PDF" => 771
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1578219010707332"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(10)70733-2"
    "estado" => "S300"
    "fechaPublicacion" => "2010-12-01"
    "aid" => "70733"
    "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2010;101:858-65"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2130
      "formatos" => array:3 [
        "EPUB" => 37
        "HTML" => 1353
        "PDF" => 740
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Treatment of Moderate-to-Severe Psoriasis in Clinical Practice&#58; A Survey of Spanish Dermatologists"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "858"
          "paginaFinal" => "865"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Realidad terap&#233;utica de la psoriasis moderada-grave en Espa&#241;a&#46; Encuesta de opini&#243;n"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "D&#46; Moreno-Ram&#237;rez, E&#46; Fonseca, P&#46; Herranz, M&#46; Ara"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Moreno-Ram&#237;rez"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Fonseca"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Herranz"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Ara"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010707332?idApp=UINPBA000044"
    "url" => "/15782190/0000010100000010/v1_201304241533/S1578219010707332/v1_201304241533/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1578219010707319"
    "issn" => "15782190"
    "doi" => "10.1016/S1578-2190(10)70731-9"
    "estado" => "S300"
    "fechaPublicacion" => "2010-12-01"
    "aid" => "70731"
    "copyright" => "Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a and Elsevier Espa&#241;a&#44; S&#46;L&#46;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2010;101:847-52"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2327
      "formatos" => array:3 [
        "EPUB" => 38
        "HTML" => 1455
        "PDF" => 834
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Condom Use and Number of Sexual Partners among Male Syphilis Patients who Report Having Sex with Men"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "847"
          "paginaFinal" => "852"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Uso de preservativo y n&#250;mero de parejas sexuales en hombres que tienen sexo con hombres con s&#237;filis"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "B&#46; Repiso, M&#46; Frieyro, F&#46; Rivas-Ruiz, M&#46; De Troya"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Repiso"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Frieyro"
            ]
            2 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Rivas-Ruiz"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "De Troya"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010707319?idApp=UINPBA000044"
    "url" => "/15782190/0000010100000010/v1_201304241533/S1578219010707319/v1_201304241533/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
    "titulo" => "Mohs Micrographic Surgery for the Treatment of Basal Cell Carcinoma"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "853"
        "paginaFinal" => "857"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "G&#46; Galimberti, A&#46; Pont&#243;n Monta&#241;o, D&#46; Ferrario, A&#46; Kowalczuk, R&#46; Galimberti"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "G&#46;"
            "apellidos" => "Galimberti"
            "email" => array:1 [
              0 => "gaston&#46;galimberti&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Pont&#243;n Monta&#241;o"
          ]
          2 => array:2 [
            "nombre" => "D&#46;"
            "apellidos" => "Ferrario"
          ]
          3 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Kowalczuk"
          ]
          4 => array:2 [
            "nombre" => "R&#46;"
            "apellidos" => "Galimberti"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Escuela de Medicina&#44; Hospital Italiano de Buenos Aires&#44; Buenos Aires&#44; Argentina"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Cirug&#237;a microgr&#225;fica de Mohs en el tratamiento de carcinoma basocelular"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2010-01-19"
    "fechaAceptado" => "2010-06-16"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec84829"
          "palabras" => array:4 [
            0 => "Mohs micrographic surgery"
            1 => "Basal cell carcinoma"
            2 => "Treatment"
            3 => "Skin cancer"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec84828"
          "palabras" => array:4 [
            0 => "Cirug&#237;a microgr&#225;fica de Mohs"
            1 => "Carcinoma basocelular"
            2 => "Tratamiento"
