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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Corticosteroid contact dermatitis and its patch testing are subject to certain peculiarities that we should be aware of&#46;</p> <span class="elsevierStyleSectionTitle">Materials and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective study of all patients who underwent patch tests with a corticosteroid battery in the Skin Allergy Unit of the Dermatology Department of Hospital General Universitario&#44; Alicante&#44; Spain&#44; between October 2004 and June 2007&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">During the study period&#44; patch tests were performed on 1065 patients in our allergy unit&#46; A corticosteroid battery was used in 34 patients &#40;3&#46;1&#37;&#41;&#46; Fourteen patients were positive for budesonide or tixocortol in the standard battery&#59; 20 were negative for these allergens but there was a clinical suspicion of steroid allergy&#46; At least one positive reaction in the corticosteroid battery was observed in 15 patients &#40;44&#46;1&#37;&#41;&#46;The substance most commonly implicated was budesonide &#40;13 patients sensitized&#41;&#46; The corticosteroid battery revealed sensitization to other groups of corticosteroids in 4 of the 15 patients with corticosteroid sensitization&#46; Seventeen patients brought drugs that were also tested&#44; obtaining positive results for 10 substances&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Allergens for contact dermatitis due to corticosteroids included in the standard battery &#40;budesonide and tixocortol&#41; detected 93&#37; of patients who are sensitized to steroids&#59; there would appear to be little benefit in performing a corticosteroid battery if those markers are negative&#46; The battery of corticosteroids and the drugs provided by patients were useful to define more exactly the corticosteroid classes that the patient should avoid&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La dermatitis de contacto por corticoides y la realizaci&#243;n de las pruebas epicut&#225;neas con estas sustancias presentan peculiaridades que hay que conocer&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Realizamos un estudio retrospectivo de todos los pacientes en los que se aplic&#243; la bater&#237;a de corticoides en la Unidad de Alergia Cut&#225;nea de la Secci&#243;n de Dermatolog&#237;a del Hospital General Universitario de Alicante&#44; durante el per&#237;odo comprendido entre octubre de 2004 y junio de 2007&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Durante el per&#237;odo de estudio se atendieron 1&#46;065 pacientes&#44; a 34 de ellos &#40;3&#44;1&#37;&#41; se les aplic&#243; la bater&#237;a de corticoides&#44; 14 pacientes con budesonida o tixocortol positivos en la bater&#237;a est&#225;ndar y 20 con estos marcadores negativos pero con sospecha cl&#237;nica de alergia a corticoides&#46; Quince pacientes &#40;44&#44;1&#37;&#41; obtuvieron alg&#250;n positivo en la bater&#237;a de corticoides&#46; La sustancia que m&#225;s positivos obtuvo fue budesonida &#40;13 pacientes sensibilizados&#41;&#46; En 4 de 15 pacientes el uso de la bater&#237;a de corticoides inform&#243; de sensibilizaci&#243;n a otros grupos de corticoides&#46; A 17 pacientes se les aplicaron los medicamentos aportados por ellos&#44; obteni&#233;ndose 10 sustancias positivas&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los marcadores para la dermatitis de contacto por corticoides presentes en la bater&#237;a est&#225;ndar &#40;budesonida y tixocortol&#41; detectaron el 93&#37; de pacientes sensibilizados a corticoides&#44; por lo que no parece rentable aplicar la bater&#237;a de corticoides si dichos marcadores son negativos&#46; La bater&#237;a de corticoides y los propios f&#225;rmacos aportados por los pacientes fueron &#250;tiles para definir mejor los grupos de corticoides que estos no pueden utilizar&#46;</p>"
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                      "titulo" => "Recommendation to include budesonide and tixocortol pivalate in the European standard series&#46; ESCD and EECDRG&#46; European Society of Contact Dermatitis"
                      "autores" => array:1 [
                        0 => array:2 [
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                          "autores" => array:4 [
                            0 => "M&#46; Isaksson"
                            1 => "F&#46;M&#46; Brand&#227;o"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10902588"
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                          "etal" => false
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                      "titulo" => "Results of patch testing to a corticosteroid series&#58; a retrospective review of 1188 patients during 6 years at Mayo Clinic"
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Vol. 100. Núm. 4.
Páginas 291-297 (mayo 2009)
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Vol. 100. Núm. 4.
Páginas 291-297 (mayo 2009)
Original articles
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Allergic Contact Dermatitis Due to Corticosteroids: A 3-Year Retrospective Study in a Hospital Skin Allergy Unit
Dermatitis de Contacto por Corticoides. Estudio Retrospectivo de 3 años en una Unidad de Alergia Cutánea Hospitalaria
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M. Pérez-Crespo
Autor para correspondencia
mariaperezcrespo@hotmail.com

