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      <span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Atopic dermatitis &#40;AD&#41; is the most common inflammatory skin disease&#44; with an estimated prevalence of 10&#37; to 15&#37; in children and 2&#37; to 10&#37; in adults in the Western population&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Up to 20&#37; of cases of AD can be classified as moderate or severe according to the different clinical measurement scales&#44; the most widely used of which include the Investigator Global Assessment &#40;IGA&#41;&#44; the Eczema Area and Severity Index &#40;EASI&#41;&#44; and the SCORing Atopic Dermatitis &#40;SCORAD&#41; scale&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Clinically&#44; 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different translational studies have found the pathogenesis to pivot around Th2&#47;Th22 response throughout the entire course of the disease&#44; with a degree participation of Th17&#44; and with an additional contribution from the Th1 axis in the chronic phase&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">However&#44; the above framework is obviously a simplification&#44; and the extent of the contribution of these responses is thought to vary according to disease subtype&#46; Indeed&#44; at least 3 immunological subtypes of AD have been characterized&#46; In these subtypes&#44; of note is the contribution of the Th17 response&#44; even though substantial Th2&#47;Th22 activation is maintained&#46; These 3 subtypes are pediatric AD&#44; which shows a higher participation of innate immunity&#44; IL-9&#44; and IL-33&#59; the intrinsic variant &#40;20&#37; in adults&#41;&#44; which typically presents with normal levels of IgE and without personal or family history of atopy&#59; and finally the Asian phenotype&#44; in which phenotypes with marked lichenification or psoriasis-like phenotypes predominate&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">There are also other potential participants in the pathogenic process&#46; Thus&#44; keratinocytes are an active element and produce cytokines&#44; such as thymic stromal lymphopoietin &#40;TSLP&#41;&#44; able to induce expression of OX40&#63;L through activation of immature dendritic cells&#44; and IL-33&#44; which induces expression of OX40&#63;L through activation of type 2 innate lymphoid cells&#44; and thus amplify Th2 response&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> These are the so called alarmins&#44; an element of innate immunity and rapid and potent amplifiers of inflammatory response&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">IL-4 and IL-13 are implicated in the synthesis of IL-31&#44; a key participant in the induction of pruritus&#44; and IL-5&#44; which mediates recruitment of Th2 and eosinophils&#46; In addition&#44; pruritus leads to scratching&#44; thus facilitating skin barrier dysfunction and colonization by <span class="elsevierStyleItalic">Staphylococcus aureus</span>&#44; in turn perpetuating Th2 response and overexpression of IL-4&#44; IL-13&#44; and IL-22&#46; Greater colonization is facilitated by the lower expression of antimicrobial peptides in lesioned skin and apparently healthy skin of patients with AD&#44; also associated with the IL-4&#47;IL-13 pathway &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">In addition to identifying key molecules in the pathogenesis of AD and&#44; therefore&#44; potential therapeutic targets for specific monoclonal antibodies&#44; other molecules implicated throughout the inflammatory process have also been shown to be important&#46; Thus&#44; participation of the Janus kinase&#47;signal transducer and activator of transcription &#40;JAK-STAT&#41; pathway activated by IL-4 has also been studied in the immune dysregulation in AD&#46; The JAK family is formed of 4 members &#40;JAK1&#44; JAK2&#44; JAK3&#44; and tyrosine kinase 2 &#91;TYK2&#93;&#41; and&#44; unlike alopecia areata or psoriasis&#44; all 4 participate in AD&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> The different elements of this family form part of the numerous cytoplasmic IL receptors &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Inhibition of these molecules&#44; therefore&#44; would have an impact on numerous IL molecules implicated in Th2 response and eosinophil activation&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Better knowledge of the inflammatory pathways in AD as well as the pathways implicated in pruritus has led to the development of drugs that specifically target different cytokines as well as drugs with broad action targeting intracellular signaling&#44; with an impact on the final production of different cytokines&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Systemic Treatments</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Biologic Agents</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Th2 Cell Response Antagonists &#40;IL-4 and IL-13&#41;</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Blockade of the IL-4&#47;IL-13 Pathway</span><p id="par0050" class="elsevierStylePara elsevierViewall">IL-4 and IL-13 are key elements in Th2 response&#46; They trigger and control immune response in AD&#44; such that specific antagonism of these cytokines has revolutionized therapeutics in this disease&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Dupilumab is a monoclonal antibody that inhibits IL-4 and IL-13 by blocking the a subunit shared by the receptors of these IL molecules &#40;IL-4Ra&#41;&#46; In 2 phase <span class="elsevierStyleSmallCaps">iii</span> randomized clinical trials &#40;RCTs&#41; &#40;SOLO-1 and SOLO-2&#41;&#44; with identical design in a total of 1379 adult patients with moderate to severe AD&#44; dupilumab 300&#63;mg every 2 weeks for 16 weeks was superior to placebo for the primary outcome measure &#40;IGA of 0 or 1&#58; 38&#37; and 36&#37; for dupilumab compared with 10&#37; and 8&#37; for placebo&#44; respectively&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Dupilumab was also superior for all secondary outcome measures &#40;EASI-75&#44; reduction of pruritus&#44; symptoms of anxiety and depression&#44; quality of life&#44; and need for rescue medication&#41; compared with placebo&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a> Another phase <span class="elsevierStyleSmallCaps">iii</span> RCT has also reported positive findings for dupilumab in combination with topical corticosteroids compared with placebo after 1&#63;year of treatment &#40;EASI-75&#59; 65&#37; for dupilumab 300&#63;mg every 2 weeks compared with 22&#37; for placebo&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;001&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Two recent meta-analyses show superior efficacy of treatment compared with placebo&#44; with similar benefits for regimens of 300&#63;mg weekly or every 2 weeks&#46; The main specific adverse effects were local injection site reactions to the drug and conjuntivitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;16</span></a> At present&#44; 2 phase <span class="elsevierStyleSmallCaps">iii</span> RCTs in pediatric patients are in their final stages&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;18</span></a> In March of 2019&#44; the FDA extended the approval for dupilumab to adolescent patients aged 12 to 17 years&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Tralokinumab is a monoclonal antibody targeting IL-13&#46; It competitively blocks binding to 2 different receptors&#58; the heterodimeric receptor composed of IL-4Ra &#40;antagonized by dupilumab&#41; and IL-13Ra1&#44; and the decoy receptor IL-13Ra2&#44; which mediates endogenous regulation of IL-13&#46; This pathway enables assessment&#44; therefore&#44; of the extent to which inhibition of IL-4 may be redundant compared with IL-13 in the pathogenesis of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> In a phase <span class="elsevierStyleSmallCaps">ii</span>b RCT with 204 adults patient with moderate to severe AD&#44; administration of tralokinumab at a dose of 300&#63;mg every 2 weeks for 12 weeks achieved a decrease in EASI compared with placebo &#40;mean baseline-adjusted change of -15&#46;7&#37; vs&#46;&#63;-&#63;10&#46;8&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;011&#41; and a higher percentage of patients had IGA 0 or 1 &#40;26&#46;7 vs&#46; 11&#46;8&#37;&#41;&#46; These results also show a high response to placebo&#44; probably because of the concomitant use of topical corticosteroids in this RCT&#46; There was also a significant improvement in SCORAD&#44; the Dermatology Life Quality Index&#44; and pruritus&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Currently&#44; phase <span class="elsevierStyleSmallCaps">iii</span> RTCs are ongoing with tralokinumab in adults<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> and adolescent patients&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Lebrikizumab is another monoclonal antibody that targets IL-13&#46; It binds to soluble IL-13 and inhibits binding to IL-4Ra&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> In a phase <span class="elsevierStyleSmallCaps">II</span> RCT in 209 patients with moderate to severe AD&#44; the group treated with lebrikizumab 125&#63;mg every 4 weeks presented a greater percentage of EASI-50 responders than the placebo-treated group &#40;82&#46;4&#37; vs&#46; 62&#46;3&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;026&#41;&#46; Once again&#44; there were notable responses in the placebo group&#44; and these could be attributed to the concomitant use of topical corticosteroids&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> At present&#44; a trial is ongoing to assess efficacy at a dose of 250&#63;mg every 2 and 4 weeks&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">35</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Specific blockade of IL-13 has also been assessed in asthma&#44; with modest improvements for tralokinumab and lebrikizumab&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;27</span></a> As is the case for AD&#44; response may be greater in those patients with higher concentrations of markers related to IL-13&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> However&#44; RCTs with monotherapy are needed to assess the utility of blockade IL-13 on its own&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Blockade of Induction of Th2 Response&#58; TSLP&#44; OX40L&#44; and IL-33</span><p id="par0075" class="elsevierStylePara elsevierViewall">The Th2 axis also includes the TSLP pathway&#44; key in the interaction between the epidermis and innate and adaptive immune activation&#44; given that inflammatory response leads to an allergic phenotype through activation of immature dendritic cells that express OX40&#63;L&#44; thus permitting polarization towards a Th2 response&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> Similarly&#44; IL-33&#44; produced by epithelial cells&#44; can positively regulate the TSLP-dendritic cell-OX40&#63;L axis&#44; participating in the induction and maintenance of Th2 response&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">29&#44;30</span></a> Inhibition of this pathway could be interesting from the point of view of early treatment&#44; given its participation in initial Th2 response&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Tezepelumab is an anti-TSLP monoclonal antibody that was recently assessed in a phase <span class="elsevierStyleSmallCaps">II</span>a RCT without showing superior efficacy to placebo after 16 weeks&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> At present&#44; another dose-finding RCT is ongoing with tezepelumab &#40;NCT03809663&#41;&#46; Another molecule&#44; MK-8226&#44; antagonist of the TSLP receptor&#44; was assessed in a phase <span class="elsevierStyleSmallCaps">I</span> RCT at different intravenous doses&#59; a significant decrease in EASI at a dose of 3&#63;mg&#47;kg compared with placebo at 12 weeks was observed &#40;10&#46;20 vs&#46; 0&#46;38&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;015&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">A monoclonal antibody against OX40&#44; GBR 830&#44; has been tested at an intravenous dose of 10&#63;mg&#47;kg&#47;4 weeks for 2 months against placebo with positive results&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> At present&#44; RCTs with another OX40 inhibitor&#44; the KHK4093 molecule &#40;NCT03096223 and NCT03703102&#41;&#44; and with etokimab&#47;ANB020&#44; an anti-IL-33 antibody &#40;NCT03533751&#41; are ongoing&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Antagonism of Th22 Response</span><p id="par0090" class="elsevierStylePara elsevierViewall">Th22 lymphocytes are the main IL-22 producers and they participate in both acute and chronic forms of AD&#46; IL-22 can increase barrier dysfunction&#44; induce epidermal hyperplasia&#44; and inhibit proteins that are important in normal keratinization&#44; such as filaggrin&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">In a phase <span class="elsevierStyleSmallCaps">ii</span>a RCT&#44; the use of fezakinumab &#40;IVL-094&#41;&#44; an anti-IL-22 agent&#44; at a dose of 300&#63;mg every 2 weeks achieved an improvement &#40;measured as a decrease on SCORAD&#41;&#44; although not a significant one&#44; compared with placebo in patients with moderate to severe AD&#46; The subanalysis of patients with severe AD did show significant differences in the reduction of Body Surface Area &#40;BSA&#41; and IGA&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> The benefit achieved with this drug might be limited to patients with worse response to Th2 blockade and with higher expression of Th22&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> although the evidence to date is limited&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Antagonism of Th17 Response</span><p id="par0100" class="elsevierStylePara elsevierViewall">As mentioned earlier&#44; in the chronic phase of AD and in certain groups of patients&#44; Th2 and Th22 response is sustained&#44; but there is parallel activation of the Th1&#47;Th17 axis&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> Recently&#44; blockade of IL-17A and IL-17C has been studied&#46; Although data on inhibition of this axis in AD are still very premature&#44; development in this area is of interest given the therapeutic potential in certain AD subphenotypes&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Secukinumab&#44; a selective inhibitor of IL-17A&#44; approved in psoriasis&#44; has recently been studied in a phase <span class="elsevierStyleSmallCaps">II</span> RCT in AD &#40;NCT03533751&#41;&#44; with the induction regimen used in psoriasis and with a maintenance dose of 300&#63;mg&#47;4 weeks or intensified to 300&#63;mg&#47;2 weeks&#46; The results are pending publication&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">In addition&#44; there are ongoing studies &#40;NCT03568071&#44; NCT03689829&#44; NCT03864627&#41; with an anti-IL-17C antibody&#44; MOR106&#44; which could mediate a decrease in levels of IgE and Th2 cytokines&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Blockade of the IL-31 and OSMR&#223; Pathway &#40;Pruritus Signaling&#41;</span><p id="par0115" class="elsevierStylePara elsevierViewall">IL-31 is a cytokine produced mainly by Th2 lymphocytes and is closely linked with pruritus in different cell types&#44; including peripheral neurons&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">40&#44;41</span></a> IL-31 binds to a heterodimeric receptor composed of an IL-31 receptor a &#40;IL-31Ra&#41; and oncastatin M receptor &#223; &#40;OSMR&#223;&#41;&#46; Blockade&#44; therefore&#44; could also break the vicious circle of pruritus&#44; scratching&#44; and compromise of epidermal barrier function&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Nemolizumab blocks IL-31 receptor a &#40;IL-31Ra&#41;&#46; To date&#44; a placebo-controlled phase <span class="elsevierStyleSmallCaps">II</span> RCT in adults treated with nemolizumab &#40;dose of 0&#46;1&#63;mg&#47;kg&#44; 0&#46;5&#63;mg&#47;kg&#44; and 2&#63;mg&#47;kg every 4 weeks for 12 weeks&#41; showed decreases in pruritus&#59; however&#44; improvement on the clinical scales was not statistically significant&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">40&#44;42</span></a> Nemolizumab could be effective in reducing pruritus&#44; as well as improving daily activities and work productivity&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> with an acceptable safety profile&#46; At present&#44; a dose-finding RCT is pending completion &#40;NCT03100344&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">The phase <span class="elsevierStyleSmallCaps">I</span> RCT &#40;NCT01614756&#41; that investigated the use of an anti-IL-31 agent &#40;BMS-981164&#41; was terminated early and the results were not published&#46; It is therefore unknown whether the effects of blockade of IL-31 would be limited to an effect on the symptoms of pruritus&#44; given that there was no significant improvement in the skin inflammation outcome measures&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">In addition&#44; a phase <span class="elsevierStyleSmallCaps">I</span>a&#47;<span class="elsevierStyleSmallCaps">I</span>b RCT has been conducted with KPL-716&#44; an anti-OSMR&#223; antibody that has demonstrated an improvement in EASI and in the pruritus scales compared with placebo&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">IgE Antagonism</span><p id="par0135" class="elsevierStylePara elsevierViewall">Omalizumab&#44; an anti-IgE agent approved for the treatment of asthma&#44; has been assessed in a meta-analysis&#59; no evidence of overall effectiveness in adults with AD was found&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> Its use in pediatric patients is being assessed &#40;NCT02300701&#41;&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Small Molecules</span><p id="par0140" class="elsevierStylePara elsevierViewall">The group of small molecules includes orally administered agents that generate a broad reduction&#44; although less specific&#44; in the release of mediators&#46; This strategy has advantages in AD as&#44; unlike psoriasis&#44; there is no evidence of a key molecule involved in the pathogenesis of the disease&#46; However&#44; the lower specificity could be associated with potential issues with safety&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Inhibition of the JAK-STAT Signaling Pathway</span><p id="par0145" class="elsevierStylePara elsevierViewall">At present&#44; there are 4 orally administered JAK inhibitors under study&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Baricitinib antagonizes JAK 1 &#40;associated with modulation of the cytokines IL-4&#44; IL-6&#44; IL-10&#44; IL-13&#44; IL-31&#44; and IFN-&#63;&#41; and JAK2 &#40;which modulates the cytokines IL-5&#44; IL-6&#44; IL-23&#44; IL-31&#44; and IFN-&#63;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;46</span></a> In the first phase <span class="elsevierStyleSmallCaps">II</span> RCT&#44; administration of baricitinib at a dose of 4&#63;mg a day orally in patients with moderate to severe AD was associated with a higher proportion of patients achieving EASI-50 compared with placebo &#40;61&#37; vs&#46; 37&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;027&#41; at 16 weeks&#44; with good tolerability&#46; Adverse effects reported included asymptomatic creatine kinase elevation&#44; but there were no cases of thrombotic events or herpes zoster&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">Upadacitinib &#40;ABT-494&#41; and abrocitinib &#40;PF-04965842&#41; are selective JAK1 inhibitors&#44; and early results with these agents are promising&#46; A phase <span class="elsevierStyleSmallCaps">II</span>b RCT studied the use of upadacitinib at doses of 7&#46;5&#44; 15&#44; and 30&#63;mg compared with placebo for 16 weeks&#46; The decrease in EASI compared with baseline was 71&#37;&#44; 62&#37;&#44; and 39&#37; for the doses of 30&#44; 15&#44; and 7&#46;5&#63;mg&#44; respectively&#46; These improvements were similar to those obtained with dupilumab&#46; At present&#44; a phase <span class="elsevierStyleSmallCaps">III</span> RCT is ongoing to evaluate the efficacy of upadacitinib in adults and adolescents &#40;NCT03607422&#41;&#46; Another phase <span class="elsevierStyleSmallCaps">II</span>b RCT assessed the use of abrocitinib at doses of 10&#44; 30&#44; 100 and 200&#63;mg a day compared with placebo&#59; the reductions in EASI were only significant for the 200&#63;mg dose &#40;82&#46;6&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;\n
      &lt;!--?.001) and 100?mg dose (59%;--&gt; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;009&#41; compared with placebo &#40;35&#46;2&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> Several phase <span class="elsevierStyleSmallCaps">III</span> RCTs are ongoing with abrocitinib at doses of 100 and 200&#63;mg compared with placebo &#40;NCT03349060&#44; NCT03575871&#44; NCT03627767&#44; and NCT03422822&#41;&#44; as well as a phase <span class="elsevierStyleSmallCaps">III</span> RCT with dupilumab as the comparator &#40;NCT03720470&#41;&#46; Finally&#44; ASN002 is a dual inhibitor of the JAK and SYK pathways&#46; PAN-JAK inhibition impacts the signaling of several cytokines implicated in AD &#40;IL-4&#44; IL-13&#44; IL-31&#44; and IL-33&#41;&#44; whereas SYK inhibition suppresses signaling of proinflammatory cytokines &#40;IL-1&#223;&#44; IL-10&#44; and IL-17&#41;&#46; In the first phase <span class="elsevierStyleSmallCaps">I</span>b RCT with ASN002&#44; the percentage of patients who achieved EASI-50 at 28 days was higher than in placebo for doses of 40 and 80&#63;mg&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">Currently&#44; phase <span class="elsevierStyleSmallCaps">III</span> RCTs are ongoing with these 4 drugs&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Phosphodiesterase 4 Antagonism</span><p id="par0160" class="elsevierStylePara elsevierViewall">Recently&#44; treatment with phosphodiesterase 4 &#40;PDE4&#41;&#44; administered both topically and orally&#44; has been investigated&#46; In AD&#44; PDE4 activity in different inflammatory cells is increased compared with healthy skin&#46; PDE degrades cyclic adenosine monophosphate &#40;cAMP&#41;&#44; a molecule that in normal conditions inhibits the production of several proinflammatory cytokines such as IL-4&#44; IL-32&#44; and PGE-2&#46; PDE4 antagonism has a broad and nonspecific action&#44; as it elevates intracellular cAMP and enables a reduction in cytokine and chemokine release&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">In a phase <span class="elsevierStyleSmallCaps">II</span> study&#44; apremilast at a dose of 40&#63;mg&#47;12&#63;hours achieved a greater reduction in EASI than placebo &#40;31&#46;57&#37; vs&#46; 10&#46;98&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;034&#41;&#46; However&#44; there were no statistically significant differences in EASI-50 or pruritus&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> At present&#44; there are no new RCTs with apremilast in AD&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Histamine 4 Receptor Antagonism</span><p id="par0170" class="elsevierStylePara elsevierViewall">In recent years&#44; the role of histamine 4 receptor antagonism has been studied&#46; This could in principle not only achieve an antipruritic effect but also an anti-inflammatory one&#44; given that activation of the receptor in keratinocytes interferes in proliferation and barrier function&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">In a phase <span class="elsevierStyleSmallCaps">II</span>a RCT with the histamine 4 receptor antagonist&#44; JNJ-39758979&#44; there were significant differences in the reduction of pruritus but not EASI&#46; However&#44; this RCT was terminated early due to 2 cases of severe neutropenia&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a> Recently&#44; the results have been published of a phase <span class="elsevierStyleSmallCaps">II</span> RCT with another histamine 4 receptor antagonist&#44; ZPL-3893787&#44; with significant reductions compared with placebo for EASI but no significant decrease in pruritus&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a></p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Neurokinin 1 Receptor Blockade</span><p id="par0180" class="elsevierStylePara elsevierViewall">Substance P&#44; a mediator in pruritus&#44; binds mainly to the neurokinin 1 receptor&#44; which is expressed both in the central nervous system and in skin&#46; Thus&#44; an oral neurokinin 1 receptor antagonist such as aprepitant could potentially improve pruritus&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a> However&#44; use of this agent in AD does not seem to be beneficial&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a> Other inhibitors of the neurokinin 1 receptor&#44; tradipitant and serlopitant&#44; are under