            3 => "C&#225;ncer de piel"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinoma accounts for 75&#37; of all nonmelanoma skin cancer&#46; Although various treatment modalities are available&#44; the most frequently used option is surgical excision&#46; Here&#44; we evaluate the efficacy of Mohs micrographic surgery for the treatment of basal cell carcinoma&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective review of cases of basal cell carcinoma treated with Mohs micrographic surgery between October 2003 and June 2009 was performed using patient records from Hospital Italiano in Buenos Aires&#44; Argentina&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 2412 basal cell carcinomas treated with Mohs micrographic surgery were identified&#59; 50&#46;5&#37; were in women and 49&#46;5&#37; in men&#46; The mean age of the patients was 70&#46;7 years &#40;range&#44; 8&#8211;100 years&#41;&#46; The histologic type of the tumor was solid in 65&#46;3&#37; of cases and in 89&#37; of cases the tumor was located on the head or neck&#46; Ten percent of the tumors were recurrent following previous treatment&#46; A mean of 1&#46;74 Mohs stages were used&#44; with a mean of 3&#46;81 sections&#46; The mean size of the initial defect was 0&#46;86 cm<span class="elsevierStyleSup">2</span> and the mean final defect was 1&#46;88 cm<span class="elsevierStyleSup">2</span>&#46; The ratio of initial tumor size to final defect was estimated at 1&#46;02&#46; Over a mean follow-up of 32 months&#44; there were 9 cases of tumor recurrence &#40;0&#46;37&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In our experience&#44; Mohs micrographic surgery is effective for the treatment of high-risk basal cell carcinoma&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El carcinoma basocelular constituye el 75&#37; de todos los carcinomas cut&#225;neos no melanoma&#46; Para su tratamiento existen m&#250;ltiples modalidades siendo la escisi&#243;n quir&#250;rgica la m&#225;s frecuentemente usada&#46; Se plantea evaluar la eficacia de la cirug&#237;a microgr&#225;fica de Mohs en el tratamiento del carcinoma basocelular&#46;</p> <span class="elsevierStyleSectionTitle">Materiales y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Revisi&#243;n retrospectiva en la base de datos del Hospital Italiano de Buenos Aires de los casos de carcinoma basocelular tratados con cirug&#237;a microgr&#225;fica de Mohs entre octubre del 2003 y junio del 2009&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se encontraron 2&#46;412 casos &#40;85&#44;3&#37;&#41;&#59; el 50&#44;5&#37; se presentaron en mujeres y el 49&#44;5&#37; en hombres&#46; La media de edad fue de 70&#44;7 a&#241;os &#40;rango entre 8 y 100 a&#241;os&#41;&#46; El 65&#44;3&#37; de los tumores eran del tipo histol&#243;gico s&#243;lido y la ubicaci&#243;n m&#225;s frecuente fue la cabeza y el cuello &#40;89&#37;&#41;&#46; El 10&#37; de los carcinomas basocelulares eran recidivas de tratamientos previos&#46; El n&#250;mero medio de estadios fue de 1&#44;74 con una media de 3&#44;81 cortes&#46; La media del defecto inicial fue de 0&#44;86 cm<span class="elsevierStyleSup">2</span> y del defecto final de 1&#44;88 cm<span class="elsevierStyleSup">2</span>&#46; La relaci&#243;n defecto final&#47;defecto inicial se estim&#243; en 1&#44;02 cm<span class="elsevierStyleSup">2</span>&#46; Nueve tumores presentaron recidiva &#40;0&#44;37&#37;&#41; con una media de seguimiento de 32 meses&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Consideramos que la cirug&#237;a microgr&#225;fica de Mohs es eficaz en el tratamiento del carcinoma basocelular de alto riesgo&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:22 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The epidemiology of skin cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;M&#46; Gloster"
                            1 => "D&#46;G&#46; Brodland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg"
                        "fecha" => "1996"
                        "volumen" => "22"
                        "paginaInicial" => "217"
                        "paginaFinal" => "226"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8599733"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Basal cell carcinoma&#58; treatment options and prognosis&#44; a scientific approach to the common malignancy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Kuijper"
                            1 => "M&#46; Thiessen"
                            2 => "M&#46; Nuemann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Clin Dermatol"
                        "fecha" => "2002"
                        "volumen" => "3"
                        "paginaInicial" => "247"
                        "paginaFinal" => "259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12010070"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chemosurgery&#44; a microscopically controlled method of cancer excision"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Mohs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Surg"
                        "fecha" => "1941"
                        "volumen" => "42"
                        "paginaInicial" => "279"
                        "paginaFinal" => "295"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mohs micrographic surgery referral patterns&#58; the University of Missouri experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Gaston"
                            1 => "C&#46; Naugle"
                            2 => "D&#46; Clark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Surg"
                        "fecha" => "1999"
                        "volumen" => "25"
                        "paginaInicial" => "862"
                        "paginaFinal" => "866"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10594598"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Five-year of Moh&#39;s micrographic surgery for aggressive facial basal cell carcinoma in Sweden"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Wennberg"
                            1 => "O&#46; Larko"
                            2 => "B&#46; Stenquist"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "1999"
                        "volumen" => "79"
