array:24 [
  "pii" => "S0001731016000983"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2015.09.025"
  "estado" => "S300"
  "fechaPublicacion" => "2017-06-01"
  "aid" => "1378"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2016"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2017;108:e33-7"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 763
    "formatos" => array:3 [
      "EPUB" => 68
      "HTML" => 378
      "PDF" => 317
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S1578219017301385"
      "issn" => "15782190"
      "doi" => "10.1016/j.adengl.2015.09.026"
      "estado" => "S300"
      "fechaPublicacion" => "2017-06-01"
      "aid" => "1378"
      "copyright" => "Elsevier España, S.L.U. and AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2017;108:e33-7"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 970
        "formatos" => array:3 [
          "EPUB" => 45
          "HTML" => 815
          "PDF" => 110
        ]
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">e-Case Report</span>"
        "titulo" => "Dermoscopy of Disseminated Superficial Actinic Porokeratosis"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "e33"
            "paginaFinal" => "e37"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Dermatoscopia de la poroqueratosis act&#237;nica superficial diseminada"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figure 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 629
                "Ancho" => 1600
                "Tamanyo" => 124824
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic images of disseminated superficial actinic porokeratosis&#46; &#40;A&#41; Patient 5&#44; with a scar-like area&#46; &#40;B&#41; Patient 6&#44; who presented central atrophy with irregular vessels and a hyperkeratotic border&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46; Nicola, J&#46; Magliano"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Nicola"
              ]
              1 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Magliano"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0001731016000983"
          "doi" => "10.1016/j.ad.2015.09.025"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016000983?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017301385?idApp=UINPBA000044"
      "url" => "/15782190/0000010800000005/v1_201706021312/S1578219017301385/v1_201706021312/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S000173101630271X"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2016.05.020"
    "estado" => "S300"
    "fechaPublicacion" => "2017-06-01"
    "aid" => "1474"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2017;108:467-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 378
      "formatos" => array:3 [
        "EPUB" => 4
        "HTML" => 308
        "PDF" => 66
      ]
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Casos para el diagn&#243;stico</span>"
      "titulo" => "N&#243;dulo umbilical cong&#233;nito en paciente de un a&#241;o"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "467"
          "paginaFinal" => "468"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Congenital Umbilical Nodule in a 1-Year-Old Infant"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figura 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1538
              "Ancho" => 1333
              "Tamanyo" => 496703
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hematoxilina-eosina &#215;100&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46; P&#233;rez-Mesonero, V&#46; Melgar-Molero, A&#46; Mart&#237;n-Fuentes"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "P&#233;rez-Mesonero"
            ]
            1 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Melgar-Molero"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mart&#237;n-Fuentes"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1578219017300781"
        "doi" => "10.1016/j.adengl.2017.03.019"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300781?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101630271X?idApp=UINPBA000044"
    "url" => "/00017310/0000010800000005/v1_201706010052/S000173101630271X/v1_201706010052/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0001731017300753"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2017.01.014"
    "estado" => "S300"
    "fechaPublicacion" => "2017-06-01"
    "aid" => "1619"
    "copyright" => "AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2017;108:457-65"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 502
      "formatos" => array:3 [
        "EPUB" => 2
        "HTML" => 394
        "PDF" => 106
      ]
    ]
    "es" => array:14 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Angiosarcoma cut&#225;neo&#58; estudio cl&#237;nico-patol&#243;gico de 16 casos"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:3 [
        0 => "es"
        1 => "es"
        2 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "457"
          "paginaFinal" => "465"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Cutaneous Angiosarcoma&#58; Clinical and Pathology Study of 16 Cases"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 1
        "multimedia" => array:5 [
          "identificador" => "fig0040"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => false
          "mostrarDisplay" => true
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "fx1.jpeg"
              "Alto" => 833
              "Ancho" => 1333
              "Tamanyo" => 93501
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Requena, E&#46; Sendra, B&#46; Llombart, O&#46; Sanmart&#237;n, C&#46; Guill&#233;n, J&#46; Lavernia, V&#46; Traves, J&#46; Cruz"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Requena"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Sendra"
            ]
            2 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Llombart"
            ]
            3 => array:2 [
              "nombre" => "O&#46;"
              "apellidos" => "Sanmart&#237;n"
            ]
            4 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Guill&#233;n"
            ]
            5 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Lavernia"
            ]
            6 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Traves"
            ]
            7 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Cruz"
            ]
          ]
        ]
      ]
      "resumen" => array:1 [
        0 => array:3 [
          "titulo" => "Graphical abstract"
          "clase" => "graphical"
