Original Article
Protein Contact Dermatitis: Review of 27 Cases
Dermatitis de contacto por proteínas. Revisión de 27 casos
P. Hernández-Bel
, J. De La Cuadra, R. García, V. Alegre
Corresponding author
Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain
Read
6875
Timeswas read the article
2630
Total PDF
4245
Total HTML
Share statistics
array:23 [ "pii" => "S1578219011708162" "issn" => "15782190" "doi" => "10.1016/S1578-2190(11)70816-2" "estado" => "S300" "fechaPublicacion" => "2011-06-01" "aid" => "70816" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2011" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2011;102:336-43" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2396 "formatos" => array:3 [ "EPUB" => 36 "HTML" => 1628 "PDF" => 732 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219011708174" "issn" => "15782190" "doi" => "10.1016/S1578-2190(11)70817-4" "estado" => "S300" "fechaPublicacion" => "2011-06-01" "aid" => "70817" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2011;102:344-53" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2406 "formatos" => array:3 [ "EPUB" => 44 "HTML" => 1545 "PDF" => 817 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Descriptive Dermoscopic Study of Depigmentation in Melanocytic Nevi Without a Visible Halo" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "344" "paginaFinal" => "353" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio descriptivo dermatoscópico de los nevos melanocíticos con despigmentación sin halo clínico" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.M. Martín, J. Núñez, V. López, M. Rubio, C. Monteagudo, E. Jordá" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.M." "apellidos" => "Martín" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Núñez" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "López" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Rubio" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Monteagudo" ] 5 => array:2 [ "nombre" => "E." "apellidos" => "Jordá" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011708174?idApp=UINPBA000044" "url" => "/15782190/0000010200000005/v1_201304241545/S1578219011708174/v1_201304241545/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219011708150" "issn" => "15782190" "doi" => "10.1016/S1578-2190(11)70815-0" "estado" => "S300" "fechaPublicacion" => "2011-06-01" "aid" => "70815" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Dermosifiliogr. 2011;102:325-35" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2078 "formatos" => array:3 [ "EPUB" => 34 "HTML" => 1251 "PDF" => 793 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Portfolios: A Tool for the Training and Assessment of Residents in Dermatology, Part 2" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "325" "paginaFinal" => "335" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El portafolio como herramienta de formación y evaluación de los residentes de Dermatología (II)" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.M. Casanova, X. Soria, L. Borrego, D. De Argila, M. Ribera, R.M. Pujol" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.M." "apellidos" => "Casanova" ] 1 => array:2 [ "nombre" => "X." "apellidos" => "Soria" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Borrego" ] 3 => array:2 [ "nombre" => "D." "apellidos" => "De Argila" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Ribera" ] 5 => array:2 [ "nombre" => "R.M." "apellidos" => "Pujol" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011708150?idApp=UINPBA000044" "url" => "/15782190/0000010200000005/v1_201304241545/S1578219011708150/v1_201304241545/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Protein Contact Dermatitis: Review of 27 Cases" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "336" "paginaFinal" => "343" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P. Hernández-Bel, J. De La Cuadra, R. García, V. Alegre" "autores" => array:4 [ 0 => array:4 [ "nombre" => "P." "apellidos" => "Hernández-Bel" "email" => array:1 [ 0 => "pablohernandezbel@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "J." "apellidos" => "De La Cuadra" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "García" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Alegre" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dermatitis de contacto por proteínas. Revisión de 27 casos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-08-04" "fechaAceptado" => "2011-02-09" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec84925" "palabras" => array:5 [ 0 => "Protein contact dermatitis" 1 => "Food preparation workers" 2 => "Hand eczema" 3 => "Latex" 4 => "Prick-by-prick test" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84924" "palabras" => array:5 [ 0 => "Dermatitis de contacto proteínica" 1 => "Manipuladores de alimentos" 2 => "Eczema de manos" 3 => "Látex" 4 => "Prick-by-prick test" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Protein contact dermatitis (PCD) is a rare and underdiagnosed condition that many dermatologists fail to recognize. Nevertheless, increasing awareness of the condition and the substances responsible has led to a rise in the number of published cases in recent years.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine the clinical characteristics and allergens implicated in PCD in our setting.