                        "paginaInicial" => "370"
                        "paginaFinal" => "372"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10494714"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systemic review of treatment modalities for primary basal cell carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Thissen"
                            1 => "M&#46; Neumann"
                            2 => "L&#46; Schouten"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1999"
                        "volumen" => "135"
                        "paginaInicial" => "1177"
                        "paginaFinal" => "1183"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10522664"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Criocirug&#237;a en dermatolog&#237;a&#58; Experiencia en el Hospital Cl&#237;nico Quir&#250;rgico Universitario &#8220;Hermanos Ameijeiras&#8221; Dermatol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Alonso Trujillo"
                            1 => "A&#46; Castillo Oliva"
                            2 => "M&#46; Rodr&#237;guez Garc&#237;a"
                            3 => "S&#46; Collazo Caballero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Per&#250;"
                        "fecha" => "2007"
                        "volumen" => "17"
                        "paginaInicial" => "161"
                        "paginaFinal" => "169"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Photodynamic therapy for multiple skin cancers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Pennington"
                            1 => "M&#46; Waner"
                            2 => "A&#46; Knox"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Plast Reconstr Surg"
                        "fecha" => "1988"
                        "volumen" => "82"
                        "paginaInicial" => "1067"
                        "paginaFinal" => "1071"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3059383"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Photodynamic therapy expands its horizons"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46; Reynolds"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "1997"
                        "volumen" => "89"
                        "paginaInicial" => "112"
                        "paginaFinal" => "114"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8998175"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mohs Surgery&#58; The informed view"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; McGovern"
                            1 => "D&#46; Leffell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "1999"
                        "volumen" => "135"
                        "paginaInicial" => "1255"
                        "paginaFinal" => "1259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10522675"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cirug&#237;a microgr&#225;fica de Mohs del canto interno del ojo&#46; Estudio de casos y controles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Nagore Engu&#237;danos"
                            1 => "B&#46; Llombart Cussac"
                            2 => "A&#46; Compa&#241; Quilis"
                            3 => "O&#46; Sanmart&#237;n Jim&#233;nez"
                            4 => "A&#46; Sevila Llinares"
                            5 => "R&#46; Botella Estrada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2002"
                        "volumen" => "93"
                        "paginaInicial" => "406"
                        "paginaFinal" => "412"
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510710019450"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cirug&#237;a de Mohs&#58; nuestros primeros cien pacientes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Alonso"
                            1 => "P&#46; S&#225;nchez"
                            2 => "A&#46; Gonz&#225;lez"
                            3 => "J&#46; Ingelmo"
                            4 => "I&#46; Ruiz"
                            5 => "S&#46; Delgado"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2008"
                        "volumen" => "99"
                        "paginaInicial" => "275"
                        "paginaFinal" => "280"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18394403"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510712026557"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recurrence rates of treated basal cell carcinomas&#46; Part 1&#58; Overview"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;K&#46; Silverman"
                            1 => "A&#46;W&#46; Kopf"
                            2 => "C&#46;M&#46; Grin"
                            3 => "R&#46;S&#46; Bart"
                            4 => "M&#46;J&#46; Levenstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Dermatol Surg Oncol"
                        "fecha" => "1991"
                        "volumen" => "17"
                        "paginaInicial" => "713"
                        "paginaFinal" => "718"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1890243"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510710016810"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of developing a subsequent nonmelanoma skin cancer in patients with a history of nonmelanoma skin cancer&#58; a critical review of the literature and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46; Marcil"
