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2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Orcein stain was positive only in the areas with abnormal elastic fibers&#44; including some within the stratum corneum&#46; Orcein stain also revealed altered elastic fibers &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">What Is Your Diagnosis&#63;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Elastosis perforans serpiginosa&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Clinical Course and Treatment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Two sessions of cryotherapy were administered at an interval of 6 weeks&#46; 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A keratin plug can sometimes be observed on the surface&#44; and there many be multinucleated giant cells and a pericanalicular inflammatory infiltrate&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Specific stains for elastic fibers &#40;Verhoeff-Van Gieson or orcein&#41; show the abnormal morphology of these elastic fibers&#46; In penicillamine-induced cases&#44; slight differences can be seen on optical and electron microscopy&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The etiology and pathogenesis of EPS are unknown&#46; It is thought that the abnormal fibers may be identified as foreign bodies&#44; provoking a granulomatous reaction that results in their elimination&#46; The granulomatous reaction around the elastic fibers may play an important role in the pathophysiology of elastosis perforans serpiginosa&#44; as may the keratinocytes that surround the elastotic material and express the elastin receptor &#40;67-kDa&#41;&#46; This receptor could be implicated in the interaction of the keratinocytes with the elastin and its subsequent elimination&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The clinical differential diagnosis principally includes granuloma annulare&#44; prurigo nodularis&#44; tinea&#44; annular sarcoidosis&#44; cutaneous calcinosis&#44; and porokeratosis of Mibelli&#46; Histopathologically&#44; EPS must be distinguished from congenital reactive perforating collagenosis&#8212;a rare genodermatosis usually of autosomal dominant inheritance that typically occurs in association with renal dysfunction or diabetes mellitus&#8212;and the acquired forms &#40;Kyrle disease and perforating folliculitis&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Most forms of treatment are unsatisfactory although good cosmetic results have been achieved with cryotherapy&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> electrocoagulation&#44; 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Vol. 102. Núm. 9.
Páginas 731-732 (noviembre 2011)
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8466
Vol. 102. Núm. 9.
Páginas 731-732 (noviembre 2011)
Case for Diagnosis
Acceso a texto completo
Asymptomatic Lesion on the Forehead
Lesión asintomática en la región frontal
Visitas
8466
V. Fuentelsaz-del Barrioa,
Autor para correspondencia
victoriafuentelsaz@hotmail.com

Corresponding author.
, A. Pulidoa, V. Parrab
a Servicio de Dermatología, Hospital Gregorio Marañón, Madrid, Spain
b Servicio de Anatomía Patológica, Hospital Gregorio Marañón, Madrid, Spain
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Medical History

A 54-year-old man with a history of hypertension on treatment with enalapril and simvastatin consulted for the appearance of an asymptomatic lesion that had appeared on the right frontal region 4 months earlier and that had increased progressively in size. He reported no local trauma or use of topical treatments.

Physical Examination

An irregular plaque of normal skin color, measuring 1 x 0.8cm and with a slightly depressed centre was observed; it was formed of small papules following a serpiginous path in the periphery of the lesion. No other lesions of interest were observed on other areas of the body (Fig. 1).

Figure 1.

Asymptomatic lesion on the right frontal region.

(0.08MB).
Histopathology

A biopsy taken from the border of the lesion revealed an accumulation of acellular eosinophilic material associated with thick hypereosinophilic elastic fibers in the superficial papillary dermis. There was a moderate inflammatory infiltrate of lymphocytes and plasma cells in the adjacent dermis, with frequent multinucleated giant cells. One area of the overlying epidermis presented a perforation and there was transepidermal elimination of the acellular eosinophilic material associated with small clusters of neutrophils (Fig. 2).

Figure 2.

Hematoxylin-eosin, original magnification x200.

(0.15MB).

Orcein stain was positive only in the areas with abnormal elastic fibers, including some within the stratum corneum. Orcein stain also revealed altered elastic fibers (Fig. 3).

Figure 3.

Orcein, original magnification x200.

(0.15MB).

What Is Your Diagnosis?

Diagnosis

Elastosis perforans serpiginosa.

Clinical Course and Treatment

Two sessions of cryotherapy were administered at an interval of 6 weeks. Three months after the second session, the skin on the treated area was slightly atrophied and hypopigmented. At 9 months of follow-up there was no recurrence and no new lesions had appeared.

