Original Article
Mohs Micrographic Surgery for the Treatment of Basal Cell Carcinoma
Cirugía micrográfica de Mohs en el tratamiento de carcinoma basocelular
G. Galimberti
, A. Pontón Montaño, D. Ferrario, A. Kowalczuk, R. Galimberti
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Servicio de Dermatología, Escuela de Medicina, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
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Encuesta de opinión" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Moreno-Ramírez, E. Fonseca, P. Herranz, M. Ara" "autores" => array:4 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Moreno-Ramírez" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Fonseca" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Herranz" ] 3 => array:2 [ "nombre" => "M." 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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2010;101:847-52" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2327 "formatos" => array:3 [ "EPUB" => 38 "HTML" => 1455 "PDF" => 834 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Condom Use and Number of Sexual Partners among Male Syphilis Patients who Report Having Sex with Men" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "847" "paginaFinal" => "852" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Uso de preservativo y número de parejas sexuales en hombres que tienen sexo con hombres con sífilis" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "B. Repiso, M. Frieyro, F. Rivas-Ruiz, M. De Troya" "autores" => array:4 [ 0 => array:2 [ "nombre" => "B." "apellidos" => "Repiso" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Frieyro" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Rivas-Ruiz" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "De Troya" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010707319?idApp=UINPBA000044" "url" => "/15782190/0000010100000010/v1_201304241533/S1578219010707319/v1_201304241533/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Mohs Micrographic Surgery for the Treatment of Basal Cell Carcinoma" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "853" "paginaFinal" => "857" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "G. Galimberti, A. Pontón Montaño, D. Ferrario, A. Kowalczuk, R. Galimberti" "autores" => array:5 [ 0 => array:4 [ "nombre" => "G." "apellidos" => "Galimberti" "email" => array:1 [ 0 => "gaston.galimberti@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Pontón Montaño" ] 2 => array:2 [ "nombre" => "D." "apellidos" => "Ferrario" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Kowalczuk" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Galimberti" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Escuela de Medicina, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Cirugía micrográfica de Mohs en el tratamiento de carcinoma basocelular" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-01-19" "fechaAceptado" => "2010-06-16" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84829" "palabras" => array:4 [ 0 => "Mohs micrographic surgery" 1 => "Basal cell carcinoma" 2 => "Treatment" 3 => "Skin cancer" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84828" "palabras" => array:4 [ 0 => "Cirugía micrográfica de Mohs" 1 => "Carcinoma basocelular" 2 => "Tratamiento" 3 => "Cáncer de piel" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Basal cell carcinoma accounts for 75% of all nonmelanoma skin cancer. Although various treatment modalities are available, the most frequently used option is surgical excision. Here, we evaluate the efficacy of Mohs micrographic surgery for the treatment of basal cell carcinoma.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective review of cases of basal cell carcinoma treated with Mohs micrographic surgery between October 2003 and June 2009 was performed using patient records from Hospital Italiano in Buenos Aires, Argentina.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 2412 basal cell carcinomas treated with Mohs micrographic surgery were identified; 50.5% were in women and 49.5% in men. The mean age of the patients was 70.7 years (range, 8–100 years). The histologic type of the tumor was solid in 65.3% of cases and in 89% of cases the tumor was located on the head or neck. Ten percent of the tumors were recurrent following previous treatment. A mean of 1.74 Mohs stages were used, with a mean of 3.81 sections. The mean size of the initial defect was 0.86 cm<span class="elsevierStyleSup">2</span> and the mean final defect was 1.88 cm<span class="elsevierStyleSup">2</span>. The ratio of initial tumor size to final defect was estimated at 1.02. Over a mean follow-up of 32 months, there were 9 cases of tumor recurrence (0.37%).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In our experience, Mohs micrographic surgery is effective for the treatment of high-risk basal cell carcinoma.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El carcinoma basocelular constituye el 75% de todos los carcinomas cutáneos no melanoma. Para su tratamiento existen múltiples modalidades siendo la escisión quirúrgica la más frecuentemente usada. Se plantea evaluar la eficacia de la cirugía micrográfica de Mohs en el tratamiento del carcinoma basocelular.</p> <span class="elsevierStyleSectionTitle">Materiales y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Revisión retrospectiva en la base de datos del Hospital Italiano de Buenos Aires de los casos de carcinoma basocelular tratados con cirugía micrográfica de Mohs entre octubre del 2003 y junio del 2009.