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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lupus panniculitis &#40;LP&#41; is a rare variant of cutaneous lupus erythematosus &#40;CLE&#41; that primarily affects the deep dermis and adipose tissue&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It develops in 1&#37; to 3&#37; of patients with CLE&#46; Antinuclear antibodies &#40;ANA&#41; are positive in 70&#37; of cases&#44; but only 25&#37; to 50&#37; satisfy the criteria for systemic lupus erythematosus&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The diagnosis of LP is based on the correlation of clinical&#44; serological&#44; and&#44; most importantly&#44; histopathological findings&#46; Direct immunofluorescence is positive in 70&#37; to 80&#37; of cases and can help to confirm the diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> LP with a linear or annular morphology is extremely rare&#59; only 14 cases of linear LP have been described&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;7</span></a> and just 1 case of LP with annular lesions<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Of these 15 cases&#44; 9 affected the scalp&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 34-year-old man who consulted because of a plaque of alopecia that had been present in the right parietal region for 12 months&#46; Three months earlier he had been diagnosed with alopecia areata but the plaque did not respond to treatment with topical corticosteroids and subsequently had increased in size and had become erythematous and painful&#46; The patient did not report fever&#44; joint pain&#44; oral aphthous ulcers&#44; or other associated symptoms&#46; Physical examination revealed an erythematous&#44; edematous plaque of alopecia in the right parietal region&#46; The plaque had an annular morphology and measured about 6<span class="elsevierStyleHsp" style=""></span>cm in diameter &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Skin biopsy findings were compatible with lupus panniculitis&#44; and direct immunofluorescence revealed granular deposits of immunoglobulin&#160;M in the basement membrane&#46; Complete blood count and serum biochemistry were normal&#44; and immunological study was positive for ANA at a titer of 1&#58;320 and for Anti-Ro&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A new plaque of alopecia simulating alopecia areata was observed in the occipital region at subsequent follow-up visits &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A diagnosis of LP was made based on the clinical&#44; histological&#44; and serological findings&#44; and a 5-month course of treatment with hydroxychloroquine was started at a dose of 400<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#46; This regimen produced a reduction in the erythema and induration of the plaque and resolution of the alopecia&#46; The patient did not attend the scheduled follow-up&#44; but came to an unscheduled visit at 12 months&#44; at which time he presented multiple firm erythematous nodules and nonscarring alopecia with an annular and linear morphology located in the occipital and both parietal regions &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; Oral prednisone was prescribed at a dose of 30<span class="elsevierStyleHsp" style=""></span>mg&#47;d tapered over 3 weeks&#59; there was an initial improvement&#44; but the lesions recurred after treatment was discontinued&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Linear LP localized to the scalp was first described by Nagai et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> in 2003&#46; A further 7 cases of LP in a linear pattern on the scalp have been described and 1 case of LP at the same site with an annular pattern&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;8</span></a> Most of the cases have been reported in southwest Asia&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> suggesting a genetic or ethnic predisposition&#59; the condition affects both sexes and occurs mainly in young patients&#46; Clinical presentation takes the form of plaques of alopecia&#59; these are usually nonscarring and follow the Blaschko lines&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> which&#44; on the scalp&#44; have a spiral distribution centered on the vertex<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46; It would appear that inflammatory dermatoses that follow the Blaschko lines are the result of a genetic mosaicism&#44; in which a clone of abnormal cells remains inactive until an environmental factor stimulates its growth&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> The overlying skin may be normal&#44; erythematous&#44; or show signs of discoid lupus&#46; The histopathology findings in linear LP include a predominantly lobular lymphocytic panniculitis with hyaline fat necrosis&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> as observed in other forms of LP&#46; Our patient underwent 2 skin biopsies&#46; The first showed a dense lymphocytic infiltrate mainly affecting the deep dermis and adipose tissue&#44; with areas of fat necrosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41; and vacuolar damage of the basal layer of the epidermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46; The second biopsy revealed nodular lymphoid aggregates in which plasma cells were observed&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The main condition to be excluded in the differential diagnosis of linear LP affecting the scalp is alopecia areata&#46; The presence of erythema&#44; edema&#44; and pain supports a diagnosis of LP&#44; although the overlying skin may show no changes in the early stages&#46; Other conditions to be considered in the differential diagnosis are morphea en coup de sabre&#44; lipedematous alopecia&#44; and panniculitis-like T-cell lymphoma&#46; The most widely used drugs have been the antimalarials and topical&#44; intralesional&#44; and oral corticosteroids&#59; these treatments have achieved a good response in most cases&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In summary&#44; linear LP is a rare clinical variant of LP distributed along the Blaschko lines that presents a linear&#44; annular&#44; or arcuate pattern depending on the site of the lesions&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">We have reported the second case of annular LP localized to the scalp&#46; The condition presented clinically as painful erythematous plaques of nonscarring alopecia in a young white man&#46; LP should be included in the differential diagnosis of focal&#44; linear&#44; or annular plaques of alopecia situated on the scalp&#44; particularly if they are erythematous or painful&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Mitxelena J&#44; Mart&#237;nez-Pe&#241;uela A&#44; Cordoba A&#44; Yanguas I&#46; Paniculitis l&#250;pica de distribuci&#243;n lineal y anular localizada en el cuero cabelludo&#46; Actas Dermosifiliogr&#46; 2013&#59;104&#58;936&#8211;939&#46;</p>"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; ANA&#44; antinuclear antibodies&#59; CR&#44; complete remission&#59; Cy&#44; cyclophosphamide&#59; DP&#44; dapsone&#59; F&#44; female&#59; HCQ&#44; hydroxychloroquine&#59; IC&#44; intralesional corticosteroids&#59; IVC&#44; intravenous corticosteroids&#59; M&#44; male&#59; OC&#44; oral corticosteroids&#59; SA&#44; scarring alopecia&#59; SLE&#44; systemic lupus erythematosus&#59; TC&#44; topical corticosteroids&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Reference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Age&#44; y&#47;Sex&#47;Country&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Site&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Lesion morphology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Immunological Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Response&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tada et al&#46;&#44; 1991&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#47;M&#47;Japan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Left leg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Improvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Innocenzi et al&#46;&#44; 1997&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#47;M&#47;Italy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Breast&#44; right arm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ANA 1&#58;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not mentioned&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tamada et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#59; 1999&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#47;M&#47;Japan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Left arm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Improvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nagai et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#59; 2003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#47;F&#47;Japan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Scalp&#44; forehead&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ANA 