Comment

Elastosis perforans serpiginosa is a rare dermatosis caused by the transepidermal elimination of thickened elastic fibers. It has traditionally been classified into 3 types: idiopathic; secondary to treatment with D-penicillamine; and associated with other disorders such as Down syndrome, Marfan syndrome, osteogenesis imperfecta, Ehlers-Danlos syndrome, acrogeria, morphea, Rothmund-Thomson syndrome, and pseudoxanthoma elasticum.1,2 Some familial cases have also been described, with variable inheritance patterns.

The lesions typically appear in early adulthood, with a male to female ratio of 4 to 1.3 Clinically, elastosis perforans serpiginosa consists of the appearance of asymptomatic or slightly pruritic, skin colored or erythematous papules with a central keratin plug; bleeding occurs if the plug is removed. The papules tend to occur in a curvilinear or serpiginous distribution, preferentially on the face, neck, or extremities. The lesions sometimes resolve spontaneously after months or even years, leaving hypopigmented atrophic scars.

Histological features include the presence of abnormal, thickened elastic fibers that are eliminated via transepidermal channels that form grooves in an acanthotic epidermis. A keratin plug can sometimes be observed on the surface, and there many be multinucleated giant cells and a pericanalicular inflammatory infiltrate.4 Specific stains for elastic fibers (Verhoeff-Van Gieson or orcein) show the abnormal morphology of these elastic fibers. In penicillamine-induced cases, slight differences can be seen on optical and electron microscopy.

The etiology and pathogenesis of EPS are unknown. It is thought that the abnormal fibers may be identified as foreign bodies, provoking a granulomatous reaction that results in their elimination. The granulomatous reaction around the elastic fibers may play an important role in the pathophysiology of elastosis perforans serpiginosa, as may the keratinocytes that surround the elastotic material and express the elastin receptor (67-kDa). This receptor could be implicated in the interaction of the keratinocytes with the elastin and its subsequent elimination.5

The clinical differential diagnosis principally includes granuloma annulare, prurigo nodularis, tinea, annular sarcoidosis, cutaneous calcinosis, and porokeratosis of Mibelli. Histopathologically, EPS must be distinguished from congenital reactive perforating collagenosis—a rare genodermatosis usually of autosomal dominant inheritance that typically occurs in association with renal dysfunction or diabetes mellitus—and the acquired forms (Kyrle disease and perforating folliculitis).

Most forms of treatment are unsatisfactory although good cosmetic results have been achieved with cryotherapy,6 electrocoagulation, tazarotene, imiquimod, subcutaneous hydrocortisone, cellophane tape stripping, bichloroacetic acid, carbon-dioxide laser, and oral isotretinoin.

The interesting feature in this case of elastosis perforans serpiginosa is the unusually late onset and presentation in the form of a single lesion. We believe that further lesions may appear in the future despite the good initial response to cryotherapy.

References
[1]
M.A. Barnadas, R. Curell, R. Puyol, J.M. de Moragas, A. Alomar.
Elastosis perforans serpiginosa en una enferma afecta de pseudoxantoma elástico.
Actas Dermosifiliogr, 97 (2006), pp. 451-455
[2]
R.K. Mehta, N.P. Burrows, C.M. Payne, S.S. Mendelsohn, F.M. Pope, E. Rytina.
Elastosis perforans serpiginosa and associated disorders.
Clin Exp Dermatol, 26 (2001), pp. 521-524
[3]
G.J. Díaz, D. Berk, A.L. Bruckner, J. Kim.
Annular and keratotic papules and plaques in a teenager. Elastosis perforans serpiginosa (EPS).
Arch Dermatol, 145 (2009), pp. 931-936
[4]
M.B. Morgan, C.A. Truitt, J. Taira, S. Somach, J.V. Pitha, M.A. Everett.
Fibronectin and the extracellular matrix in the perforating disorders of the skin.
Am J Dermatopathol, 20 (1998), pp. 147-154
[5]
N. Fujimoto, S. Tajima, A. Ishibashi.
Elastin peptides induce migration and terminal differentiation of cultured keratinocytes via 67 Kda elastin receptor in vitro: 67kDa elastin receptor is expressed in the keratinocytes eliminating elastic materials in elastosis perforans serpiginosa.
J Invest Dermatol, 115 (2000), pp. 633-639
[6]
S. Humphrey, I. Hemmati, R. Randhawa, R.I. Crawford, C.H. Hong.
Elastosis perforans serpignosa: treatment with liquin nitrogen cryotherapy and review of the literature.
J Cutan Med Surg, 14 (2010), pp. 38-42

Please cite this article as: Fuentelsaz-del Barrio V, et al. Lesión asintomática en la región frontal. Actas Dermosifiliogr.2011;102:733-734.

Copyright © 2011. Elsevier España, S.L. and AEDV
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