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Vol. 103. Issue 1.
Pages 21-28 (January - February 2012)
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Vol. 103. Issue 1.
Pages 21-28 (January - February 2012)
Controversies in Dermatology
DOI: 10.1016/j.adengl.2011.05.004
Lichen Sclerosus and Squamous Cell Carcinoma
Liquen escleroso y carcinoma escamoso
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M. Gutiérrez-Pascual??
Corresponding author
mgutierrezpas@hotmail.com

Corresponding author.
, F.J. Vicente-Martín, J.L. López-Estebaranz
Servicio de Dermatología, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain
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Table 1. Published Cases of Verrucous Carcinoma (VC) Associated With Genital Lichen Sclerosus (LS).
Abstract

Lichen sclerosus is a chronic inflammatory disease that can progress to malignancy. The literature indicates an association with anogenital squamous cell carcinoma and verrucous carcinoma. Two pathogenic pathways, differentiated vulvar and penile intraepithelial neoplasias, which have recently been described in relation to squamous cell carcinoma, are both highly associated with genital lichen sclerosus independently of human papilloma virus (HPV) infection. Furthermore, tumor-promoting molecular changes unrelated to HPV infection have been demonstrated and may explain the malignant potential of lichen sclerosus. The possible relationship between HPV and genital lichen sclerosus currently remains open to discussion, and the prognostic importance of the overlapping of these 2 diseases is still unclear. This review considers the relationship between lichen sclerosus and squamous cell and verrucous carcinomas, the possible oncogenic mechanisms involved, and their possible association with HPV infection.

Keywords:
Lichen sclerosus
Squamous cell carcinoma
Verrucous carcinoma
Human papilloma virus
Vulvar intraepithelial neoplasia
Penile intraepithelial neoplasia
Resumen

El liquen escleroso (LE) es una enfermedad inflamatoria crónica con un potencial maligno conocido. En la literatura se recogen datos de su asociación tanto con el carcinoma epidermoide (CE) como con el carcinoma verrucoso de localización anogenital. Recientemente se han descrito dos modalidades de neoplasias intraepiteliales de vulva y pene, el Vulva Intraepithelial Neoplasia (Neoplasia Intraepitelial Vulvar [VIN]) y el Penile Intraepithelial Neoplasia (Neoplasia Intraepitelial de Pene [PIN]) diferenciados, relacionadas con el CE genital. Ambas son entidades altamente ligadas al LE genital e independientes de la infección por el virus del papiloma humano (VPH). Además, se han demostrado alteraciones moleculares oncogénicas independientes de la infección por VPH que podrían explicar el potencial maligno del LE por sí mismo. La posible relación entre el VPH y el LE genital sigue siendo un tema controvertido en el momento actual, y se desconoce la implicación pronóstica cuando coexisten ambas entidades. En el presente artículo revisaremos la relación del LE con el carcinoma epidermoide y el carcinoma verrucoso, los mecanismos oncogénicos implicados, así como su posible asociación con el VPH.

Palabras clave:
Liquen escleroso
Carcinoma epidermoide
Carcinoma verrucoso
Virus del papiloma humano
Neoplasia Intraepitelial Vulvar diferenciado
Neoplasia Intraepitelial de Pene diferenciado

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