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se encontraron 2.412 casos (85,3%); el 50,5% se presentaron en mujeres y el 49,5% en hombres. La media de edad fue de 70,7 años (rango entre 8 y 100 años). El 65,3% de los tumores eran del tipo histológico sólido y la ubicación más frecuente fue la cabeza y el cuello (89%). El 10% de los carcinomas basocelulares eran recidivas de tratamientos previos. El número medio de estadios fue de 1,74 con una media de 3,81 cortes. La media del defecto inicial fue de 0,86 cm<span class="elsevierStyleSup">2</span> y del defecto final de 1,88 cm<span class="elsevierStyleSup">2</span>. La relación defecto final/defecto inicial se estimó en 1,02 cm<span class="elsevierStyleSup">2</span>. Nueve tumores presentaron recidiva (0,37%) con una media de seguimiento de 32 meses.</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Consideramos que la cirugía micrográfica de Mohs es eficaz en el tratamiento del carcinoma basocelular de alto riesgo.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The epidemiology of skin cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H.M. Gloster" 1 => "D.G. Brodland" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "1996" "volumen" => "22" "paginaInicial" => "217" "paginaFinal" => "226" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8599733" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basal cell carcinoma: treatment options and prognosis, a scientific approach to the common malignancy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Kuijper" 1 => "M. Thiessen" 2 => "M. Nuemann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Dermatol" "fecha" => "2002" "volumen" => "3" "paginaInicial" => "247" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12010070" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemosurgery, a microscopically controlled method of cancer excision" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Mohs" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Surg" "fecha" => "1941" "volumen" => "42" "paginaInicial" => "279" "paginaFinal" => "295" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mohs micrographic surgery referral patterns: the University of Missouri experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Gaston" 1 => "C. Naugle" 2 => "D. Clark" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg" "fecha" => "1999" "volumen" => "25" "paginaInicial" => "862" "paginaFinal" => "866" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10594598" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Five-year of Moh's micrographic surgery for aggressive facial basal cell carcinoma in Sweden" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Wennberg" 1 => "O. Larko" 2 => "B. Stenquist" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "1999" "volumen" => "79" "paginaInicial" => "370" "paginaFinal" => "372" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10494714" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A systemic review of treatment modalities for primary basal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Thissen" 1 => "M. Neumann" 2 => "L. Schouten" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1999" "volumen" => "135" "paginaInicial" => "1177" "paginaFinal" => "1183" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10522664" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Criocirugía en dermatología: Experiencia en el Hospital Clínico Quirúrgico Universitario “Hermanos Ameijeiras” Dermatol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I. Alonso Trujillo" 1 => "A. Castillo Oliva" 2 => "M. Rodríguez García" 3 => "S. Collazo Caballero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Perú" "fecha" => "2007" "volumen" => "17" "paginaInicial" => "161" "paginaFinal" => "169" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy for multiple skin cancers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Pennington" 1 => "M. Waner" 2 => "A. Knox" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Plast Reconstr Surg" "fecha" => "1988" "volumen" => "82" "paginaInicial" => "1067" "paginaFinal" => "1071" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3059383" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Photodynamic therapy expands its horizons" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Reynolds" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "1997" "volumen" => "89" "paginaInicial" => "112" "paginaFinal" => "114" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8998175" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mohs Surgery: The informed view" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. McGovern" 1 => "D. Leffell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1999" "volumen" => "135" "paginaInicial" => "1255" "paginaFinal" => "1259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10522675" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cirugía micrográfica de Mohs del canto interno del ojo. Estudio de casos y controles" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Nagore Enguídanos" 1 => "B. Llombart Cussac" 2 => "A. Compañ Quilis" 3 => "O. Sanmartín Jiménez" 4 => "A. Sevila Llinares" 5 => "R. Botella Estrada" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2002" "volumen" => "93" "paginaInicial" => "406" "paginaFinal" => "412" "itemHostRev" => array:3 [ "pii" => "S0016510710019450" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cirugía de Mohs: nuestros primeros cien pacientes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Alonso" 1 => "P. Sánchez" 2 => "A. González" 3 => "J. Ingelmo" 4 => "I. Ruiz" 5 => "S. Delgado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2008" "volumen" => "99" "paginaInicial" => "275" "paginaFinal" => "280" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18394403" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510712026557" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recurrence rates of treated basal cell carcinomas. Part 1: Overview" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.K. Silverman" 1 => "A.W. Kopf" 2 => "C.M. Grin" 3 => "R.S. Bart" 4 => "M.J. Levenstein" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Dermatol Surg Oncol" "fecha" => "1991" "volumen" => "17" "paginaInicial" => "713" "paginaFinal" => "718" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1890243" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510710016810" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of developing a subsequent nonmelanoma skin cancer in patients with a history of nonmelanoma skin cancer: a critical review of the literature and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I. Marcil" 1 => "R. Stern" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2000" "volumen" => "136" "paginaInicial" => "1524" "paginaFinal" => "1530" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11115165" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer recurrence following Mohs micrographic surgery: a mechanism of tumor persistence" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Y. Eliezri" 1 => "P. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Plast Reconstr Surg" "fecha" => "1992" "volumen" => "90" "paginaInicial" => "121" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1615072" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "False-negative tumor-free margins following Mohs surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L. Dzubow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Dermatol Surg Oncol" "fecha" => "1988" "volumen" => "14" "paginaInicial" => "600" "paginaFinal" => "6002" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3372843" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mohs micrographic surgery local recurrences" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. Hruza" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Dermatol Surg Oncol" "fecha" => "1994" "volumen" => "20" "paginaInicial" => "573" "paginaFinal" => "577" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8089356" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adjuvant cytokeratin staining in Mohs micrographic surgery for basal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N.W. Smeets" 1 => "A.J. Stavast-Kooy" 2 => "G.A. Krekels" 3 => "M.J. Daemen" 4 => "H.A. Newmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Dermatol Surg" "fecha" => "2003" "volumen" => "29" "paginaInicial" => "375" "paginaFinal" => "377" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12656816" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510707026570" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three-dimensional reconstruction of the superficial multicentric basal cell carcinoma using serial sections and a computer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Lang" 1 => "A. McKelvey" 2 => "J. Nicholson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "1987" "volumen" => "9" "paginaInicial" => "198" "paginaFinal" => "203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3631446" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S001651070702278X" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mohs micrographic surgery: a cost analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Cook" 1 => "J. Zitelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1998" "volumen" => "39" "paginaInicial" => "698" "paginaFinal" => "703" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9810885" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation and management of non melanoma skin cancer. The military perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Welch" 1 => "L. Anderson" 2 => "W. Grabski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Clin" "fecha" => "1999" "volumen" => "17" "paginaInicial" => "19" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9986993" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cirugía de Mohs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Ríos-Buceta" 1 => "A. Picoto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2003" "volumen" => "94" "paginaInicial" => "502" "paginaFinal" => "503" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010100000010/v1_201304241533/S1578219010707320/v1_201304241533/en/main.assets" "Apartado" => array:4 [ "identificador" => "6256" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010100000010/v1_201304241533/S1578219010707320/v1_201304241533/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219010707320?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
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| 2023 Enero | 43 | 24 | 67 |
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| 2022 Marzo | 33 | 56 | 89 |
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| 2021 Diciembre | 23 | 43 | 66 |
| 2021 Noviembre | 28 | 47 | 75 |
| 2021 Octubre | 44 | 54 | 98 |
| 2021 Septiembre | 30 | 58 | 88 |
| 2021 Agosto | 27 | 40 | 67 |
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| 2020 Octubre | 29 | 14 | 43 |
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| 2016 Agosto | 36 | 9 | 45 |
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| 2015 Noviembre | 11 | 2 | 13 |
| 2015 Octubre | 5 | 0 | 5 |
| 2015 Septiembre | 3 | 5 | 8 |
| 2015 Agosto | 11 | 7 | 18 |
| 2015 Julio | 36 | 9 | 45 |
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| 2015 Mayo | 61 | 18 | 79 |
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| 2015 Febrero | 18 | 7 | 25 |
| 2015 Enero | 12 | 15 | 27 |
| 2014 Diciembre | 37 | 3 | 40 |
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| 2014 Octubre | 29 | 9 | 38 |
| 2014 Septiembre | 26 | 14 | 40 |
| 2014 Agosto | 22 | 13 | 35 |
| 2014 Julio | 30 | 17 | 47 |
| 2014 Junio | 36 | 10 | 46 |
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| 2014 Marzo | 35 | 19 | 54 |
| 2014 Febrero | 26 | 15 | 41 |
| 2014 Enero | 28 | 11 | 39 |
| 2013 Diciembre | 30 | 17 | 47 |
| 2013 Noviembre | 22 | 18 | 40 |
| 2013 Octubre | 25 | 16 | 41 |
| 2013 Septiembre | 27 | 21 | 48 |
| 2013 Agosto | 15 | 17 | 32 |
| 2013 Julio | 26 | 33 | 59 |
| 2013 Junio | 23 | 30 | 53 |
| 2013 Mayo | 17 | 17 | 34 |
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| 2013 Febrero | 11 | 12 | 23 |
| 2013 Enero | 3 | 2 | 5 |
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