          "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0040"></elsevierMultimedia></p></span>"
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1578219017300926"
        "doi" => "10.1016/j.adengl.2017.03.032"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219017300926?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017300753?idApp=UINPBA000044"
    "url" => "/00017310/0000010800000005/v1_201706010052/S0001731017300753/v1_201706010052/es/main.assets"
  ]
  "en" => array:17 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">e-Case Report</span>"
    "titulo" => "Dermoscopy of Disseminated Superficial Actinic Porokeratosis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "e33"
        "paginaFinal" => "e37"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Nicola, J&#46; Magliano"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Nicola"
            "email" => array:1 [
              0 => "anicola33&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "J&#46;"
            "apellidos" => "Magliano"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "C&#225;tedra de Dermatolog&#237;a &#8220;Prof&#46; Miguel Mart&#237;nez&#8221;&#44; Hospital de Cl&#237;nicas &#8220;Dr&#46; Manuel Quintela&#8221;&#44; Montevideo&#44; Uruguay"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Dermatoscopia de la poroqueratosis act&#237;nica superficial diseminada"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 590
            "Ancho" => 1599
            "Tamanyo" => 131161
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic images of disseminated superficial actinic porokeratosis&#46; &#40;A&#41; Patient 1&#44; who presented central atrophy and an annular border with scales&#46; &#40;B&#41; Patient 2&#44; who presenting vascular structures with a peripheral hyperkeratotic border&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Porokeratosis &#40;PK&#41; is a group of chronic&#44; progressive disorders of keratinization that includes several subtypes with a broad clinical spectrum&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Five clinical variants of PK have been described based on different patterns of distribution&#46; PK of Mibelli&#44; disseminated superficial PK&#44; linear PK&#44; punctate palmoplantar PK&#44; and disseminated superficial actinic PK &#40;DSAP&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">2&#44;3</span></a> An eruptive form of PK with a rapidly progressive clinical course has also been described&#44; with lesions affecting the entire skin surface&#46; This form of porokeratosis has been associated with malignancies&#44; immunosuppression&#44; and proinflammatory states&#44; although the small number of reported cases makes relationships difficult to demonstrate&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> Other proposed variants include malignant disseminated PK&#44; PK plantaris discreta&#44; and reticular PK&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">DSAP is the most common clinical subtype&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">2&#44;6&#44;7</span></a> It is a chronic&#44; autosomal dominant disease characterized by multiple erythematous-to-brownish papules and annular plaques with a well-defined hyperkeratotic border around a sometimes atrophic central area&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">5&#44;8</span></a> Lesions usually start to appear in adolescence&#44; in exposed areas&#59; complete penetrance is reached in the third or fourth decade of life&#46; The disease is rare in black individuals and in the elderly&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">1&#44;5</span></a> Histopathology shows a narrow column of parakeratotic cells&#44; the cornoid lamella&#44; extending through the stratum corneum&#46; This correlates clinically with the raised hyperkeratotic border&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">2&#44;6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The dermoscopic features of DSAP suggest the diagnosis&#46; We describe a series of 6 patients in which we detected several dermoscopic features associated with DSAP that are useful for diagnosis and follow-up&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case descriptions</span><p id="par0025" class="elsevierStylePara elsevierViewall">The clinical findings of each case are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The following dermoscopic alterations were observed&#58; in case 1&#44; a central area of atrophy was surrounded by an annular border with scales &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#59; in case 2&#44; the lesions presented vascular structures and a hyperkeratotic border &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#59; brownish dots and central atrophy were observed in case 3 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#59; central hairpin vessels were seen crossing the plaques in case 4 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#59; in case 5 there was a scar-like area &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#41;&#59; and in case 6&#44; irregular vessels were visible in a central area of atrophy surrounded by a hyperkeratotic border &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Biopsy was performed in all patients to confirm the diagnosis of DSAP&#46; At the time of writing&#44; the clinical and dermoscopic follow-up had been of 18&#8211;36 months&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Porokeratosis is a group of disorders in which there is a disturbance of keratinization&#46; DSAP typically affects sun-exposed areas&#44; suggesting that UV radiation may be the most important extrinsic factor&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Although the aetiology is unknown&#44; recent studies have suggested a mutation of the mevalonate kinase &#40;<span class="elsevierStyleItalic">MVK</span>&#41; gene on chromosome 12q24 as the cause of DSAP&#46; This mutation has been detected in several patients diagnosed with DSAP&#44; but because of the few cases that have been reported&#44; the exact causes of the gene mutation are unknown&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Mevalonate kinase&#44; encoded by the <span class="elsevierStyleItalic">MVK</span> gene&#44; is an enzyme involved in cholesterol synthesis&#46; Overexpression of this protein promotes differentiation of keratinocytes that produce type 1 keratin&#46; The expression of this protein protects keratinocytes from UV-A-induced apoptosis&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> DSAP is primarily associated with UV radiation