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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Medical History</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 56-year-old man presented with multiple small asymptomatic whitish papules that had appeared 3 months earlier on both hands&#46; The patient&#39;s past history included systemic hypertension on treatment with valsartan&#44; untreated hyperuricemia&#44; dyslipidemia&#44; and moderate alcohol consumption with findings on magnetic resonance imaging suggestive of chronic pancreatitis&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Physical Examination</span><p id="par0010" class="elsevierStylePara elsevierViewall">Physical examination showed numerous small &#40;2-3<span class="elsevierStyleHsp" style=""></span>mm&#41; whitish papules on the palms and fingertips of both hands&#46; The papules were hard and smooth and some of them were ulcerated &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Additional Tests</span><p id="par0015" class="elsevierStylePara elsevierViewall">A biopsy was performed of 1 of the lesions&#46; Microscopy revealed a large nodular deposit of amorphous material containing acicular clefts in the dermis&#44; surrounded by pseudopalisading histiocytes and a marked foreign body giant cell reaction&#46; In close proximity to the main lesion we observed multiple&#44; small&#44; coalescing nodular deposits comprised of similar material with a marked associated giant cell reaction&#46; The epidermis showed no significant changes &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figs&#46; 2 and 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">What Is Your Diagnosis&#63;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Milia-like cutaneous tophi</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical Course and Treatment</span><p id="par0030" class="elsevierStylePara elsevierViewall">The patient was referred to the rheumatology department and treated with allopurinol &#40;100<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#41;&#44; resulting in a gradual improvement in the lesions&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">The clinical features of gout are caused by deposits of monosodium urate crystals in the tissues&#46; The main clinical manifestations of gout are gouty arthritis&#44; the accumulation of crystals in the connective tissues &#40;tophi&#41;&#44; uric acid nephrolithiasis&#44; and renal failure&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Tophi appear after a long period of hyperuricemia&#46; The prevalence of this condition has been reduced by effective therapies and is now limited to patients who fail to comply with treatment and those in whom the diagnosis of gout is delayed&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Rarely&#44; tophi may be the first sign of hyperuricemia&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Tophi appear as whitish-yellowish dermal papules or subcutaneous nodules that are firm to the touch&#46; The borders may be smooth or lobulated&#46; They appear most frequently on the skin covering the joints and on the helix of the ear&#46; Presentation as numerous small papules appearing rapidly on the hands is very rare&#46; Historically&#44; this condition has been referred to as intradermal tophi or pustular gouty tophi&#46; The term milia-like tophi has recently been proposed for this entity based on the similarity between these lesions and millet seeds as well as the wider distribution of the lesions involving not only the fingertips&#44; which has been previously described&#44; but also the palms&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The main histologic feature of gouty tophi is the presence deposits of an amorphous material within the dermis and subcutaneous cellular tissue&#46; These deposits contain acicular clefts&#44; caused by the dissolution of urate crystals&#44; and are surrounded by an infiltrate comprised of histiocytes&#44; in the form of multinucleated giant cells&#44; and lymphocytes&#44; sometimes with the presence of a fibrous capsule&#46; The epidermis may be intact or ulcerated&#46; During standard processing and fixing techniques most of the urate crystals are dissolved and fixation in ethanol or freezing of the tissue is therefore necessary to identify the crystals&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">When observed under a polarized light filter&#44; the acicular crystals exhibit negative birefringence&#46; The clinical differential diagnosis of gouty tophi should include xanthomas&#44; rheumatoid nodules&#44; and calcinosis cutis&#46; The prolonged use of medications that reduce uric acid levels such as allopurinol can successfully treat newer&#44; smaller lesions&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> while larger lesions may be removed surgically&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflict of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Journal Information
Vol. 104. Issue 4.
Pages 349-350 (May 2013)
Visits
13034
Vol. 104. Issue 4.
Pages 349-350 (May 2013)
Case for Diagnosis
Full text access
Whitish Papules on the Hands
Pápulas Blanquecinas en las Manos
Visits
13034
J. Bernat Garcíaa,
Corresponding author
josefabernat@hotmail.com

Corresponding author.
, E. Barberá Montesinosa, P. Soriano Sarriob
a Servicio de Dermatología, Hospital Universitario Doctor Peset, Valencia, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Doctor Peset, Valencia, Spain
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Medical History

A 56-year-old man presented with multiple small asymptomatic whitish papules that had appeared 3 months earlier on both hands. The patient's past history included systemic hypertension on treatment with valsartan, untreated hyperuricemia, dyslipidemia, and moderate alcohol consumption with findings on magnetic resonance imaging suggestive of chronic pancreatitis.

