Información de la revista
Vol. 113. Núm. 3.
Páginas 305 (Marzo 2022)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 113. Núm. 3.
Páginas 305 (Marzo 2022)
Images in Dermatology
Open Access
Eyelid Amyloid Deposition in Systemic Light Chain Amyloidosis
Depósito de amiloides en párpados en amiloidosis de cadena ligera sistémica
Visitas
...
R. Bouceiro-Mendesa,
Autor para correspondencia
rita.bouceiro.mendes@gmail.com

Corresponding author.
, L. Soares-de-Almeidaa,b, C. Lopesc
a Dermatology Department, University Hospital Lisbon North, Lisbon, Portugal
b Molecular Medicine Institute, Lisbon Medical School, Lisbon, Portugal
c Haematology Department, University Hospital Lisbon North, Lisbon, Portugal
Contenido relaccionado
R. Bouceiro-Mendes, L. Soares-de-Almeida, C. Lopes
Información del artículo
Texto completo
Descargar PDF
Estadísticas
Figuras (1)
Texto completo

A 52-year-old women presented with a 1-year history of a slow growing yellowish and nodular plaque on the right upper eyelid (Fig. 1A). She had a recent diagnosis of bilateral carpal tunnel syndrome. Physical examination revealed a similar but more subtle lesion in the contralateral eyelid along with macroglossia and petechiae in her thighs. Using special stains, eyelid skin and tongue biopsies showed abundant amyloid deposits. Laboratory studies revealed mild normocytic anaemia, hypercreatinaemia, elevated levels of free light λ chains and a decreased serum k/λ free light chains ratio. Serum protein electrophoresis with immunofixation showed a monoclonal λ band and Bence–Jones protein was identified in the urine. Bone marrow biopsy confirmed 80% infiltration by myeloma cells. Further studies disclosed a right orbital extramedullary plasmacytoma. In one month, the eyelid plaque evolved to form an impressive mass (Fig. 1B). The patient underwent induction chemotherapy and local orbital radiotherapy with partial response. She is proposed for autologous stem cell transplantation.

Figure 1
(0,16MB).

In light chain amyloidosis the deposition of amyloid can occur in any organ including the skin. Clinicians, including dermatologists, face diagnostic challenges due to lack of awareness and clinical heterogeneity of this rare and serious condition.

Copyright © 2021. AEDV
Idiomas
Actas Dermo-Sifiliográficas

Suscríbase a la newsletter

Opciones de artículo
Herramientas
es

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?