Original article
Localized Cutaneous Amyloidosis Secondary to Porokeratosis: A Retrospective Histopathologic Study of 30 Patients
Amiloidosis Cutánea Localizada Secundaria A Poroqueratosis. Estudio Histopatológico Retrospectivo de 30 Pacientes
A. Ramírez-Santos
, O. Suárez-Amor, L. Pérez-Pérez, M. Loureiro, C. Peteiro, J. Toribio
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jaime.toribio@usc.es
Correspondence: Departamento de Dermatología, Facultad de Medicina, C/ San Francisco, s/n 15782 Santiago de Compostela, La Coruña, Spain.
Correspondence: Departamento de Dermatología, Facultad de Medicina, C/ San Francisco, s/n 15782 Santiago de Compostela, La Coruña, Spain.
Servicio de Dermatología, Facultad de Medicina, Santiago de Compostela, La Coruña, Spain
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Guiote-Domínguez, A. Muñoz-Hoyos, M.T. Gutiérrez-Salmerón" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M.V." "apellidos" => "Guiote-Domínguez" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Muñoz-Hoyos" ] 2 => array:2 [ "nombre" => "M.T." "apellidos" => "Gutiérrez-Salmerón" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703305?idApp=UINPBA000044" "url" => "/15782190/0000009900000008/v1_201304241439/S1578219008703305/v1_201304241439/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Localized Cutaneous Amyloidosis Secondary to Porokeratosis: A Retrospective Histopathologic Study of 30 Patients" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "639" "paginaFinal" => "643" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Ramírez-Santos, O. Suárez-Amor, L. Pérez-Pérez, M. Loureiro, C. Peteiro, J. Toribio" "autores" => array:6 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Ramírez-Santos" "email" => array:1 [ 0 => "jaime.toribio@usc.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "O." "apellidos" => "Suárez-Amor" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Pérez-Pérez" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Loureiro" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Peteiro" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Toribio" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Facultad de Medicina, Santiago de Compostela, La Coruña, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Departamento de Dermatología, Facultad de Medicina, C/ San Francisco, s/n 15782 Santiago de Compostela, La Coruña, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Amiloidosis Cutánea Localizada Secundaria A Poroqueratosis. Estudio Histopatológico Retrospectivo de 30 Pacientes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-02-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84275" "palabras" => array:3 [ 0 => "porokeratosis" 1 => "amyloid" 2 => "secondary amyloidosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84276" "palabras" => array:3 [ 0 => "poroqueratosis" 1 => "amiloide" 2 => "amiloidosis secundaria" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Porokeratosis is a rare disorder of keratinization. The presence of amyloid deposits has been observed in inflammatory and tumoral skin diseases.</p> <span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to determine the frequency of cutaneous amyloidosis in histology samples from various types of porokeratosis diagnosed in our department from 1988 to 2005.