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3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Additional Tests</span><p id="par0020" class="elsevierStylePara elsevierViewall">Fine-needle aspiration of the retroauricular nodule revealed reactive lymphadenitis without evidence of tumor cells&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">What Is Your Diagnosis&#63;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Proliferating trichilemmal tumor &#40;PTT&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Course and Treatment</span><p id="par0035" class="elsevierStylePara elsevierViewall">The lesion was completely excised with safety margins of 1<span class="elsevierStyleHsp" style=""></span>cm and no evidence of recurrence has been observed after 2 years of follow-up&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Comment</span><p id="par0040" class="elsevierStylePara elsevierViewall">PTT is a rare malignancy derived from the follicular outer root sheath that was first described in 1966 by Wilson-Jones&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> PTT is more common in women over 60 years of age&#46; 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and a squamous epithelium with an area of abrupt keratinization&#44; giving rise to cystic cavities that contain a homogeneous eosinophilic material that can show foci of calcification in 25&#37; of cases&#46; Dyskeratosis&#44; mitotic figures&#44; and cells with low-grade nuclear atypia are observed in some cases&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Although the lesions can have an aggressive histologic appearance&#44; the behavior of PTT is benign in most cases&#46; However&#44; there is a malignant variant that can cause lymph node or distant metastases in 30&#37; of cases and is associated with high mortality&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Factors associated with a risk of malignant transformation include non-scalp location&#44; history of rapid growth&#44; size &#62;5<span class="elsevierStyleHsp" style=""></span>cm&#44; infiltrative growth pattern&#44; and the presence of marked cytologic atypia with abundant mitotic figures&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Immunohistochemistry and flow cytometry can sometimes be useful to predict the behavior of these tumors&#44; as it has been observed that some malignant PTTs have a higher rate of cell proliferation&#44; decreased CD34 expression&#44; and DNA aneuploidy&#44; although the diagnosis should be based mainly on histologic findings&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The differential diagnosis includes epidermoid carcinomas&#44; epidermoid cysts&#44; sweat gland tumors&#44; dermatofibrosarcoma protuberans&#44; pilomatrixomas&#44; and angiosarcomas&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Treatment consists of surgical excision with safety margins of 1<span class="elsevierStyleHsp" style=""></span>cm &#40;deep to the galea aponeurotica&#41; or Mohs surgery because PTT is a tumor with a high rate of recurrence&#44; despite its benign behavior&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;6</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">We have reported this case because PTT is a rare tumor that can have a very alarming clinical appearance&#44; although histologic examination and clinical follow-up show it to be benign&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of Interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Vol. 109. Núm. 1.
Páginas 63-64 (enero - febrero 2018)
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5388
Vol. 109. Núm. 1.
Páginas 63-64 (enero - febrero 2018)
Case and Research Letters
Acceso a texto completo
Large, Long-standing Tumor on the Scalp and Ipsilateral Lymphadenopathy
Tumoración en cuero cabelludo de gran tamaño de larga evolución con adenopatías ipsilaterales
Visitas
5388
A. Hermosa-Gelbarda,
Autor para correspondencia
ahermosagelbard@gmail.com

Corresponding author.
, C. Moreno García del Realb, S. Vañó-Galvána
a Servicio de Dermatología Médico-Quirúrgica, Hospital Universitario Ramón y Cajal, Madrid, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, Spain
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Medical History

A healthy 57-year-old man presented with a ulcerated lesion in the right parietal region that had first appeared 30 years earlier and had grown slowly and progressively, as well as an asymptomatic ipsilateral nodule in the retroauricular region that had first appeared 20 years earlier.

Physical Examination

Physical examination revealed a hard, well-defined, lobulated, ulcerated lesion measuring 10cm×8cm in the right parietal region. A skin-colored nodule of elastic consistency, not adherent to the deeper tissues, was observed in the ipsilateral retroauricular region (Fig. 1).

Figure 1
(0.46MB).
Histopathology

In both the initial biopsy and the complete excision of the lesion, specimens were obtained for hematoxylin-eosin staining. Both specimens showed a well-defined, unencapsulated cystic tumor formed by several different-sized lobules composed of an external layer of basaloid cells and several layers of eosinophilic spindle cells with abrupt keratinization (Fig. 2). No atypia or mitotic figures were observed at higher magnification (Fig. 3).

