Journal Information
Vol. 109. Issue 9.
Pages 827 (November 2018)
Vol. 109. Issue 9.
Pages 827 (November 2018)
Images in Dermatology
DOI: 10.1016/j.adengl.2018.09.003
Full text access
Necrobiotic Xanthogranuloma: A Cutaneous Manifestation of Monoclonal Gammopathy
Xantogranuloma necrobiótico, manifestación cutánea de las gammapatías monoclonales
Visits
...
I. Pérez-Lópeza,
Corresponding author
ipl_elmadrono@hotmail.com

Corresponding author.
, J.D. Herrera-Garcíab, A. Martínez-Lópeza, E. García-Duráa
a Unidad de Gestión Clínica de Dermatología Médico-Quirúrgica y Venereología, Complejo Hospitalario Universitario de Granada, Granada, España
b Unidad de Gestión Clínica de Neurología, Complejo Hospitalario Universitario de Granada, Granada, España
Article information
Full Text
Download PDF
Statistics
Figures (1)
Full Text

A 74-year-old woman with no relevant past medical history presented with lesions of 4 years’ duration that had started in the submammary region and extended to the presternal and periorbital region. The patient had been administered corticosteroids but there had been no improvement. She also reported chronic asthenia and exercise intolerance. The physical examination showed well-circumscribed, yellowish-orange, xanthomatous plaques with palpable, erythematous edges. The central area of these lesions showed marked atrophy and telangiectasias (Fig. 1). The general blood analysis with serology, autoimmunity tests, and protein profile showed an increase in immunoglobulin G (3060) with free κ chains (4.79). Positron emission tomography and bone marrow studies were normal. The skin biopsy results confirmed a diagnosis of necrobiotic xanthogranuloma associated with monoclonal gammopathy of undetermined significance.

(0.14MB).

Necrobiotic xanthogranuloma is an uncommon entity classified within the histiocytoses. Clinically, it tends to present as indurated red-violaceous papules and plaques that are variable in location although they are mostly found in the periorbital region. Prognosis depends on the severity of the lesions and level of extracutaneous involvement, because, as seen with our patient, necrobiotic xanthogranuloma sometimes occurs in association with gammopathies or lymphoproliferative disorders.

Please cite this article as: Pérez-López I, Herrera-García JD, Martínez-López A, García-Durá E. Xantogranuloma necrobiótico, manifestación cutánea de las gammapatías monoclonales. Actas Dermosifiliogr. 2018;109:827.

Copyright © 2018. Elsevier España, S.L.U. and AEDV
Idiomas
Actas Dermo-Sifiliográficas (English Edition)

Subscribe to our newsletter

Article options
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1263])
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1263])
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1263])
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1263])
  • Additional material
Tools
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1263])
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1263])
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1263])
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1263])
Supplemental materials
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.