                            1 => "R&#46; Stern"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2000"
                        "volumen" => "136"
                        "paginaInicial" => "1524"
                        "paginaFinal" => "1530"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11115165"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer recurrence following Mohs micrographic surgery&#58; a mechanism of tumor persistence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Y&#46; Eliezri"
                            1 => "P&#46; Cohen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Plast Reconstr Surg"
                        "fecha" => "1992"
                        "volumen" => "90"
                        "paginaInicial" => "121"
                        "paginaFinal" => "125"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1615072"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "False-negative tumor-free margins following Mohs surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46; Dzubow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol Surg Oncol"
                        "fecha" => "1988"
                        "volumen" => "14"
                        "paginaInicial" => "600"
                        "paginaFinal" => "6002"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3372843"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mohs micrographic surgery local recurrences"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46; Hruza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol Surg Oncol"
                        "fecha" => "1994"
                        "volumen" => "20"
                        "paginaInicial" => "573"
                        "paginaFinal" => "577"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8089356"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adjuvant cytokeratin staining in Mohs micrographic surgery for basal cell carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46;W&#46; Smeets"
                            1 => "A&#46;J&#46; Stavast-Kooy"
                            2 => "G&#46;A&#46; Krekels"
                            3 => "M&#46;J&#46; Daemen"
                            4 => "H&#46;A&#46; Newmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Dermatol Surg"
                        "fecha" => "2003"
                        "volumen" => "29"
                        "paginaInicial" => "375"
                        "paginaFinal" => "377"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12656816"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510707026570"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Three-dimensional reconstruction of the superficial multicentric basal cell carcinoma using serial sections and a computer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Lang"
                            1 => "A&#46; McKelvey"
                            2 => "J&#46; Nicholson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Dermatopathol"
                        "fecha" => "1987"
                        "volumen" => "9"
                        "paginaInicial" => "198"
                        "paginaFinal" => "203"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3631446"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S001651070702278X"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mohs micrographic surgery&#58; a cost analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Cook"
                            1 => "J&#46; Zitelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1998"
                        "volumen" => "39"
                        "paginaInicial" => "698"
                        "paginaFinal" => "703"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9810885"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation and management of non melanoma skin cancer&#46; The military perspective"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Welch"
                            1 => "L&#46; Anderson"
                            2 => "W&#46; Grabski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Clin"
                        "fecha" => "1999"
                        "volumen" => "17"
                        "paginaInicial" => "19"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9986993"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cirug&#237;a de Mohs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; R&#237;os-Buceta"
                            1 => "A&#46; Picoto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2003"
                        "volumen" => "94"
                        "paginaInicial" => "502"
                        "paginaFinal" => "503"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010100000010/v1_201304241533/S1578219010707320/v1_201304241533/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6256"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010100000010/v1_201304241533/S1578219010707320/v1_201304241533/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010707320?idApp=UINPBA000044"
]
Compartir
Información de la revista
Vol. 101. Núm. 10.
Páginas 853-857 (diciembre 2010)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 101. Núm. 10.
Páginas 853-857 (diciembre 2010)
Original Article
Acceso a texto completo
Mohs Micrographic Surgery for the Treatment of Basal Cell Carcinoma
Cirugía micrográfica de Mohs en el tratamiento de carcinoma basocelular
Visitas
5807
G. Galimberti
Autor para correspondencia
gaston.galimberti@gmail.com