study&#44; although also with modest results&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> summarizes the main RTCs with the new systemic treatments&#44; and <a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a> show the main therapeutic targets&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Topical Treatments</span><p id="par0190" class="elsevierStylePara elsevierViewall">Despite progress in the development of systemic drugs&#44; topical treatments continue to be essential both for barrier function repair and delivery of anti-inflammatory molecules&#46; In addition to ointments&#44; corticosteroids&#44; and calcineurin inhibitors&#44; new small molecules have been developed that can be used topically&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Topical Inhibitors of JAK&#47;STAT Signaling</span><p id="par0195" class="elsevierStylePara elsevierViewall">At present&#44; topical inhibitors of the JAK&#47;STAT pathway are under investigation&#46; These include topical tofacitinib 2&#37; and ruxolitinib 1&#46;5&#37;&#44; and these agents appear to be effective at reducing EASI and pruritus&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> In a Japanese RCT&#44; a PAN-JAK inhibitor also showed improvements in EASI that were larger than with vehicle alone&#44; without significant adverse effects&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a></p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">PDE4 Topical Inhibitors</span><p id="par0200" class="elsevierStylePara elsevierViewall">Topical crisaborol 2&#37; is the first PDE4 inhibitor approved in adults and children over 2 years of age with mild to moderate AD&#46; Phase <span class="elsevierStyleSmallCaps">III</span> RCTs demonstrated significantly greater efficacy measured in terms of IGA-0 &#40;51&#46;7&#37;&#41; and IGA-1 &#40;48&#46;5&#37;&#41; compared with vehicle &#40;40&#46;6&#37; and 29&#46;7&#37;&#44; respectively&#41; at 4 weeks&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">57</span></a> Mild adverse reactions have been reported&#44; such as application-site pain or burning&#46; RCTs are ongoing with other PDE4 inhibitors&#44; such as the molecules E6005 and AN2898&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a></p><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Ominagan</span><p id="par0205" class="elsevierStylePara elsevierViewall">The decreased production of antimicrobial peptides in AD facilitates microbial colonization and infection&#44; and increases inflammatory response&#46; Ominagan&#44; is an antimicrobial peptide&#44; developed in a gel formulation&#44; that is being studied in 2 phase <span class="elsevierStyleSmallCaps">II</span> RCTs&#59; although no efficacy findings are available&#44; good tolerability of the agent has been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a></p></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Tapinarof</span><p id="par0210" class="elsevierStylePara elsevierViewall">Tapinarof is a nonsteroidal anti-inflammatory agent that acts as an agonist of the aryl hydrocarbon receptor&#44; an action which may improve barrier function and limit Th2 response&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> In a phase <span class="elsevierStyleSmallCaps">II</span> study&#44; the use of tapinarof 1&#37; twice a day showed significant differences in IGA 0-1 and reduction of EASI&#44; SCORAD&#44; and BSA&#44; compared with vehicle&#59; the drug was well tolerated and there were 2 cases of contact dermatitis out of 165 patients treated&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a></p></span><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">PR022 &#40;Hypochlorous Acid&#41;</span><p id="par0215" class="elsevierStylePara elsevierViewall">In a series of patients with AD&#44; the use of topical hypochlorous acid at 0&#46;008&#37; and 0&#46;002&#37; in a hydrogel formulation was associated with a decrease in pruritus&#46; It is thought that hypochlorous acid could lower the concentrations of different cytokines such as TNF-a&#44; IL-2&#44; IFN-&#63;&#44; and histamine&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a> A phase <span class="elsevierStyleSmallCaps">II</span> study is being conducted in adults with mild-moderate AD &#40;NCT03351777&#41;&#46;</p></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">SP14019&#47;Cyclatop</span><p id="par0220" class="elsevierStylePara elsevierViewall">SP14019&#47;cyclatop is a topical drug formulated as a cyclosporin 5&#37; spray under study in a phase <span class="elsevierStyleSmallCaps">ii</span> RCT in patients aged more than 2 years &#40;NCT02865356&#41;&#46; The results&#44; presented in the European dermatology congress in 2018&#44; showed significant benefits in EASI and IGA compared with vehicle at 4 weeks&#44; with good tolerability and limited systemic absorption&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a></p><p id="par0225" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> summarizes the topical drugs under investigation&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span></span></span></span><span id="sec0120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Conclusions</span><p id="par0230" class="elsevierStylePara elsevierViewall">In recent years&#44; a better understanding of the pathogenesis of AD extending beyond the Th2 axis has led to the development of new biologics and small molecules&#44; administered both topically and systemically&#44; that target key elements of inflammation&#46; Although psoriasis is a reference for translational medicine given its similarities with AD&#44; the results for AD are still some way off those achieved with psoriasis&#46; Currently&#44; there is still discussion as to whether the best strategy is to target specific elements of the inflammatory process via monoclonal antibodies&#44; for example dupilumab&#44; or use broader-action molecules with a less specific mechanism of action such as upadacitinib&#46; Progress in the study of new therapies and stratification of AD into different subtypes and subphenotypes in the coming years is essential to develop effective&#44; long-term treatments with an acceptable safety profile&#44; especially in the moderate to severe forms&#46;</p></span><span id="sec0125" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflicts of interest</span><p id="par0235" class="elsevierStylePara elsevierViewall">J&#46;M&#46; Carrascosa has received speaker and consultant fees from Sanofi and as an investigator in clinical trials for Sanofi&#44; Lilly&#44; Leo-Pharma&#44; Pfizer&#44; and Amgen&#46; M&#46; Munera-Campos has participated as an investigator and received fees for clinical trials sponsored by Lilly&#44; Leo-Pharma&#44; and Pfizer&#46;</p></span></span>
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          "titulo" => "Introduction"
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          "titulo" => "Pathogenesis"
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          "titulo" => "Systemic Treatments"
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              "identificador" => "sec0020"
              "titulo" => "Biologic Agents"
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                0 => array:3 [
                  "identificador" => "sec0025"
                  "titulo" => "Th2 Cell Response Antagonists &#40;IL-4 and IL-13&#41;"
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                    0 => array:2 [
                      "identificador" => "sec0030"
                      "titulo" => "Blockade of the IL-4&#47;IL-13 Pathway"
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                      "identificador" => "sec0035"
                      "titulo" => "Blockade of Induction of Th2 Response&#58; TSLP&#44; OX40L&#44; and IL-33"
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                1 => array:2 [
                  "identificador" => "sec0040"
                  "titulo" => "Antagonism of Th22 Response"
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                  "identificador" => "sec0045"
                  "titulo" => "Antagonism of Th17 Response"
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                3 => array:2 [
                  "identificador" => "sec0050"
                  "titulo" => "Blockade of the IL-31 and OSMR&#223; Pathway &#40;Pruritus Signaling&#41;"
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                  "identificador" => "sec0055"
                  "titulo" => "IgE Antagonism"
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                5 => array:2 [
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                  "titulo" => "Small Molecules"
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                  "identificador" => "sec0065"
                  "titulo" => "Inhibition of the JAK-STAT Signaling Pathway"
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                  "identificador" => "sec0070"
                  "titulo" => "Phosphodiesterase 4 Antagonism"
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                  "titulo" => "Histamine 4 Receptor Antagonism"
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                  "identificador" => "sec0080"
                  "titulo" => "Neurokinin 1 Receptor Blockade"
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                  "identificador" => "sec0085"
                  "titulo" => "Topical Treatments"
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                  "titulo" => "Topical Inhibitors of JAK&#47;STAT Signaling"
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                  "identificador" => "sec0095"
                  "titulo" => "PDE4 Topical Inhibitors"
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                      "identificador" => "sec0100"
                      "titulo" => "Ominagan"
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                      "identificador" => "sec0105"
                      "titulo" => "Tapinarof"
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                      "identificador" => "sec0110"
                      "titulo" => "PR022 &#40;Hypochlorous Acid&#41;"
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                      "identificador" => "sec0115"
                      "titulo" => "SP14019&#47;Cyclatop"
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          "identificador" => "sec0120"
          "titulo" => "Conclusions"
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          "titulo" => "Conflicts of interest"
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          "titulo" => "References"
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    "pdfFichero" => "main.pdf"
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    "fechaRecibido" => "2019-07-05"
    "fechaAceptado" => "2019-11-04"
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          "clase" => "keyword"
          "titulo" => "Keywords"
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            0 => "Atopic dermatitis"
            1 => "Pathogenesis"
            2 => "Biologics"
            3 => "Dupilumab"
            4 => "JAK"
            5 => "Topical treatment"
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          "palabras" => array:6 [
            0 => "Dermatitis at&#243;pica"
            1 => "Patogenia"
            2 => "Biol&#243;gicos"
            3 => "Dupilumab"
            4 => "JAK"
            5 => "Tratamiento t&#243;pico"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Atopic dermatitis is the most common inflammatory skin disease and up to 20&#37; of cases can be classified as moderate to severe&#46; Our understanding of the pathogenesis of this disease has improved in recent years&#46; The process is primarily driven by the Th2 pathway&#44; but with significant contributions from the Th22 pathway&#44; the Th1 and Th17 axes&#44; epidermal barrier dysfunction&#44; pruritus&#44; and JAK&#47;STAT signaling&#46; Advances in our understanding of the pathogenesis of atopic dermatitis have led to the development of new systemic treatments&#46; Of particular note are biologic agents targeting IL-4 and IL-13 &#40;e&#46; g&#46;&#44; dupilumab&#44; tralokinumab&#44; and lebrikizumab&#41; and small molecules&#44; such as JAK inhibitors &#40;e&#46; g&#46;&#44; baricitinib&#44; upadacitinib&#44; and abrocitinib&#41;&#46; Novel topical treatments include phosphodiesterase 4 and JAK&#47;STAT inhibitors&#46; In this article&#44; we review the main advances in the treatment of atopic dermatitis&#46; Characterization of clinical and molecular phenotypes with a key pathogenic role is essential for driving these advances&#46;</p></span>"
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      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">La dermatitis at&#243;pica &#40;DA&#41; es la dermatosis inflamatoria m&#225;s frecuente y hasta un 20&#37; de los casos pueden clasificarse como moderados a graves&#46; En los &#250;ltimos a&#241;os se ha producido un avance en el conocimiento de la patogenia&#44; centrada en la v&#237;a Th2&#44; pero con una participaci&#243;n marcada de la v&#237;a Th22 y de los ejes Th1 y Th17&#44; de la disfunci&#243;n de barrera epid&#233;rmica&#44; el prurito&#44;y la se&#241;alizaci&#243;n JAK&#47;STAT&#46; Este progreso ha condicionado el desarrollo de nuevas terapias sist&#233;micas&#44; entre las que destacan f&#225;rmacos biol&#243;gicos dirigidos frente a la IL-4&#47;13&#44; como dupilumab&#44; tralokinumab y lebrikizumab&#44; pero tambi&#233;n mol&#233;culas peque&#241;as&#44; como los inhibidores de JAK&#44; entre los que se incluyen baricitinib&#44; upadicitinib y abrocitinib&#46; Entre las innovaciones en los tratamientos t&#243;picos se incluyen los inhibidores de la PDE4 y de JAK&#47;STAT&#46; Este art&#237;culo repasa los principales avances terap&#233;uticos en DA&#44; para los que son esenciales la caracterizaci&#243;n de los subtipos cl&#237;nicos y moleculares clave en su patog&#233;nesis&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Munera-Campos M&#44; Carrascosa JM&#46; Innovaci&#243;n en dermatitis at&#243;pica&#58; de la patogenia a la terap&#233;utica&#46; Actas Dermosifiliogr&#46; 2020&#59;111&#58;205&#8211;221&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Biologic agents and specific targets in the pathogenesis of atopic dermatitis&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; IgE&#44; immunoglobulin E&#59; IL&#44; interleukin&#59; OSMR&#223;&#59; oncostatin M receptor &#223;&#59; Th&#44; T helper &#40;lymphocyte&#41;&#59; TSLP&#44; thymic stromal lymphopoietin&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Small Molecules and Specific Targets in the Pathogenesis of Atopic Dermatitis&#46;</p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; AC&#44; adenylyl cyclase&#59; ATP&#44; adenosine triphosphate&#59; cAMP&#44; cyclic adenosine monophosphate&#59; CREB&#44; cAMP response element-binging protein&#59; DGLA&#44; dihomo-&#63;-linolenic acid&#59; H4R&#44; histamine 4 receptor&#59; IL&#44; interleukin&#59; JAK&#44; Janus kinase&#59; &#63;OR&#44; &#63;-opioid receptor&#59; NF-&#63;B&#44; nuclear factor kappa-light-chain-enhancer of activated B cells&#59; NFAT&#44; nuclear factor of activated T-cells&#59; NK-1R&#44; neurokinin 1 receptor 1&#59; PDE4&#44; phosphodiesterase 4&#59; PGD1&#44; prostaglandin D1&#59; PGD2&#44; prostaglandin D2&#59; PGE1&#44; prostaglandin E1&#59; PKA&#44; protein kinase A&#59; STAT&#44; signal transducer and activator of transcription&#59; Th&#44; T helper &#40;lymphocyte&#41;&#59; TSLP&#44; thymic stromal lymphopoietin&#59; TYK&#44; tyrosine-kinase&#46;</p>"
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          "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#44; AD&#44; atopic dermatitis&#59; BSA Body Surface Area&#59; CsA&#44; ciclosporin A&#59; DGLA&#44; dihomo-&#63;-linoleic acid&#59; DLQI&#44; Dermatology Life Quality Index&#59; EASI&#44; Eczema Area and Severity Index&#59; GISS&#44; Global Individual Signs Score&#59; H4R&#44; histamine 4 receptor&#59; IGA&#44; Investigator Global Assessment&#59; IL&#44; interleukin&#59; IV&#44; intravenous&#59; JAK&#44; Janus kinase&#59; kOR&#44; kappa opioid receptor&#59; NKR1&#44; neurokinin receptor 1&#59; PDE4&#44; phosphodiesterase 4&#59; PO&#44; oral route&#59; SC&#44; subcutaneous&#59; SCORAD&#44; SCORing Atopic Dermatitis&#59; SD&#44; single dose&#59; Th&#44; &#40;lymphocyte&#41; T <span class="elsevierStyleItalic">helper&#59;</span> TSLP&#44; thymic stromal lymphopoietin&#59; TYK&#44; tyrosine-kinase&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Data mentioned explicitly in the table are derived from clinical trials &#40;ID&#41; with text underlined&#46;</p>"
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                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Effectiveness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Safety&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Clinical Trials &#40;ID&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Biologic Agents</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Th2 axis antagonism</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Specific IL-4&#47;IL-13 antagonism</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dupilumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-4&#44; IL-13 &#40;IL-4Ra&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">III<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1 &#40;dupilumab 300&#63;mg&#47;7&#63;d vs&#46; 300&#63;mg&#47;15&#63;d vs&#46; placebo&#41;For 16 weeks&#42;Dupilumab groups&#58; loading dose of 600&#63;mg on day 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dupilumab 300&#63;mg&#47;7&#63;d vs&#46; 300&#63;mg&#47;15&#63;d vs&#46; placeboPrimary outcome measure&#58; IGA 0-1 SOLO-1&#58; 37&#37; vs&#46; 38&#37; vs&#46; 10&#37;SOLO-2&#58; 36&#37; vs&#46; 36&#37; vs&#46; 8&#37;Significant improvement in EASI-75&#44; BSA&#44; SCORAD&#44; GISS&#44; pruritus&#44; and quality of life&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Injection site reactionsConjunctivitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02277743</span> &#40;SOLO-1&#41;<span class="elsevierStyleUnderline">NCT02277769</span> &#40;SOLO-2&#41;NCT02612454NCT03054428&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tralokinumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-13 &#40;IL-13Ra1 and IL-13Ra2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IIbIII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1&#58;1 &#40;tralokinumab 45&#44; 150&#44; and 300&#63;mg&#47;15&#63;d vs&#46; placebo&#41;Concomitant use of topical corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tralokinumab 300&#63;mg&#58; reduction in EASI &#40;mean adjusted difference&#44; -4&#46;94&#59; 95&#37; CI&#63;-&#63;8&#46;76 to -1&#46;13&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;01&#41;&#46; IGA 0-1&#58; 26&#46;7&#37; vs&#46; 11&#46;8&#37; for placebo&#46; Significant improvement in SCORAD&#44; DLQI&#44; and pruritus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Injection site reactions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02347176</span>NCT03131648NCT03160885NCT03363854NCT03526861&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lebrikizumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1&#58;1 &#40;lebrikizumab 125&#63;mg &#40;SD&#41; vs&#46; 250&#63;mg &#40;SD&#41; vs&#46; 125&#63;mg&#47;4&#63;wk vs&#46; placebo&#41;Concomitant use of topical corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Primary outcome measureEASI-50&#58; lebrikizumab 125&#63;mg&#47;4&#63;wk &#40;82&#46;4&#37;&#41; vs&#46; placebo &#40;62&#46;3&#37;&#41;&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;026&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Injection site reactionsMild herpes-like reactions&#44; peripheral eosinophilia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02340234</span>NCT03443024&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;<span class="elsevierStyleHsp" style=""></span>Antagonism of Th2 polarization&#58; TSLP&#44; OX40&#63;L&#44; and IL-33</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tezepelumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TSLP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IIaIIb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1 &#40;tezepelumab 280&#63;mg&#47;2&#63;wk vs&#46; placebo&#41;Concomitant use of topical corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EASI-50 &#40;tezepelumab 64&#46;7&#37; vs&#46; placebo 48&#46;2&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;091&#41;No statistically significant differences&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Injection site reactions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02525094</span>NCT03809663&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MK-8226&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TSLP-R&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Discontinued&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT01732510</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GBR 830&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OX40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVSC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IIaIIb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 3&#58;1GBR 830 10&#63;mg&#47;kg vs&#46; placebo days 1 and 29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Percentage of patients who achieved EASI-50 with GBR 830 superior to placebo&#44; but not statistically significant differences &#40;44&#37; vs&#46; 20&#37;&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02683928</span>NCT03568162&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>KHK4083&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OX40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">KHK-4083 0&#46;003 and 0&#46;001&#63;mg&#47;kg and ascending doses up to 10&#63;mg&#47;kg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tolerability&#44; safety&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&#46; The development of anti-KHK4083 antibodies was described&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT03096223</span>NCT03703102&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Etokinab &#40;ANB020&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Active&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Etokinab vs&#46; placebo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT03533751</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Antagonism of Th22 response</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fezakinumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 2&#58;1Fezakinumab 600&#63;mg &#40;day 0&#41;&#44; followed by 300&#63;mg&#47;2&#63;weeks &#40;last administration week 10&#41; vs&#46; placebo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Decrease in SCORAD only in the subgroup of severe AD at 12 weeks &#40;36&#46;4&#37; vs&#46; 22&#46;3&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;05&#41; and at 20 weeks &#40;46&#46;2&#37; vs&#46; 22&#46;6&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;\n