Correspondence: Servicio de Dermatología, Hospital General Universitario de Alicante, C/ Pintor Baeza, s/n. 03010 Alicante, Spain.
, J.F. Silvestre, A. Lucas, J. Mataix, I. Ballester
Sección de Dermatología, Hospital General Universitario de Alicante, Spain
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Abstract
Background

Corticosteroid contact dermatitis and its patch testing are subject to certain peculiarities that we should be aware of.

Materials and methods

We performed a retrospective study of all patients who underwent patch tests with a corticosteroid battery in the Skin Allergy Unit of the Dermatology Department of Hospital General Universitario, Alicante, Spain, between October 2004 and June 2007.

Results

During the study period, patch tests were performed on 1065 patients in our allergy unit. A corticosteroid battery was used in 34 patients (3.1%). Fourteen patients were positive for budesonide or tixocortol in the standard battery; 20 were negative for these allergens but there was a clinical suspicion of steroid allergy. At least one positive reaction in the corticosteroid battery was observed in 15 patients (44.1%).The substance most commonly implicated was budesonide (13 patients sensitized). The corticosteroid battery revealed sensitization to other groups of corticosteroids in 4 of the 15 patients with corticosteroid sensitization. Seventeen patients brought drugs that were also tested, obtaining positive results for 10 substances.

Conclusions

Allergens for contact dermatitis due to corticosteroids included in the standard battery (budesonide and tixocortol) detected 93% of patients who are sensitized to steroids; there would appear to be little benefit in performing a corticosteroid battery if those markers are negative. The battery of corticosteroids and the drugs provided by patients were useful to define more exactly the corticosteroid classes that the patient should avoid.

Key words:
allergic contact dermatitis
corticosteroids
patch test
standard battery
Resumen
Introducción

La dermatitis de contacto por corticoides y la realización de las pruebas epicutáneas con estas sustancias presentan peculiaridades que hay que conocer.

Material y métodos

Realizamos un estudio retrospectivo de todos los pacientes en los que se aplicó la batería de corticoides en la Unidad de Alergia Cutánea de la Sección de Dermatología del Hospital General Universitario de Alicante, durante el período comprendido entre octubre de 2004 y junio de 2007.

Resultados

Durante el período de estudio se atendieron 1.065 pacientes, a 34 de ellos (3,1%) se les aplicó la batería de corticoides, 14 pacientes con budesonida o tixocortol positivos en la batería estándar y 20 con estos marcadores negativos pero con sospecha clínica de alergia a corticoides. Quince pacientes (44,1%) obtuvieron algún positivo en la batería de corticoides. La sustancia que más positivos obtuvo fue budesonida (13 pacientes sensibilizados). En 4 de 15 pacientes el uso de la batería de corticoides informó de sensibilización a otros grupos de corticoides. A 17 pacientes se les aplicaron los medicamentos aportados por ellos, obteniéndose 10 sustancias positivas.

Conclusiones

Los marcadores para la dermatitis de contacto por corticoides presentes en la batería estándar (budesonida y tixocortol) detectaron el 93% de pacientes sensibilizados a corticoides, por lo que no parece rentable aplicar la batería de corticoides si dichos marcadores son negativos. La batería de corticoides y los propios fármacos aportados por los pacientes fueron útiles para definir mejor los grupos de corticoides que estos no pueden utilizar.

Palabras clave:
dermatitis de contacto alérgica
corticoides
pruebas epicutáneas
batería estándar GEIDAC
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Copyright © 2009. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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