Corresponding author.
, A. Pontón Montaño, D. Ferrario, A. Kowalczuk, R. Galimberti
Servicio de Dermatología, Escuela de Medicina, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Este artículo ha recibido
Información del artículo
Resumen
Bibliografía
Descargar PDF
Estadísticas
Abstract
Introduction

Basal cell carcinoma accounts for 75% of all nonmelanoma skin cancer. Although various treatment modalities are available, the most frequently used option is surgical excision. Here, we evaluate the efficacy of Mohs micrographic surgery for the treatment of basal cell carcinoma.

Material and methods

A retrospective review of cases of basal cell carcinoma treated with Mohs micrographic surgery between October 2003 and June 2009 was performed using patient records from Hospital Italiano in Buenos Aires, Argentina.

Results

A total of 2412 basal cell carcinomas treated with Mohs micrographic surgery were identified; 50.5% were in women and 49.5% in men. The mean age of the patients was 70.7 years (range, 8–100 years). The histologic type of the tumor was solid in 65.3% of cases and in 89% of cases the tumor was located on the head or neck. Ten percent of the tumors were recurrent following previous treatment. A mean of 1.74 Mohs stages were used, with a mean of 3.81 sections. The mean size of the initial defect was 0.86 cm2 and the mean final defect was 1.88 cm2. The ratio of initial tumor size to final defect was estimated at 1.02. Over a mean follow-up of 32 months, there were 9 cases of tumor recurrence (0.37%).

Conclusions

In our experience, Mohs micrographic surgery is effective for the treatment of high-risk basal cell carcinoma.

Keywords:
Mohs micrographic surgery
Basal cell carcinoma
Treatment
Skin cancer
Resumen
Introducción

El carcinoma basocelular constituye el 75% de todos los carcinomas cutáneos no melanoma. Para su tratamiento existen múltiples modalidades siendo la escisión quirúrgica la más frecuentemente usada. Se plantea evaluar la eficacia de la cirugía micrográfica de Mohs en el tratamiento del carcinoma basocelular.

Materiales y métodos

Revisión retrospectiva en la base de datos del Hospital Italiano de Buenos Aires de los casos de carcinoma basocelular tratados con cirugía micrográfica de Mohs entre octubre del 2003 y junio del 2009.

Resultados

Se encontraron 2.412 casos (85,3%); el 50,5% se presentaron en mujeres y el 49,5% en hombres. La media de edad fue de 70,7 años (rango entre 8 y 100 años). El 65,3% de los tumores eran del tipo histológico sólido y la ubicación más frecuente fue la cabeza y el cuello (89%). El 10% de los carcinomas basocelulares eran recidivas de tratamientos previos. El número medio de estadios fue de 1,74 con una media de 3,81 cortes. La media del defecto inicial fue de 0,86 cm2 y del defecto final de 1,88 cm2. La relación defecto final/defecto inicial se estimó en 1,02 cm2. Nueve tumores presentaron recidiva (0,37%) con una media de seguimiento de 32 meses.

Conclusión

Consideramos que la cirugía micrográfica de Mohs es eficaz en el tratamiento del carcinoma basocelular de alto riesgo.