                  &lt;!--?.01). Not statistically significant overall (including moderate AD)--&gt;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nasopharyngitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT01941537</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Antagonism of Th17 and IL-23 response</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Secukinumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-17A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Study in parallel with secukinumab &#40;same regimen as for psoriasis&#41; vs&#46; placebo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Assessment at 16 weeks&#46; Results pending publication&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02594098</span>NCT03568136&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MOR106&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-17C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Active&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MOR106 at different doses vs&#46; placebo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT03568071</span>NCT03689829NCT03864627&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ustekinumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-12&#44; IL-23 &#40;p40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cross-over study with ustekinumab &#40;same regimen as for psoriasis&#41; vs&#46; placebo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Greater percentage of patients achieved SCORAD-50 response vs&#46; placebo&#44; but the difference was not statistically significant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT01806662</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Blockade of the IL-31 and OSMR&#223; pathway</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nemolizumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-31RA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1&#58;1Nemolizumab &#40;0&#46;1&#44; 0&#46;5&#44; or 2&#63;mg&#47;kg&#44; placebo&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Significant dose-dependent reductions in pruritus for nemolizumab &#40;-63&#46;1&#37; for doses of 0&#46;5&#63;mg&#47;kg vs&#46;&#63;-&#63;20&#46;9&#37;&#41;&#46; Improvement in EASI and SCORAD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Injection site reactions&#44; nasopharyngitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT01986933</span>NCT03100344&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>BMS-981164&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Discontinued&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No results available&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT01614756</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">KPL-716&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OSMR&#223;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IV&#47;SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Doses of 0&#46;3&#44; 1&#46;5&#44; and 7&#46;5&#63;mg&#47;kg vs&#46; placebo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Better outcomes for decrease in EASI and pruritus for doses of 7&#46;5&#63;mg&#47;kg vs&#46; placebo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerabilityHeadache&#44; hyporexia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mikhak et al&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">IgE or IL-5 antagonism</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Omalizumab &#40;approved for asthma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severeSevere&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IIIV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CompletedActive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OmalizumabOmalizumab vs&#46; placebo in patients aged 4 to 19 years with IgE&#63;&#62;&#63;300&#63;KU&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Results not published&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Results not published&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT01179529</span><span class="elsevierStyleUnderline">NCT02300701</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ligelizumab &#40;QGE031&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IgE &#40;higher affinity than omalizumab&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1 &#40;ligelizumab&#47;2&#63;wk vs&#46; placebo vs&#46; CsA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Results not published&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Results not published&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT01552629</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mepolizumab &#40;approved in asthma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IL-5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Discontinued &#40;futility&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mepolizumab 100&#63;mg&#47;4&#63;wk vs&#46; placebo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Early termination of trial after interim data analysis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Efficacy was not demonstrated&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT03055195</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;<span class="elsevierStyleBold">Small Molecules</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Inhibition of the JAK-STAT signaling pathway</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Baricitinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">JAK1&#44; JAK2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IIIII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CompletedActive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1 &#40;baricitinib 2&#63;mg&#44; 4&#63;mg&#44; placebo&#41; once dailyAlong with topical application of corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EASI-50&#58; higher proportion of patients for baricitinib 4&#63;mg&#47;d vs&#46; placebo &#40;61&#37; vs&#46; 37&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;027&#41; at 16 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability &#40;no cases of neoplasm or thrombotic or cardiovascular events&#41;&#44; no cases of herpes zoster&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02576938</span>NCT03334396NCT03334422NCT03334435NCT03428100NCT03435081NCT03559270NCT03733301NCT03952559&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Upadacitinib &#40;ABT-494&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">JAK1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IIbIII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CompletedActive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1&#58;1 &#40;upadacitinib 7&#46;5&#44; 15 and 30&#63;mg vs&#46; placebo&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mean reduction in EASI at 16 weeks for doses of 30&#47;15&#47;7&#46;5&#63;mg was 74&#37;&#47;62&#37;&#47;39&#37; vs&#46; placebo &#40;23&#37;&#41;&#59; <span class="elsevierStyleItalic">P</span>&#63;\n
                  &lt;!--?.05--&gt;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&#46; Upper respiratory tract infection and acne&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02925117</span>NCT03607422NCT03568318NCT03738397NCT03661138&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Abrocitinib &#40;PF-04965842&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">JAK1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IIbIII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CompletedActive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1&#58;1&#58;1 &#40;abrocitinib 10&#44; 30&#44; 100&#44; and 200&#63;mg&#44; placebo&#41; once daily&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Percentage IGA 0-1 and improvement of &#63;&#61;&#63;2 points compared with baseline&#44; significantly greater for abrocitinib 200&#63;mg&#47;d vs&#46; placebo &#40;44&#46;5&#37; vs&#46; 6&#46;3&#37;&#41; at 12 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&#44; on case of eczema herpeticum and one of pneumonia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02780167</span>NCT03349060NCT03422822NCT03575871NCT03627767NCT03720470&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ASN002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PAN-JAK &#40;JAK1&#44; JAK2&#44; JAK3&#44; TYK&#41;&#44; SYK&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1&#58;1 &#40;ASN002 20&#44; 40 and 80&#63;mg vs&#46; placebo&#41;For 28 days&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Proportion of patients who achieved EASI-75 significantly greater for ASN002 40&#63;mg &#40;71&#46;4&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;06&#41; and for ASN002 80&#63;mg &#40;33&#46;3&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;65&#41; vs&#46; placebo &#40;22&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT03139981</span>NCT03531957&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">PDE4 antagonism</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Apremilast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PDE4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parallel design 1&#58;1&#58;1&#58;1 &#40;apremilast 30&#63;mg&#47;12&#63;h&#44; 40&#63;mg&#47;12&#63;h vs&#46; placebo&#47;apremilast 30&#63;mg&#47;12&#63;h vs&#46; placebo&#47;apremilast 40&#63;mg&#47;12&#63;h&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Significant reduction in EASI compared with baseline at 12 weeks with apremilast 40&#63;mg&#47;12&#63;h vs&#46; placebo &#40;31&#46;57&#37; vs&#46; 10&#46;98&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;034&#41;&#46; No benefit in terms of EASI&#47;50 or pruritus&#46; No significant differences at 30&#63;mg&#47;12&#63;h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diarrhea&#44; nausea&#44; abdominal discomfort&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02087943</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">H4R antagonism</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">JNJ-39758979&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">H4R&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Discontinued &#40;adverse effects&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">JNJ-39758979 300 or 100&#63;mg vs&#46; placebo once daily&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Early termination of the clinical trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Two cases of neutropenia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT01497119</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ZPL389&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">H4R&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ZPL-389 30&#63;mg vs&#46; placebo once daily&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Significant improvement in EASI &#40;50&#37; vs&#46; 27&#37;&#41;&#46; No significant differences in terms of pruritus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02424253</span>NCT03517566&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">NKR1 blockade</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Serlopitant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NKR1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild&#44; moderate&#44; or severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1 &#40;serlopitant 1 and 5&#63;mg vs&#46; placebo&#41;6 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nonsignificant reduction in pruritus compared with placebo &#40;-2&#46;25 vs&#46;&#63;-&#63;2&#46;32 vs&#46;&#63;-&#63;2&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02975206</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tradipitant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NKR1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild&#44; moderate&#44; or severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IIIIIII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CompletedCompletedActive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1 &#40;tradipitant 100&#63;mg&#47;24&#63;h vs&#46; placebo&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nonsignificant reduction in pruritus compared with placeboNo other results&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02004041</span>NCT02651714NCT03568331&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">kOR agonism</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Asimadolin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">kOR agonist&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild&#44; moderate&#44; or severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1 &#40;amisadolin 2&#46;5&#63;mg&#47;12&#63;h vs&#46; placebo&#47;12&#63;h&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No results available&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No results available&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NCT02475447&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;10&#93;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Other molecules</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DS107&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DGLA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1 &#40;DS107 1&#63;g vs&#46; 2&#63;g vs&#46; placebo&#41;Once daily&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Results not published&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Results not published&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NCT02864498&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#44; ADSI Atopic Dermatitis Severity Index&#59; AhR&#44; aryl hydrocarbon receptor&#59; AMP&#44; antimicrobial peptide&#59; BSA&#44; Body Surface Area&#59; CRTH2&#44; prostaglandin 2 transmembrane receptor&#59; CsA&#44; ciclosporin A&#59; EASI&#44; Eczema Area and Severity Index&#59; IGA&#44; Investigator Global Assessment&#59; LXR&#44; liver X receptors&#59; JAK&#44; Janus kinase&#59; PDE4&#44; phosphodiesterase 4&#59; PGA&#44; physician global assessment&#59; SCORAD&#44; SCORing Atopic Dermatitis&#59; SYK&#44; spleen tyrosine kinase&#59; TEWL&#44; transepidermal water loss&#59; TrkA&#44; tyrosine receptor kinase-A&#59; VAS&#44; visual analog scale&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Data mentioned explicitly in the table are derived from clinical trials &#40;ID&#41; with text underlined&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Drug&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Therapeutic target&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Severity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Phase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Status&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Effectiveness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Safety&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Clinical trials &#40;ID&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="9" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Topical Inhibitors of JAK&#47;STAT Signaling</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tofacitinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PAN-JAK &#40;more selective JAK1 and JAK3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild to moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1Topical tofacitinib 2&#37; vs&#46; placebo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Improvement in EASI compared with baseline significantly greater than for vehicle &#40;-81&#46;7&#37; vs&#46;&#63;-&#63;29&#46;9&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;\n
                  &lt;!--?.001). Significant improvements in PGA, BSA, and pruritus--&gt;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&#46; Pain&#47;burning at injection site&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02001181</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ruxolitinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">JAK1&#44; JAK2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild to moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ruxolitinib at different concentrations vs&#46; triamcinolone 0&#46;1&#37; vs placebo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Improvement in EASI compared to baseline significantly greater than placebo for the 1&#46;5&#37; dose&#44; once or twice a day&#44; and 0&#46;5&#37; dose once a day at 4 weeks &#40;71&#46;6&#37;&#47;67&#37;&#47;52&#46;2&#37; vs&#46; 15&#46;5&#37;&#59; <span class="elsevierStyleItalic">P</span>&#63;\n
                  &lt;!--?.001)--&gt;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT03011892</span>NCT03257644NCT03745651NCT03920852&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cerdulatinib &#40;RVT-502&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PAN-JAK&#44; SYK&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Delgocitinib &#40;JTE-052&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PAN-JAK&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 2&#58;2&#58;2&#58;2&#58;1&#58;1 &#40;delgocitinib 0&#46;25&#37;&#44; 0&#46;5&#37;&#44; 1&#37;&#44; 3&#37;&#44; vehicle&#44; tacrolimus 0&#46;1&#37;&#41; twice daily&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Improvement in EASI compared to baseline for all doses of delgocitinib &#40;0&#46;25&#37;&#44; 0&#46;5&#37;&#44; 1&#37;&#44; and 3&#37;&#41; significantly greater than vehicle &#40;-41&#46;7&#37;&#44; -57&#46;1&#37;&#44; -54&#46;9&#37;&#44; -72&#46;9&#37; vs&#46; 12&#46;2&#37;&#44; respectively&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;001&#41;&#46; Reduction in pruritus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">JapicCTI-152887</span>NCT03725722NCT03826901NCT03683719&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SNA-125&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">JAK3&#44; TrkA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&#47;II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="9" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;9&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="9" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;9&#93;<span class="elsevierStyleItalic">PDE4 inhibitors</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Crisaborol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PDE4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild to moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 trials with identical intervention&#44; patients &#63;&#61;&#63;2 yearsRandomization 2&#58;1 &#40;crisaborol&#58;vehicle&#41;Application twice a day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Assessment at 4 weeks of IGA 0&#47;1&#44; with significant improvements compared with vehicle&#58; 51&#46;7&#37; vs&#46; 40&#46;6&#37;&#44; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;005&#59; 48&#46;5&#37; vs&#46; 29&#46;7&#37;&#44; <span class="elsevierStyleItalic">P</span> &nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pain&#47;burning at injection site&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02118766</span><span class="elsevierStyleUnderline">NCT02118792</span>NCT01301508NCT01602341NCT01652885NCT03233529NCT03260595NCT03250663&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>E6005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PDE4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild to moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1 &#40;E6005 0&#46;2&#37; vs&#46; vehicle&#41;Application twice a day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Assessment at week 12&#58; significant reduction in EASI compared with baseline &#40;<span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;030&#41; and SCORAD &#40;<span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT01461941</span>NCT01179880NCT02094235&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AN2898&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PDE4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild to moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comparison of AN2898 2&#37; with placebo in active lesion vs&#46; placebo in another active lesionApplication twice a day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Significant improvement in ADSI compared with baseline&#44; higher proportion of lesions with total or partial clearance of ADSI &#63;&#61;&#63;2&#59; 48&#37; vs&#46; 33&#37;&#41; in comparison with vehicle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT01301508</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MM36 &#40;OPA-15406&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PDE4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild to moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IIIII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CompletedActive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1MM36 0&#46;3&#37; vs&#46; 1&#37; vs&#46; vehicleApplication twice a day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reduction in IGA of 0&#47;1 or reduction of 2 points&#58; MM36 1&#37;&#58; 20&#46;9&#37; vs&#46; 2&#46;7&#37; for vehicle&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;0165&#41; at week 4&#46; Decrease in EASI&#58; OPA-15406 1&#37;&#58; 39&#37; vs&#46; 3&#37; for vehicle&#59; <span class="elsevierStyleItalic">P</span>&#63;&#61;&#63;&#46;005&#41; at week 2Reduction in pruritus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02068352</span>NCT02945657NCT02914548NCT03018691NCT01702181NCT02334787NCT03961529&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Roflumilast&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PDE4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IIa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1Roflumilast 0&#46;5&#37; vs&#46; vehicleApplication twice a day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No differences were observed in SCORAD&#44; pruritus &#40;VAS 100&#63;mm&#41; or TEWL at week 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT01856764</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="9" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;9&#93;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="9" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;1&#8211;9&#93;<span class="elsevierStyleItalic">Other Targets</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Omiganan&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">This is an AMP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild to moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1&#58;1 &#40;omiganan 1&#37;&#44; 1&#46;75&#37;&#44; 2&#46;5&#37;&#44; vehicle&#41;Application twice a day&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Assessment of SCORAD&#44; EASI&#44; and IGA at 7 weeks Results not published&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Results not published&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NCT03091426NCT02456480&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tapinarof &#40;GSK2894512&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AhR agonist&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1&#58;1&#58;1&#58;1 &#40;tapinarof 1&#37; twice daily&#44; 1&#37; once daily&#44; 0&#46;5&#37; twice daily&#44; 0&#46;5&#37; once daily&#44; vehicle twice daily&#44; vehicle once daily&#41;&#42;Patients aged 12-65 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Proportion of patients with IGA 0 or 1&#58; 53&#37; &#40;tapinarof 1&#37; twice daily&#41; vs&#46; 24&#37; &#40;vehicle twice daily&#41; at 12 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerabilityContact dermatitis &#40;infrequent&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02564055</span>NCT01098734NCT00837551&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PR022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypochlorous acid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild to moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Active&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1&#58;1 &#40;PR022 0&#46;05&#37;&#44; 0&#46;1&#37;&#44; vehicle&#41;For 28 days&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No results available&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No results available&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT03351777</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SP14019&#47;Cyclatop&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Topical CsA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild to moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Randomization 1&#58;1Ciclosporin 5&#37; solution vs&#46; vehicleFor 4 weeksPatients&#63;&#62;&#63;2 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Significant improvements in Cyclatop compared with vehicle in EASI &#40;51&#46;2&#37; vs&#46; 23&#46;6&#37;&#41;&#44; ADSI &#40;55&#46;4&#37; vs&#46; 34&#37;&#41;&#44; and IGA &#40;61&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02865356</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Q301&#47;Zyleuton&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CRTH2 antagonist&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Moderate to severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Randomization 1&#58;1Q301 as a cream &#40;dose not stated&#41; vs&#46; placebo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Results not published&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Results not published&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02426359</span>NCT03571620&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>VTP-38543&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">LXR agonist&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Mild to moderate&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">I&#47;II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Completed&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Randomization 1&#58;1&#58;1&#58;1&#58;1 &#40;VTP-38543 0&#46;05&#37;&#47;12&#63;h&#44; 0&#46;15&#37;&#47;12&#63;h vs&#46; vehicle without Transcutol&#47;12&#63;h&#44; vs&#46; VTP-38543 1&#37;&#47;12&#63;h vs&#46; vehicle without Transcutol&#47;12&#63;h&#41;For 28 days&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">No significant reduction in EASI or SCORAD compared with vehicle&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Good tolerability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleUnderline">NCT02655679</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Summary of the New Topical Treatments in Development and in Phases of Investigation for Atopic Dermatitis&#46;</p>"
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      "titulo" => "References"
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Información de la revista
Vol. 111. Núm. 3.
Páginas 205-221 (abril 2020)
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15653
Vol. 111. Núm. 3.
Páginas 205-221 (abril 2020)
Review
Open Access
Innovation in Atopic Dermatitis: From Pathogenesis to Treatment
Innovación en dermatitis atópica: de la patogenia a la terapéutica
Visitas
15653
M. Munera-Campos?
Autor para correspondencia
monicamunera@hotmail.com

