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Vol. 110. Num. 2.
Pages e7-e12 Pages 87-180 (March 2019)
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Vol. 110. Num. 2.
Pages e7-e12 Pages 87-180 (March 2019)
Brief Comunication
DOI: 10.1016/j.adengl.2019.01.006
Postirradiation Morphea in Patients With Breast Cancer: Possible Association With Other Autoimmune Diseases
Morfea postradioterapia en pacientes con cáncer de mama. Posible relación con otras enfermedades autoinmunes
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A. Diago
Corresponding author
adridiago@hotmail.com

Corresponding author.
, B. Llombart, C. Requena, O. Sanmartín, C. Guillén
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España
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Table 1. Past Personal History and Time From Radiation Therapy to Onset of Postirradiation Morphea (Latency) in the Present Series.
Table 2. Cases of Postirradiation Morphea Published Since 1989.
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Abstract

Postirradiation morphea is an uncommon entity that has been mostly described in women with breast cancer. The increasing use of radiotherapy to treat breast cancer and the clinical similarities between morphea and other conditions, such as radiodermatitis, postirradiation fibrosis, and tumor recurrence, highlights the need for dermatologists to be familiar with this entity. We present a series of 6 women with a mean age of 64.2 years and a mean latency of 9.5 years between radiotherapy for breast cancer and onset of morphea. Four of the patients had a history of autoimmune disease: rheumatoid arthritis, Sjögren syndrome, vitiligo, and Crohn disease. No specific risk factors for postirradiation morphea have been identified to date, although it would appear that a history of autoimmune disease could be associated with an increased risk of morphea in patients treated with radiation therapy.

Keywords:
Morphea
Radiotherapy
Systemic sclerosis
Breast cancer
Autoimmune diseases
Resumen

La morfea postradioterapia es una entidad poco frecuente descrita mayoritariamente en mujeres con cáncer de mama. El uso creciente de la radioterapia en el tratamiento del cáncer de mama, así como la similitud clínica de la morfea con otros cuadros tales como la radiodermitis, la fibrosis postradiación o la recidiva tumoral, obligan al dermatólogo al conocimiento de esta entidad. Presentamos una serie de 6 mujeres, con una media de edad de 64,2 años y un tiempo medio de latencia entre la radioterapia y la morfea de 9,5 años. Cuatro de las 6pacientes presentaban algún trastorno de base autoinmune (artritis reumatoide, síndrome de Sjögren, vitíligo y enfermedad de Crohn) entre sus antecedentes. Hasta el momento actual no se han encontrado factores de riesgo que predispongan al desarrollo de morfea tras el tratamiento con radioterapia, si bien parece que presentar algún trastorno de base autoinmune puede condicionar la aparición de morfea en pacientes tratados con radioterapia.

Palabras clave:
Morfea
Radioterapia
Esclerosis sistémica
Cáncer de mama
Enfermedades autoinmunes

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