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A retrospective observational study of all patients diagnosed with PCD in the last 10 years was undertaken in the Skin Allergies Unit of the Department of Dermatology at Hospital General Universitario in Valencia, Spain. All patients were assessed by skinprick test with the standard GEIDAC allergen panel and by prick-by-prick test with foods or other products that were linked to immediate skin symptoms following handling.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Twenty-seven patients (8 men and 19 women) were diagnosed with PCD, and 26 of the cases were occupational in origin. The mean age of the patients was 32.3 years and 51.8% had a history of atopy. The latency period varied from 2 months to 27 years. The most commonly affected areas were the backs of the hands and the forearms. Four patients had an oral allergy syndrome. In order of frequency, the substances responsible for PCD were fish (9 patients, 33.3%), latex (8 patients, 29.6%), potato (4 patients, 14.8%), chicken (3 patients, 11.1%), flour (3 patients, 11.1%), alpha amylase (2 patients, 7.4%), aubergine (2 patients, 7.4%), pork (1 patient, 3.7%), garlic (1 patient, 3.7%), and <span class="elsevierStyleItalic">Anisakis</span> (1 patient, 3.7%).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">PCD is a clinically relevant condition that dermatologists should include in the differential diagnosis of chronic dermatitis affecting the hands or forearms in patients at high occupational risk, particular those in the food preparation industry.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La dermatitis de contacto por proteínas (DCP) es una patología infrecuente, poco conocida por el dermatólogo e infradiagnosticada. Recientemente el número de casos publicados de DCP ha ido en aumento por un mayor conocimiento de esta entidad, así como del espectro de sustancias responsables de la misma.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estudiar las características clínicas y los alérgenos implicados en la DCP en nuestro entorno.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se trata de un estudio observacional y retrospectivo de todos los pacientes diagnosticados de DCP en los últimos 10 años en la Sección de alergia cutánea del Servicio de Dermatología del Hospital General Universitario de Valencia. Todos los pacientes fueron estudiados mediante pruebas epicutáneas con la batería estándar del GEIDAC y mediante pruebas cutáneas con los alimentos y/o productos que al manipularlos relacionaban con síntomas cutáneos inmediatos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Un total de 27 pacientes (8 varones y 19 mujeres) fueron diagnosticados de DCP, 26 de los cuales fueron de origen laboral. La edad media fue de 32,3 años, y el 51,8% tenían historia personal de atopia. El tiempo de sensibilización fue variable, entre dos meses y 27 años. Las áreas más frecuentemente afectadas fueron el dorso de las manos y los antebrazos. Cuatro pacientes presentaron un síndrome oral de alergia. Las sustancias responsables de la DCP fueron, por orden de frecuencia, pescados (9/27, 33,3%), látex (8/27, 29,6%), patata (4/27, 14,8%), pollo y harina (3/27, 11,1%), alfa-amilasa y berenjena (2/27, 7,4%) y carne de cerdo, ajo y anisakis (1/27, 3,7%).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La DCP es una entidad de relevancia clínica que el dermatólogo debe considerar en el diagnóstico diferencial de una dermatitis crónica de las manos y/o antebrazos en pacientes con alto riesgo ocupacional, particularmente manipuladores de alimentos.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:33 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occupational protein contact dermatitis in food handlers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N. Hjorth" 1 => "J. Roed-Petersen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1976" "volumen" => "2" "paginaInicial" => "28" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/145923" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Causes of eczema in the food industry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N.K. Veien" 1 => "T. Hattel" 2 => "O. Justesen" 3 => "A. Norholm" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Derm Beruf Umwelt" "fecha" => "1983" "volumen" => "31" "paginaInicial" => "84" "paginaFinal" => "86" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6223796" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatitis de contacto inmediata a alimentos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Cuadra" 1 => "M. Torres" 2 => "J. Latasa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Boletín Informativo GEIDC" "fecha" => "1982" "volumen" => "4" "paginaInicial" => "57" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Protein contact dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Romaguera" 1 => "F. Grimalt" 2 => "J. Vilaplana" 3 => "A. Telese" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1986" "volumen" => "14" "paginaInicial" => "184" "paginaFinal" => "185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3709166" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contact eczema from cow