and immunosuppression&#44; but also occurs in organ transplants recipients&#44; patients with psoriasis&#44; or after the administration of thiazides &#40;phototoxic drugs&#41;&#44; and in several cases has been related to primary lymphedema&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;6&#44;8</span></a> The malignant potential&#44; thought to be due to overexpression of p53 protein&#44; must be taken into consideration as there is an association with squamous cell carcinoma&#44; basal cell carcinoma&#44; and Bowen disease&#46; The risk of malignant transformation appears to be higher with a longstanding history of injuries&#44; in larger lesions&#44; and in elderly or immunocompromised patients&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The diverse clinical presentations represent different phenotypic expressions of the same genetic alteration due to the coexistence of distinct types of porokeratosis in the same patient or in different members of a single family&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">5&#44;7</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Porokeratosis presents clinically as annular erythematous-to-brownish lesions surrounded by a hyperkeratotic border which corresponds to the typical histopathologic feature&#44; the cornoid lamella&#46; The cornoid lamella is a column of parakeratotic cells located in a depression in the epidermis where the granular layer is absent&#59; it is a characteristic but not pathognomonic sign of porokeratosis&#46; All forms of porokeratosis have similar histopathologic features&#46; A further important histologic finding observed in most cases is the presence of dyskeratotic keratinocytes and a mild dermal inflammatory infiltrate composed of plasma cells and occasional granulocytes&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">2&#44;3</span></a> Dermoscopy is of recognized value in the differentiation of erythematous diseases with similar clinical features&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> In DSAP&#44; dermoscopy is useful because it reveals specific diagnostic criteria&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">9&#44;10</span></a> The dermoscopic findings in the 6 patients analyzed match those already reported in the literature &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; UV dermoscopy highlights the hyperkeratotic border&#44; which glints&#44; resembling a diamond necklace&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> Ink has been used to stain porokeratosis lesions&#44; revealing large pores with keratotic plugs&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">The treatment of DSAP by excisional surgery is impractical in the majority of cases&#46; However&#44; given its potential for malignant transformation&#44; dermoscopic monitoring of lesions enables early treatment to be provided when necessary&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Several treatments have been proposed&#44; but they are unsatisfactory in most cases and none is globally effective&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">5&#44;8</span></a> The need for meticulous sun protection&#44; emollients&#44; and monitoring due to the risk of malignant transformation are key elements of therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a> Use of the different modalities to treat a purely cosmetic alteration&#44; such as DSAP&#44; is questionable&#46; Proposed treatments include 5-fluorouracil&#44; imiquimod&#44; vitamin D analogues&#44; and cryotherapy&#59; recent descriptions of photodynamic therapy with topical hypericin have reported variable degrees of success&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">2&#44;5</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">In conclusion&#44; dermoscopy is a rapid technique that can help to improve the clinical diagnosis of DSAP&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">2&#44;3</span></a> In view of the extensive therapeutic arsenal and the variable results&#44; it is important to reach a correct diagnosis&#46; Dermoscopic monitoring should be performed because of the risk of malignant transformation&#44; especially into squamous cell carcinoma&#44; with a reported incidence between 3&#46;4&#37; and 11&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">We have highlighted the value of dermoscopic evaluation in cases in which the clinical features are consistent with a diagnosis of porokeratosis&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Protection of human and animal subjects</span><p id="par0095" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed were in accordance with the regulations of the responsible Clinical Research Ethics Committee and in accordance with those of the World Medical Association and the Helsinki Declaration&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Confidentiality of data</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work centre on the publication of patient data&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Right to privacy and informed consent</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors must have obtained the informed consent of the patients and&#47;or subjects mentioned in the article&#46; The author for correspondence must be in possession of this document&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflict of interest</span><p id="par0115" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres845671"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec840478"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres845670"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec840477"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Case descriptions"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:3 [
          "identificador" => "sec0020"
          "titulo" => "Ethical disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        8 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Conflict of interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec840478"
          "palabras" => array:3 [
            0 => "Disseminated superficial actinic porokeratosis"
            1 => "Porokeratosis"
            2 => "Dermoscopy"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec840477"
          "palabras" => array:3 [
            0 => "Poroqueratosis act&#237;nica superficial diseminada"
            1 => "Poroqueratosis"
