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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Protein contact dermatitis &#40;PCD&#41; is a rare and underdiagnosed condition that many dermatologists fail to recognize&#46; Nevertheless&#44; increasing awareness of the condition and the substances responsible has led to a rise in the number of published cases in recent years&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine the clinical characteristics and allergens implicated in PCD in our setting&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A retrospective observational study of all patients diagnosed with PCD in the last 10 years was undertaken in the Skin Allergies Unit of the Department of Dermatology at Hospital General Universitario in Valencia&#44; Spain&#46; All patients were assessed by skinprick test with the standard GEIDAC allergen panel and by prick-by-prick test with foods or other products that were linked to immediate skin symptoms following handling&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Twenty-seven patients &#40;8 men and 19 women&#41; were diagnosed with PCD&#44; and 26 of the cases were occupational in origin&#46; The mean age of the patients was 32&#46;3 years and 51&#46;8&#37; had a history of atopy&#46; The latency period varied from 2 months to 27 years&#46; The most commonly affected areas were the backs of the hands and the forearms&#46; Four patients had an oral allergy syndrome&#46; In order of frequency&#44; the substances responsible for PCD were fish &#40;9 patients&#44; 33&#46;3&#37;&#41;&#44; latex &#40;8 patients&#44; 29&#46;6&#37;&#41;&#44; potato &#40;4 patients&#44; 14&#46;8&#37;&#41;&#44; chicken &#40;3 patients&#44; 11&#46;1&#37;&#41;&#44; flour &#40;3 patients&#44; 11&#46;1&#37;&#41;&#44; alpha amylase &#40;2 patients&#44; 7&#46;4&#37;&#41;&#44; aubergine &#40;2 patients&#44; 7&#46;4&#37;&#41;&#44; pork &#40;1 patient&#44; 3&#46;7&#37;&#41;&#44; garlic &#40;1 patient&#44; 3&#46;7&#37;&#41;&#44; and <span class="elsevierStyleItalic">Anisakis</span> &#40;1 patient&#44; 3&#46;7&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">PCD is a clinically relevant condition that dermatologists should include in the differential diagnosis of chronic dermatitis affecting the hands or forearms in patients at high occupational risk&#44; particular those in the food preparation industry&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La dermatitis de contacto por prote&#237;nas &#40;DCP&#41; es una patolog&#237;a infrecuente&#44; poco conocida por el dermat&#243;logo e infradiagnosticada&#46; Recientemente el n&#250;mero de casos publicados de DCP ha ido en aumento por un mayor conocimiento de esta entidad&#44; as&#237; como del espectro de sustancias responsables de la misma&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estudiar las caracter&#237;sticas cl&#237;nicas y los al&#233;rgenos implicados en la DCP en nuestro entorno&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se trata de un estudio observacional y retrospectivo de todos los pacientes diagnosticados de DCP en los &#250;ltimos 10 a&#241;os en la Secci&#243;n de alergia cut&#225;nea del Servicio de Dermatolog&#237;a del Hospital General Universitario de Valencia&#46; Todos los pacientes fueron estudiados mediante pruebas epicut&#225;neas con la bater&#237;a est&#225;ndar del GEIDAC y mediante pruebas cut&#225;neas con los alimentos y&#47;o productos que al manipularlos relacionaban con s&#237;ntomas cut&#225;neos inmediatos&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Un total de 27 pacientes &#40;8 varones y 19 mujeres&#41; fueron diagnosticados de DCP&#44; 26 de los cuales fueron de origen laboral&#46; La edad media fue de 32&#44;3 a&#241;os&#44; y el 51&#44;8&#37; ten&#237;an historia personal de atopia&#46; El tiempo de sensibilizaci&#243;n fue variable&#44; entre dos meses y 27 a&#241;os&#46; Las &#225;reas m&#225;s frecuentemente afectadas fueron el dorso de las manos y los antebrazos&#46; Cuatro pacientes presentaron un s&#237;ndrome oral de alergia&#46; Las sustancias responsables de la DCP fueron&#44; por orden de frecuencia&#44; pescados &#40;9&#47;27&#44; 33&#44;3&#37;&#41;&#44; l&#225;tex &#40;8&#47;27&#44; 29&#44;6&#37;&#41;&#44; patata &#40;4&#47;27&#44; 14&#44;8&#37;&#41;&#44; pollo y harina &#40;3&#47;27&#44; 11&#44;1&#37;&#41;&#44; alfa-amilasa y berenjena &#40;2&#47;27&#44; 7&#44;4&#37;&#41; y carne de cerdo&#44; ajo y anisakis &#40;1&#47;27&#44; 3&#44;7&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La DCP es una entidad de relevancia cl&#237;nica que el dermat&#243;logo debe considerar en el diagn&#243;stico diferencial de una dermatitis cr&#243;nica de las manos y&#47;o antebrazos en pacientes con alto riesgo ocupacional&#44; particularmente manipuladores de alimentos&#46;</p>"
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Journal Information
Vol. 102. Issue 5.
Pages 336-343 (June - July 2011)
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Vol. 102. Issue 5.
Pages 336-343 (June - July 2011)
Original Article
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Protein Contact Dermatitis: Review of 27 Cases
Dermatitis de contacto por proteínas. Revisión de 27 casos
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P. Hernández-Bel
Corresponding author
pablohernandezbel@hotmail.com