saliva" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.G. Camarasa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1986" "volumen" => "5" "paginaInicial" => "117" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic contact dermatitis from squid (Loligo opalescens)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Goday Buján" 1 => "A. Aguirre" 2 => "N. Gil Ibarra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1991" "volumen" => "24" "paginaInicial" => "307" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1868723" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occupational protein contact dermatitis from herring" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.D. Alonso" 1 => "L. Davila" 2 => "L. Conde-Salazar" 3 => "M. Cuevas" 4 => "J.A. Martin" 5 => "D. Guimaraens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "1993" "volumen" => "48" "paginaInicial" => "349" "paginaFinal" => "352" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8368462" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occupational protein contact dermatitis from lettuce" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.D. Alonso" 1 => "J.A. Martin" 2 => "M. Cuevas" 3 => "F. Parra" 4 => "A. Lezaun" 5 => "L. Conde Salazar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1993" "volumen" => "29" "paginaInicial" => "109" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8365175" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Protein contact dermatitis: myth or reality?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V. Janssens" 1 => "M. Morren" 2 => "A. Dooms-Goossens" 3 => "H. Degreef" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1995" "volumen" => "132" "paginaInicial" => "1" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7756118" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic contact dermatitis: clinical manifestations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N.M. Stone" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Latex intolerance: basic science, epidemiology, and clinical management" "paginaInicial" => "122" "paginaFinal" => "123" "serieFecha" => "2005" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contact dermatitis to food and spices" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.F. Chan" 1 => "C. Mowad" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Contact Dermat" "fecha" => "1998" "volumen" => "9" "paginaInicial" => "71" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9601906" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Protein contact dermatitis in slaughterhouse workers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K. Stagis-Hansen" 1 => "H. Overgard-Petersen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1989" "volumen" => "21" "paginaInicial" => "221" "paginaFinal" => "224" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2532113" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Protein contact dermatitis with positive RAST caused by bovine blood and amniotic fluid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Degreef" 1 => "M. Bourgeois" 2 => "C. Naert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1984" "volumen" => "11" "paginaInicial" => "129" "paginaFinal" => "130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6237879" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occupational protein contact dermatitis from shrimps" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Scharer" 1 => "J. Hafner" 2 => "B. Wuthrich" 3 => "C. Bucher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2002" "volumen" => "46" "paginaInicial" => "181" "paginaFinal" => "182" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12000333" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicutaneous natural rubber latex sensitization induces T helper 2-type dermatitis and strong prohevein-specific IgE response" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Lehto" 1 => "M. Koivuluhta" 2 => "G. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1747.2003.12104.x" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2003" "volumen" => "120" "paginaInicial" => "633" "paginaFinal" => "640" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12648228" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A study of the epidermal barrier in atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. White" 1 => "I. Dods" 2 => "C. Vickers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Immunological and pharmacological aspects of atopic and contact eczema" "paginaInicial" => "658" "paginaFinal" => "659" "serieFecha" => "1991" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occupational contact urticaria and protein contact dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.S. Doutre" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Dermatol" "fecha" => "2005" "volumen" => "15" "paginaInicial" => "419" "paginaFinal" => "424" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16280292" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occupational dermatitis from Lactuca sativa (lettuce) and Cichorium (endive). Simultaneous occurrence of immediate and delayed allergy as a cause of contact dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. Krook" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1997" "volumen" => "3" "paginaInicial" => "27" "paginaFinal" => "36" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/139283" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scratch-chamber tests in food handler dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Niinimaki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1987" "volumen" => "16" "paginaInicial" => "11" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2949931" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-lasting contact urticaria from castor bean" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Kanerva" 1 => "T. Estlander" 2 => "R. Jolanki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1990" "volumen" => "23" "paginaInicial" => "351" "paginaFinal" => "355" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2144303" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alpha-amylase, a flour additive as an important cause of protein contact dermatitis in bakers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Morren" 1 => "V. Janssens" 2 => "A. Dooms-Goossens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1993" "volumen" => "29" "paginaInicial" => "723" "paginaFinal" => "728" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8227545" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergy and toxicodermia from shiitake mushroom" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Taravainen" 1 => "J.P. Salonen" 2 => "L. Kanerva" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1991" "volumen" => "24" "paginaInicial" => "64" "paginaFinal" => "66" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1999532" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vivo methods for study of allergy: skin tests, techniques and interpretation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Bousquet" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Allergy: principles and practice" "paginaInicial" => "419" "edicion" => "3rd ed." "serieFecha" => "1998" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IgE-mediated RAST-negative occupational protein contact dermatitis from taxonomically unrelated fish species" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Kanerva" 1 => "M. Pajari-Backas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1999" "volumen" => "41" "paginaInicial" => "295" "paginaFinal" => "296" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10554071" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatitis in food service workers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.M. Adams" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy Proc" "fecha" => "1990" "volumen" => "11" "paginaInicial" => "123" "paginaFinal" => "124" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2142470" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic tests in dermatology: patch and photopatch testing and contact urticaria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Amin" 1 => "A. Lauerma" 2 => "H.I. Maibach" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Dermatotoxicology" "paginaInicial" => "109" "paginaFinal" => "112" "edicion" => "6th ed." "serieFecha" => "2004" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Graded continuity, or all or none-studies of the human immune response" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.S. Friedmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol" "fecha" => "1991" "volumen" => "16" "paginaInicial" => "79" "paginaFinal" => "84" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2032380" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occupational dermatitis with simultaneous immediate and delayed allergy to chrysanthemum" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Tanaka" 1 => "S.I. Moriwaki" 2 => "T. Horio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1987" "volumen" => "16" "paginaInicial" => "152" "paginaFinal" => "154" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2953551" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hand dermatitis: a review of clinical features therapeutic options, and long-term outcomes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Warshaw" 1 => "G. Lee" 2 => "F.J. Storrs" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Contact Dermat" "fecha" => "2003" "volumen" => "14" "paginaInicial" => "119" "paginaFinal" => "137" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14744403" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Protein contact dermatitis: allergens, pathogenesis, and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Levin" 1 => "E. Warshaw" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatitis" "fecha" => "2008" "volumen" => "19" "paginaInicial" => "241" "paginaFinal" => "251" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18845114" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of protein contact dermatitis with topical tacrolimus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Mercader" 1 => "J. Cuadra-Oyanguren" 2 => "M. Rodríguez-Serna" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/00015550510037693" "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2005" "volumen" => "85" "paginaInicial" => "555" "paginaFinal" => "556" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16396818" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dermatitis