Corresponding author.
, J.M. Carrascosa
Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain
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Table 1. Summary of the New Systemic Treatments in Development and in Phases of Investigation for Atopic Dermatitis.
Table 2. Summary of the New Topical Treatments in Development and in Phases of Investigation for Atopic Dermatitis.
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Abstract

Atopic dermatitis is the most common inflammatory skin disease and up to 20% of cases can be classified as moderate to severe. Our understanding of the pathogenesis of this disease has improved in recent years. The process is primarily driven by the Th2 pathway, but with significant contributions from the Th22 pathway, the Th1 and Th17 axes, epidermal barrier dysfunction, pruritus, and JAK/STAT signaling. Advances in our understanding of the pathogenesis of atopic dermatitis have led to the development of new systemic treatments. Of particular note are biologic agents targeting IL-4 and IL-13 (e. g., dupilumab, tralokinumab, and lebrikizumab) and small molecules, such as JAK inhibitors (e. g., baricitinib, upadacitinib, and abrocitinib). Novel topical treatments include phosphodiesterase 4 and JAK/STAT inhibitors. In this article, we review the main advances in the treatment of atopic dermatitis. Characterization of clinical and molecular phenotypes with a key pathogenic role is essential for driving these advances.

Keywords:
Atopic dermatitis
Pathogenesis
Biologics
Dupilumab
JAK
Topical treatment
Resumen