Palabras clave:
Cirugía micrográfica de Mohs
Carcinoma basocelular
Tratamiento
Cáncer de piel
El Texto completo está disponible en PDF
References
[1.]
H.M. Gloster, D.G. Brodland.
The epidemiology of skin cancer.
Dermatol Surg, 22 (1996), pp. 217-226
[2.]
D. Kuijper, M. Thiessen, M. Nuemann.
Basal cell carcinoma: treatment options and prognosis, a scientific approach to the common malignancy.
Am J Clin Dermatol, 3 (2002), pp. 247-259
[3.]
F. Mohs.
Chemosurgery, a microscopically controlled method of cancer excision.
Arch Surg, 42 (1941), pp. 279-295
[4.]
D. Gaston, C. Naugle, D. Clark.
Mohs micrographic surgery referral patterns: the University of Missouri experience.
Dermatol Surg, 25 (1999), pp. 862-866
[5.]
A. Wennberg, O. Larko, B. Stenquist.
Five-year of Moh's micrographic surgery for aggressive facial basal cell carcinoma in Sweden.
Acta Derm Venereol, 79 (1999), pp. 370-372
[6.]
M. Thissen, M. Neumann, L. Schouten.
A systemic review of treatment modalities for primary basal cell carcinoma.
Arch Dermatol, 135 (1999), pp. 1177-1183
[7.]
I. Alonso Trujillo, A. Castillo Oliva, M. Rodríguez García, S. Collazo Caballero.
Criocirugía en dermatología: Experiencia en el Hospital Clínico Quirúrgico Universitario “Hermanos Ameijeiras” Dermatol.
Perú, 17 (2007), pp. 161-169
[8.]
D. Pennington, M. Waner, A. Knox.
Photodynamic therapy for multiple skin cancers.
Plast Reconstr Surg, 82 (1988), pp. 1067-1071
[9.]
T. Reynolds.
Photodynamic therapy expands its horizons.
J Natl Cancer Inst, 89 (1997), pp. 112-114
[10.]
T. McGovern, D. Leffell.
Mohs Surgery: The informed view.
Arch Dermatol, 135 (1999), pp. 1255-1259
[11.]
E. Nagore Enguídanos, B. Llombart Cussac, A. Compañ Quilis, O. Sanmartín Jiménez, A. Sevila Llinares, R. Botella Estrada, et al.
Cirugía micrográfica de Mohs del canto interno del ojo. Estudio de casos y controles.
Actas Dermosifiliogr, 93 (2002), pp. 406-412
[12.]
T. Alonso, P. Sánchez, A. González, J. Ingelmo, I. Ruiz, S. Delgado, et al.
Cirugía de Mohs: nuestros primeros cien pacientes.
Actas Dermosifiliogr, 99 (2008), pp. 275-280
[13.]
M.K. Silverman, A.W. Kopf, C.M. Grin, R.S. Bart, M.J. Levenstein.
Recurrence rates of treated basal cell carcinomas. Part 1: Overview.
J Dermatol Surg Oncol, 17 (1991), pp. 713-718
[14.]
I. Marcil, R. Stern.
Risk of developing a subsequent nonmelanoma skin cancer in patients with a history of nonmelanoma skin cancer: a critical review of the literature and meta-analysis.
Arch Dermatol, 136 (2000), pp. 1524-1530
[15.]
Y. Eliezri, P. Cohen.
Cancer recurrence following Mohs micrographic surgery: a mechanism of tumor persistence.
Plast Reconstr Surg, 90 (1992), pp. 121-125
[16.]
L. Dzubow.
False-negative tumor-free margins following Mohs surgery.
J Dermatol Surg Oncol, 14 (1988), pp. 600-6002
[17.]
G. Hruza.
Mohs micrographic surgery local recurrences.
J Dermatol Surg Oncol, 20 (1994), pp. 573-577
[18.]
N.W. Smeets, A.J. Stavast-Kooy, G.A. Krekels, M.J. Daemen, H.A. Newmann.
Adjuvant cytokeratin staining in Mohs micrographic surgery for basal cell carcinoma.
Dermatol Surg, 29 (2003), pp. 375-377
[19.]
P. Lang, A. McKelvey, J. Nicholson.
Three-dimensional reconstruction of the superficial multicentric basal cell carcinoma using serial sections and a computer.
Am J Dermatopathol, 9 (1987), pp. 198-203
[20.]
J. Cook, J. Zitelli.
Mohs micrographic surgery: a cost analysis.
J Am Acad Dermatol, 39 (1998), pp. 698-703
[21.]
M. Welch, L. Anderson, W. Grabski.
Evaluation and management of non melanoma skin cancer. The military perspective.
Dermatol Clin, 17 (1999), pp. 19-28
[22.]
L. Ríos-Buceta, A. Picoto.
Cirugía de Mohs.
Actas Dermosifiliogr, 94 (2003), pp. 502-503
Copyright © 2010. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
Descargar PDF
Idiomas
Actas Dermo-Sifiliográficas
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?