of the hands in caterers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E. Cronin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "1987" "volumen" => "17" "paginaInicial" => "265" "paginaFinal" => "269" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2963723" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immediate contact skin reactions, an update of Contact Urticaria, Contact Urticaria Syndrome and Protein Contact Dermatitis - “A Never Ending Story”" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Giménez-Arnau" 1 => "M. Maurer" 2 => "J. De la Cuadra" 3 => "H. Maibach" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur J Dermatol" "fecha" => "2010" "volumen" => "20" "paginaInicial" => "1" "paginaFinal" => "11" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010200000005/v1_201304241545/S1578219011708162/v1_201304241545/en/main.assets" "Apartado" => array:4 [ "identificador" => "6256" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010200000005/v1_201304241545/S1578219011708162/v1_201304241545/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219011708162?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 8 | 17 |
| 2024 October | 50 | 50 | 100 |
| 2024 September | 72 | 24 | 96 |
| 2024 August | 104 | 50 | 154 |
| 2024 July | 68 | 37 | 105 |
| 2024 June | 68 | 25 | 93 |
| 2024 May | 71 | 38 | 109 |
| 2024 April | 71 | 22 | 93 |
| 2024 March | 54 | 47 | 101 |
| 2024 February | 58 | 36 | 94 |
| 2024 January | 56 | 36 | 92 |
| 2023 December | 62 | 36 | 98 |
| 2023 November | 71 | 48 | 119 |
| 2023 October | 67 | 37 | 104 |
| 2023 September | 53 | 29 | 82 |
| 2023 August | 43 | 29 | 72 |
| 2023 July | 53 | 59 | 112 |
| 2023 June | 49 | 27 | 76 |
| 2023 May | 51 | 27 | 78 |
| 2023 April | 32 | 16 | 48 |
| 2023 March | 29 | 32 | 61 |
| 2023 February | 30 | 22 | 52 |
| 2023 January | 35 | 42 | 77 |
| 2022 December | 43 | 60 | 103 |
| 2022 November | 25 | 37 | 62 |
| 2022 October | 21 | 20 | 41 |
| 2022 September | 16 | 42 | 58 |
| 2022 August | 25 | 40 | 65 |
| 2022 July | 20 | 31 | 51 |
| 2022 June | 25 | 32 | 57 |
| 2022 May | 33 | 41 | 74 |
| 2022 April | 38 | 41 | 79 |
| 2022 March | 40 | 52 | 92 |
| 2022 February | 33 | 36 | 69 |
| 2022 January | 23 | 40 | 63 |
| 2021 December | 41 | 41 | 82 |
| 2021 November | 46 | 58 | 104 |
| 2021 October | 53 | 65 | 118 |
| 2021 September | 51 | 47 | 98 |
| 2021 August | 32 | 44 | 76 |
| 2021 July | 36 | 39 | 75 |
| 2021 June | 49 | 47 | 96 |
| 2021 May | 38 | 23 | 61 |
| 2021 April | 83 | 39 | 122 |
| 2021 March | 46 | 11 | 57 |
| 2021 February | 74 | 35 | 109 |
| 2021 January | 42 | 12 | 54 |
| 2020 December | 45 | 11 | 56 |
| 2020 November | 31 | 19 | 50 |
| 2020 October | 65 | 14 | 79 |
| 2020 September | 56 | 14 | 70 |
| 2020 August | 43 | 31 | 74 |
| 2020 July | 30 | 12 | 42 |
| 2020 June | 46 | 23 | 69 |
| 2020 May | 48 | 21 | 69 |
| 2020 April | 35 | 14 | 49 |
| 2020 March | 26 | 28 | 54 |
| 2020 February | 3 | 2 | 5 |
| 2020 January | 0 | 9 | 9 |
| 2019 December | 0 | 10 | 10 |
| 2019 November | 0 | 1 | 1 |
| 2019 October | 0 | 7 | 7 |
| 2019 September | 0 | 2 | 2 |
| 2019 July | 0 | 4 | 4 |
| 2019 June | 0 | 3 | 3 |
| 2019 May | 2 | 45 | 47 |
| 2019 April | 0 | 2 | 2 |
| 2019 March | 0 | 6 | 6 |
| 2018 June | 1 | 1 | 2 |
| 2018 May | 0 | 4 | 4 |
| 2018 April | 0 | 2 | 2 |
| 2018 March | 0 | 1 | 1 |
| 2018 February | 14 | 2 | 16 |
| 2018 January | 27 | 7 | 34 |
| 2017 December | 38 | 5 | 43 |
| 2017 November | 29 | 4 | 33 |
| 2017 October | 19 | 20 | 39 |
| 2017 September | 21 | 10 | 31 |
| 2017 August | 37 | 10 | 47 |
| 2017 July | 22 | 2 | 24 |
| 2017 June | 32 | 10 | 42 |
| 2017 May | 33 | 15 | 48 |
| 2017 April | 28 | 10 | 38 |
| 2017 March | 21 | 17 | 38 |
| 2017 February | 23 | 13 | 36 |
| 2017 January | 31 | 14 | 45 |
| 2016 December | 41 | 7 | 48 |
| 2016 November | 45 | 9 | 54 |
| 2016 October | 37 | 9 | 46 |
| 2016 September | 38 | 4 | 42 |
| 2016 August | 47 | 12 | 59 |
| 2016 July | 36 | 10 | 46 |
| 2016 June | 16 | 4 | 20 |
| 2016 May | 7 | 11 | 18 |
| 2016 April | 3 | 0 | 3 |
| 2016 March | 5 | 1 | 6 |
| 2016 February | 6 | 1 | 7 |
| 2016 January | 6 | 0 | 6 |
| 2015 December | 4 | 1 | 5 |
| 2015 November | 5 | 3 | 8 |
| 2015 October | 9 | 2 | 11 |
| 2015 September | 4 | 5 | 9 |
| 2015 August | 15 | 7 | 22 |
| 2015 July | 48 | 6 | 54 |
| 2015 June | 41 | 7 | 48 |
| 2015 May | 77 | 12 | 89 |
| 2015 April | 43 | 7 | 50 |
| 2015 March | 28 | 6 | 34 |
| 2015 February | 29 | 6 | 35 |
| 2015 January | 21 | 7 | 28 |
| 2014 December | 33 | 7 | 40 |
| 2014 November | 25 | 5 | 30 |
| 2014 October | 29 | 18 | 47 |
| 2014 September | 24 | 12 | 36 |
| 2014 August | 36 | 12 | 48 |
| 2014 July | 31 | 22 | 53 |
| 2014 June | 35 | 9 | 44 |
| 2014 May | 47 | 15 | 62 |
| 2014 April | 35 | 13 | 48 |
| 2014 March | 38 | 9 | 47 |
| 2014 February | 32 | 16 | 48 |
| 2014 January | 35 | 19 | 54 |
| 2013 December | 37 | 12 | 49 |
| 2013 November | 24 | 12 | 36 |
| 2013 October | 36 | 21 | 57 |
| 2013 September | 35 | 17 | 52 |
| 2013 August | 22 | 24 | 46 |
| 2013 July | 35 | 24 | 59 |
| 2013 June | 23 | 25 | 48 |
| 2013 May | 7 | 18 | 25 |
| 2013 April | 8 | 17 | 25 |
| 2013 March | 7 | 24 | 31 |
| 2013 February | 5 | 7 | 12 |
Show all