            2 => "Dermatoscopia"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We present a series of 6 cases of disseminated superficial actinic porokeratosis and describe their dermoscopic features&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopy is a noninvasive in vivo technique that is useful as a tool for the diagnosis and follow-up of porokeratosis&#46; This condition has specific dermoscopic features that were observed in our series of cases and that are consistent with reports in the international literature&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Presentamos una serie de 6 casos de poroqueratosis act&#237;nica superficial diseminada en los cuales se describen las caracter&#237;sticas dermatosc&#243;picas halladas en cada uno de ellos&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La dermatoscopia es una t&#233;cnica no invasiva in vivo &#250;til como herramienta diagn&#243;stica y de seguimiento en la poroqueratosis ya que se describen elementos dermatosc&#243;picos espec&#237;ficos de esta entidad observados en nuestra serie de casos&#44; que concuerdan con lo comunicado en la literatura internacional&#46;</p></span>"
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 590
            "Ancho" => 1599
            "Tamanyo" => 131161
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic images of disseminated superficial actinic porokeratosis&#46; &#40;A&#41; Patient 1&#44; who presented central atrophy and an annular border with scales&#46; &#40;B&#41; Patient 2&#44; who presenting vascular structures with a peripheral hyperkeratotic border&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 669
            "Ancho" => 1600
            "Tamanyo" => 139634
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic images of disseminated superficial actinic porokeratosis&#46; &#40;A&#41; Brownish dots and central atrophy visible in patient 3&#46; &#40;B&#41; Patient 4&#44; showing hairpin vessels crossing the lesion&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 629
            "Ancho" => 1600
            "Tamanyo" => 124824
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic images of disseminated superficial actinic porokeratosis&#46; &#40;A&#41; Patient 5&#44; with a scar-like area&#46; &#40;B&#41; Patient 6&#44; who presented central atrophy with irregular vessels and a hyperkeratotic border&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>&#58; F&#44; female&#59; M&#44; male&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Phototype&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Relevant past history&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Disease duration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Symptoms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Site&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Clinical findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Dermoscopy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pruritus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sun exposed areas of upper limbs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Multiple&#44; well-defined&#44; slightly erythematous papules with peripheral enhancement&#46; Fine pigmented desquamation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Occupational sun exposure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sun exposed areas of lower limbs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Same clinical features as patient 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pruritus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sun exposed areas of upper and lower limbs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Erythematous-to-brownish papules with fine scales and pale central area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Asthma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sun exposed areas of both lower limbs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Erythematous and brown plaques with fine peripheral scales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Upper limbs and upper back&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Brown-to-grey plaques of 1-cm diameter&#44; with a raised scaly grey border and a hypopigmented central area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sun exposed areas of the limbs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Same clinical features as patient 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1428058.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Clinical details of the case series&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">White peripheral border also more prosaically known as <span class="elsevierStyleItalic">lines of volcanic crater seen from above</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Homogeneous central white scar-like area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Brownish globules or dots&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vascular structures&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>- pinpoint vessels&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>- irregular linear vessels crossing the lesion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1428057.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic features of disseminated superficial actinic porokeratosis&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Late-onset disseminated superficial actinic porokeratosis in an elderly woman"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Khaled"
                            1 => "M&#46; Kourda"
                            2 => "F&#46; Abdelmoula"
                            3 => "L&#46; M&#39;ssedi"
                            4 => "M&#46;N&#46; Tougourti"
                            5 => "M&#46;R&#46; Kamoun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther"
                        "fecha" => "2011"
                        "volumen" => "1"
                        "paginaInicial" => "15"
                        "paginaFinal" => "19"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermoscopy for the diagnosis of porokeratosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Delfino"
                            1 => "G&#46; Argenziano"
                            2 => "M&#46; Nino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2004"
                        "volumen" => "18"
                        "paginaInicial" => "194"
                        "paginaFinal" => "195"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15009303"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disseminated superficial actinic porokeratosis diagnosed by dermoscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "V&#46; Panasiti"