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Thirty patients were selected and 34 biopsies of lesions clinically and histologically compatible with porokeratosis were performed. Sections were stained with hematoxylin-eosin and thioflavin T.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Amyloid deposits were observed in 11 biopsies from 9 patients. Most were women in their sixties, with disseminated superficial actinic porokeratosis that had begun at least 5 years earlier. No notable histologic differences were observed between porokeratosis specimens with and without amyloid deposits.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The coexistence of porokeratosis and amyloidosis is a rare occurrence but may be underdiagnosed. In our opinion, the advanced age of the patients and the chronic nature of the lesions would have been predisposing factors for amyloid deposition. The possibility of racial or genetic influences, however, cannot be ruled out.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Las poroqueratosis son alteraciones de la queratinización poco frecuentes. La presencia de material amiloide se ha observado en dermatosis de etiología inflamatoria y tumoral.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Determinar la incidencia de amiloidosis cutánea en las muestras histológicas de distintos tipos de poroqueratosis diagnosticados en nuestro servicio entre 1988-2005.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron 30 pacientes y se realizaron 34 biopsias de lesiones compatibles clínica e histológicamente con poroqueratosis. Se realizaron tinciones con hematoxilina-eosina y tioflavina T en todas ellas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se detectaron depósitos de amiloide en 11 biopsias que pertenecían a 9 pacientes. La mayoría eran mujeres en la sexta década de la vida, con la variante de poroqueratosis actínica superficial diseminada y con un tiempo de evolución superior a 5 años. No se encontraron diferencias histológicas significativas entre las biopsias de poroqueratosis con amiloide y sin él, a excepción del material anómalo.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La coexistencia de poroqueratosis y amiloidosis es un hecho poco frecuente, posiblemente infradiagnosticado. Consideramos que la edad avanzada y la cronicidad de las lesiones serían factores predisponentes, sin poder descartarse una implicación racial o genética.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 7 | 13 |
| 2024 October | 57 | 43 | 100 |
| 2024 September | 46 | 22 | 68 |
| 2024 August | 80 | 54 | 134 |
| 2024 July | 58 | 33 | 91 |
| 2024 June | 65 | 32 | 97 |
| 2024 May | 57 | 40 | 97 |
| 2024 April | 46 | 34 | 80 |
| 2024 March | 57 | 46 | 103 |
| 2024 February | 48 | 35 | 83 |
| 2024 January | 50 | 47 | 97 |
| 2023 December | 40 | 30 | 70 |
| 2023 November | 45 | 38 | 83 |
| 2023 October | 37 | 33 | 70 |
| 2023 September | 35 | 30 | 65 |
| 2023 August | 27 | 22 | 49 |
| 2023 July | 34 | 73 | 107 |
| 2023 June | 51 | 18 | 69 |
| 2023 May | 51 | 35 | 86 |
| 2023 April | 32 | 27 | 59 |
| 2023 March | 50 | 40 | 90 |
| 2023 February | 24 | 19 | 43 |
| 2023 January | 31 | 25 | 56 |
| 2022 December | 36 | 43 | 79 |
| 2022 November | 12 | 21 | 33 |
| 2022 October | 13 | 18 | 31 |
| 2022 September | 18 | 35 | 53 |
| 2022 August | 20 | 45 | 65 |
| 2022 July | 8 | 25 | 33 |
| 2022 June | 15 | 30 | 45 |
| 2022 May | 24 | 40 | 64 |
| 2022 April | 56 | 59 | 115 |