La dermatitis atópica (DA) es la dermatosis inflamatoria más frecuente y hasta un 20% de los casos pueden clasificarse como moderados a graves. En los últimos años se ha producido un avance en el conocimiento de la patogenia, centrada en la vía Th2, pero con una participación marcada de la vía Th22 y de los ejes Th1 y Th17, de la disfunción de barrera epidérmica, el prurito,y la señalización JAK/STAT. Este progreso ha condicionado el desarrollo de nuevas terapias sistémicas, entre las que destacan fármacos biológicos dirigidos frente a la IL-4/13, como dupilumab, tralokinumab y lebrikizumab, pero también moléculas pequeñas, como los inhibidores de JAK, entre los que se incluyen baricitinib, upadicitinib y abrocitinib. Entre las innovaciones en los tratamientos tópicos se incluyen los inhibidores de la PDE4 y de JAK/STAT. Este artículo repasa los principales avances terapéuticos en DA, para los que son esenciales la caracterización de los subtipos clínicos y moleculares clave en su patogénesis.

Palabras clave:
Dermatitis atópica
Patogenia
Biológicos
Dupilumab
JAK
Tratamiento tópico
Texto completo
Introduction

Atopic dermatitis (AD) is the most common inflammatory skin disease, with an estimated prevalence of 10% to 15% in children and 2% to 10% in adults in the Western population.1 Up to 20% of cases of AD can be classified as moderate or severe according to the different clinical measurement scales, the most widely used of which include the Investigator Global Assessment (IGA), the Eczema Area and Severity Index (EASI), and the SCORing Atopic Dermatitis (SCORAD) scale.2,3

Clinically, there is a notable phenotypic variability driven by a complex interaction between genetics, immune function, and the environment. In recent years, a revolution in translational research has extended knowledge of pathogenesis of AD and led to the development of new molecules targeting key inflammatory elements of the disease.

This article reviews key aspects in the pathogenesis of the disease with potential application for therapeutic targets.

Pathogenesis

AD is considered a model of imbalance between response of T helper (Th) lymphocytes 1 and 2, with predominance of Th2 response. Th2 lymphocytes produce interleukin (IL)-4 and IL-13, which inhibit the expression of filaggrin, thus establishing a relationship between immune dysfunction and disruption of barrier function typical in AD.4 In recent years, different translational studies have found the pathogenesis to pivot around Th2/Th22 response throughout the entire course of the disease, with a degree participation of Th17, and with an additional contribution from the Th1 axis in the chronic phase.5

However, the above framework is obviously a simplification, and the extent of the contribution of these responses is thought to vary according to disease subtype. Indeed, at least 3 immunological subtypes of AD have been characterized. In these subtypes, of note is the contribution of the Th17 response, even though substantial Th2/Th22 activation is maintained. These 3 subtypes are pediatric AD, which shows a higher participation of innate immunity, IL-9, and IL-33; the intrinsic variant (20% in adults), which typically presents with normal levels of IgE and without personal or family history of atopy; and finally the Asian phenotype, in which phenotypes with marked lichenification or psoriasis-like phenotypes predominate.6–8

There are also other potential participants in the pathogenic process. Thus, keratinocytes are an active element and produce cytokines, such as thymic stromal lymphopoietin (TSLP), able to induce expression of OX40?L through activation of immature dendritic cells, and IL-33, which induces expression of OX40?L through activation of type 2 innate lymphoid cells, and thus amplify Th2 response.9 These are the so called alarmins, an element of innate immunity and rapid and potent amplifiers of inflammatory response.

IL-4 and IL-13 are implicated in the synthesis of IL-31, a key participant in the induction of pruritus, and IL-5, which mediates recruitment of Th2 and eosinophils. In addition, pruritus leads to scratching, thus facilitating skin barrier dysfunction and colonization by Staphylococcus aureus, in turn perpetuating Th2 response and overexpression of IL-4, IL-13, and IL-22. Greater colonization is facilitated by the lower expression of antimicrobial peptides in lesioned skin and apparently healthy skin of patients with AD, also associated with the IL-4/IL-13 pathway (Fig. 1).4

Figure 1.

Biologic agents and specific targets in the pathogenesis of atopic dermatitis.