                            1 => "M&#46; Rossi"
                            2 => "M&#46; Curzio"
                            3 => "F&#46; Bruni"
                            4 => "S&#46; Calvieri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-4632.2008.03379.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "2008"
                        "volumen" => "47"
                        "paginaInicial" => "308"
                        "paginaFinal" => "310"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18289344"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eruptive disseminated porokeratosis&#58; a new classification system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Shoimer"
                            1 => "L&#46;H&#46; Robertson"
                            2 => "G&#46; Storwick"
                            3 => "R&#46;M&#46; Haber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2014.04.034"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2014"
                        "volumen" => "71"
                        "paginaInicial" => "398"
                        "paginaFinal" => "400"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25037793"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disseminated superficial actinic porokeratosis&#58; a clinical study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;P&#46; Shumack"
                            1 => "C&#46;A&#46; Commens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1998"
                        "volumen" => "20"
                        "paginaInicial" => "1015"
                        "paginaFinal" => "1022"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2754051"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0886335009007457"
                          "estado" => "S300"
                          "issn" => "08863350"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Poroqueratosis act&#237;nica superficial diseminada asociada a linfedema cr&#243;nico primario"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;T&#46; Bordel"
                            1 => "G&#46; Mart&#237;nez"
                            2 => "A&#46; Miranda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2004"
                        "volumen" => "95"
                        "paginaInicial" => "113"
                        "paginaFinal" => "116"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A novel MVK gene mutation in a Chinese patient with disseminated superficial actinic porokeratosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Xu"
                            1 => "X&#46; Fu"
                            2 => "B&#46; Yang"
                            3 => "H&#46; Liu"
                            4 => "F&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Sin"
                        "fecha" => "2015"
                        "volumen" => "33"
                        "paginaInicial" => "45"
                        "paginaFinal" => "46"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Topical treatment of disseminated superficial actinic porokeratosis with hypericin-photodynamic therapy&#58; a case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Boiy"
                            1 => "P&#46;A&#46;M&#46; de Witte"
                            2 => "R&#46; Roelandts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Photodiagn Photodyn"
                        "fecha" => "2010"
                        "volumen" => "7"
                        "paginaInicial" => "123"
                        "paginaFinal" => "125"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermoscopy and confocal microscopy clues in the diagnosis of psoriasis and porokeratosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; Moscarella"
                            1 => "C&#46; Longo"
                            2 => "I&#46; Zalaudek"
                            3 => "G&#46; Argenziano"
                            4 => "S&#46; Piana"
                            5 => "A&#46; Lallas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2013.06.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2013"
                        "volumen" => "69"
                        "paginaInicial" => "e231"
                        "paginaFinal" => "e233"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24124843"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Diamond necklace&#8221; appearance in superficial porokeratosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;S&#46; Thatte"
                            1 => "V&#46;D&#46; Kharkar"
                            2 => "U&#46;S&#46; Khopkar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2013.12.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2014"
                        "volumen" => "70"
                        "paginaInicial" => "e125"
                        "paginaFinal" => "e126"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24831329"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Open pores with plugs in porokeratosis clearly visualized with dermoscopy furrow ink test&#58; report of 3 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46; Uhara"
                            1 => "F&#46; Kamijo"
                            2 => "R&#46; Okuyama"
                            3 => "T&#46; Saida"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archdermatol.2011.174"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dermatol"
                        "fecha" => "2011"
                        "volumen" => "147"
                        "paginaInicial" => "866"
                        "paginaFinal" => "867"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21768494"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000010800000005/v1_201706010052/S0001731016000983/v1_201706010052/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "24962"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "e-Casos cl&#237;nicos"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000010800000005/v1_201706010052/S0001731016000983/v1_201706010052/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016000983?idApp=UINPBA000044"
]
Compartir
Información de la revista
Vol. 108. Núm. 5.
Páginas e33-e37 (junio 2017)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Visitas
6066
Vol. 108. Núm. 5.
Páginas e33-e37 (junio 2017)
e-Case Report
Acceso a texto completo
Dermoscopy of Disseminated Superficial Actinic Porokeratosis
Dermatoscopia de la poroqueratosis actínica superficial diseminada
Visitas
6066
A. Nicola
Autor para correspondencia
anicola33@hotmail.com