1&#58;320&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Improvement&#44; SA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wu et al&#46;&#44; 2004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#47;F&#47;Taiwan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HCQ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;0&#93;Marzano et al&#46;&#44; 2005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#47;F&#47;Italy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Scalp&#44; forehead&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ANA 1&#58;280&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OC&#44; Cy&#44; IVC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SLE&#44; SA&#44; skin atrophy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#47;F&#47;Italy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Right arm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ANA 1&#58;640&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OC&#44; HCQ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Skin atrophy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bacanli et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#59; 2005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#47;F&#47;Turkey&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Scalp&#44; axilla&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Annular&#44; linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ANA 1&#58;320&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HCQ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Improvement&#44; SA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Shin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#59; 2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#47;M&#47;Korea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TC&#44; IC&#44; OC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Improvement&#44; skin atrophy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;0&#93;Rhee et al&#46;&#44; 2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#47;M&#47;Korea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not mentioned&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HCQ&#44; OC&#44; IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#47;M&#47;Korea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Not mentioned&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tamiya et al&#46;&#44; 2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#47;F&#47;Japan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Face&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OC&#44; TC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lee et al&#46;&#44; 2011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#47;F&#47;Korea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Back&#44; right thigh&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ANA 1&#58;2560&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HCQ&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lipoatrophy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#59; 2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#47;M&#47;Taiwan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HCQ&#44; IC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tsuzaka et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#59; 2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#47;F&#47;Japan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Scalp&#44; forehead&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ANA 1&#58;1280&#44; Anti-Ro&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Present case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#47;M&#47;Spain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Scalp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Annular&#44; linear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ANA 1&#58;320&#44; Anti-Ro&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HCQ&#44; OC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Improvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "imagenFichero" => array:1 [
                0 => "xTab430519.png"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Review of the Published Cases of Lupus Panniculitis With a Linear or Annular Pattern&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
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            0 => array:3 [
              "identificador" => "bib0005"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lupus erythematosus panniculitis&#58; Clinicopathological&#44; immunophenotypic and molecular studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46;S&#46; Park"
                            1 => "J&#46;W&#46; Choi"
                            2 => "B&#46;K&#46; Kim"
                            3 => "K&#46;H&#46; Cho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/DAD.0b013e3181b4a5ec"
                      "Revista" => array:6 [
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                        "fecha" => "2010"
                        "volumen" => "32"
                        "paginaInicial" => "24"
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20098081"
                            "web" => "Medline"
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            1 => array:3 [
              "identificador" => "bib0010"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paniculitis l&#250;pica asociada a lupus eritematoso sist&#233;mico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "S&#46;I&#46; Palencia"
                            1 => "S&#46; L&#243;pez"
                            2 => "F&#46; Vanaclocha"
                            3 => "J&#46;L&#46; Rodr&#237;guez"
                            4 => "L&#46; Iglesias"
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            2 => array:3 [
              "identificador" => "bib0015"
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              "referencia" => array:1 [
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                  "contribucion" => array:1 [
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                      "titulo" => "Linear lupus erythematosus profundus in a young man"
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                        0 => array:2 [
                          "etal" => false
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                            0 => "Y&#46; Tamada"
                            1 => "S&#46; Arisawa"
                            2 => "T&#46; Ikeya"
                            3 => "T&#46; Yokoi"
                            4 => "K&#46; Hara"
                            5 => "Y&#46; Matsumoto"
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                      "Revista" => array:7 [
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                          "pii" => "S0015028207002762"
                          "estado" => "S300"
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              "identificador" => "bib0020"
              "etiqueta" => "4"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Linear lupus erythematosus profundus on the scalp following the lines of Blaschko"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Y&#46; Nagai"
                            1 => "O&#46; Ishikawa"
                            2 => "T&#46; Hattori"
                            3 => "T&#46; Ogawa"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Dermatol"
                        "fecha" => "2003"
                        "volumen" => "13"
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12804993"
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              "etiqueta" => "5"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of linear lupus erythematosus profundus on the scalp presenting as alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;K&#46; Shin"
                            1 => "T&#46;H&#46; Cho"
                            2 => "B&#46;L&#46; Lew"
                            3 => "W&#46;Y&#46; Sim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Korean J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "45"
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              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Linear lupus panniculitis of the scalp presenting as alopecia along Blaschko&#39;s lines&#58; a distinct variant of lupus panniculitis in East Asians"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Y&#46;A&#46; Chen"
                            1 => "C&#46;K&#46; Hsu"
                            2 => "J&#46;Y&#46; Lee"
                            3 => "C&#46;C&#46; Yang"
                          ]
                        ]
                      ]
                    ]
                  ]
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Vol. 104. Núm. 10.
Páginas 936-939 (diciembre 2013)
Vol. 104. Núm. 10.
Páginas 936-939 (diciembre 2013)
Case and Research Letter
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Linear and Annular Lupus Panniculitis of the Scalp
Paniculitis lúpica de distribución lineal y anular localizada en el cuero cabelludo
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9809
J. Mitxelenaa,
Autor para correspondencia
mitxezeiza@yahoo.es