Abbreviations: IgE, immunoglobulin E; IL, interleukin; OSMRß; oncostatin M receptor ß; Th, T helper (lymphocyte); TSLP, thymic stromal lymphopoietin.

(0.42MB).

In addition to identifying key molecules in the pathogenesis of AD and, therefore, potential therapeutic targets for specific monoclonal antibodies, other molecules implicated throughout the inflammatory process have also been shown to be important. Thus, participation of the Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway activated by IL-4 has also been studied in the immune dysregulation in AD. The JAK family is formed of 4 members (JAK1, JAK2, JAK3, and tyrosine kinase 2 [TYK2]) and, unlike alopecia areata or psoriasis, all 4 participate in AD.10 The different elements of this family form part of the numerous cytoplasmic IL receptors (Fig. 2). Inhibition of these molecules, therefore, would have an impact on numerous IL molecules implicated in Th2 response and eosinophil activation.11

Figure 2.

Small Molecules and Specific Targets in the Pathogenesis of Atopic Dermatitis.

Abbreviations: AC, adenylyl cyclase; ATP, adenosine triphosphate; cAMP, cyclic adenosine monophosphate; CREB, cAMP response element-binging protein; DGLA, dihomo-?-linolenic acid; H4R, histamine 4 receptor; IL, interleukin; JAK, Janus kinase; ?OR, ?-opioid receptor; NF-?B, nuclear factor kappa-light-chain-enhancer of activated B cells; NFAT, nuclear factor of activated T-cells; NK-1R, neurokinin 1 receptor 1; PDE4, phosphodiesterase 4; PGD1, prostaglandin D1; PGD2, prostaglandin D2; PGE1, prostaglandin E1; PKA, protein kinase A; STAT, signal transducer and activator of transcription; Th, T helper (lymphocyte); TSLP, thymic stromal lymphopoietin; TYK, tyrosine-kinase.

(0.39MB).

Better knowledge of the inflammatory pathways in AD as well as the pathways implicated in pruritus has led to the development of drugs that specifically target different cytokines as well as drugs with broad action targeting intracellular signaling, with an impact on the final production of different cytokines.

Systemic TreatmentsBiologic AgentsTh2 Cell Response Antagonists (IL-4 and IL-13)Blockade of the IL-4/IL-13 Pathway

IL-4 and IL-13 are key elements in Th2 response. They trigger and control immune response in AD, such that specific antagonism of these cytokines has revolutionized therapeutics in this disease.

Dupilumab is a monoclonal antibody that inhibits IL-4 and IL-13 by blocking the a subunit shared by the receptors of these IL molecules (IL-4Ra). In 2 phase iii randomized clinical trials (RCTs) (SOLO-1 and SOLO-2), with identical design in a total of 1379 adult patients with moderate to severe AD, dupilumab 300?mg every 2 weeks for 16 weeks was superior to placebo for the primary outcome measure (IGA of 0 or 1: 38% and 36% for dupilumab compared with 10% and 8% for placebo, respectively).12 Dupilumab was also superior for all secondary outcome measures (EASI-75, reduction of pruritus, symptoms of anxiety and depression, quality of life, and need for rescue medication) compared with placebo.12,13 Another phase iii RCT has also reported positive findings for dupilumab in combination with topical corticosteroids compared with placebo after 1?year of treatment (EASI-75; 65% for dupilumab 300?mg every 2 weeks compared with 22% for placebo; P?=?.001).14 Two recent meta-analyses show superior efficacy of treatment compared with placebo, with similar benefits for regimens of 300?mg weekly or every 2 weeks. The main specific adverse effects were local injection site reactions to the drug and conjuntivitis.15,16 At present, 2 phase iii RCTs in pediatric patients are in their final stages.17,18 In March of 2019, the FDA extended the approval for dupilumab to adolescent patients aged 12 to 17 years.

Tralokinumab is a monoclonal antibody targeting IL-13. It competitively blocks binding to 2 different receptors: the heterodimeric receptor composed of IL-4Ra (antagonized by dupilumab) and IL-13Ra1, and the decoy receptor IL-13Ra2, which mediates endogenous regulation of IL-13. This pathway enables assessment, therefore, of the extent to which inhibition of IL-4 may be redundant compared with IL-13 in the pathogenesis of the disease.19 In a phase iib RCT with 204 adults patient with moderate to severe AD, administration of tralokinumab at a dose of 300?mg every 2 weeks for 12 weeks achieved a decrease in EASI compared with placebo (mean baseline-adjusted change of -15.7% vs.?-?10.8; P?=?.011) and a higher percentage of patients had IGA 0 or 1 (26.7 vs. 11.8%). These results also show a high response to placebo, probably because of the concomitant use of topical corticosteroids in this RCT. There was also a significant improvement in SCORAD, the Dermatology Life Quality Index, and pruritus.20 Currently, phase iii RTCs are ongoing with tralokinumab in adults21 and adolescent patients.22

Lebrikizumab is another monoclonal antibody that targets IL-13. It binds to soluble IL-13 and inhibits binding to IL-4Ra.23 In a phase II RCT in 209 patients with moderate to severe AD, the group treated with lebrikizumab 125?mg every 4 weeks presented a greater percentage of EASI-50 responders than the placebo-treated group (82.4% vs. 62.3%; P?=?.026). Once again, there were notable responses in the placebo group, and these could be attributed to the concomitant use of topical corticosteroids.24 At present, a trial is ongoing to assess efficacy at a dose of 250?mg every 2 and 4 weeks.35

Specific blockade of IL-13 has also been assessed in asthma, with modest improvements for tralokinumab and lebrikizumab.26,27 As is the case for AD, response may be greater in those patients with higher concentrations of markers related to IL-13.20 However, RCTs with monotherapy are needed to assess the utility of blockade IL-13 on its own.

Blockade of Induction of Th2 Response: TSLP, OX40L, and IL-33

The Th2 axis also includes the TSLP pathway, key in the interaction between the epidermis and innate and adaptive immune activation, given that inflammatory response leads to an allergic phenotype through activation of immature dendritic cells that express OX40?L, thus permitting polarization towards a Th2 response.28 Similarly, IL-33, produced by epithelial cells, can positively regulate the TSLP-dendritic cell-OX40?L axis, participating in the induction and maintenance of Th2 response.29,30 Inhibition of this pathway could be interesting from the point of view of early treatment, given its participation in initial Th2 response.

Tezepelumab is an anti-TSLP monoclonal antibody that was recently assessed in a phase IIa RCT without showing superior efficacy to placebo after 16 weeks.31 At present, another dose-finding RCT is ongoing with tezepelumab (NCT03809663). Another molecule, MK-8226, antagonist of the TSLP receptor, was assessed in a phase I RCT at different intravenous doses; a significant decrease in EASI at a dose of 3?mg/kg compared with placebo at 12 weeks was observed (10.20 vs. 0.38; P?=?.015).32

A monoclonal antibody against OX40, GBR 830, has been tested at an intravenous dose of 10?mg/kg/4 weeks for 2 months against placebo with positive results.33 At present, RCTs with another OX40 inhibitor, the KHK4093 molecule (NCT03096223 and NCT03703102), and with etokimab/ANB020, an anti-IL-33 antibody (NCT03533751) are ongoing.

Antagonism of Th22 Response

Th22 lymphocytes are the main IL-22 producers and they participate in both acute and chronic forms of AD. IL-22 can increase barrier dysfunction, induce epidermal hyperplasia, and inhibit proteins that are important in normal keratinization, such as filaggrin.34

In a phase iia RCT, the use of fezakinumab (IVL-094), an anti-IL-22 agent, at a dose of 300?mg every 2 weeks achieved an improvement (measured as a decrease on SCORAD), although not a significant one, compared with placebo in patients with moderate to severe AD. The subanalysis of patients with severe AD did show significant differences in the reduction of Body Surface Area (BSA) and IGA.35 The benefit achieved with this drug might be limited to patients with worse response to Th2 blockade and with higher expression of Th22,36 although the evidence to date is limited.

Antagonism of Th17 Response

As mentioned earlier, in the chronic phase of AD and in certain groups of patients, Th2 and Th22 response is sustained, but there is parallel activation of the Th1/Th17 axis.37 Recently, blockade of IL-17A and IL-17C has been studied. Although data on inhibition of this axis in AD are still very premature, development in this area is of interest given the therapeutic potential in certain AD subphenotypes.

Secukinumab, a selective inhibitor of IL-17A, approved in psoriasis, has recently been studied in a phase II RCT in AD (NCT03533751), with the induction regimen used in psoriasis and with a maintenance dose of 300?mg/4 weeks or intensified to 300?mg/2 weeks. The results are pending publication.38

In addition, there are ongoing studies (NCT03568071, NCT03689829, NCT03864627) with an anti-IL-17C antibody, MOR106, which could mediate a decrease in levels of IgE and Th2 cytokines.39

Blockade of the IL-31 and OSMRß Pathway (Pruritus Signaling)

IL-31 is a cytokine produced mainly by Th2 lymphocytes and is closely linked with pruritus in different cell types, including peripheral neurons.40,41 IL-31 binds to a heterodimeric receptor composed of an IL-31 receptor a (IL-31Ra) and oncastatin M receptor ß (OSMRß). Blockade, therefore, could also break the vicious circle of pruritus, scratching, and compromise of epidermal barrier function.

Nemolizumab blocks IL-31 receptor a (IL-31Ra). To date, a placebo-controlled phase II RCT in adults treated with nemolizumab (dose of 0.1?mg/kg, 0.5?mg/kg, and 2?mg/kg every 4 weeks for 12 weeks) showed decreases in pruritus; however, improvement on the clinical scales was not statistically significant.40,42 Nemolizumab could be effective in reducing pruritus, as well as improving daily activities and work productivity,43 with an acceptable safety profile. At present, a dose-finding RCT is pending completion (NCT03100344).

The phase I RCT (NCT01614756) that investigated the use of an anti-IL-31 agent (BMS-981164) was terminated early and the results were not published. It is therefore unknown whether the effects of blockade of IL-31 would be limited to an effect on the symptoms of pruritus, given that there was no significant improvement in the skin inflammation outcome measures.

In addition, a phase Ia/Ib RCT has been conducted with KPL-716, an anti-OSMRß antibody that has demonstrated an improvement in EASI and in the pruritus scales compared with placebo.44

IgE Antagonism

Omalizumab, an anti-IgE agent approved for the treatment of asthma, has been assessed in a meta-analysis; no evidence of overall effectiveness in adults with AD was found.45 Its use in pediatric patients is being assessed (NCT02300701).

Small Molecules

The group of small molecules includes orally administered agents that generate a broad reduction, although less specific, in the release of mediators. This strategy has advantages in AD as, unlike psoriasis, there is no evidence of a key molecule involved in the pathogenesis of the disease. However, the lower specificity could be associated with potential issues with safety.

Inhibition of the JAK-STAT Signaling Pathway

At present, there are 4 orally administered JAK inhibitors under study.11 Baricitinib antagonizes JAK 1 (associated with modulation of the cytokines IL-4, IL-6, IL-10, IL-13, IL-31, and IFN-?) and JAK2 (which modulates the cytokines IL-5, IL-6, IL-23, IL-31, and IFN-?).11,46 In the first phase II RCT, administration of baricitinib at a dose of 4?mg a day orally in patients with moderate to severe AD was associated with a higher proportion of patients achieving EASI-50 compared with placebo (61% vs. 37%; P?=?.027) at 16 weeks, with good tolerability. Adverse effects reported included asymptomatic creatine kinase elevation, but there were no cases of thrombotic events or herpes zoster.47

Upadacitinib (ABT-494) and abrocitinib (PF-04965842) are selective JAK1 inhibitors, and early results with these agents are promising. A phase IIb RCT studied the use of upadacitinib at doses of 7.5, 15, and 30?mg compared with placebo for 16 weeks. The decrease in EASI compared with baseline was 71%, 62%, and 39% for the doses of 30, 15, and 7.5?mg, respectively. These improvements were similar to those obtained with dupilumab. At present, a phase III RCT is ongoing to evaluate the efficacy of upadacitinib in adults and adolescents (NCT03607422). Another phase IIb RCT assessed the use of abrocitinib at doses of 10, 30, 100 and 200?mg a day compared with placebo; the reductions in EASI were only significant for the 200?mg dose (82.6%; P? P?=?.009) compared with placebo (35.2%).46 Several phase III RCTs are ongoing with abrocitinib at doses of 100 and 200?mg compared with placebo (NCT03349060, NCT03575871, NCT03627767, and NCT03422822), as well as a phase III RCT with dupilumab as the comparator (NCT03720470). Finally, ASN002 is a dual inhibitor of the JAK and SYK pathways. PAN-JAK inhibition impacts the signaling of several cytokines implicated in AD (IL-4, IL-13, IL-31, and IL-33), whereas SYK inhibition suppresses signaling of proinflammatory cytokines (IL-1ß, IL-10, and IL-17). In the first phase Ib RCT with ASN002, the percentage of patients who achieved EASI-50 at 28 days was higher than in placebo for doses of 40 and 80?mg.48

Currently, phase III RCTs are ongoing with these 4 drugs.