Corresponding author.
, J. Magliano
Cátedra de Dermatología “Prof. Miguel Martínez”, Hospital de Clínicas “Dr. Manuel Quintela”, Montevideo, Uruguay
Este artículo ha recibido
Información del artículo
Resumen
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Figuras (3)
Mostrar másMostrar menos
Tablas (2)
Table 1. Clinical details of the case series.
Table 2. Dermoscopic features of disseminated superficial actinic porokeratosis.
Mostrar másMostrar menos
Abstract

We present a series of 6 cases of disseminated superficial actinic porokeratosis and describe their dermoscopic features.

Dermoscopy is a noninvasive in vivo technique that is useful as a tool for the diagnosis and follow-up of porokeratosis. This condition has specific dermoscopic features that were observed in our series of cases and that are consistent with reports in the international literature.

Keywords:
Disseminated superficial actinic porokeratosis
Porokeratosis
Dermoscopy
Resumen

Presentamos una serie de 6 casos de poroqueratosis actínica superficial diseminada en los cuales se describen las características dermatoscópicas halladas en cada uno de ellos.

La dermatoscopia es una técnica no invasiva in vivo útil como herramienta diagnóstica y de seguimiento en la poroqueratosis ya que se describen elementos dermatoscópicos específicos de esta entidad observados en nuestra serie de casos, que concuerdan con lo comunicado en la literatura internacional.

Palabras clave:
Poroqueratosis actínica superficial diseminada
Poroqueratosis
Dermatoscopia
Texto completo
Introduction

Porokeratosis (PK) is a group of chronic, progressive disorders of keratinization that includes several subtypes with a broad clinical spectrum.1

Five clinical variants of PK have been described based on different patterns of distribution. PK of Mibelli, disseminated superficial PK, linear PK, punctate palmoplantar PK, and disseminated superficial actinic PK (DSAP).2,3 An eruptive form of PK with a rapidly progressive clinical course has also been described, with lesions affecting the entire skin surface. This form of porokeratosis has been associated with malignancies, immunosuppression, and proinflammatory states, although the small number of reported cases makes relationships difficult to demonstrate.4 Other proposed variants include malignant disseminated PK, PK plantaris discreta, and reticular PK.5

DSAP is the most common clinical subtype.2,6,7 It is a chronic, autosomal dominant disease characterized by multiple erythematous-to-brownish papules and annular plaques with a well-defined hyperkeratotic border around a sometimes atrophic central area.5,8 Lesions usually start to appear in adolescence, in exposed areas; complete penetrance is reached in the third or fourth decade of life. The disease is rare in black individuals and in the elderly.1,5 Histopathology shows a narrow column of parakeratotic cells, the cornoid lamella, extending through the stratum corneum. This correlates clinically with the raised hyperkeratotic border.2,6

The dermoscopic features of DSAP suggest the diagnosis. We describe a series of 6 patients in which we detected several dermoscopic features associated with DSAP that are useful for diagnosis and follow-up.

Case descriptions

The clinical findings of each case are summarized in Table 1. The following dermoscopic alterations were observed: in case 1, a central area of atrophy was surrounded by an annular border with scales (Fig. 1A); in case 2, the lesions presented vascular structures and a hyperkeratotic border (Fig. 1B); brownish dots and central atrophy were observed in case 3 (Fig. 2A); central hairpin vessels were seen crossing the plaques in case 4 (Fig. 2B); in case 5 there was a scar-like area (Fig. 3A); and in case 6, irregular vessels were visible in a central area of atrophy surrounded by a hyperkeratotic border (Fig. 3B).

Table 1.

Clinical details of the case series.