Corresponding author.
, J. De La Cuadra, R. García, V. Alegre
Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain
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Abstract
Background

Protein contact dermatitis (PCD) is a rare and underdiagnosed condition that many dermatologists fail to recognize. Nevertheless, increasing awareness of the condition and the substances responsible has led to a rise in the number of published cases in recent years.

Objective

To determine the clinical characteristics and allergens implicated in PCD in our setting.

Material and methods

A retrospective observational study of all patients diagnosed with PCD in the last 10 years was undertaken in the Skin Allergies Unit of the Department of Dermatology at Hospital General Universitario in Valencia, Spain. All patients were assessed by skinprick test with the standard GEIDAC allergen panel and by prick-by-prick test with foods or other products that were linked to immediate skin symptoms following handling.

Results

Twenty-seven patients (8 men and 19 women) were diagnosed with PCD, and 26 of the cases were occupational in origin. The mean age of the patients was 32.3 years and 51.8% had a history of atopy. The latency period varied from 2 months to 27 years. The most commonly affected areas were the backs of the hands and the forearms. Four patients had an oral allergy syndrome. In order of frequency, the substances responsible for PCD were fish (9 patients, 33.3%), latex (8 patients, 29.6%), potato (4 patients, 14.8%), chicken (3 patients, 11.1%), flour (3 patients, 11.1%), alpha amylase (2 patients, 7.4%), aubergine (2 patients, 7.4%), pork (1 patient, 3.7%), garlic (1 patient, 3.7%), and Anisakis (1 patient, 3.7%).

Conclusions

PCD is a clinically relevant condition that dermatologists should include in the differential diagnosis of chronic dermatitis affecting the hands or forearms in patients at high occupational risk, particular those in the food preparation industry.

Keywords:
Protein contact dermatitis
Food preparation workers
Hand eczema
Latex
Prick-by-prick test
Introducción

La dermatitis de contacto por proteínas (DCP) es una patología infrecuente, poco conocida por el dermatólogo e infradiagnosticada. Recientemente el número de casos publicados de DCP ha ido en aumento por un mayor conocimiento de esta entidad, así como del espectro de sustancias responsables de la misma.

Objetivo

Estudiar las características clínicas y los alérgenos implicados en la DCP en nuestro entorno.

Material y métodos

Se trata de un estudio observacional y retrospectivo de todos los pacientes diagnosticados de DCP en los últimos 10 años en la Sección de alergia cutánea del Servicio de Dermatología del Hospital General Universitario de Valencia. Todos los pacientes fueron estudiados mediante pruebas epicutáneas con la batería estándar del GEIDAC y mediante pruebas cutáneas con los alimentos y/o productos que al manipularlos relacionaban con síntomas cutáneos inmediatos.

Resultados

Un total de 27 pacientes (8 varones y 19 mujeres) fueron diagnosticados de DCP, 26 de los cuales fueron de origen laboral. La edad media fue de 32,3 años, y el 51,8% tenían historia personal de atopia. El tiempo de sensibilización fue variable, entre dos meses y 27 años. Las áreas más frecuentemente afectadas fueron el dorso de las manos y los antebrazos. Cuatro pacientes presentaron un síndrome oral de alergia. Las sustancias responsables de la DCP fueron, por orden de frecuencia, pescados (9/27, 33,3%), látex (8/27, 29,6%), patata (4/27, 14,8%), pollo y harina (3/27, 11,1%), alfa-amilasa y berenjena (2/27, 7,4%) y carne de cerdo, ajo y anisakis (1/27, 3,7%).

Conclusiones

La DCP es una entidad de relevancia clínica que el dermatólogo debe considerar en el diagnóstico diferencial de una dermatitis crónica de las manos y/o antebrazos en pacientes con alto riesgo ocupacional, particularmente manipuladores de alimentos.

Palabras clave:
Dermatitis de contacto proteínica
Manipuladores de alimentos
Eczema de manos
Látex
Prick-by-prick test
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Copyright © 2011. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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