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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Porokeratosis is a rare disorder of keratinization&#46; The presence of amyloid deposits has been observed in inflammatory and tumoral skin diseases&#46;</p> <span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to determine the frequency of cutaneous amyloidosis in histology samples from various types of porokeratosis diagnosed in our department from 1988 to 2005&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Thirty patients were selected and 34 biopsies of lesions clinically and histologically compatible with porokeratosis were performed&#46; Sections were stained with hematoxylin-eosin and thioflavin T&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Amyloid deposits were observed in 11 biopsies from 9 patients&#46; Most were women in their sixties&#44; with disseminated superficial actinic porokeratosis that had begun at least 5 years earlier&#46; No notable histologic differences were observed between porokeratosis specimens with and without amyloid deposits&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The coexistence of porokeratosis and amyloidosis is a rare occurrence but may be underdiagnosed&#46; In our opinion&#44; the advanced age of the patients and the chronic nature of the lesions would have been predisposing factors for amyloid deposition&#46; The possibility of racial or genetic influences&#44; however&#44; cannot be ruled out&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Las poroqueratosis son alteraciones de la queratinizaci&#243;n poco frecuentes&#46; La presencia de material amiloide se ha observado en dermatosis de etiolog&#237;a inflamatoria y tumoral&#46;</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Determinar la incidencia de amiloidosis cut&#225;nea en las muestras histol&#243;gicas de distintos tipos de poroqueratosis diagnosticados en nuestro servicio entre 1988-2005&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron 30 pacientes y se realizaron 34 biopsias de lesiones compatibles cl&#237;nica e histol&#243;gicamente con poroqueratosis&#46; Se realizaron tinciones con hematoxilina-eosina y tioflavina T en todas ellas&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se detectaron dep&#243;sitos de amiloide en 11 biopsias que pertenec&#237;an a 9 pacientes&#46; La mayor&#237;a eran mujeres en la sexta d&#233;cada de la vida&#44; con la variante de poroqueratosis act&#237;nica superficial diseminada y con un tiempo de evoluci&#243;n superior a 5 a&#241;os&#46; No se encontraron diferencias histol&#243;gicas significativas entre las biopsias de poroqueratosis con amiloide y sin &#233;l&#44; a excepci&#243;n del material an&#243;malo&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La coexistencia de poroqueratosis y amiloidosis es un hecho poco frecuente&#44; posiblemente infradiagnosticado&#46; Consideramos que la edad avanzada y la cronicidad de las lesiones ser&#237;an factores predisponentes&#44; sin poder descartarse una implicaci&#243;n racial o gen&#233;tica&#46;</p>"
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Vol. 99. Issue 8.
Pages 639-643 (October 2008)
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Vol. 99. Issue 8.
Pages 639-643 (October 2008)
Original article
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Localized Cutaneous Amyloidosis Secondary to Porokeratosis: A Retrospective Histopathologic Study of 30 Patients
Amiloidosis Cutánea Localizada Secundaria A Poroqueratosis. Estudio Histopatológico Retrospectivo de 30 Pacientes
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A. Ramírez-Santos
Corresponding author
jaime.toribio@usc.es

Correspondence: Departamento de Dermatología, Facultad de Medicina, C/ San Francisco, s/n 15782 Santiago de Compostela, La Coruña, Spain.
, O. Suárez-Amor, L. Pérez-Pérez, M. Loureiro, C. Peteiro, J. Toribio
Servicio de Dermatología, Facultad de Medicina, Santiago de Compostela, La Coruña, Spain
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Abstract
Introduction

Porokeratosis is a rare disorder of keratinization. The presence of amyloid deposits has been observed in inflammatory and tumoral skin diseases.

Objectives

The aim of this study was to determine the frequency of cutaneous amyloidosis in histology samples from various types of porokeratosis diagnosed in our department from 1988 to 2005.

Material and methods

Thirty patients were selected and 34 biopsies of lesions clinically and histologically compatible with porokeratosis were performed. Sections were stained with hematoxylin-eosin and thioflavin T.

Results

Amyloid deposits were observed in 11 biopsies from 9 patients. Most were women in their sixties, with disseminated superficial actinic porokeratosis that had begun at least 5 years earlier. No notable histologic differences were observed between porokeratosis specimens with and without amyloid deposits.

Conclusions

The coexistence of porokeratosis and amyloidosis is a rare occurrence but may be underdiagnosed. In our opinion, the advanced age of the patients and the chronic nature of the lesions would have been predisposing factors for amyloid deposition. The possibility of racial or genetic influences, however, cannot be ruled out.

Key words:
porokeratosis
amyloid
secondary amyloidosis
Resumen
Introducción

Las poroqueratosis son alteraciones de la queratinización poco frecuentes. La presencia de material amiloide se ha observado en dermatosis de etiología inflamatoria y tumoral.

Objetivos

Determinar la incidencia de amiloidosis cutánea en las muestras histológicas de distintos tipos de poroqueratosis diagnosticados en nuestro servicio entre 1988-2005.

Material y métodos

Se seleccionaron 30 pacientes y se realizaron 34 biopsias de lesiones compatibles clínica e histológicamente con poroqueratosis. Se realizaron tinciones con hematoxilina-eosina y tioflavina T en todas ellas.

Resultados

Se detectaron depósitos de amiloide en 11 biopsias que pertenecían a 9 pacientes. La mayoría eran mujeres en la sexta década de la vida, con la variante de poroqueratosis actínica superficial diseminada y con un tiempo de evolución superior a 5 años. No se encontraron diferencias histológicas significativas entre las biopsias de poroqueratosis con amiloide y sin él, a excepción del material anómalo.

Conclusiones

La coexistencia de poroqueratosis y amiloidosis es un hecho poco frecuente, posiblemente infradiagnosticado. Consideramos que la edad avanzada y la cronicidad de las lesiones serían factores predisponentes, sin poder descartarse una implicación racial o genética.

Palabras clave:
poroqueratosis
amiloide
amiloidosis secundaria
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Copyright © 2008. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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