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Vol. 114. Núm. 10.
Páginas T926 (noviembre - diciembre 2023)
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Vol. 114. Núm. 10.
Páginas T926 (noviembre - diciembre 2023)
Letter to the Editor
Acceso a texto completo
Comment on “Epidemic Scabies: New Treatment Challenges in an Ancient Disease”
Comentario a «Epidemia de escabiosis: los nuevos retos de una enfermedad ancestral»
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Ó. Suárez-Amora,
Autor para correspondencia
osuamo@yahoo.es

Corresponding author.
, B. Monteagudob, M. Cabanillasa
a Dermatología, Hospital Ribera Juan Cardona, Ferrol, Spain
b Servicio de Dermatología, Complejo Hospitalario Universitario de Ferrol, Ferrol, Spain
Contenido relacionado
Actas Dermosifiliogr. 2023;114:92610.1016/j.ad.2023.05.027
Ó. Suárez-Amor, B. Monteagudo, M. Cabanillas
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To the Editor,

We read with interest the article by Lluch-Galcerá et al.1 on the current scabies epidemic. First, we would like to commend the authors on their excellent review of this topic. We would also like to add a small point and clarify a controversial issue regarding the use of oral ivermectin, which we think stems from a section of the summary of product characteristics that currently states “the influence of food on absorption is unknown”.2

The bioavailability of ivermectin is increased by the intake of food, particularly fatty food.3 What differs in the studies published to date is the intensity of the effect, which ranges from zero to a 2.6-fold increase.4 The discrepancies could be linked to the different doses of ivermectin used in the respective studies.4

In their article, Lluch-Galcerá et al.1 indicate that ivermectin should be taken after fasting, and this is indeed stipulated in several guidelines, including the German guidelines on the diagnosis and treatment of scabies.5 Most authors, however, believe that ivermectin should be taken with fatty foods to increase its absorption and potential effectiveness.6,7 The Centers for Disease Control and Prevention8 and the European Academy of Dermatology and Venereology both specifically recommend taking ivermectin with food.9

Funding

No funding of any type was received for this article.

References
[1]
J.J. Lluch-Galcerá, J.M. Carrascosa, A. Boada.
Epidemia de escabiosis: los nuevos retos de una enfermedad ancestral.
Actas Dermosifiliogr, 114 (2023), pp. 132-140
[2]
Ficha técnica. Available from: https://cima.aemps.es/cima/pdfs/es/ft/85728/FT_85728.pdf [cited 2023 May 1].
[3]
C.A. Elston, D.M. Elston.
Systemic antiparasitic agents.
Comprehensive dermatologic drug therapy, pp. 126-128
[4]
U. Duthaler, R. Leisegang, M.O. Karlsson, S. Krähenbühl, F. Hammann.
The effect of food on the pharmacokinetics of oral ivermectin.
J Antimicrob Chemother, 75 (2020), pp. 438-440
[5]
C. Sunderkötter, H. Feldmeier, R. Fölster-Holst, B. Geissel, S. Klinke-Rehbein, A. Nast, et al.
S1 guidelines on the diagnosis and treatment of scabies – short version.
J Dtsch Dermatol Ges, 14 (2016), pp. 1155-1167
[6]
C. Bernigaud, K. Fischer, O. Chosidow.
The management of scabies in the 21st century: past, advances and potentials.
Acta Derm Venereol, 100 (2020),
[7]
N.S. Richards.
Scabies: diagnostic and therapeutic update.
J Cutan Med Surg, 25 (2021), pp. 95-101
[8]
Centers for Disease Control and Prevention. Medications. Available from: https://www.cdc.gov/parasites/scabies/health_professionals/meds.html [cited 2023 May 1].
[9]
C.M. Salavastru, O. Chosidow, M.J. Boffa, M. Janier, G.S. Tiplica.
European guideline for the management of scabies.
J Eur Acad Dermatol Venereol, 31 (2017), pp. 1248-1253
Copyright © 2023. AEDV
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