Corresponding author.
, A. Martínez-Peñuelab, A. Cordobab, I. Yanguasa
a Servicio de Dermatología, Complejo Hospitalario de Navarra, Pamplona-Iruña, Spain
b Servicio de Anatomía Patológica, Complejo Hospitalario de Navarra, Pamplona-Iruña, Spain
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Table 1. Review of the Published Cases of Lupus Panniculitis With a Linear or Annular Pattern.
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To the Editor:

Lupus panniculitis (LP) is a rare variant of cutaneous lupus erythematosus (CLE) that primarily affects the deep dermis and adipose tissue.1 It develops in 1% to 3% of patients with CLE. Antinuclear antibodies (ANA) are positive in 70% of cases, but only 25% to 50% satisfy the criteria for systemic lupus erythematosus.2 The diagnosis of LP is based on the correlation of clinical, serological, and, most importantly, histopathological findings. Direct immunofluorescence is positive in 70% to 80% of cases and can help to confirm the diagnosis.2 LP with a linear or annular morphology is extremely rare; only 14 cases of linear LP have been described,3–7 and just 1 case of LP with annular lesions8 (Table 1). Of these 15 cases, 9 affected the scalp.

Table 1.

Review of the Published Cases of Lupus Panniculitis With a Linear or Annular Pattern.