Figure 2.

Hematoxylin-eosin, original magnification ×2.

(0.33MB).
Figure 3.

Hematoxylin-eosin, original magnification ×10.

(0.29MB).
Additional Tests

Fine-needle aspiration of the retroauricular nodule revealed reactive lymphadenitis without evidence of tumor cells.

What Is Your Diagnosis?

Diagnosis

Proliferating trichilemmal tumor (PTT).

Clinical Course and Treatment

The lesion was completely excised with safety margins of 1cm and no evidence of recurrence has been observed after 2 years of follow-up.

Comment

PTT is a rare malignancy derived from the follicular outer root sheath that was first described in 1966 by Wilson-Jones.1 PTT is more common in women over 60 years of age. The lesions are located on the scalp in 90% of cases, but other sites have also been reported. PTT can appear at the site of a preexisting trichilemmal cyst or arise de novo.

Clinically, PTT presents as a slow-growing tumor of variable size—from <1cm to 25cm—although in some cases the lesion can be fast-growing, which can indicate malignancy. In many cases, the lesion has a lobulated appearance, gradually becomes ulcerated, and can secrete a whitish, foul-smelling material.2

Histologically, PTT is a lobulated tumor consisting of a basement membrane that delimits the lesion, a layer of palisading basaloid cells, and a squamous epithelium with an area of abrupt keratinization, giving rise to cystic cavities that contain a homogeneous eosinophilic material that can show foci of calcification in 25% of cases. Dyskeratosis, mitotic figures, and cells with low-grade nuclear atypia are observed in some cases.

Although the lesions can have an aggressive histologic appearance, the behavior of PTT is benign in most cases. However, there is a malignant variant that can cause lymph node or distant metastases in 30% of cases and is associated with high mortality.

Factors associated with a risk of malignant transformation include non-scalp location, history of rapid growth, size >5cm, infiltrative growth pattern, and the presence of marked cytologic atypia with abundant mitotic figures.3

Immunohistochemistry and flow cytometry can sometimes be useful to predict the behavior of these tumors, as it has been observed that some malignant PTTs have a higher rate of cell proliferation, decreased CD34 expression, and DNA aneuploidy, although the diagnosis should be based mainly on histologic findings.4

The differential diagnosis includes epidermoid carcinomas, epidermoid cysts, sweat gland tumors, dermatofibrosarcoma protuberans, pilomatrixomas, and angiosarcomas.5

Treatment consists of surgical excision with safety margins of 1cm (deep to the galea aponeurotica) or Mohs surgery because PTT is a tumor with a high rate of recurrence, despite its benign behavior.2,6

We have reported this case because PTT is a rare tumor that can have a very alarming clinical appearance, although histologic examination and clinical follow-up show it to be benign.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

References
[1]
E. Wilson-Jones.
Proliferating epidermoid cysts.
Arch Dermatol, 94 (1966), pp. 11-19
[2]
A.K. Satyaprakash, D.J. Sheehan, O.P. Sangueza.
Proliferating trichilemmal tumors: A review of the literature.
Dermatol Surg, 33 (2007), pp. 1102-1108
[3]
A.L. Folpe, A.K. Reisenauer, T. Mentzel, A. Rütten, A.R. Solomon.
Proliferating trichilemmal tumors: Clinicopathologic evaluation is a guide to biologic behavior.
J Cutan Pathol, 30 (2003), pp. 492-498
[4]
S. Sethi, U.R. Singh.
Proliferating trichilemmal cyst: Report of two cases, one benign and the other malignant.
J Dermatol, 29 (2002), pp. 214-220
[5]
M.H. Brownstein, D.J. Arluk.
Proliferating trichilemmal cyst: A simulant of squamous cell carcinoma.
Cancer, 48 (1981), pp. 1207-1214
[6]
R.F. Morgan, A.L. Dellon, J.E. Hoopes.
Pilar tumors.
Plast Reconstr Surg, 63 (1979), pp. 520-524

Please cite this article as: Hermosa-Gelbard A, Moreno García del Real C, Vañó-Galván S. Tumoración en cuero cabelludo de gran tamaño de larga evolución con adenopatías ipsilaterales. Actas Dermosifiliogr. 2018;109:63–64.

Copyright © 2017. Elsevier España, S.L.U. and AEDV
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