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Vol. 110. Issue 6.
Pages 426-433 (July - August 2019)
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Vol. 110. Issue 6.
Pages 426-433 (July - August 2019)
Review
DOI: 10.1016/j.adengl.2019.05.007
Perineural Invasion in Cutaneous Squamous Cell Carcinoma
Invasión perineural en el carcinoma epidermoide cutáneo
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M.P. Pérez Garcíaa,
Corresponding author
glupipg@hotmail.com

Corresponding author.
, A. Mateu Puchadesb, O. Sanmartín Jiménezc
a Servicio de Dermatología, Hospital Marina Salud, Denia, Alicante, España
b Servicio de Dermatología, Hospital Dr. Peset, Valencia, España
c Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España
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Table 1. Classification of Perineural Infiltration by Zone in Head and Neck Tumors.
Abstract

Cutaneous squamous cell carcinoma is sometimes characterized by an increased risk of locoregional recurrence and occasionally distant metastasis. Several clinical and pathological factors, including perineural invasion, have been shown to have prognostic value in this setting. Perineural invasion, that is, the spread of tumor cells into the space surrounding a nerve, is usually an incidental finding. In the presence of symptoms or radiographic evidence of perineural spread, the diagnosis is clinical perineural invasion, which is associated with an increased risk of local recurrence and mortality.

Keywords:
Squamous cell carcinoma
Perineural infiltration
High risk
Radiotherapy
Resumen

En ocasiones el carcinoma epidermoide cutáneo se caracteriza por tener un mayor riesgo de desarrollar recurrencia locorregional y ocasionalmente metástasis a distancia. Existen diversos factores clínico-patológicos de reconocido valor pronóstico, entre ellos la presencia de infiltración perineural. Esta consiste en la diseminación de células tumorales a través de los nervios, siendo en la mayoría de los casos un hallazgo incidental. Cuando aparecen síntomas y/o evidencia radiológica de la extensión de la infiltración perineural, se clasifica como infiltración perineural clínica y se asocia a un mayor riesgo de recurrencia local y de mortalidad.

Palabras clave:
Carcinoma epidermoide
Infiltración perineural
Alto riesgo
Radioterapia

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