Patient  Sex  Age, y  Phototype  Relevant past history  Disease duration  Symptoms  Site  Clinical findings  Dermoscopy 
45  II  No  5 years  Pruritus  Sun exposed areas of upper limbs  Multiple, well-defined, slightly erythematous papules with peripheral enhancement. Fine pigmented desquamation  Fig. 1
37  III  Occupational sun exposure  6 months  No  Sun exposed areas of lower limbs  Same clinical features as patient 1  Fig. 1
51  III  Smoker  Unknown  Pruritus  Sun exposed areas of upper and lower limbs  Erythematous-to-brownish papules with fine scales and pale central area  Fig. 2
62  II  Asthma  18 months  No  Sun exposed areas of both lower limbs  Erythematous and brown plaques with fine peripheral scales  Fig. 2
55  II  No  2 years  No  Upper limbs and upper back  Brown-to-grey plaques of 1-cm diameter, with a raised scaly grey border and a hypopigmented central area  Fig. 3
58  II  No  Unknown  No  Sun exposed areas of the limbs  Same clinical features as patient 4  Fig. 3

Abbreviations: F, female; M, male.

Figure 1.

Dermoscopic images of disseminated superficial actinic porokeratosis. (A) Patient 1, who presented central atrophy and an annular border with scales. (B) Patient 2, who presenting vascular structures with a peripheral hyperkeratotic border.

(0.13MB).
Figure 2.

Dermoscopic images of disseminated superficial actinic porokeratosis. (A) Brownish dots and central atrophy visible in patient 3. (B) Patient 4, showing hairpin vessels crossing the lesion.

(0.13MB).
Figure 3.

Dermoscopic images of disseminated superficial actinic porokeratosis. (A) Patient 5, with a scar-like area. (B) Patient 6, who presented central atrophy with irregular vessels and a hyperkeratotic border.

(0.12MB).

Biopsy was performed in all patients to confirm the diagnosis of DSAP. At the time of writing, the clinical and dermoscopic follow-up had been of 18–36 months.

Discussion

Porokeratosis is a group of disorders in which there is a disturbance of keratinization. DSAP typically affects sun-exposed areas, suggesting that UV radiation may be the most important extrinsic factor.3,6

Although the aetiology is unknown, recent studies have suggested a mutation of the mevalonate kinase (MVK) gene on chromosome 12q24 as the cause of DSAP. This mutation has been detected in several patients diagnosed with DSAP, but because of the few cases that have been reported, the exact causes of the gene mutation are unknown.6,7

Mevalonate kinase, encoded by the MVK gene, is an enzyme involved in cholesterol synthesis. Overexpression of this protein promotes differentiation of keratinocytes that produce type 1 keratin. The expression of this protein protects keratinocytes from UV-A-induced apoptosis.7 DSAP is primarily associated with UV radiation and immunosuppression, but also occurs in organ transplants recipients, patients with psoriasis, or after the administration of thiazides (phototoxic drugs), and in several cases has been related to primary lymphedema.3,6,8 The malignant potential, thought to be due to overexpression of p53 protein, must be taken into consideration as there is an association with squamous cell carcinoma, basal cell carcinoma, and Bowen disease. The risk of malignant transformation appears to be higher with a longstanding history of injuries, in larger lesions, and in elderly or immunocompromised patients.6

The diverse clinical presentations represent different phenotypic expressions of the same genetic alteration due to the coexistence of distinct types of porokeratosis in the same patient or in different members of a single family.5,7

Porokeratosis presents clinically as annular erythematous-to-brownish lesions surrounded by a hyperkeratotic border which corresponds to the typical histopathologic feature, the cornoid lamella. The cornoid lamella is a column of parakeratotic cells located in a depression in the epidermis where the granular layer is absent; it is a characteristic but not pathognomonic sign of porokeratosis. All forms of porokeratosis have similar histopathologic features. A further important histologic finding observed in most cases is the presence of dyskeratotic keratinocytes and a mild dermal inflammatory infiltrate composed of plasma cells and occasional granulocytes.2,3 Dermoscopy is of recognized value in the differentiation of erythematous diseases with similar clinical features.9 In DSAP, dermoscopy is useful because it reveals specific diagnostic criteria.9,10 The dermoscopic findings in the 6 patients analyzed match those already reported in the literature (Table 2). UV dermoscopy highlights the hyperkeratotic border, which glints, resembling a diamond necklace.10 Ink has been used to stain porokeratosis lesions, revealing large pores with keratotic plugs.11

Table 2.

Dermoscopic features of disseminated superficial actinic porokeratosis.

White peripheral border also more prosaically known as lines of volcanic crater seen from above 
Homogeneous central white scar-like area 
Brownish globules or dots 
Vascular structures: 
- pinpoint vessels 
- irregular linear vessels crossing the lesion 

The treatment of DSAP by excisional surgery is impractical in the majority of cases. However, given its potential for malignant transformation, dermoscopic monitoring of lesions enables early treatment to be provided when necessary.