Physical Examination

Physical examination showed numerous small (2-3mm) whitish papules on the palms and fingertips of both hands. The papules were hard and smooth and some of them were ulcerated (Fig. 1).

Figure 1
(0.05MB).
Additional Tests

A biopsy was performed of 1 of the lesions. Microscopy revealed a large nodular deposit of amorphous material containing acicular clefts in the dermis, surrounded by pseudopalisading histiocytes and a marked foreign body giant cell reaction. In close proximity to the main lesion we observed multiple, small, coalescing nodular deposits comprised of similar material with a marked associated giant cell reaction. The epidermis showed no significant changes (Figs. 2 and 3).

Figure 2.

Hematoxylin-eosin, original magnification ×10.

(0.43MB).
Figure 3.

Hematoxylin-eosin, original magnification ×40.

(0.16MB).

What Is Your Diagnosis?

Diagnosis

Milia-like cutaneous tophi

Clinical Course and Treatment

The patient was referred to the rheumatology department and treated with allopurinol (100mg/d), resulting in a gradual improvement in the lesions.

Comment

The clinical features of gout are caused by deposits of monosodium urate crystals in the tissues. The main clinical manifestations of gout are gouty arthritis, the accumulation of crystals in the connective tissues (tophi), uric acid nephrolithiasis, and renal failure.1 Tophi appear after a long period of hyperuricemia. The prevalence of this condition has been reduced by effective therapies and is now limited to patients who fail to comply with treatment and those in whom the diagnosis of gout is delayed.2 Rarely, tophi may be the first sign of hyperuricemia.3 Tophi appear as whitish-yellowish dermal papules or subcutaneous nodules that are firm to the touch. The borders may be smooth or lobulated. They appear most frequently on the skin covering the joints and on the helix of the ear. Presentation as numerous small papules appearing rapidly on the hands is very rare. Historically, this condition has been referred to as intradermal tophi or pustular gouty tophi. The term milia-like tophi has recently been proposed for this entity based on the similarity between these lesions and millet seeds as well as the wider distribution of the lesions involving not only the fingertips, which has been previously described, but also the palms.4 The main histologic feature of gouty tophi is the presence deposits of an amorphous material within the dermis and subcutaneous cellular tissue. These deposits contain acicular clefts, caused by the dissolution of urate crystals, and are surrounded by an infiltrate comprised of histiocytes, in the form of multinucleated giant cells, and lymphocytes, sometimes with the presence of a fibrous capsule. The epidermis may be intact or ulcerated. During standard processing and fixing techniques most of the urate crystals are dissolved and fixation in ethanol or freezing of the tissue is therefore necessary to identify the crystals.5

When observed under a polarized light filter, the acicular crystals exhibit negative birefringence. The clinical differential diagnosis of gouty tophi should include xanthomas, rheumatoid nodules, and calcinosis cutis. The prolonged use of medications that reduce uric acid levels such as allopurinol can successfully treat newer, smaller lesions,6 while larger lesions may be removed surgically.

Conflict of Interest

The authors declare that they have no conflicts of interest.

References
[1]
G.F. Falasca.
Metabolic diseases: gout.
Clin Dermatol, 24 (2006), pp. 498-508
[2]
Y. Apibal, S. Jirasuthus, S. Puavilai.
Abruption pustular gouty tophi of palm and sole.
J Med Assoc Thai, 92 (2009), pp. 979-982
[3]
R. Wernick, C. Winkler, S. Campbell.
Tophi as the initial manifestation of gout. Report of six cases and review of the literature.
Arch Intern Med, 152 (1992), pp. 873-876
[4]
C. Meseguer-Yebra, C. Martínez-Morán, A. Romero-Maté, A. Moreno, D. Arias-Palomo, J. Borbujo.
Joint destruction and presence of small papules on the palms and soles.
Clin Exp Dermatol, 37 (2012), pp. 450-452
[5]
A. Ramírez-Santos, R. Martín-Polo, P. Sánchez-Sambucety, M.A. Rodríguez-Prieto.
Ulcerated nodules on the posterior aspect of the legs.
Actas Dermosifiliogr, 101 (2010), pp. 263-265
[6]
F. Perez-Ruiz, M. Calabozo, J.I. Pijoan, A.M. Herrero-Beites, A. Ruibal.
Effect of urate-lowering therapy on the velocity of size reduction of tophi in chronic gout.
Arthritis Rheum, 47 (2002), pp. 356-360

Please cite this article as: Bernat García J, et al. Pápulas blanquecinas en las manos. Actas Dermosifiliogr. 2013;104:349–50.

Copyright © 2012. Elsevier España, S.L. and AEDV
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