Phosphodiesterase 4 Antagonism

Recently, treatment with phosphodiesterase 4 (PDE4), administered both topically and orally, has been investigated. In AD, PDE4 activity in different inflammatory cells is increased compared with healthy skin. PDE degrades cyclic adenosine monophosphate (cAMP), a molecule that in normal conditions inhibits the production of several proinflammatory cytokines such as IL-4, IL-32, and PGE-2. PDE4 antagonism has a broad and nonspecific action, as it elevates intracellular cAMP and enables a reduction in cytokine and chemokine release.49

In a phase II study, apremilast at a dose of 40?mg/12?hours achieved a greater reduction in EASI than placebo (31.57% vs. 10.98%; P?=?.034). However, there were no statistically significant differences in EASI-50 or pruritus.50 At present, there are no new RCTs with apremilast in AD.

Histamine 4 Receptor Antagonism

In recent years, the role of histamine 4 receptor antagonism has been studied. This could in principle not only achieve an antipruritic effect but also an anti-inflammatory one, given that activation of the receptor in keratinocytes interferes in proliferation and barrier function.51

In a phase IIa RCT with the histamine 4 receptor antagonist, JNJ-39758979, there were significant differences in the reduction of pruritus but not EASI. However, this RCT was terminated early due to 2 cases of severe neutropenia.52 Recently, the results have been published of a phase II RCT with another histamine 4 receptor antagonist, ZPL-3893787, with significant reductions compared with placebo for EASI but no significant decrease in pruritus.53

Neurokinin 1 Receptor Blockade

Substance P, a mediator in pruritus, binds mainly to the neurokinin 1 receptor, which is expressed both in the central nervous system and in skin. Thus, an oral neurokinin 1 receptor antagonist such as aprepitant could potentially improve pruritus.54 However, use of this agent in AD does not seem to be beneficial.55 Other inhibitors of the neurokinin 1 receptor, tradipitant and serlopitant, are under study, although also with modest results.

Table 1 summarizes the main RTCs with the new systemic treatments, and Figs. 1 and 2 show the main therapeutic targets.

Table 1.

Summary of the New Systemic Treatments in Development and in Phases of Investigation for Atopic Dermatitis.

Drug  Therapeutic Target  Route of Administration  Severity  Phase  Status  Intervention  Effectiveness  Safety  Clinical Trials (ID) 
Biologic Agents
Th2 axis antagonism
Specific IL-4/IL-13 antagonism
Dupilumab  IL-4, IL-13 (IL-4Ra)  SC  Moderate to severe  IIIa  Completed  Randomization 1:1:1 (dupilumab 300?mg/7?d vs. 300?mg/15?d vs. placebo)For 16 weeks*Dupilumab groups: loading dose of 600?mg on day 1  Dupilumab 300?mg/7?d vs. 300?mg/15?d vs. placeboPrimary outcome measure: IGA 0-1 SOLO-1: 37% vs. 38% vs. 10%SOLO-2: 36% vs. 36% vs. 8%Significant improvement in EASI-75, BSA, SCORAD, GISS, pruritus, and quality of life  Injection site reactionsConjunctivitis  NCT02277743 (SOLO-1)NCT02277769 (SOLO-2)NCT02612454NCT03054428 
Tralokinumab  IL-13 (IL-13Ra1 and IL-13Ra2)  SC  Moderate to severe  IIbIII  Completed  Randomization 1:1:1:1 (tralokinumab 45, 150, and 300?mg/15?d vs. placebo)Concomitant use of topical corticosteroids  Tralokinumab 300?mg: reduction in EASI (mean adjusted difference, -4.94; 95% CI?-?8.76 to -1.13; P?=?.01). IGA 0-1: 26.7% vs. 11.8% for placebo. Significant improvement in SCORAD, DLQI, and pruritus  Injection site reactions  NCT02347176NCT03131648NCT03160885NCT03363854NCT03526861 
Lebrikizumab  IL-13  SC  Moderate to severe  II  Completed  Randomization 1:1:1:1 (lebrikizumab 125?mg (SD) vs. 250?mg (SD) vs. 125?mg/4?wk vs. placebo)Concomitant use of topical corticosteroids  Primary outcome measureEASI-50: lebrikizumab 125?mg/4?wk (82.4%) vs. placebo (62.3%); P?=?.026  Injection site reactionsMild herpes-like reactions, peripheral eosinophilia  NCT02340234NCT03443024 
[0,1–10]
[0,1–10]Antagonism of Th2 polarization: TSLP, OX40?L, and IL-33
Tezepelumab  TSLP  SC  Moderate to severe  IIaIIb  Completed  Randomization 1:1 (tezepelumab 280?mg/2?wk vs. placebo)Concomitant use of topical corticosteroids  EASI-50 (tezepelumab 64.7% vs. placebo 48.2%; P?=?.091)No statistically significant differences  Injection site reactions  NCT02525094NCT03809663 
MK-8226  TSLP-R  IV  Moderate to severe  Discontinued  –  –  –  NCT01732510 
GBR 830  OX40  IVSC  Moderate to severe  IIaIIb  Completed  Randomization 3:1GBR 830 10?mg/kg vs. placebo days 1 and 29  Percentage of patients who achieved EASI-50 with GBR 830 superior to placebo, but not statistically significant differences (44% vs. 20%).  Good tolerability  NCT02683928NCT03568162 
KHK4083  OX40  IV  Moderate to severe  III  Completed  KHK-4083 0.003 and 0.001?mg/kg and ascending doses up to 10?mg/kg  Tolerability, safety  Good tolerability. The development of anti-KHK4083 antibodies was described  NCT03096223NCT03703102 
Etokinab (ANB020)  IL-33  SC  Moderate to severe  II  Active  Etokinab vs. placebo  –  –  NCT03533751 
[0,1–10]
[0,1–10]Antagonism of Th22 response
Fezakinumab  IL-22  IV  Moderate to severe  II  Completed  Randomization 2:1Fezakinumab 600?mg (day 0), followed by 300?mg/2?weeks (last administration week 10) vs. placebo  Decrease in SCORAD only in the subgroup of severe AD at 12 weeks (36.4% vs. 22.3%; P?=?.05) and at 20 weeks (46.2% vs. 22.6%; P?   Nasopharyngitis  NCT01941537 
[0,1–10]
[0,1–10]Antagonism of Th17 and IL-23 response
Secukinumab  IL-17A  SC  Moderate to severe  II  Completed  Study in parallel with secukinumab (same regimen as for psoriasis) vs. placebo  Assessment at 16 weeks. Results pending publication  Good tolerability  NCT02594098NCT03568136 
MOR106  IL-17C  IV  Moderate to severe  II  Active  MOR106 at different doses vs. placebo  –  –  NCT03568071NCT03689829NCT03864627 
Ustekinumab  IL-12, IL-23 (p40)  SC  Moderate to severe  II  Completed  Cross-over study with ustekinumab (same regimen as for psoriasis) vs. placebo  Greater percentage of patients achieved SCORAD-50 response vs. placebo, but the difference was not statistically significant  Good tolerability  NCT01806662 
[0,1–10]
[0,1–10]Blockade of the IL-31 and OSMRß pathway
Nemolizumab  IL-31RA  SC  Moderate to severe  II  Completed  Randomization 1:1:1:1Nemolizumab (0.1, 0.5, or 2?mg/kg, placebo)  Significant dose-dependent reductions in pruritus for nemolizumab (-63.1% for doses of 0.5?mg/kg vs.?-?20.9%). Improvement in EASI and SCORAD  Injection site reactions, nasopharyngitis  NCT01986933NCT03100344 
BMS-981164  IL-31  SC  Moderate to severe  Discontinued    No results available    NCT01614756 
KPL-716  OSMRß  IV/SC  Moderate to severe  Ia  Completed  Doses of 0.3, 1.5, and 7.5?mg/kg vs. placebo  Better outcomes for decrease in EASI and pruritus for doses of 7.5?mg/kg vs. placebo  Good tolerabilityHeadache, hyporexia  Mikhak et al.44 
[0,1–10]
[0,1–10]IgE or IL-5 antagonism
Omalizumab (approved for asthma)  IgE  IV  Moderate to severeSevere  IIIV  CompletedActive  OmalizumabOmalizumab vs. placebo in patients aged 4 to 19 years with IgE?>?300?KU/l  Results not published–  Results not published–  NCT01179529NCT02300701 
Ligelizumab (QGE031)  IgE (higher affinity than omalizumab)  SC  Moderate to severe  II  Completed  Randomization 1:1:1 (ligelizumab/2?wk vs. placebo vs. CsA)  Results not published  Results not published  NCT01552629 
Mepolizumab (approved in asthma)  IL-5  SC  Moderate to severe  II  Discontinued (futility)  Mepolizumab 100?mg/4?wk vs. placebo  Early termination of trial after interim data analysis  Efficacy was not demonstrated.  NCT03055195 
[0,1–10]
[0,1–10]Small Molecules
[0,1–10]Inhibition of the JAK-STAT signaling pathway
Baricitinib  JAK1, JAK2  PO  Moderate to severe  IIIII  CompletedActive  Randomization 1:1:1 (baricitinib 2?mg, 4?mg, placebo) once dailyAlong with topical application of corticosteroids  EASI-50: higher proportion of patients for baricitinib 4?mg/d vs. placebo (61% vs. 37%; P?=?.027) at 16 weeks  Good tolerability (no cases of neoplasm or thrombotic or cardiovascular events), no cases of herpes zoster  NCT02576938NCT03334396NCT03334422NCT03334435NCT03428100NCT03435081NCT03559270NCT03733301NCT03952559 
Upadacitinib (ABT-494)  JAK1  PO  Moderate to severe  IIbIII  CompletedActive  Randomization 1:1:1:1 (upadacitinib 7.5, 15 and 30?mg vs. placebo)  Mean reduction in EASI at 16 weeks for doses of 30/15/7.5?mg was 74%/62%/39% vs. placebo (23%); P?   Good tolerability. Upper respiratory tract infection and acne.  NCT02925117NCT03607422NCT03568318NCT03738397NCT03661138 
Abrocitinib (PF-04965842)  JAK1  PO  Moderate to severe  IIbIII  CompletedActive  Randomization 1:1:1:1:1 (abrocitinib 10, 30, 100, and 200?mg, placebo) once daily  Percentage IGA 0-1 and improvement of ?=?2 points compared with baseline, significantly greater for abrocitinib 200?mg/d vs. placebo (44.5% vs. 6.3%) at 12 weeks  Good tolerability, on case of eczema herpeticum and one of pneumonia  NCT02780167NCT03349060NCT03422822NCT03575871NCT03627767NCT03720470 
ASN002  PAN-JAK (JAK1, JAK2, JAK3, TYK), SYK  PO  Moderate to severe  III  Completed  Randomization 1:1:1:1 (ASN002 20, 40 and 80?mg vs. placebo)For 28 days  Proportion of patients who achieved EASI-75 significantly greater for ASN002 40?mg (71.4%; P?=?.06) and for ASN002 80?mg (33.3%; P?=?.65) vs. placebo (22.2%)  Good tolerability  NCT03139981NCT03531957 
[0,1–10]
[0,1–10]PDE4 antagonism
Apremilast  PDE4  PO  Moderate to severe  II  Completed  Parallel design 1:1:1:1 (apremilast 30?mg/12?h, 40?mg/12?h vs. placebo/apremilast 30?mg/12?h vs. placebo/apremilast 40?mg/12?h)  Significant reduction in EASI compared with baseline at 12 weeks with apremilast 40?mg/12?h vs. placebo (31.57% vs. 10.98%; P?=?.034). No benefit in terms of EASI/50 or pruritus. No significant differences at 30?mg/12?h  Diarrhea, nausea, abdominal discomfort  NCT02087943 
[0,1–10]
H4R antagonism
JNJ-39758979  H4R  PO  Moderate  II  Discontinued (adverse effects)  JNJ-39758979 300 or 100?mg vs. placebo once daily  Early termination of the clinical trial  Two cases of neutropenia  NCT01497119 
ZPL389  H4R  PO  Moderate to severe  II  Completed  ZPL-389 30?mg vs. placebo once daily  Significant improvement in EASI (50% vs. 27%). No significant differences in terms of pruritus  Good tolerability  NCT02424253NCT03517566 
[0,1–10]
[0,1–10]NKR1 blockade
Serlopitant  NKR1  PO  Mild, moderate, or severe  II  Completed  Randomization 1:1:1 (serlopitant 1 and 5?mg vs. placebo)6 weeks  Nonsignificant reduction in pruritus compared with placebo (-2.25 vs.?-?2.32 vs.?-?2.01)  Good tolerability  NCT02975206 
Tradipitant  NKR1  PO  Mild, moderate, or severe  IIIIIII  CompletedCompletedActive  Randomization 1:1 (tradipitant 100?mg/24?h vs. placebo)  Nonsignificant reduction in pruritus compared with placeboNo other results  Good tolerability  NCT02004041NCT02651714NCT03568331 
[0,1–10]
kOR agonism
Asimadolin  kOR agonist  PO  Mild, moderate, or severe  II  Completed  Randomization 1:1 (amisadolin 2.5?mg/12?h vs. placebo/12?h)  No results available  No results available  NCT02475447 
[0,1–10]
[0,1–10]Other molecules
DS107  DGLA  PO  Moderate to severe  II  Completed  Randomization 1:1:1 (DS107 1?g vs. 2?g vs. placebo)Once daily  Results not published  Results not published  NCT02864498 

Abbreviations, AD, atopic dermatitis; BSA Body Surface Area; CsA, ciclosporin A; DGLA, dihomo-?-linoleic acid; DLQI, Dermatology Life Quality Index; EASI, Eczema Area and Severity Index; GISS, Global Individual Signs Score; H4R, histamine 4 receptor; IGA, Investigator Global Assessment; IL, interleukin; IV, intravenous; JAK, Janus kinase; kOR, kappa opioid receptor; NKR1, neurokinin receptor 1; PDE4, phosphodiesterase 4; PO, oral route; SC, subcutaneous; SCORAD, SCORing Atopic Dermatitis; SD, single dose; Th, (lymphocyte) T helper; TSLP, thymic stromal lymphopoietin; TYK, tyrosine-kinase.