Reference  Age, y/Sex/Country  Site  Lesion morphology  Immunological Study  Treatment  Response 
Tada et al., 1991  9/M/Japan  Left leg  Linear  Negative  TC  Improvement 
Innocenzi et al., 1997  17/M/Italy  Breast, right arm  Linear  ANA 1:40  Not mentioned   
Tamada et al.3; 1999  19/M/Japan  Left arm  Linear  Negative  IC  Improvement 
Nagai et al.4; 2003  10/F/Japan  Scalp, forehead  Linear  ANA 1:320  TC  Improvement, SA 
Wu et al., 2004  21/F/Taiwan  Scalp  Linear  Negative  HCQ  CR 
[1,0]Marzano et al., 2005  21/F/Italy  Scalp, forehead  Linear  ANA 1:280  OC, Cy, IVC  SLE, SA, skin atrophy 
  32/F/Italy  Right arm  Linear  ANA 1:640  OC, HCQ  Skin atrophy 
Bacanli et al.8; 2005  16/F/Turkey  Scalp, axilla  Annular, linear  ANA 1:320  HCQ  Improvement, SA 
Shin et al.5; 2007  20/M/Korea  Scalp  Linear  Negative  TC, IC, OC  Improvement, skin atrophy 
[1,0]Rhee et al., 2009  14/M/Korea  Scalp  Linear  Not mentioned  HCQ, OC, IC  CR 
  21/M/Korea  Scalp  Linear  Not mentioned  DP  CR 
Tamiya et al., 2010  6/F/Japan  Face  Linear  Negative  OC, TC  CR 
Lee et al., 2011  28/F/Korea  Back, right thigh  Linear  ANA 1:2560  HCQ  Lipoatrophy 
Chen et al.6; 2012  32/M/Taiwan  Scalp  Linear  Negative  HCQ, IC  CR 
Tsuzaka et al.7; 2012  26/F/Japan  Scalp, forehead  Linear  ANA 1:1280, Anti-Ro+  OC  CR 
Present case  34/M/Spain  Scalp  Annular, linear  ANA 1:320, Anti-Ro+  HCQ, OC  Improvement 

Abbreviations: ANA, antinuclear antibodies; CR, complete remission; Cy, cyclophosphamide; DP, dapsone; F, female; HCQ, hydroxychloroquine; IC, intralesional corticosteroids; IVC, intravenous corticosteroids; M, male; OC, oral corticosteroids; SA, scarring alopecia; SLE, systemic lupus erythematosus; TC, topical corticosteroids.

We present the case of a 34-year-old man who consulted because of a plaque of alopecia that had been present in the right parietal region for 12 months. Three months earlier he had been diagnosed with alopecia areata but the plaque did not respond to treatment with topical corticosteroids and subsequently had increased in size and had become erythematous and painful. The patient did not report fever, joint pain, oral aphthous ulcers, or other associated symptoms. Physical examination revealed an erythematous, edematous plaque of alopecia in the right parietal region. The plaque had an annular morphology and measured about 6cm in diameter (Fig. 1A). Skin biopsy findings were compatible with lupus panniculitis, and direct immunofluorescence revealed granular deposits of immunoglobulin M in the basement membrane. Complete blood count and serum biochemistry were normal, and immunological study was positive for ANA at a titer of 1:320 and for Anti-Ro.

Figure 1.

A, Annular plaque of alopecia situated at the vertex. B, Plaque of alopecia that simulates alopecia areata. C. Arcuate plaque of alopecia that appears to follow the Blaschko lines. D, Distribution of the Blaschko lines on the scalp (pattern proposed by Happle9).

(0.56MB).

A new plaque of alopecia simulating alopecia areata was observed in the occipital region at subsequent follow-up visits (Fig. 1B).

A diagnosis of LP was made based on the clinical, histological, and serological findings, and a 5-month course of treatment with hydroxychloroquine was started at a dose of 400mg/d. This regimen produced a reduction in the erythema and induration of the plaque and resolution of the alopecia. The patient did not attend the scheduled follow-up, but came to an unscheduled visit at 12 months, at which time he presented multiple firm erythematous nodules and nonscarring alopecia with an annular and linear morphology located in the occipital and both parietal regions (Fig. 1C). Oral prednisone was prescribed at a dose of 30mg/d tapered over 3 weeks; there was an initial improvement, but the lesions recurred after treatment was discontinued.

Linear LP localized to the scalp was first described by Nagai et al.4 in 2003. A further 7 cases of LP in a linear pattern on the scalp have been described and 1 case of LP at the same site with an annular pattern.5–8 Most of the cases have been reported in southwest Asia,6 suggesting a genetic or ethnic predisposition; the condition affects both sexes and occurs mainly in young patients. Clinical presentation takes the form of plaques of alopecia; these are usually nonscarring and follow the Blaschko lines,6 which, on the scalp, have a spiral distribution centered on the vertex9 (Fig. 1D). It would appear that inflammatory dermatoses that follow the Blaschko lines are the result of a genetic mosaicism, in which a clone of abnormal cells remains inactive until an environmental factor stimulates its growth.10 The overlying skin may be normal, erythematous, or show signs of discoid lupus. The histopathology findings in linear LP include a predominantly lobular lymphocytic panniculitis with hyaline fat necrosis,7 as observed in other forms of LP. Our patient underwent 2 skin biopsies. The first showed a dense lymphocytic infiltrate mainly affecting the deep dermis and adipose tissue, with areas of fat necrosis (Fig. 2A) and vacuolar damage of the basal layer of the epidermis (Fig. 2B). The second biopsy revealed nodular lymphoid aggregates in which plasma cells were observed.