Several treatments have been proposed, but they are unsatisfactory in most cases and none is globally effective.5,8 The need for meticulous sun protection, emollients, and monitoring due to the risk of malignant transformation are key elements of therapy.5 Use of the different modalities to treat a purely cosmetic alteration, such as DSAP, is questionable. Proposed treatments include 5-fluorouracil, imiquimod, vitamin D analogues, and cryotherapy; recent descriptions of photodynamic therapy with topical hypericin have reported variable degrees of success.2,5

In conclusion, dermoscopy is a rapid technique that can help to improve the clinical diagnosis of DSAP.2,3 In view of the extensive therapeutic arsenal and the variable results, it is important to reach a correct diagnosis. Dermoscopic monitoring should be performed because of the risk of malignant transformation, especially into squamous cell carcinoma, with a reported incidence between 3.4% and 11%.1,3

We have highlighted the value of dermoscopic evaluation in cases in which the clinical features are consistent with a diagnosis of porokeratosis.

Ethical disclosuresProtection of human and animal subjects

The authors declare that the procedures followed were in accordance with the regulations of the responsible Clinical Research Ethics Committee and in accordance with those of the World Medical Association and the Helsinki Declaration.

Confidentiality of data

The authors declare that they have followed the protocols of their work centre on the publication of patient data.

Right to privacy and informed consent

The authors must have obtained the informed consent of the patients and/or subjects mentioned in the article. The author for correspondence must be in possession of this document.

Conflict of interest

The authors declare no conflict of interest.

References
[1]
A. Khaled, M. Kourda, F. Abdelmoula, L. M'ssedi, M.N. Tougourti, M.R. Kamoun.
Late-onset disseminated superficial actinic porokeratosis in an elderly woman.
Dermatol Ther, 1 (2011), pp. 15-19
[2]
M. Delfino, G. Argenziano, M. Nino.
Dermoscopy for the diagnosis of porokeratosis.
J Eur Acad Dermatol Venereol, 18 (2004), pp. 194-195
[3]
V. Panasiti, M. Rossi, M. Curzio, F. Bruni, S. Calvieri.
Disseminated superficial actinic porokeratosis diagnosed by dermoscopy.
Int J Dermatol, 47 (2008), pp. 308-310
[4]
I. Shoimer, L.H. Robertson, G. Storwick, R.M. Haber.
Eruptive disseminated porokeratosis: a new classification system.
J Am Acad Dermatol, 71 (2014), pp. 398-400
[5]
S.P. Shumack, C.A. Commens.
Disseminated superficial actinic porokeratosis: a clinical study.
J Am Acad Dermatol, 20 (1998), pp. 1015-1022
[6]
M.T. Bordel, G. Martínez, A. Miranda.
Poroqueratosis actínica superficial diseminada asociada a linfedema crónico primario.
Actas Dermosifiliogr, 95 (2004), pp. 113-116
[7]
Y. Xu, X. Fu, B. Yang, H. Liu, F. Zhang.
A novel MVK gene mutation in a Chinese patient with disseminated superficial actinic porokeratosis.
Dermatol Sin, 33 (2015), pp. 45-46
[8]
A. Boiy, P.A.M. de Witte, R. Roelandts.
Topical treatment of disseminated superficial actinic porokeratosis with hypericin-photodynamic therapy: a case report.
Photodiagn Photodyn, 7 (2010), pp. 123-125
[9]
E. Moscarella, C. Longo, I. Zalaudek, G. Argenziano, S. Piana, A. Lallas.
Dermoscopy and confocal microscopy clues in the diagnosis of psoriasis and porokeratosis.
J Am Acad Dermatol, 69 (2013), pp. e231-e233
[10]
S.S. Thatte, V.D. Kharkar, U.S. Khopkar.
“Diamond necklace” appearance in superficial porokeratosis.
J Am Acad Dermatol, 70 (2014), pp. e125-e126
[11]
H. Uhara, F. Kamijo, R. Okuyama, T. Saida.
Open pores with plugs in porokeratosis clearly visualized with dermoscopy furrow ink test: report of 3 cases.
Arch Dermatol, 147 (2011), pp. 866-867
Copyright © 2016. AEDV
Descargar PDF
Idiomas
Actas Dermo-Sifiliográficas
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?