| 2022 March | 34 | 80 | 114 |
| 2022 February | 30 | 42 | 72 |
| 2022 January | 26 | 43 | 69 |
| 2021 December | 20 | 49 | 69 |
| 2021 November | 43 | 48 | 91 |
| 2021 October | 47 | 52 | 99 |
| 2021 September | 30 | 35 | 65 |
| 2021 August | 33 | 30 | 63 |
| 2021 July | 23 | 29 | 52 |
| 2021 June | 24 | 42 | 66 |
| 2021 May | 37 | 50 | 87 |
| 2021 April | 72 | 33 | 105 |
| 2021 March | 123 | 28 | 151 |
| 2021 February | 59 | 27 | 86 |
| 2021 January | 32 | 24 | 56 |
| 2020 December | 35 | 18 | 53 |
| 2020 November | 19 | 25 | 44 |
| 2020 October | 17 | 11 | 28 |
| 2020 September | 28 | 12 | 40 |
| 2020 August | 30 | 15 | 45 |
| 2020 July | 18 | 8 | 26 |
| 2020 June | 19 | 25 | 44 |
| 2020 May | 27 | 20 | 47 |
| 2020 April | 16 | 21 | 37 |
| 2020 March | 20 | 24 | 44 |
| 2020 February | 1 | 6 | 7 |
| 2020 January | 0 | 8 | 8 |
| 2019 December | 0 | 4 | 4 |
| 2019 November | 0 | 6 | 6 |
| 2019 October | 0 | 2 | 2 |
| 2019 September | 0 | 2 | 2 |
| 2019 August | 0 | 2 | 2 |
| 2019 July | 0 | 10 | 10 |
| 2019 June | 0 | 4 | 4 |
| 2019 May | 2 | 37 | 39 |
| 2019 April | 0 | 1 | 1 |
| 2019 March | 0 | 12 | 12 |
| 2019 February | 3 | 6 | 9 |
| 2019 January | 1 | 0 | 1 |
| 2018 December | 0 | 4 | 4 |
| 2018 November | 2 | 1 | 3 |
| 2018 October | 4 | 0 | 4 |
| 2018 September | 2 | 1 | 3 |
| 2018 August | 0 | 4 | 4 |
| 2018 July | 0 | 1 | 1 |
| 2018 June | 0 | 2 | 2 |
| 2018 May | 0 | 5 | 5 |
| 2018 April | 0 | 1 | 1 |
| 2018 March | 1 | 0 | 1 |
| 2018 February | 11 | 8 | 19 |
| 2018 January | 19 | 9 | 28 |
| 2017 December | 16 | 6 | 22 |
| 2017 November | 14 | 6 | 20 |
| 2017 October | 19 | 4 | 23 |
| 2017 September | 15 | 4 | 19 |
| 2017 August | 25 | 7 | 32 |
| 2017 July | 18 | 3 | 21 |
| 2017 June | 31 | 14 | 45 |
| 2017 May | 31 | 8 | 39 |
| 2017 April | 18 | 15 | 33 |
| 2017 March | 15 | 51 | 66 |
| 2017 February | 18 | 9 | 27 |
| 2017 January | 15 | 9 | 24 |
| 2016 December | 31 | 8 | 39 |
| 2016 November | 26 | 6 | 32 |
| 2016 October | 29 | 16 | 45 |
| 2016 September | 42 | 6 | 48 |
| 2016 August | 28 | 3 | 31 |
| 2016 July | 24 | 5 | 29 |
| 2016 June | 9 | 2 | 11 |
| 2016 May | 9 | 4 | 13 |
| 2016 April | 6 | 4 | 10 |
| 2016 March | 1 | 8 | 9 |
| 2016 February | 6 | 10 | 16 |
| 2016 January | 7 | 10 | 17 |
| 2015 December | 7 | 7 | 14 |
| 2015 November | 10 | 10 | 20 |
| 2015 October | 6 | 1 | 7 |
| 2015 September | 4 | 5 | 9 |
| 2015 August | 8 | 2 | 10 |
| 2015 July | 15 | 7 | 22 |
| 2015 June | 14 | 5 | 19 |
| 2015 May | 47 | 8 | 55 |
| 2015 April | 21 | 12 | 33 |
| 2015 March | 30 | 9 | 39 |
| 2015 February | 21 | 6 | 27 |
| 2015 January | 12 | 8 | 20 |
| 2014 December | 7 | 7 | 14 |
| 2014 November | 25 | 9 | 34 |
| 2014 October | 17 | 9 | 26 |
| 2014 September | 24 | 12 | 36 |
| 2014 August | 31 | 26 | 57 |
| 2014 July | 30 | 22 | 52 |
| 2014 June | 24 | 16 | 40 |
| 2014 May | 29 | 21 | 50 |
| 2014 April | 25 | 11 | 36 |
| 2014 March | 30 | 20 | 50 |
| 2014 February | 22 | 11 | 33 |
| 2014 January | 43 | 13 | 56 |
| 2013 December | 28 | 17 | 45 |
| 2013 November | 21 | 28 | 49 |
| 2013 October | 16 | 20 | 36 |
| 2013 September | 26 | 14 | 40 |
| 2013 August | 23 | 43 | 66 |
| 2013 July | 15 | 30 | 45 |
| 2013 June | 21 | 28 | 49 |
| 2013 May | 23 | 33 | 56 |
| 2013 April | 16 | 36 | 52 |
| 2013 March | 23 | 19 | 42 |
| 2013 February | 23 | 12 | 35 |
| 2013 January | 13 | 5 | 18 |
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