Figure 2.

A, Predominantly lymphocytic infiltrate in the deep dermis and adipose tissue, with hyaline fat necrosis (hematoxylin-eosin, original magnification ×40). B, Vacuolar changes in the basal layer of the epidermis (hematoxylin-eosin, original magnification ×200).

(1.07MB).

The main condition to be excluded in the differential diagnosis of linear LP affecting the scalp is alopecia areata. The presence of erythema, edema, and pain supports a diagnosis of LP, although the overlying skin may show no changes in the early stages. Other conditions to be considered in the differential diagnosis are morphea en coup de sabre, lipedematous alopecia, and panniculitis-like T-cell lymphoma. The most widely used drugs have been the antimalarials and topical, intralesional, and oral corticosteroids; these treatments have achieved a good response in most cases.7 In summary, linear LP is a rare clinical variant of LP distributed along the Blaschko lines that presents a linear, annular, or arcuate pattern depending on the site of the lesions.

We have reported the second case of annular LP localized to the scalp. The condition presented clinically as painful erythematous plaques of nonscarring alopecia in a young white man. LP should be included in the differential diagnosis of focal, linear, or annular plaques of alopecia situated on the scalp, particularly if they are erythematous or painful.

References
[1]
H.S. Park, J.W. Choi, B.K. Kim, K.H. Cho.
Lupus erythematosus panniculitis: Clinicopathological, immunophenotypic and molecular studies.
Am J Dermatopathol, 32 (2010), pp. 24-30
[2]
S.I. Palencia, S. López, F. Vanaclocha, J.L. Rodríguez, L. Iglesias.
Paniculitis lúpica asociada a lupus eritematoso sistémico.
Actas Dermosifiliogr, 93 (2002), pp. 181-183
[3]
Y. Tamada, S. Arisawa, T. Ikeya, T. Yokoi, K. Hara, Y. Matsumoto.
Linear lupus erythematosus profundus in a young man.
Br J Dermatol, 140 (1999), pp. 177-178
[4]
Y. Nagai, O. Ishikawa, T. Hattori, T. Ogawa.
Linear lupus erythematosus profundus on the scalp following the lines of Blaschko.
Eur J Dermatol, 13 (2003), pp. 294-296
[5]
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A case of linear lupus erythematosus profundus on the scalp presenting as alopecia.
Korean J Dermatol, 45 (2007), pp. 1280-1283
[6]
Y.A. Chen, C.K. Hsu, J.Y. Lee, C.C. Yang.
Linear lupus panniculitis of the scalp presenting as alopecia along Blaschko's lines: a distinct variant of lupus panniculitis in East Asians.
J Dermatol, 39 (2012), pp. 385-388
[7]
S. Tsuzaka, N. Ishiguro, R. Akashi, M. Kawashima.
A case of lupus erythematosus profundus with multiple arc-shaped erythematous plaques on the scalp and review of the literature.
Lupus, 21 (2012), pp. 662-665
[8]
A. Bacanli, S. Uzun, M.A. Ciftciaglu, E. Alpsoy.
A case of lupus erythematosus profundus with unusual manifestations.
Lupus, 14 (2005), pp. 403-405
[9]
R. Happle, A. Assim.
The lines of Blaschko on the head and neck.
J Am Acad Dermatol, 44 (2001), pp. 612-615
[10]
M. Cabanillas, B. Monteagudo, C. de las Heras, J.M. Cacharrón.
Liquen escleroatrófico lineal blaschkoide y zosteriforme.
Actas Dermosifiliogr, 100 (2009), pp. 155-157

Please cite this article as: Mitxelena J, Martínez-Peñuela A, Cordoba A, Yanguas I. Paniculitis lúpica de distribución lineal y anular localizada en el cuero cabelludo. Actas Dermosifiliogr. 2013;104:936–939.

Copyright © 2012. Elsevier España, S.L. and AEDV
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