Data mentioned explicitly in the table are derived from clinical trials (ID) with text underlined.

a

Approved in adults Extension to use in adolescents?=?12 years approved by the FDA.

Topical Treatments

Despite progress in the development of systemic drugs, topical treatments continue to be essential both for barrier function repair and delivery of anti-inflammatory molecules. In addition to ointments, corticosteroids, and calcineurin inhibitors, new small molecules have been developed that can be used topically.

Topical Inhibitors of JAK/STAT Signaling

At present, topical inhibitors of the JAK/STAT pathway are under investigation. These include topical tofacitinib 2% and ruxolitinib 1.5%, and these agents appear to be effective at reducing EASI and pruritus.46 In a Japanese RCT, a PAN-JAK inhibitor also showed improvements in EASI that were larger than with vehicle alone, without significant adverse effects.56

PDE4 Topical Inhibitors

Topical crisaborol 2% is the first PDE4 inhibitor approved in adults and children over 2 years of age with mild to moderate AD. Phase III RCTs demonstrated significantly greater efficacy measured in terms of IGA-0 (51.7%) and IGA-1 (48.5%) compared with vehicle (40.6% and 29.7%, respectively) at 4 weeks.57 Mild adverse reactions have been reported, such as application-site pain or burning. RCTs are ongoing with other PDE4 inhibitors, such as the molecules E6005 and AN2898.58

Ominagan

The decreased production of antimicrobial peptides in AD facilitates microbial colonization and infection, and increases inflammatory response. Ominagan, is an antimicrobial peptide, developed in a gel formulation, that is being studied in 2 phase II RCTs; although no efficacy findings are available, good tolerability of the agent has been reported.59

Tapinarof

Tapinarof is a nonsteroidal anti-inflammatory agent that acts as an agonist of the aryl hydrocarbon receptor, an action which may improve barrier function and limit Th2 response.60 In a phase II study, the use of tapinarof 1% twice a day showed significant differences in IGA 0-1 and reduction of EASI, SCORAD, and BSA, compared with vehicle; the drug was well tolerated and there were 2 cases of contact dermatitis out of 165 patients treated.61

PR022 (Hypochlorous Acid)

In a series of patients with AD, the use of topical hypochlorous acid at 0.008% and 0.002% in a hydrogel formulation was associated with a decrease in pruritus. It is thought that hypochlorous acid could lower the concentrations of different cytokines such as TNF-a, IL-2, IFN-?, and histamine.59 A phase II study is being conducted in adults with mild-moderate AD (NCT03351777).

SP14019/Cyclatop

SP14019/cyclatop is a topical drug formulated as a cyclosporin 5% spray under study in a phase ii RCT in patients aged more than 2 years (NCT02865356). The results, presented in the European dermatology congress in 2018, showed significant benefits in EASI and IGA compared with vehicle at 4 weeks, with good tolerability and limited systemic absorption.62

Table 2 summarizes the topical drugs under investigation.

Table 2.

Summary of the New Topical Treatments in Development and in Phases of Investigation for Atopic Dermatitis.

Drug  Therapeutic target  Severity  Phase  Status  Intervention  Effectiveness  Safety  Clinical trials (ID) 
Topical Inhibitors of JAK/STAT Signaling
Tofacitinib  PAN-JAK (more selective JAK1 and JAK3)  Mild to moderate  II  Completed  Randomization 1:1Topical tofacitinib 2% vs. placebo  Improvement in EASI compared with baseline significantly greater than for vehicle (-81.7% vs.?-?29.9%; P?   Good tolerability. Pain/burning at injection site  NCT02001181 
Ruxolitinib  JAK1, JAK2  Mild to moderate  II  Completed  Ruxolitinib at different concentrations vs. triamcinolone 0.1% vs placebo  Improvement in EASI compared to baseline significantly greater than placebo for the 1.5% dose, once or twice a day, and 0.5% dose once a day at 4 weeks (71.6%/67%/52.2% vs. 15.5%; P?   Good tolerability  NCT03011892NCT03257644NCT03745651NCT03920852 
Cerdulatinib (RVT-502)  PAN-JAK, SYK  –  –  –  –  –  – 
Delgocitinib (JTE-052)  PAN-JAK  Moderate to severe  II  Completed  Randomization 2:2:2:2:1:1 (delgocitinib 0.25%, 0.5%, 1%, 3%, vehicle, tacrolimus 0.1%) twice daily  Improvement in EASI compared to baseline for all doses of delgocitinib (0.25%, 0.5%, 1%, and 3%) significantly greater than vehicle (-41.7%, -57.1%, -54.9%, -72.9% vs. 12.2%, respectively; P?=?.001). Reduction in pruritus  Good tolerability  JapicCTI-152887NCT03725722NCT03826901NCT03683719 
SNA-125  JAK3, TrkA  –  I/II  –  –  –  –  – 
[0,1–9]
[0,1–9]PDE4 inhibitors
Crisaborol  PDE4  Mild to moderate  III  Completed  2 trials with identical intervention, patients ?=?2 yearsRandomization 2:1 (crisaborol:vehicle)Application twice a day  Assessment at 4 weeks of IGA 0/1, with significant improvements compared with vehicle: 51.7% vs. 40.6%, P?=?.005; 48.5% vs. 29.7%, P   Pain/burning at injection site  NCT02118766NCT02118792NCT01301508NCT01602341NCT01652885NCT03233529NCT03260595NCT03250663 
E6005  PDE4  Mild to moderate  II  Completed  Randomization 1:1 (E6005 0.2% vs. vehicle)Application twice a day  Assessment at week 12: significant reduction in EASI compared with baseline (P?=?.030) and SCORAD (P  Good tolerability  NCT01461941NCT01179880NCT02094235 
AN2898  PDE4  Mild to moderate  II  Completed  Comparison of AN2898 2% with placebo in active lesion vs. placebo in another active lesionApplication twice a day  Significant improvement in ADSI compared with baseline, higher proportion of lesions with total or partial clearance of ADSI ?=?2; 48% vs. 33%) in comparison with vehicle  Good tolerability  NCT01301508 
MM36 (OPA-15406)  PDE4  Mild to moderate  IIIII  CompletedActive  Randomization 1:1:1MM36 0.3% vs. 1% vs. vehicleApplication twice a day  Reduction in IGA of 0/1 or reduction of 2 points: MM36 1%: 20.9% vs. 2.7% for vehicle; P?=?.0165) at week 4. Decrease in EASI: OPA-15406 1%: 39% vs. 3% for vehicle; P?=?.005) at week 2Reduction in pruritus  Good tolerability  NCT02068352NCT02945657NCT02914548NCT03018691NCT01702181NCT02334787NCT03961529 
Roflumilast  PDE4  Moderate  IIa  Completed  Randomization 1:1Roflumilast 0.5% vs. vehicleApplication twice a day  No differences were observed in SCORAD, pruritus (VAS 100?mm) or TEWL at week 2  Good tolerability  NCT01856764 
[0,1–9]
[0,1–9]Other Targets
Omiganan  This is an AMP  Mild to moderate  II  Completed  Randomization 1:1:1:1 (omiganan 1%, 1.75%, 2.5%, vehicle)Application twice a day  Assessment of SCORAD, EASI, and IGA at 7 weeks Results not published  Results not published  NCT03091426NCT02456480 
Tapinarof (GSK2894512)  AhR agonist  Moderate to severe  II  Completed  Randomization 1:1:1:1:1:1 (tapinarof 1% twice daily, 1% once daily, 0.5% twice daily, 0.5% once daily, vehicle twice daily, vehicle once daily)*Patients aged 12-65 years  Proportion of patients with IGA 0 or 1: 53% (tapinarof 1% twice daily) vs. 24% (vehicle twice daily) at 12 weeks  Good tolerabilityContact dermatitis (infrequent)  NCT02564055NCT01098734NCT00837551 
PR022  Hypochlorous acid  Mild to moderate  II  Active  Randomization 1:1:1 (PR022 0.05%, 0.1%, vehicle)For 28 days  No results available  No results available  NCT03351777 
SP14019/Cyclatop  Topical CsA  Mild to moderate  II  Completed  Randomization 1:1Ciclosporin 5% solution vs. vehicleFor 4 weeksPatients?>?2 years  Significant improvements in Cyclatop compared with vehicle in EASI (51.2% vs. 23.6%), ADSI (55.4% vs. 34%), and IGA (61.5%)  Good tolerability  NCT02865356 
Q301/Zyleuton  CRTH2 antagonist  Moderate to severe  II  Completed  Randomization 1:1Q301 as a cream (dose not stated) vs. placebo  Results not published  Results not published  NCT02426359NCT03571620 
VTP-38543  LXR agonist  Mild to moderate  I/II  Completed  Randomization 1:1:1:1:1 (VTP-38543 0.05%/12?h, 0.15%/12?h vs. vehicle without Transcutol/12?h, vs. VTP-38543 1%/12?h vs. vehicle without Transcutol/12?h)For 28 days  No significant reduction in EASI or SCORAD compared with vehicle  Good tolerability  NCT02655679 

Abbreviations, ADSI Atopic Dermatitis Severity Index; AhR, aryl hydrocarbon receptor; AMP, antimicrobial peptide; BSA, Body Surface Area; CRTH2, prostaglandin 2 transmembrane receptor; CsA, ciclosporin A; EASI, Eczema Area and Severity Index; IGA, Investigator Global Assessment; LXR, liver X receptors; JAK, Janus kinase; PDE4, phosphodiesterase 4; PGA, physician global assessment; SCORAD, SCORing Atopic Dermatitis; SYK, spleen tyrosine kinase; TEWL, transepidermal water loss; TrkA, tyrosine receptor kinase-A; VAS, visual analog scale.

Data mentioned explicitly in the table are derived from clinical trials (ID) with text underlined.

Conclusions

In recent years, a better understanding of the pathogenesis of AD extending beyond the Th2 axis has led to the development of new biologics and small molecules, administered both topically and systemically, that target key elements of inflammation. Although psoriasis is a reference for translational medicine given its similarities with AD, the results for AD are still some way off those achieved with psoriasis. Currently, there is still discussion as to whether the best strategy is to target specific elements of the inflammatory process via monoclonal antibodies, for example dupilumab, or use broader-action molecules with a less specific mechanism of action such as upadacitinib. Progress in the study of new therapies and stratification of AD into different subtypes and subphenotypes in the coming years is essential to develop effective, long-term treatments with an acceptable safety profile, especially in the moderate to severe forms.

Conflicts of interest

J.M. Carrascosa has received speaker and consultant fees from Sanofi and as an investigator in clinical trials for Sanofi, Lilly, Leo-Pharma, Pfizer, and Amgen. M. Munera-Campos has participated as an investigator and received fees for clinical trials sponsored by Lilly, Leo-Pharma, and Pfizer.

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Please cite this article as: Munera-Campos M, Carrascosa JM. Innovación en dermatitis atópica: de la patogenia a la terapéutica. Actas Dermosifiliogr. 2020;111:205–221.

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